Abstract: Candida spp. are common and aggressive pathogens.
Because of the growing resistance of Candida spp. to current
antifungals, novel targets, found in Candida spp. but not in humans
or other flora, have to be identified. The alternative oxidase (AOX)
is one such possibility. This enzyme is insensitive to cyanide, but is
sensitive to compounds such as salicylhydroxamic acid (SHAM),
disulfiram and n-alkyl gallates. The growth Candida albicans was
inhibited by SHAM (Ki = 9-15 mM) and cyanide (Ki = 2-4 mM),
albeit to differing extents. The rate of O2 uptake was inhibited by
less than 10% by 25 mM SHAM and by about 90% by 250 μM
KCN. Although SHAM substantially inhibited the growth of C.
albicans, it is unlikely that the inhibition of AOX was the cause.
Salicylhydroxamic acid is used therapeutically in the treatment of
urinary tract infections and urolithiasis, but it also has some potential
in the treatment of C. albicans infection.
Abstract: Cooktop burners are widely used nowadays. In
cooktop burner design, nozzle efficiency and greenhouse
gas(GHG) emissions mainly depend on heat transfer from the
premixed flame to the impinging surface. This is a complicated
issue depending on the individual and combined effects of various
input combustion variables. Optimal operating conditions for
sustainable burner design were rarely addressed, especially in the
case of multiple slot-jet burners. Through evaluating the optimal
combination of combustion conditions for a premixed slot-jet
array, this paper develops a practical approach for the sustainable
design of gas cooktop burners. Efficiency, CO and NOx emissions
in respect of an array of slot jets using premixed flames were
analysed. Response surface experimental design were applied to
three controllable factors of the combustion process, viz.
Reynolds number, equivalence ratio and jet-to-vessel distance.
Desirability Function Approach(DFA) is the analytic technique
used for the simultaneous optimization of the efficiency and
emission responses.
Abstract: The present work is concerned with the effect of turning process parameters (cutting speed, feed rate, and depth of cut) and distance from the center of work piece as input variables on the chip micro-hardness as response or output. Three experiments were conducted; they were used to investigate the chip micro-hardness behavior at diameter of work piece for 30[mm], 40[mm], and 50[mm]. Response surface methodology (R.S.M) is used to determine and present the cause and effect of the relationship between true mean response and input control variables influencing the response as a two or three dimensional hyper surface. R.S.M has been used for designing a three factor with five level central composite rotatable factors design in order to construct statistical models capable of accurate prediction of responses. The results obtained showed that the application of R.S.M can predict the effect of machining parameters on chip micro-hardness. The five level factorial designs can be employed easily for developing statistical models to predict chip micro-hardness by controllable machining parameters. Results obtained showed that the combined effect of cutting speed at it?s lower level, feed rate and depth of cut at their higher values, and larger work piece diameter can result increasing chi micro-hardness.
Abstract: This paper describes the shape optimization of impeller
blades for a anti-heeling bidirectional axial flow pump used in ships.
In general, a bidirectional axial pump has an efficiency much lower
than the classical unidirectional pump because of the symmetry of the
blade type. In this paper, by focusing on a pump impeller, the shape of
blades is redesigned to reach a higher efficiency in a bidirectional axial
pump. The commercial code employed in this simulation is CFX v.13.
CFD result of pump torque, head, and hydraulic efficiency was
compared. The orthogonal array (OA) and analysis of variance
(ANOVA) techniques and surrogate model based optimization using
orthogonal polynomial, are employed to determine the main effects
and their optimal design variables. According to the optimal design,
we confirm an effective design variable in impeller blades and explain
the optimal solution, the usefulness for satisfying the constraints of
pump torque and head.
Abstract: Chemical detection is still a continuous challenge when
it comes to designing single-walled carbon nanotube (SWCNT)
sensors with high selectivity, especially in complex chemical
environments. A perfect example of such an environment would be in
thermally oxidized soybean oil. At elevated temperatures, oil oxidizes
through a series of chemical reactions which results in the formation of
monoacylglycerols, diacylglycerols, oxidized triacylglycerols, dimers,
trimers, polymers, free fatty acids, ketones, aldehydes, alcohols,
esters, and other minor products. In order to detect the rancidity of
oxidized soybean oil, carbon nanotube chemiresistor sensors have
been coated with polyethylenimine (PEI) to enhance the sensitivity
and selectivity. PEI functionalized SWCNTs are known to have a high
selectivity towards strong electron withdrawing molecules. The
sensors were very responsive to different oil oxidation levels and
furthermore, displayed a rapid recovery in ambient air without the
need of heating or UV exposure.
Abstract: This research studied the appropriate factors and conditions for laminated bamboo bending by Design of Experiments (DOE). The interested factors affecting the spring back in laminates bamboo were (1) time, (2) thickness, and (3) frequency. This experiment tested the specimen by using high frequency machine and measured its spring back immediately and next 24 hours for comparing the spring back ratio. Results from the experiments showed that significant factors having major influence to bending of laminates bamboo were thickness and frequency. The appropriate conditions of thickness and frequency were 4 mm. and 1.5 respectively.
Abstract: This paper proposed a nonlinear model predictive
control (MPC) method for the control of gantry crane. One of the main
motivations to apply MPC to control gantry crane is based on its
ability to handle control constraints for multivariable systems. A
pre-compensator is constructed to compensate the input nonlinearity
(nonsymmetric dead zone with saturation) by using its inverse
function. By well tuning the weighting function matrices, the control
system can properly compromise the control between crane position
and swing angle. The proposed control algorithm was implemented for
the control of gantry crane system in System Control Lab of University
of Technology, Sydney (UTS), and achieved desired experimental
results.
Abstract: Serious games have proven to be a useful instrument
to engage learners and increase motivation. Nevertheless, a broadly
accepted, practical instructional design approach to serious games
does not exist. In this paper, we introduce the use of an instructional
design model that has not been applied to serious games yet, and has
some advantages compared to other design approaches. We present
the case of mechanics mechatronics education to illustrate the close
match with timing and role of knowledge and information that the
instructional design model prescribes and how this has been
translated to a rigidly structured game design. The structured
approach answers the learning needs of applicable knowledge within
the target group. It combines advantages of simulations with
strengths of entertainment games to foster learner-s motivation in the
best possible way. A prototype of the game will be evaluated along a
well-respected evaluation method within an advanced test setting
including test and control group.
Abstract: In this study, inhibition of Microcystis aeruginosa by
antialgal alleochemical gramine, was studied by analyzing algal
metabolic activity (represented by esterase and total dehydrogenase
activities) and cell ultrastructure (showing morphological and
ultrastructure alterations using transmission electron microscopy and
DNA ladder analysis). After gramine exposure, esterase and total
dehydrogenase activities were increased firstly but decreased later. In
contrast with the controls, the cells exposed to gramine showed
apparent ultrastructure alterations with thylakoids in breakage,
phycobilins in decrease, lipid and cyanophycin granules abundant
firstly but dissolved afterwards, DNA in fragementation. The
occurrence of increase of metabolic activity and specific granules
reflected that the resistance of cellular response to gramine was
initiated. DNA fragementation associated with the increase of
metabolic activity and specific granules hinted that gramine caused M.
aeruginosa cells to initiate some morphotype of programmed cell
death.
Abstract: This paper investigates the effectiveness of the use of
seismic isolation devices on the overall 3D seismic response of
curved highway viaducts with an emphasis on expansion joints.
Furthermore, an evaluation of the effectiveness of the use of cable
restrainers is presented. For this purpose, the bridge seismic
performance has been evaluated on four different radii of curvature,
considering two cases: restrained and unrestrained curved viaducts.
Depending on the radius of curvature, three-dimensional non-linear
dynamic analysis shows the vulnerability of curved viaducts to
pounding and deck unseating damage. In this study, the efficiency of
using LRB supports combined with cable restrainers on curved
viaducts is demonstrated, not only by reducing in all cases the
possible damage, but also by providing a similar behavior in the
viaducts despite of curvature radius.
Abstract: Bioprocesses are appreciated as difficult to control because their dynamic behavior is highly nonlinear and time varying, in particular, when they are operating in fed batch mode. The research objective of this study was to develop an appropriate control method for a complex bioprocess and to implement it on a laboratory plant. Hence, an intelligent control structure has been designed in order to produce biomass and to maximize the specific growth rate.
Abstract: Traditional multivariate control charts assume that measurement from manufacturing processes follows a multivariate normal distribution. However, this assumption may not hold or may be difficult to verify because not all the measurement from manufacturing processes are normal distributed in practice. This study develops a new multivariate control chart for monitoring the processes with non-normal data. We propose a mechanism based on integrating the one-class classification method and the adaptive technique. The adaptive technique is used to improve the sensitivity to small shift on one-class classification in statistical process control. In addition, this design provides an easy way to allocate the value of type I error so it is easier to be implemented. Finally, the simulation study and the real data from industry are used to demonstrate the effectiveness of the propose control charts.
Abstract: The study and development of an innovative material
for building insulation is really important for a sustainable society in order to improve comfort and reducing energy consumption. The aim of this work is the development of insulating panels for
sustainable buildings based on an innovative material made by
cardboard and Phase Change Materials (PCMs).
The research has consisted in laboratory tests whose purpose has been the obtaining of the required properties for insulation panels: lightweight, porous structures and mechanical resistance. PCMs have been used for many years in the building industry as
smart insulation technology because of their properties of storage and release high quantity of latent heat at useful specific temperatures [1]- [2].
The integration of PCMs into cellulose matrix during the waste paper recycling process has been developed in order to obtain a
composite material.
Experiments on the productive process for the realization of insulating panels were done in order to make the new material
suitable for building application. The addition of rising agents
demonstrated the possibility to obtain a lighter structure with better
insulation properties.
Several tests were conducted to verify the new panel properties. The results obtained have shown the possibility to realize an
innovative and sustainable material suitable to replace insulating panels currently used.
Abstract: In two studies we tested the hypothesis that the
appropriate linguistic formulation of a deontic rule – i.e. the
formulation which clarifies the monadic nature of deontic operators
- should produce more correct responses than the conditional
formulation in Wason selection task. We tested this assumption by
presenting a prescription rule and a prohibition rule in conditional
vs. proper deontic formulation. We contrasted this hypothesis with
two other hypotheses derived from social contract theory and
relevance theory. According to the first theory, a deontic rule
expressed in terms of cost-benefit should elicit a cheater detection
module, sensible to mental states attributions and thus able to
discriminate intentional rule violations from accidental rule
violations. We tested this prevision by distinguishing the two types
of violations. According to relevance theory, performance in
selection task should improve by increasing cognitive effect and
decreasing cognitive effort. We tested this prevision by focusing
experimental instructions on the rule vs. the action covered by the
rule. In study 1, in which 480 undergraduates participated, we
tested these predictions through a 2 x 2 x 2 x 2 (type of the rule x
rule formulation x type of violation x experimental instructions)
between-subjects design. In study 2 – carried out by means of a 2 x
2 (rule formulation x type of violation) between-subjects design -
we retested the hypothesis of rule formulation vs. the cheaterdetection
hypothesis through a new version of selection task in
which intentional vs. accidental rule violations were better
discriminated. 240 undergraduates participated in this study.
Results corroborate our hypothesis and challenge the contrasting
assumptions. However, they show that the conditional formulation
of deontic rules produces a lower performance than what is
reported in literature.
Abstract: Nowadays, the earth is countered with serious problem
of air pollution. This problem has been started from the industrial
revolution and has been faster in recent years, so that leads the earth
to ecological and environmental disaster. One of its results is the
global warming problem and its related increase in global
temperature. The most important factors in air pollution especially in
urban environments are Automobiles and residential buildings that are
the biggest consumers of the fossil energies, so that if the residential
buildings as a big part of the consumers of such energies reduce their
consumption rate, the air pollution will be decreased. Since
Metropolises are the main centers of air pollution in the world,
assessment and analysis of efficient strategies in decreasing air
pollution in such cities, can lead to the desirable and suitable results
and can solve the problem at least in critical level. Tabriz city is one
of the most important metropolises in North west of Iran that about
two million people are living there. for its situation in cold dry
climate, has a high rate of fossil energies consumption that make air
pollution in its urban environment. These two factors, being both
metropolis and in cold dry climate, make this article try to analyze the
strategies of climatic design in old districts of the city and use them in
new districts of the future. These strategies can be used in this city
and other similar cities and pave the way to reduce energy
consumption and related air pollution to save whole world.
Abstract: This paper proposes a novel solution for optimizing
the size and communication overhead of a distributed multiagent
system without compromising the performance. The proposed approach
addresses the challenges of scalability especially when the
multiagent system is large. A modified spectral clustering technique
is used to partition a large network into logically related clusters.
Agents are assigned to monitor dedicated clusters rather than monitor
each device or node. The proposed scalable multiagent system is
implemented using JADE (Java Agent Development Environment)
for a large power system. The performance of the proposed topologyindependent
decentralized multiagent system and the scalable multiagent
system is compared by comprehensively simulating different
fault scenarios. The time taken for reconfiguration, the overall computational
complexity, and the communication overhead incurred are
computed. The results of these simulations show that the proposed
scalable multiagent system uses fewer agents efficiently, makes faster
decisions to reconfigure when a fault occurs, and incurs significantly
less communication overhead.
Abstract: Speed sensorless systems are intensively studied during recent years; this is mainly due to their economical benefit and fragility of mechanical sensors and also the difficulty of installing this type of sensor in many applications. These systems suffer from instability problems and sensitivity to parameter mismatch at low speed operation. In this paper an analysis of adaptive observer stability with stator resistance estimation is given.
Abstract: This paper presents the results of an analytical study
on the seismic response of a Multi-Span-Simply-Supported precast
bridge in Washington State. The bridge was built in the early 1960's
along Interstate 5 and was widened the first time in 1979 and the
second time in 2001. The primary objective of this research project
is to determine the seismic vulnerability of the bridge in order to
develop the required retrofit measure. The seismic vulnerability of
the bridge is evaluated using two seismic evaluation methods
presented in the FHWA Seismic Retrofitting Manual for Highway
Bridges, Method C and Method D2. The results of the seismic
analyses demonstrate that Method C and Method D2 vary markedly
in terms of the information they provide to the bridge designer
regarding the vulnerability of the bridge columns.
Abstract: One of the main processes of supply chain
management is supplier selection process which its accurate
implementation can dramatically increase company competitiveness.
In presented article model developed based on the features of
second tiers suppliers and four scenarios are predicted in order to
help the decision maker (DM) in making up his/her mind. In addition
two tiers of suppliers have been considered as a chain of suppliers.
Then the proposed approach is solved by a method combined of
concepts of fuzzy set theory (FST) and linear programming (LP)
which has been nourished by real data extracted from an engineering
design and supplying parts company. At the end results reveal the
high importance of considering second tier suppliers features as
criteria for selecting the best supplier.
Abstract: The present work demonstrates the design and simulation of a fuzzy control of an air conditioning system at different pressures. The first order Sugeno fuzzy inference system is utilized to model the system and create the controller. In addition, an estimation of the heat transfer rate and water mass flow rate injection into or withdraw from the air conditioning system is determined by the fuzzy IF-THEN rules. The approach starts by generating the input/output data. Then, the subtractive clustering algorithm along with least square estimation (LSE) generates the fuzzy rules that describe the relationship between input/output data. The fuzzy rules are tuned by Adaptive Neuro-Fuzzy Inference System (ANFIS). The results show that when the pressure increases the amount of water flow rate and heat transfer rate decrease within the lower ranges of inlet dry bulb temperatures. On the other hand, and as pressure increases the amount of water flow rate and heat transfer rate increases within the higher ranges of inlet dry bulb temperatures. The inflection in the pressure effect trend occurs at lower temperatures as the inlet air humidity increases.