Abstract: Chikungunya virus (CHICKV) is an arboviruses belonging to family Tagoviridae and is transmitted to human through by mosquito (Aedes aegypti and Aedes albopictus) bite. A large outbreak of chikungunya has been reported in India between 2006 and 2007, along with several other countries from South-East Asia and for the first time in Europe. It was for the first time that the CHICKV outbreak has been reported with mortality from Reunion Island and increased mortality from Asian countries. CHICKV affects all age groups, and currently there are no specific drugs or vaccine to cure the disease. The need of antiviral agents for the treatment of CHICKV infection and the success of virtual screening against many therapeutically valuable targets led us to carry out the structure based drug design against Chikungunya nSP2 protease (PDB: 3TRK). Highthroughput virtual screening of publicly available databases, ZINC12 and BindingDB, has been carried out using the Openeye tools and Schrodinger LLC software packages. Openeye Filter program has been used to filter the database and the filtered outputs were docked using HTVS protocol implemented in GLIDE package of Schrodinger LLC. The top HITS were further used for enriching the similar molecules from the database through vROCS; a shape based screening protocol implemented in Openeye. The approach adopted has provided different scaffolds as HITS against CHICKV protease. Three scaffolds: Indole, Pyrazole and Sulphone derivatives were selected based on the docking score and synthetic feasibility. Derivatives of Pyrazole were synthesized and submitted for antiviral screening against CHICKV.
Abstract: In this paper, we propose a routing scheme that guarantees
the residual lifetime of wireless sensor networks where each
sensor node operates with a limited budget of battery energy. The
scheme maximizes the communications QoS while sustaining the
residual battery lifetime of the network for a specified duration.
Communication paths of wireless nodes are translated into a directed
acyclic graph(DAG) and the maximum-flow algorithm is applied to
the graph. The found maximum flow are assigned to sender nodes, so
as to maximize their communication QoS. Based on assigned flows,
the scheme determines the routing path and the transmission rate of
data packet so that any sensor node on the path would not exhaust
its battery energy before a specified duration.
Abstract: Pre-germinated parboiled brown rice or Khao hang (in Thai) is paddy which undergoing the processes of soaking, steaming, drying and dehusking to obtain the edible form for consumption. The objectives of this research were to study the kinetic of pre-germinated parboiled brown rice drying using fluidization technique and to study the properties of pre-germinated parboiled brown rice after drying. The dryings were performed at the different temperatures of 110, 120 and 130 oC at the bed depth of 2 cm with the air velocity of 1.98 m/s. The results found that the higher drying temperature led to the faster moisture reduction. After drying until the moisture content of pre-germinated parboiled brown rice was lower than 14%wet basis, samples were taken to determine various qualities such as percentage of head rice and L* a* b* color values. The shade drying was used as a control. The results found that the higher drying temperature resulted in the decrease of head rice percentage. For the color assessment, the trend of L* and a* values was increased with the drying temperature, while the b* value was not significantly difference (p › 0.05) by drying temperatures. However, the b value of drying by fluidized bed dryer was higher than the control.
Abstract: In Geographic Information System, one of the sources
of obtaining needed geographic data is digitizing analog maps and
evaluation of aerial and satellite photos. In this study, a method will
be discussed which can be used to extract vectorial features and
creating vectorized drawing files for aerial photos. At the same time
a software developed for these purpose. Converting from raster to
vector is also known as vectorization and it is the most important step
when creating vectorized drawing files. In the developed algorithm,
first of all preprocessing on the aerial photo is done. These are;
converting to grayscale if necessary, reducing noise, applying some
filters and determining the edge of the objects etc. After these steps,
every pixel which constitutes the photo are followed from upper left
to right bottom by examining its neighborhood relationship and one
pixel wide lines or polylines obtained. The obtained lines have to be
erased for preventing confusion while continuing vectorization
because if not erased they can be perceived as new line, but if erased
it can cause discontinuity in vector drawing so the image converted
from 2 bit to 8 bit and the detected pixels are expressed as a different
bit. In conclusion, the aerial photo can be converted to vector form
which includes lines and polylines and can be opened in any CAD
application.
Abstract: Lately management strategy that put Industrial Design (ID) in its core is recognized more important, as technology and price alone cannot differentiate a product. The needs to shorten the time to develop a product also shorten the development period of ID, and it necessitates the ID process management. This research analyzes the status of integration process of ID and Engineering Design (ED) of office equipment that requires the collaboration of ID and ED to clarify the issues for the efficiency of the development and to propose solutions.
Abstract: So much energy is used in high rise buildings to fulfill
the basic needs of users such as lighting and thermal comfort.
Malaysia has hot and humid climate, buildings especially high rise
buildings receive unnecessary solar radiation that cause more solar
heat gain. Energy use specially electricity consumption in high rise
buildings has increased. There have been growing concerns about
energy consumption and its effect on environment. Building, energy
and the environment are important issues that the designers should
consider to them. Self protected form is one of possible ways against
the impact of solar radiation in high rise buildings. The Energy
performance of building envelopes was investigated in term of the
Overall Thermal Transfer Value (OTTV ).In this paper, the amount
of OTTV reduction was calculated through OTTV Equations to
clear the effectiveness of self shading strategy on minimizing energy
consumption for cooling interior spaces in high rise buildings which
has considerable envelope areas against solar radiation. Also increasing
the optimum window area was investigated using self-shading
strategy in designing high rise buildings. As result, the significant
reduction in OTTV was shown based on WWR.In addition slight
increase was demonstrated in WWR that can influence on visible
comfort interior spaces.
Abstract: With the advance of multimedia and diagnostic
images technologies, the number of radiographic images is increasing
constantly. The medical field demands sophisticated systems for
search and retrieval of the produced multimedia document. This
paper presents an ongoing research that focuses on the semantic
content of radiographic image documents to facilitate semantic-based
radiographic image indexing and a retrieval system. The proposed
model would divide a radiographic image document, based on its
semantic content, and would be converted into a logical structure or
a semantic structure. The logical structure represents the overall
organization of information. The semantic structure, which is bound
to logical structure, is composed of semantic objects with
interrelationships in the various spaces in the radiographic image.
Abstract: An effort has been taken to simulate the combustion
and performance characteristics of biodiesel fuel in direct injection
(D.I) low heat rejection (LHR) diesel engine. Comprehensive
analyses on combustion characteristics such as cylinder pressure,
peak cylinder pressure, heat release and performance characteristics
such as specific fuel consumption and brake thermal efficiency are
carried out. Compression ignition (C.I) engine cycle simulation was
developed and modified in to LHR engine for both diesel and
biodiesel fuel. On the basis of first law of thermodynamics the
properties at each degree crank angle was calculated. Preparation and
reaction rate model was used to calculate the instantaneous heat
release rate. A gas-wall heat transfer calculations are based on the
ANNAND-s combined heat transfer model with instantaneous wall
temperature to analyze the effect of coating on heat transfer. The
simulated results are validated by conducting the experiments on the
test engine under identical operating condition on a turbocharged D.I
diesel engine. In this analysis 20% of biodiesel (derived from
Jatropha oil) blended with diesel and used in both conventional and
LHR engine. The simulated combustion and performance
characteristics results are found satisfactory with the experimental
value.
Abstract: A numerical study of flow in a horizontally channel
partially filled with a porous screen with non-uniform inlet has been
performed by lattice Boltzmann method (LBM). The flow in porous
layer has been simulated by the Brinkman-Forchheimer model.
Numerical solutions have been obtained for variable porosity models
and the effects of Darcy number and porosity have been studied in
detail. It is found that the flow stabilization is reliant on the Darcy
number. Also the results show that the stabilization of flow field and
heat transfer is depended to Darcy number. Distribution of stream
field becomes more stable by decreasing Darcy number. Results
illustrate that the effect of variable porosity is significant just in the
region of the solid boundary. In addition, difference between constant
and variable porosity models is decreased by decreasing the Darcy
number.
Abstract: Numerical parametric study is conducted to study the effects of ampoule rotation on the flows and the dopant segregation in vertical bridgman (vb) crystal growth. Calculations were performed in unsteady state. The extended darcy model, which includes the time derivative and coriolis terms, has been employed in the momentum equation. It’s found that the convection, and dopant segregation can be affected significantly by ampoule rotation, and the effect is similar to that by an axial magnetic field. Ampoule rotation decreases the intensity of convection and stretches the flow cell axially. When the convection is weak, the flow can be suppressed almost completely by moderate ampoule rotation and the dopant segregation becomes diffusion-controlled. For stronger convection, the elongated flow cell by ampoule rotation may bring dopant mixing into the bulk melt reducing axial segregation at the early stage of the growth. However, if the cellular flow cannot be suppressed completely, ampoule rotation may induce larger radial segregation due to poor mixing.
Abstract: One of the most important parameters to develop and
manage urban areas is appropriate selection of land surface to
develop green spaces in these areas. In this study, in order to identify
the most appropriate sites and areas cultivated for ornamental species
in Jiroft, Landsat Enhanced Thematic Mapper Plus (ETM+) images
due to extract the most important effective climatic and adaphic
parameters for growth ornamental species were used. After geometric
and atmospheric corrections applied, to enhance accuracy of multi
spectral (XS) bands, the fusion of Landsat XS bands by IRS-1D
panchromatic band (PAN) was performed. After field sampling to
evaluate the correlation between different factors in surface soil
sampling location and different bands digital number (DN) of ETM+
sensor on the same points, correlation tables formed using the best
computational model and the map of physical and chemical
parameters of soil was produced. Then the accuracy of them was
investigated by using kappa coefficient. Finally, according to
produced maps, the best areas for cultivation of recommended
species were introduced.
Abstract: Until recently, researchers have developed various
tools and methodologies for effective clinical decision-making.
Among those decisions, chest pain diseases have been one of
important diagnostic issues especially in an emergency department. To
improve the ability of physicians in diagnosis, many researchers have
developed diagnosis intelligence by using machine learning and data
mining. However, most of the conventional methodologies have been
generally based on a single classifier for disease classification and
prediction, which shows moderate performance. This study utilizes an
ensemble strategy to combine multiple different classifiers to help
physicians diagnose chest pain diseases more accurately than ever.
Specifically the ensemble strategy is applied by using the integration
of decision trees, neural networks, and support vector machines. The
ensemble models are applied to real-world emergency data. This study
shows that the performance of the ensemble models is superior to each
of single classifiers.
Abstract: In this paper as showed a non-invasive 3D eye tracker
for optometry clinical applications. Measurements of biomechanical
variables in clinical practice have many font of errors associated with
traditional procedments such cover test (CT), near point of
accommodation (NPC), eye ductions (ED), eye vergences (EG) and,
eye versions (ES). Ocular motility should always be tested but all
evaluations have a subjective interpretations by practitioners, the
results is based in clinical experiences, repeatability and accuracy
don-t exist. Optometric-lab is a tool with 3 (tree) analogical video
cameras triggered and synchronized in one acquisition board AD.
The variables globe rotation angle and velocity can be quantified.
Data record frequency was performed with 27Hz, camera calibration
was performed in a know volume and image radial distortion
adjustments.
Abstract: Alkali Activated Slag Concrete (AASC) mixes are manufactured by activating ground granulated blast furnace slag (GGBFS) using sodium hydroxide and sodium silicate solutions. The aim of the present experimental research was to investigate the effect of increasing the dosages of sodium oxide (Na2O, in the range of 4 to 8%) and the activator modulus (Ms) (i.e. the SiO2/Na2O ratio, in the range of 0.5 to 1.5) of the alkaline solutions, on the workability and strength characteristics of self-cured (air-cured) alkali activated Indian slag concrete mixes. Further the split tensile and flexure strengths for optimal mixes were studied for each dosage of Na2O.It is observed that increase in Na2O concentration increases the compressive, split-tensile and flexural strengths, both at the early and later-ages, while increase in Ms, decreases the workability of the mixes. An optimal Ms of 1.25 is found at various Na2O dosages. No significant differences in the strength performances were observed between AASCs manufactured with alkali solutions prepared using either of potable and de-ionized water.
Abstract: Green Roofs offers numerous advantages, including lowering ambient temperature, which is of increasing interest due to global warming concerns. However, there are technical problems pertaining to waterproofing to be resolved. Currently, the only recognized green roof waterproofing test is the German standard FLL. This paper examines the potential of replicating the test in tropical climate and reducing the test duration by using pre-grown plants. A three year old sample and a new setup were used for this experimental study. The new setup was prepared with close reference to the FLL standards and was compared against the three year old sample. Results showed that the waterproofing membrane was damaged by plant roots in both setups. Joints integrity was also challenged.
Abstract: Industrial robots play a vital role in automation
however only little effort are taken for the application of robots in
machining work such as Grinding, Cutting, Milling, Drilling,
Polishing etc. Robot parallel manipulators have high stiffness,
rigidity and accuracy, which cannot be provided by conventional
serial robot manipulators. The aim of this paper is to perform the
modeling and the workspace analysis of a 3 DOF Parallel
Manipulator (3 DOF PM). The 3 DOF PM was modeled and
simulated using 'ADAMS'. The concept involved is based on the
transformation of motion from a screw joint to a spherical joint
through a connecting link. This paper work has been planned to
model the Parallel Manipulator (PM) using screw joints for very
accurate positioning. A workspace analysis has been done for the
determination of work volume of the 3 DOF PM. The position of the
spherical joints connected to the moving platform and the
circumferential points of the moving platform were considered for
finding the workspace. After the simulation, the position of the joints
of the moving platform was noted with respect to simulation time and
these points were given as input to the 'MATLAB' for getting the
work envelope. Then 'AUTOCAD' is used for determining the work
volume. The obtained values were compared with analytical
approach by using Pappus-Guldinus Theorem. The analysis had been
dealt by considering the parameters, link length and radius of the
moving platform. From the results it is found that the radius of
moving platform is directly proportional to the work volume for a
constant link length and the link length is also directly proportional
to the work volume, at a constant radius of the moving platform.
Abstract: The influence of lactulose and inulin on rheological
properties of fermented milk during storage was studied.Pasteurized
milk, freeze-dried starter culture Bb-12 (Bifidobacterium lactis, Chr.
Hansen, Denmark), inulin – RAFTILINE®HP (ORAFI, Belgium) and
syrup of lactulose (Duphalac®, the Netherlands) were used for
experiments. The fermentation process was realized at 37 oC for 16
hours and the storage of products was provided at 4 oC for 7 days.
Measurements were carried out by BROOKFIELD standard methods
and the flow curves were described by Herschel-Bulkley model.
The results of dispersion analysis have shown that both the
concentration of prebiotics (p=0.04
Abstract: Optimum communication and performance in
Wireless Sensor Networks, constitute multi-facet challenges due to
the specific networking characteristics as well as the scarce resource
availability. Furthermore, it is becoming increasingly apparent that
isolated layer based approaches often do not meet the demands posed
by WSNs applications due to omission of critical inter-layer
interactions and dependencies. As a counterpart, cross-layer is
receiving high interest aiming to exploit these interactions and
increase network performance. However, in order to clearly identify
existing dependencies, comprehensive performance studies are
required evaluating the effect of different critical network parameters
on system level performance and behavior.This paper-s main
objective is to address the need for multi-parametric performance
evaluations considering critical network parameters using a well
known network simulator, offering useful and practical conclusions
and guidelines. The results reveal strong dependencies among
considered parameters which can be utilized by and drive future
research efforts, towards designing and implementing highly efficient
protocols and architectures.
Abstract: Occurrences of spurious crests on the troughs of large,
relatively steep second-order Stokes waves are anomalous and not an
inherent characteristic of real waves. Here, the effects of such
occurrences on the statistics described by the standard second-order
stochastic model are examined theoretically and by way of
simulations. Theoretical results and simulations indicate that when
spurious occurrences are sufficiently large, the standard model leads
to physically unrealistic surface features and inaccuracies in the
statistics of various surface features, in particular, the troughs and
thus zero-crossing heights of large waves. Whereas inaccuracies can
be fairly noticeable for long-crested waves in both deep and
shallower depths, they tend to become relatively insignificant in
directional waves.
Abstract: Artificial Immune System (AIS) is relatively naive paradigm for intelligent computations. The inspiration for AIS is derived from natural Immune System (IS). Classically it is believed that IS strives to discriminate between self and non-self. Most of the existing AIS research is based on this approach. Danger Theory (DT) argues this approach and proposes that IS fights against danger producing elements and tolerates others. We, the computational researchers, are not concerned with the arguments among immunologists but try to extract from it novel abstractions for intelligent computation. This paper aims to follow DT inspiration for intelligent data processing. The approach may introduce new avenue in intelligent processing. The data used is system calls data that is potentially significant in intrusion detection applications.