Abstract: Bacterial molecular chaperone DnaK plays an essential role in protein folding, stress response and transmembrane targeting of proteins. DnaKs from many bacterial species, including Escherichia coli, Salmonella typhimurium and Haemophilus infleunzae are the molecular targets for the insect-derived antimicrobial peptide pyrrhocoricin. Pyrrhocoricin-like peptides bind in the substrate recognition tunnel. Despite the high degree of crossspecies sequence conservation in the substrate-binding tunnel, some bacteria are not sensitive to pyrrhocoricin. This work addresses the molecular mechanism of resistance of Helicobacter pylori DnaK to pyrrhocoricin. Homology modelling, structural and sequence analysis identify a single aminoacid substitution at the interface between the lid and the β-sandwich subdomains of the DnaK substrate-binding domain as the major determinant for its resistance.
Abstract: In this paper, the structural genetic algorithm is used to optimize the neural network to control the joint movements of robotic arm. The robotic arm has also been modeled in 3D and simulated in real-time in MATLAB. It is found that Neural Networks provide a simple and effective way to control the robot tasks. Computer simulation examples are given to illustrate the significance of this method. By combining Genetic Algorithm optimization method and Neural Networks for the given robotic arm with 5 D.O.F. the obtained the results shown that the base joint movements overshooting time without controller was about 0.5 seconds, while with Neural Network controller (optimized with Genetic Algorithm) was about 0.2 seconds, and the population size of 150 gave best results.
Abstract: A strategy is implemented to find the improved configuration design of an existing aircraft structure by executing topology and shape optimizations. Structural analysis of the Initial Design Space is performed in ANSYS under the loads pertinent to operating and ground conditions. By using the FEA results and data, an initial optimized layout configuration is attained by exploiting nonparametric topology optimization in TOSCA software. Topological optimized surfaces are then smoothened and imported in ANSYS to develop the geometrical features. Nodes at the critical locations of resulting voids are selected for sketching rough profiles. Rough profiles are further refined and CAD feasible geometric features are generated. The modified model is then analyzed under the same loadings and constraints as defined for topology optimization. Shape at the peak stress concentration areas are further optimized by exploiting the shape optimization in TOSCA.shape module. The harmonized stressed model with the modified surfaces is then imported in CATIA to develop the final design.
Abstract: Understanding patient factors related to physical activity behavior is important in the management of Type 2 Diabetes. This study applied the Theory of Planned Behavior model to understand physical activity behavior among sampled Type 2 diabetics in Kenya. The study was conducted within the diabetic clinic at Kisii Level 5 Hospital and adopted sequential mixed methods design beginning with qualitative phase and ending with quantitative phase. Qualitative data was analyzed using grounded theory analysis method. Structural equation modeling using maximum likelihood was used to analyze quantitative data. The common fit indices revealed that the theory of planned behavior fitted the data acceptably well among the Type 2 diabetes and within physical activity behavior {¤ç2 = 213, df = 84, n=230, p = .061, ¤ç2/df = 2.53; TLI = .97; CFI =.96; RMSEA (90CI) = .073(.029, .08)}. This theory proved to be useful in understanding physical activity behavior among Type 2 diabetics.
Abstract: An accurate optimal design of laminated composite
structures may present considerable difficulties due to the complexity
and multi-modality of the functional design space. The Big Bang
– Big Crunch (BB-BC) optimization method is a relatively new
technique and has already proved to be a valuable tool for structural
optimization. In the present study the exceptional efficiency of the
method is demonstrated by an example of the lay-up optimization
of multilayered anisotropic cylinders based on a three-dimensional
elasticity solution. It is shown that, due to its simplicity and speed,
the BB-BC is much more efficient for this class of problems when
compared to the genetic algorithms.
Abstract: Music segmentation is a key issue in music information
retrieval (MIR) as it provides an insight into the
internal structure of a composition. Structural information about
a composition can improve several tasks related to MIR such
as searching and browsing large music collections, visualizing
musical structure, lyric alignment, and music summarization.
The authors of this paper present the MTSSM framework, a twolayer
framework for the multi-track segmentation of symbolic
music. The strength of this framework lies in the combination of
existing methods for local track segmentation and the application
of global structure information spanning via multiple tracks.
The first layer of the MTSSM uses various string matching
techniques to detect the best candidate segmentations for each
track of a multi-track composition independently. The second
layer combines all single track results and determines the best
segmentation for each track in respect to the global structure of
the composition.
Abstract: loss of feedwater accident is one of the frequently sever accidents in steam boiler facilities. It threatens the system structural integrity and generates serious hazards and economic loses. The safety analysis of the thermal installations, based extensively on the numeric simulation. The simulation analysis using realistic computer codes like Relap5/Mod3.2 will help understand steam boiler thermal-hydraulic behavior during normal and abnormal conditions. In this study, we are interested on the evaluation of the radiant steam boiler assessment and response to loss-of-feedwater accident. Pressure, temperature and flow rate profiles are presented in various steam boiler system components. The obtained results demonstrate the importance and capability of the Relap5/Mod3.2 code in the thermal-hydraulic analysis of the steam boiler facilities.
Abstract: The Reverse Monte Carlo (RMC) simulation is applied in the study of an aqueous electrolyte LiCl6H2O. On the basis of the available experimental neutron scattering data, RMC computes pair radial distribution functions in order to explore the structural features of the system. The obtained results include some unrealistic features. To overcome this problem, we use the Hybrid Reverse Monte Carlo (HRMC), incorporating an energy constraint in addition to the commonly used constraints derived from experimental data. Our results show a good agreement between experimental and computed partial distribution functions (PDFs) as well as a significant improvement in pair partial distribution curves. This kind of study can be considered as a useful test for a defined interaction model for conventional simulation techniques.
Abstract: This paper presents an analytical model to estimate
the cost of an optimized design of reinforced concrete isolated
footing base on structural safety. Flexural and optimized formulas for
square and rectangular footingare derived base on ACI building code
of design, material cost and optimization. The optimization
constraints consist of upper and lower limits of depth and area of
steel. Footing depth and area of reinforcing steel are to be minimized
to yield the optimal footing dimensions. Optimized footing materials
cost of concrete, reinforcing steel and formwork of the designed
sections are computed. Total cost factor TCF and other cost factors
are developed to generalize and simplify the calculations of footing
material cost. Numerical examples are presented to illustrate the
model capability of estimating the material cost of the footing for a
desired axial load.
Abstract: Restoration of endodontically treated teeth is a
common problem in dentistry, related to the fractures occurring in
such teeth and to concentration of forces little information regarding
variation of basic preparation guidelines in stress distribution has
been available. To date, there is still no agreement in the literature
about which material or technique can optimally restore
endodontically treated teeth. The aim of the present study was to
evaluate the influence of the core height and restoration materials on
corono-radicular restored upper first premolar. The first step of the
study was to achieve 3D models in order to analyze teeth, dowel and
core restorations and overlying full ceramic crowns. The FEM model
was obtained by importing the solid model into ANSYS finite
element analysis software. An occlusal load of 100 N was conducted,
and stresses occurring in the restorations, and teeth structures were
calculated. Numerical simulations provide a biomechanical
explanation for stress distribution in prosthetic restored teeth. Within
the limitations of the present study, it was found that the core height
has no important influence on the stress generated in coronoradicular
restored premolars. It can be drawn that the cervical regions
of the teeth and restorations were subjected to the highest stress
concentrations.
Abstract: This study1 holds for the formation of international financial crisis and political factors for economic crisis in Turkey, are evaluated in chronological order. The international arena and relevant studies conducted in Turkey work in the literature are assessed. The main purpose of the study is to hold the linkage between the crises and political stability in Turkey in details, and to examine the position of Turkey in this regard. The introduction part follows the literature survey on the models explaining causes and results of the crises, the second part of the study. In the third part, the formations of the world financial crises are studied. The fourth part, financial crisis in Turkey in 1994, 2000, 2001 and 2008 are reviewed and their political reasons are analyzed. In the last part of the study the results and recommendations are held. Political administrations have laid the grounds for an economic crisis in Turkey. In this study, the emergence of an economic crisis in Turkey and the developments after the crisis are chronologically examined and an explanation is offered as to the cause and effect relationship between the political administration and economic equilibrium in the country. Economic crises can be characterized as follows: high prices of consumables, high interest rates, current account deficits, budget deficits, structural defects in government finance, rising inflation and fixed currency applications, rising government debt, declining savings rates and increased dependency on foreign capital stock. Entering into the conditions of crisis during a time when the exchange value of the country-s national currency was rising, speculative finance movements and shrinking of foreign currency reserves happened due to expectations for devaluation and because of foreign investors- resistance to financing national debt, and a financial risk occurs. During the February 2001 crisis and immediately following, devaluation and reduction of value occurred in Turkey-s stock market. While changing over to the system of floating exchange rates in the midst of this crisis, the effects of the crisis on the real economy are discussed in this study. Administered politics include financial reforms, such as the rearrangement of banking systems. These reforms followed with the provision of foreign financial support. There have been winners and losers in the imbalance of income distribution, which has recently become more evident in Turkey-s fragile economy.
Abstract: Antimicrobial (AM) starch-based films were
developed by incorporating chitosan and lauric acid as antimicrobial
agent into starch-based film. Chitosan has wide range of applications
as a biomaterial, but barriers still exist to its broader use due to its
physical and chemical limitations. In this work, a series of
starch/chitosan (SC) blend films containing 8% of lauric acid was
prepared by casting method. The structure of the film was
characterized by Fourier transform infrared spectroscopy (FTIR), Xray
diffraction (XRD), and scanning electron microscopy (SEM).
The results indicated that there were strong interactions were present
between the hydroxyl groups of starch and the amino groups of
chitosan resulting in a good miscibility between starch and chitosan
in the blend films. Physical properties and optical properties of the
AM starch-based film were evaluated. The AM starch-based films
incorporated with chitosan and lauric acid showed an improvement in
water vapour transmission rate (WVTR) and addition of starch
content provided more transparent films while the yellowness of the
film attributed to the higher chitosan content. The improvement in
water barrier properties was mainly attributed to the hydrophobicity
of lauric acid and optimum chitosan or starch content. AM starch
based film also showed excellent oxygen barrier. Obtaining films
with good oxygen permeability would be an indication of the
potential use of these antimicrobial packaging as a natural packaging
and an alternative packaging to the synthetic polymer to protect food
from oxidation reactions
Abstract: We study the dynamic response of a wind turbine
structure subjected to theoretical seismic motions, taking into account
the rotational component of ground shaking. Models are generated
for a shallow moderate crustal earthquake in the Madrid Region
(Spain). Synthetic translational and rotational time histories are
computed using the Discrete Wavenumber Method, assuming a point
source and a horizontal layered earth structure. These are used to
analyze the dynamic response of a wind turbine, represented by a
simple finite element model. Von Mises stress values at different
heights of the tower are used to study the dynamical structural
response to a set of synthetic ground motion time histories
Abstract: Middle-gate is located in Hasankeyf, Batman dating
back to 1800 BC and is one of the important historical structures in
Turkey. The ancient structure has suffered major structural cracks
due to aging as well as lateral pressure of a cracked rock which is
predicted to be about 100 tons. The existing support system was
found to be inadequate to support the load especially after a recent
rock fall in the close vicinity. Concerns were increased since the
existing support system that is integral with a damaged and cracked
gate wall needed to be replaced by a new support system. The
replacement process must be carefully monitored by crackmeters and
control mechanisms should be integrated to prevent cracks to expand
while the same crack width needs to be maintained after the
operation. The control system and actions taken during the
intervention are explained in this paper.
Abstract: XML data consists of a very flexible tree-structure
which makes it difficult to support the storing and retrieving of XML
data. The node numbering scheme is one of the most popular
approaches to store XML in relational databases. Together with the
node numbering storage scheme, structural joins can be used to
efficiently process the hierarchical relationships in XML. However, in
order to process a tree-structured XPath query containing several
hierarchical relationships and conditional sentences on XML data,
many structural joins need to be carried out, which results in a high
query execution cost. This paper introduces mechanisms to reduce the
XPath queries including branch nodes into a much more efficient form
with less numbers of structural joins. A two step approach is proposed.
The first step merges duplicate nodes in the tree-structured query and
the second step divides the query into sub-queries, shortens the paths
and then merges the sub-queries back together. The proposed
approach can highly contribute to the efficient execution of XML
queries. Experimental results show that the proposed scheme can
reduce the query execution cost by up to an order of magnitude of the
original execution cost.
Abstract: The performance of sensor-less controlled induction
motor drive depends on the accuracy of the estimated speed.
Conventional estimation techniques being mathematically complex
require more execution time resulting in poor dynamic response. The
nonlinear mapping capability and powerful learning algorithms of
neural network provides a promising alternative for on-line speed
estimation. The on-line speed estimator requires the NN model to be
accurate, simpler in design, structurally compact and computationally
less complex to ensure faster execution and effective control in real
time implementation. This in turn to a large extent depends on the
type of Neural Architecture. This paper investigates three types of
neural architectures for on-line speed estimation and their
performance is compared in terms of accuracy, structural
compactness, computational complexity and execution time. The
suitable neural architecture for on-line speed estimation is identified
and the promising results obtained are presented.
Abstract: The theatre-auditorium under investigation following
the highly reflective characteristics of materials used in it (marble,
painted wood, smooth plaster, etc), architectural and structural
features of the Protocol and its intended use (very multifunctional:
Auditorium, theatre, cinema, musicals, conference room) from the
analysis of the statement of fact made by the acoustic simulation
software Ramsete and supported by data obtained through a
campaign of acoustic measurements of the state of fact made on the
spot by a Fonomet Svantek model SVAN 957, appears to be
acoustically inadequate. After the completion of the 3D model
according to the specifications necessary software used forecast in
order to be recognized by him, have made three simulations, acoustic
simulation of the state of and acoustic simulation of two design
solutions.
Improved noise characteristics found in the first design solution,
compared to the state in fact consists therefore in lowering
Reverberation Time that you turn most desirable value, while the
Indicators of Clarity, the Baricentric Time, the Lateral Efficiency,
Ratio of Low Tmedia BR and defined the Speech Intelligibility
improved significantly. Improved noise characteristics found instead
in the second design solution, as compared to first design solution, is
finally mostly in a more uniform distribution of Leq and in lowering
Reverberation Time that you turn the optimum values. Indicators of
Clarity, and the Lateral Efficiency improve further but at the expense
of a value slightly worse than the BR. Slightly vary the remaining
indices.
Abstract: For evaluating the severity of Chronic Obstructive Pulmonary Disease (COPD), one is interested in inspecting the airway wall thickening due to inflammation. Although airway segmentations have being well developed to reconstruct in high order, airway wall segmentation remains a challenge task. While tackling such problem as a multi-surface segmentation, the interrelation within surfaces needs to be considered. We propose a new method for three-dimensional airway wall segmentation using spring structural active contour model. The method incorporates the gravitational field of the image and repelling force field of the inner lumen as the soft constraint and the geometric spring structure of active contour as the hard constraint to approximate a three-dimensional coupled surface readily for thickness measurements. The results show the preservation of topology constraints of coupled surfaces. In conclusion, our springy, soft-tissue-like structure ensures the globally optimal solution and waives the shortness following by the inevitable improper inner surface constraint.
Abstract: Monitored 3-Dimensional (3D) video experience can be utilized as “feedback information” to fine tune the service parameters for providing a better service to the demanding 3D service customers. The 3D video experience which includes both video quality and depth perception is influenced by several contextual and content related factors (e.g., ambient illumination condition, content characteristics, etc) due to the complex nature of the 3D video. Therefore, effective factors on this experience should be utilized while assessing it. In this paper, structural information of the depth map sequences of the 3D video is considered as content related factor effective on the depth perception assessment. Cartoon-like filter is utilized to abstract the significant depth levels in the depth map sequences to determine the structural information. Moreover, subjective experiments are conducted using 3D videos associated with cartoon-like depth map sequences to investigate the effectiveness of ambient illumination condition, which is a contextual factor, on depth perception. Using the knowledge gained through this study, 3D video experience metrics can be developed to deliver better service to the 3D video service users.
Abstract: Cast metal inlays can be used on molars requiring a
class II restoration instead amalgam and offer a durable alternative.
Because it is known that class II inlays may increase the
susceptibility to fracture, it is important to ensure optimal
performance in selection of the adequate preparation design to reduce
stresses in teeth structures and also in the restorations. The aim of the
study was to investigate the influence of preparation design on stress
distribution in molars with different class II preparations and in cast
metal inlays. The first step of the study was to achieve 3D models in
order to analyze teeth and cast metal class II inlays. The geometry of
the intact tooth was obtained by 3D scanning using a manufactured
device. With a NURBS modeling program the preparations and the
appropriately inlays were designed. 3D models of first upper molars
of the same shape and size were created. Inlay cavities designs were
created using literature data. The geometrical model was exported
and the mesh structure of the solid 3D model was created for
structural simulations. Stresses were located around the occlusal
contact areas. For the studied cases, the stress values were not
significant influenced by the taper of the preparation. it was
demonstrated stresses are higher in the cast metal restorations and
therefore the strength of the teeth is not affected.