Abstract: The mechanisms underlying the association between
obesity and asthma may be related to a decreased immunological
tolerance induced by a defective function of regulatory T cells
(Tregs). The aim of this study is to establish the potential link
between these diseases and CD4+, CD25+ FoxP3+ Tregs as well as T
helper cells (Ths) in children. This is a prospective case control
study. Obese (n:40), asthmatic (n:40), asthmatic obese (n:40) and
healthy children (n:40), who don't have any acute or chronic diseases,
were included in this study. Obese children were evaluated according
to WHO criteria. Asthmatic patients were chosen based on GINA
criteria. Parents were asked to fill up the questionnaire. Informed
consent forms were taken. Blood samples were marked with CD4+,
CD25+ and FoxP3+ in order to determine Tregs and Ths by flow
cytometric method. Statistical analyses were performed. p≤0.05 was
chosen as meaningful threshold. Tregs exhibiting anti-inflammatory
nature were significantly lower in obese (0,16%; p≤0,001), asthmatic
(0,25%; p≤0,01) and asthmatic obese (0,29%; p≤0,05) groups than
the control group (0,38%). Ths were counted higher in asthma group
than the control (p≤0,01) and obese (p≤0,001) groups. T cell
immunity plays important roles in obesity and asthma pathogeneses.
Decreased numbers of Tregs found in obese, asthmatic and asthmatic
obese children may help to elucidate some questions in
pathophysiology of these diseases. For HOMA-IR levels, any
significant difference was not noted between control and obese
groups, but statistically higher values were found for obese
asthmatics. The values obtained in all groups were found to be below
the critical cut off points. This finding has made the statistically
significant difference observed between Tregs of obese, asthmatic,
obese asthmatic and control groups much more valuable. These
findings will be useful in diagnosis and treatment of these disorders
and future studies are needed. The production and propagation of
Tregs may be promising in alternative asthma and obesity treatments.
Abstract: Many organizations are investing in web applications
and technologies in order to be competitive, some of them could not
achieve its goals. The quality of web-based applications could play
an important role for organizations to be competitive. So the aim of
this study is to investigate the impact of quality of web-based
applications to achieve a competitive advantage. A new model has
been developed. An empirical investigation was performed on a
banking sector in Jordan to test the new model. The results show that
impact of web-based applications on competitive advantage is
significant. Finally, further work is planned to validate and evaluate
the proposed model using several domains.
Abstract: Background - The TrendCare Patient Dependency
System is currently used by a large number of maternity Services
across Australia, New Zealand and Singapore. In 2012, 2013 and
2014 validation studies were initiated in all three countries to validate
the acuity tools used for women in labour, and postnatal mothers and
babies. This paper will present the findings of the validation study.
Aim - The aim of this study was to; identify if the care hours
provided by the TrendCare acuity system was an accurate reflection
of the care required by women and babies; obtain evidence of
changes required to acuity indicators and/or category timings to
ensure the TrendCare acuity system remains reliable and valid across
a range of maternity care models in three countries.
Method - A non-experimental action research methodology was
used across maternity services in four District Health Boards in New
Zealand, a large tertiary and a large secondary maternity service in
Singapore and a large public maternity service in Australia.
Standardised data collection forms and timing devices were used to
collect midwife contact times, with women and babies included in the
study. Rejection processes excluded samples when care was not
completed/rationed, and contact timing forms were incomplete. The
variances between actual timed midwife/mother/baby contact and the
TrendCare acuity category times were identified and investigated.
Results - Thirty two (88.9%) of the 36 TrendCare acuity category
timings, fell within the variance tolerance levels when compared to
the actual timings recorded for midwifery care. Four (11.1%)
TrendCare categories provided less minutes of care than the actual
timings and exceeded the variance tolerance level. These were all
night shift category timings. Nine postnatal categories were not able
to be compared as the sample size for these categories was
statistically insignificant. 100% of labour ward TrendCare categories
matched actual timings for midwifery care, all falling within the
variance tolerance levels.
The actual time provided by core midwifery staff to assist lead
maternity carer (LMC) midwives in New Zealand labour wards
showed a significant deviation to previous studies. The findings of
the study demonstrated the need for additional time allocations in
TrendCare to accommodate an increased level of assistance given to
LMC midwives.
Conclusion - The results demonstrated the importance of regularly
validating the TrendCare category timings with actual timings of the
care hours provided. It was evident from the findings that variances
to models of care and length of stay in maternity units have increased
midwifery workloads on the night shift. The level of assistance
provided by the core labour ward staff to the LMC midwife has
increased substantially.
Outcomes - As a consequence of this study, changes were made to
the night duty TrendCare maternity categories, additional acuity
indicators were developed and times for assisting LMC midwives in
labour ward increased. The updated TrendCare version was delivered
to maternity services in 2014.
Abstract: This paper presents a study of SIW circuits (Substrate
Integrated Waveguide) with a rigorous and fast original approach
based on Iterative process (WCIP). The theoretical suggested study is
validated by the simulation of two different examples of SIW
circuits. The obtained results are in good agreement with those of
measurement and with software HFSS.
Abstract: The aim of the present study was to examine whether
increasing molybdenum (Mo) concentration affects the growth and
Mo concentration of maize (Zea mays L. cv Norma SC) and
sunflower (Helianthus annuus L. cv Arena PR) seedlings within
laboratory conditions.
In this experiment, calcareous chernozem soil was used and Mo
was supplemented into the soil as ammonium molybdate
[(NH4)6Mo7O24.4H2O] in four different concentrations as follow: 0
(control), 30, 90 and 270 mg·kg-1.
In this study, we found that molybdenum in small amount (30
mg·kg-1) affects positively on growth of maize and sunflower
seedlings, however, higher concentration of Mo reduces the dry
weights of shoots and roots. In the case of maize the highest Mo
treatment (270 mg·kg-1) and in sunflower 90 mg·kg-1 treatment
caused significant reduction in plant growth.
In addition, we observed that molybdenum contents in the roots
and shoots were very low in case of control soil but were
significantly elevated with increasing concentration of Mo treatment.
Only in case of sunflower the highest 270 mg·kg-1 Mo treatment
caused decrease in Mo concentration.
Abstract: Rural tourism is usually associated with rural
development because it has strong linkages to rural resources; but it
remains underdeveloped compared to urban tourism. This
underdevelopment of rural tourism serves as a motivation for this
study whose aim is to examine the factors affecting the perceived
satisfaction of rural tourists. The objectives of this study are: to
identify and design theories and models on rural tourism satisfaction,
and to empirically validate these models and theories through a
survey of tourists from the Malealea Lodge which is located in the
Mafeteng District, in the Mountain Kingdom of Lesotho. Data
generated by the collection of questionnaires used by this survey was
analyzed quantitatively using descriptive statistics and correlations in
SPSS after checking the validity and the reliability of the
questionnaire. The main hypothesis behind this study is the
relationship between the demographics of rural tourists, their
motivation, and their satisfaction, as supported by existing literature;
except that motivation is measured in this study according to three
dimensions: push factors, pull factors, and perceived usefulness of
ICTs in the rural tourism experience. Findings from this study
indicate that among the demographics factors, continent of origin and
marital status influence the satisfaction of rural tourists; and their
occupation affects their perceptions on the use of ICTs in rural
tourism. Moreover, only pull factors were found to influence the
satisfaction of rural tourists.
Abstract: Parabolic solar trough systems have seen limited
deployments in cold northern climates as they are more suitable for
electricity production in southern latitudes. A numerical dynamic
model is developed to simulate troughs installed in cold climates and
validated using a parabolic solar trough facility in Winnipeg. The
model is developed in Simulink and will be utilized to simulate a trigeneration
system for heating, cooling and electricity generation in
remote northern communities. The main objective of this simulation
is to obtain operational data of solar troughs in cold climates and use
the model to determine ways to improve the economics and address
cold weather issues.
In this paper the validated Simulink model is applied to simulate a
solar assisted absorption cooling system along with electricity
generation using Organic Rankine Cycle (ORC) and thermal storage.
A control strategy is employed to distribute the heated oil from solar
collectors among the above three systems considering the
temperature requirements. This modelling provides dynamic
performance results using measured meteorological data recorded
every minute at the solar facility location. The purpose of this
modeling approach is to accurately predict system performance at
each time step considering the solar radiation fluctuations due to
passing clouds. Optimization of the controller in cold temperatures is
another goal of the simulation to for example minimize heat losses in
winter when energy demand is high and solar resources are low.
The solar absorption cooling is modeled to use the generated heat
from the solar trough system and provide cooling in summer for a
greenhouse which is located next to the solar field.
The results of the simulation are presented for a summer day in
Winnipeg which includes comparison of performance parameters of
the absorption cooling and ORC systems at different heat transfer
fluid (HTF) temperatures.
Abstract: The aim of this paper is to understand emerging
learning conditions, when a visual analytics is implemented and used
in K 12 (education). To date, little attention has been paid to the role
visual analytics (digital media and technology that highlight visual
data communication in order to support analytical tasks) can play in
education, and to the extent to which these tools can process
actionable data for young students. This study was conducted in three
public K 12 schools, in four social science classes with students aged
10 to 13 years, over a period of two to four weeks at each school.
Empirical data were generated using video observations and analyzed
with help of metaphors within Actor-network theory (ANT). The
learning conditions are found to be distinguished by broad
complexity, characterized by four dimensions. These emerge from
the actors’ deeply intertwined relations in the activities. The paper
argues in relation to the found dimensions that novel approaches to
teaching and learning could benefit students’ knowledge building as
they work with visual analytics, analyzing visualized data.
Abstract: The work allowed gaining knowledge about redox and
speciation changes of As, Cr and Sb ionic forms in Klodnica River
water. This kind of studies never has been conducted in this region of
Poland. In study optimized and validated previously HPLC-ICP-MS
methods for determination of As, Sb and Cr was used. Separation
step was done using high-performance liquid chromatograph
equipped with ion-exchange column followed by ICP-MS
spectrometer detector. Preliminary studies included determination of
the total concentration of As, Sb and Cr, pH, Eh, temperature and
conductivity of the water samples. The study was conducted monthly
from March to August 2014, at six points on the Klodnica River. The
results indicate that exceeded at acceptable concentration of total Cr
and Sb was observed in Klodnica River and we should qualify
Klodnica River waters below the second purity class. In Klodnica
River waters dominates oxidized antimony and arsenic forms, as well
as the two forms of chromium Cr(VI) and Cr(III). Studies have also
shown the methyl derivative of arsenic's presence.
Abstract: The paper tackles the topic of determining the cost of
innovation in software development projects. Innovation can be
achieved either in a planned or unplanned manner. The paper
approaches the scenarios were innovation is planned for. As a starting
point an innovative software development project is analyzed. The
project is depicted step by step as it was implemented, from inception
to delivery. Costs that are proprietary to innovation in software
development are isolated based on the author’s personal experience
in managing the above mentioned project. Innovation costs
components identified by the author are then validated using open
discussions with software development professionals and projects
managers on LinkedIn groups. In order to receive relevant feedback
only groups that focus on software development and innovation
management are targeted. Additional innovation cost components
suggested by software development professionals and projects
managers are also considered. Based on the identified cost
components an indicator is built. The indicator is meant to formalize
the process of determining the cost of innovation in a software
development project. The indicator aggregates all the innovation cost
components that are identified in the research process. The process of
calculating each cost component is also described. Conclusions are
formulated and new related research topics are submitted for debate.
Abstract: This paper introduces a proposal scheme for an
Intelligent System applied to Pedagogical Advising using Case-Based
Reasoning, to find consolidated solutions before used for the new
problems, making easier the task of advising students to the
pedagogical staff. We do intend, through this work, introduce the
motivation behind the choices for this system structure, justifying the
development of an incremental and smart web system who learns
bests solutions for new cases when it’s used, showing technics and
technology.
Abstract: The thermal control in many systems is widely
accomplished applying mixed convection process due to its low cost,
reliability and easy maintenance. Typical applications include the
aircraft electronic equipment, rotating-disc heat exchangers, turbo
machinery, and nuclear reactors, etc. Natural convection in an inclined
square enclosure heated via wall heater has been studied numerically.
Finite volume method is used for solving momentum and energy
equations in the form of stream function–vorticity. The right and left
walls are kept at a constant temperature, while the other parts are
adiabatic. The range of the inclination angle covers a whole revolution.
The method is validated for a vertical cavity. A general power law
dependence of the Nusselt number with respect to the Rayleigh
number with the coefficient and exponent as functions of the
inclination angle is presented. For a fixed Rayleigh number, the
inclination angle increases or decreases is found.
Abstract: Background: The objectives of this study were to
assess patient’s knowledge of appropriate sublingual glyceryl
trinitrate (GTN) use as well as to investigate how patients commonly
store and carry their sublingual GTN tablets. Methodology: This was
a cross-sectional survey, using a validated researcher-administered
questionnaire. The study involved cardiac patients receiving
sublingual GTN attending the outpatient and inpatient departments of
Taiping Hospital, a non-academic public care hospital. The minimum
calculated sample size was 92, but 100 patients were conveniently
sampled. Respondents were interviewed on 3 areas, including
demographic data, knowledge and use of sublingual GTN. Eight
items were used to calculate each subject’s knowledge score and six
items were used to calculate use score. Results: Of the 96 patients
who consented to participate, majority (96.9%) were well aware of
the indication of sublingual GTN. With regards to the mechanism of
action of sublingual GTN, 73 (76%) patients did not know how the
medication works. Majority of the patients (66.7%) knew about the
proper storage of the tablet. In relation to the maximum number of
sublingual GTN tablets that can be taken during each angina episode,
36.5% did not know that up to 3 tablets of sublingual GTN can be
taken during each episode of angina. Fifty four (56.2%) patients were
not aware that they need to replace sublingual GTN every 8 weeks
after receiving the tablets. Majority (69.8%) of the patients
demonstrated lack of knowledge with regards to the use of sublingual
GTN as prevention of chest pain. Conclusion: Overall, patients’
knowledge regarding the self-administration of sublingual GTN is
still inadequate. The findings support the need for more frequent
reinforcement of patient education, especially in the areas of
preventive use, storage and drug stability.
Abstract: The building sector is responsible, in many
industrialized countries, for about 40% of the total energy
requirements, so it seems necessary to devote some efforts in this
area in order to achieve a significant reduction of energy
consumption and of greenhouse gases emissions.
The paper presents a study aiming at providing a design
methodology able to identify the best configuration of the system
building/plant, from a technical, economic and environmentally point
of view.
Normally, the classical approach involves a building's energy
loads analysis under steady state conditions, and subsequent selection
of measures aimed at improving the energy performance, based on
previous experience made by architects and engineers in the design
team. Instead, the proposed approach uses a sequence of two wellknown
scientifically validated calculation methods (TRNSYS and
RETScreen), that allow quite a detailed feasibility analysis.
To assess the validity of the calculation model, an existing,
historical building in Central Italy, that will be the object of
restoration and preservative redevelopment, was selected as a casestudy.
The building is made of a basement and three floors, with a
total floor area of about 3,000 square meters.
The first step has been the determination of the heating and
cooling energy loads of the building in a dynamic regime by means,
which allows simulating the real energy needs of the building in
function of its use. Traditional methodologies, based as they are on
steady-state conditions, cannot faithfully reproduce the effects of
varying climatic conditions and of inertial properties of the structure.
With this model is possible to obtain quite accurate and reliable
results that allow identifying effective combinations building-HVAC
system.
The second step has consisted of using output data obtained as
input to the calculation model, which enables to compare different
system configurations from the energy, environmental and financial
point of view, with an analysis of investment, and operation and
maintenance costs, so allowing determining the economic benefit of
possible interventions.
The classical methodology often leads to the choice of
conventional plant systems, while our calculation model provides a
financial-economic assessment for innovative energy systems and
low environmental impact.
Computational analysis can help in the design phase, particularly
in the case of complex structures with centralized plant systems, by
comparing the data returned by the calculation model for different
design options.
Abstract: Cemented carbide balls are usually implemented in
industry under the environment of high speed, high temperature,
corrosiveness and strong collisions. However, its application is limited
due to high fabrication cost, processing efficiency and quality. A novel
eccentric lapping method with two rotatable lapping plates was
proposed in this paper. A mathematical model was constructed to
analyze the influence of each design parameter on this lapping method.
To validate this new lapping method, an orthogonal experiment was
conducted with cemented carbide balls (YG6). The simulation model
was verified and the optimal lapping parameters were derived. The
results show that the surface roundness of the balls reaches to 0.65um
from 2um in 1 hour using this lapping method. So, using this novel
lapping method, it can effectively improve the machining precision
and efficiency of cemented carbide balls.
Abstract: Meeting the growth in demand for digital services
such as social media, telecommunications, and business and cloud
services requires large scale data centres, which has led to an increase
in their end use energy demand. Generally, over 30% of data centre
power is consumed by the necessary cooling overhead. Thus energy
can be reduced by improving the cooling efficiency. Air and liquid
can both be used as cooling media for the data centre. Traditional
data centre cooling systems use air, however liquid is recognised as a
promising method that can handle the more densely packed data
centres. Liquid cooling can be classified into three methods; rack heat
exchanger, on-chip heat exchanger and full immersion of the
microelectronics. This study quantifies the improvements of heat
transfer specifically for the case of immersed microelectronics by
varying the CPU and heat sink location. Immersion of the server is
achieved by filling the gap between the microelectronics and a water
jacket with a dielectric liquid which convects the heat from the CPU
to the water jacket on the opposite side. Heat transfer is governed by
two physical mechanisms, which is natural convection for the fixed
enclosure filled with dielectric liquid and forced convection for the
water that is pumped through the water jacket. The model in this
study is validated with published numerical and experimental work
and shows good agreement with previous work. The results show that
the heat transfer performance and Nusselt number (Nu) is improved
by 89% by placing the CPU and heat sink on the bottom of the
microelectronics enclosure.
Abstract: Power systems are operating under stressed condition
due to continuous increase in demand of load. This can lead to
voltage instability problem when face additional load increase or
contingency. In order to avoid voltage instability suitable size of
reactive power compensation at optimal location in the system is
required which improves the load margin. This work aims at
obtaining optimal size as well as location of compensation in the 39-
bus New England system with the help of Bacteria Foraging and
Genetic algorithms. To reduce the computational time the work
identifies weak candidate buses in the system, and then picks only
two of them to take part in the optimization. The objective function is
based on a recently proposed voltage stability index which takes into
account the weighted average sensitivity index is a simpler and faster
approach than the conventional CPF algorithm. BFOA has been
found to give better results compared to GA.
Abstract: Africa enjoys some of the best solar radiation levels in
the world averaging between 4-6 kWh/m2/day for most of the year
and the global economic and political conditions that tend to make
African countries more dependent on their own energy resources
have caused growing interest in renewable energy based
technologies. However to-date, implementation of modern Energy
Technologies in Africa is still very low especially the use of solar
conversion technologies. This paper presents literature review and
analysis relating to the techno-economic feasibility of solar
photovoltaic power generation in Africa. The literature is basically
classified into the following four main categories. Techno-economic
feasibility of solar photovoltaic power generation, design methods,
performance evaluations of various systems and policy of potential
future of technological development of photovoltaic (PV) in Africa
by exploring the impact of alternative policy instruments and
technology cost reductions on the financial viability of investing solar
photovoltaic in Africa.
Abstract: Skin aging is a slow multifactorial process influenced
by both internal as well as external factors. Ultra-violet radiations
(UV), diet, smoking and personal habits are the most common
environmental factors that affect skin aging. Fat contents and fibrous
proteins as collagen and elastin are core internal structural
components. The direct influence of UV on elastin integrity and
health is central on aging of skin especially by time. The deposition
of abnormal elastic material is a major marker in a photo-aged skin.
Searching for compounds that may protect against cutaneous photodamage
is exceedingly valued. Retinoids and alpha hydroxy acids
have been endorsed by some researchers as possible candidates for
protecting and or repairing the effect of UV damaged skin. For
consolidating a better system of anti- and protective effects of such
anti-aging agents, we evaluated the combinatory effects of various
dosages of lactic acid and retinol on the dermal fibroblast’s elastin
levels exposed to UV. The UV exposed cells showed significant
reduction in the elastin levels. A combination of drugs with a higher
concentration of lactic acid (30 -35 mM) and a lower concentration of
retinol (10-15mg/mL) showed to work better in maintaining elastin
concentration in UV exposed cells. We assume this preservation
could be the result of increased tropo-elastin gene expression
stimulated by retinol whereas lactic acid probably repaired the UV
irradiated damage by enhancing the amount and integrity of the
elastin fibers.
Abstract: Numerical studies were conducted using Lattice
Boltzmann Method (LBM) to study the natural convection in a square
cavity in the presence of roughness. An algorithm based on a single
relaxation time Bhatnagar-Gross-Krook (BGK) model of Lattice
Boltzmann Method (LBM) was developed. Roughness was
introduced on both the hot and cold walls in the form of sinusoidal
roughness elements. The study was conducted for a Newtonian fluid
of Prandtl number (Pr) 1.0. The range of Ra number was explored
from 10^3 to 10^6 in a laminar region. Thermal and hydrodynamic
behavior of fluid was analyzed using a differentially heated square
cavity with roughness elements present on both the hot and cold wall.
Neumann boundary conditions were introduced on horizontal walls
with vertical walls as isothermal. The roughness elements were at the
same boundary condition as corresponding walls. Computational
algorithm was validated against previous benchmark studies
performed with different numerical methods, and a good agreement
was found to exist. Results indicate that the maximum reduction in
the average heat transfer was 16.66 percent at Ra number 10^5.