Abstract: Kidney cancer is the most lethal urological cancer
accounting for 3% of adult malignancies. VHL, a tumor-suppressor
gene, is best known to be associated with renal cell carcinoma
(RCC). The VHL functions as negative regulator of hypoxia inducible
factors. Recent sequencing efforts have identified several novel
frequent mutations of histone modifying and chromatin remodeling
genes in ccRCC (clear cell RCC) including PBRM1 and SETD2. The
PBRM1 gene encodes the BAF180 protein, which involved in
transcriptional activation and repression of selected genes. SETD2
encodes a histone methyltransferase, which may play a role in
suppressing tumor development. In this study, RNAs of 30 paired
tumor and normal samples that were grouped according to the types
of kidney cancer and clinical characteristics of patients, including
gender and average age were examined by RT-PCR, SSCP and
sequencing techniques. VHL, PBRM1 and SETD2 expressions were
relatively down-regulated. However, statistically no significance was
found (Wilcoxon signed rank test, p>0.05). Interestingly, no mutation
was observed on the contrary of previous studies. Understanding the
molecular mechanisms involved in the pathogenesis of RCC has
aided the development of molecular-targeted drugs for kidney cancer.
Further analysis is required to identify the responsible genes rather
than VHL, PBRM1 and SETD2 in kidney cancer.
Abstract: The atmospheres in many cities along the coastal lines
in the world have been rapidly changed to coastal-industrial
atmosphere. Hence, it is vital to investigate the corrosion behavior of
steel exposed to this kind of environment. In this present study,
Electrochemical Impedance Spectrography (EIS) and film thickness
measurement were applied to monitor the corrosion behavior of
weathering steel covered with a thin layer of the electrolyte in a
wet-dry cyclic condition, simulating a coastal-industrial environment
at 25oC and 60% RH. The results indicate that in all cycles, the
corrosion rate increases during the drying process due to an increase in
anion concentration and an acceleration of oxygen diffusion enhanced
by the effect of the thinning out of the electrolyte. During the wet-dry
cyclic corrosion test, the long-term corrosion behavior of this steel
depends on the periods of exposure. Corrosion process is first
accelerated and then decelerated. The decelerating corrosion process is
contributed to the formation of the protective rust, favored by the
wet-dry cycle and the acid regeneration process during the rusting
process.
Abstract: In Hungary, the society has changed a lot for the past
25 years, and these changes could be detected in educational
situations as well. The number and the intensity of conflicts have
been increased in most fields of life, as well as at schools. Teachers
have difficulties to be able to handle school conflicts. What is more,
the new net generation, generation Z has values and behavioural
patterns different from those of the previous one, which might
generate more serious conflicts at school, especially with teachers
who were mainly socialising in a traditional teacher – student
relationship.
In Hungary, the bill CCIV of 2011 declared the foundation of
Institutes of Teacher Training in higher education institutes. One of
the tasks of the Institutes is to survey the competences and needs of
teachers working in public education and to provide further trainings
and services for them according to their needs and requirements. This
job is supported by the Social Renewal Operative Programs 4.1.2.B.
The professors of a college carried out a questionnaire and surveyed
the needs and the requirements of teachers working in the region.
Based on the results, the professors of the Institute of Teacher
Training decided to meet the requirements of teachers and to launch
short teacher further training courses in spring 2015. One of the
courses is going to focus on school conflict management through
mediation.
The aim of the pilot course is to provide conflict management
techniques for teachers and to present different mediation techniques
to them. The theoretical part of the course (5 hours) will enable
participants to understand the main points and the advantages of
mediation, while the practical part (10 hours) will involve teachers in
role plays to learn how to cope with conflict situations applying
mediation. We hope if conflicts could be reduced, it would influence
school atmosphere in a positive way and the teaching – learning
process could be more successful and effective.
Abstract: In this work, we explore the capability of the mean
shift algorithm as a powerful preprocessing tool for improving the
quality of spatial data, acquired from airborne scanners, from densely
built urban areas. On one hand, high resolution image data corrupted
by noise caused by lossy compression techniques are appropriately
smoothed while at the same time preserving the optical edges and, on
the other, low resolution LiDAR data in the form of normalized
Digital Surface Map (nDSM) is upsampled through the joint mean
shift algorithm. Experiments on both the edge-preserving smoothing
and upsampling capabilities using synthetic RGB-z data show that the
mean shift algorithm is superior to bilateral filtering as well as to
other classical smoothing and upsampling algorithms. Application of
the proposed methodology for 3D reconstruction of buildings of a
pilot region of Athens, Greece results in a significant visual
improvement of the 3D building block model.
Abstract: Networking is important among students to achieve
better understanding. Social networking plays an important role in the
education. Realizing its huge potential, various organizations,
including institutions of higher learning have moved to the area of
social networks to interact with their students especially through
Facebook. Therefore, measuring the effectiveness of Facebook as a
learning tool has become an area of interest to academicians and
researchers. Therefore, this study tried to integrate and propose new
theoretical and empirical evidences by linking the western idea of
adopting Facebook as an alternative learning platform from a
Malaysian perspective. This study, thus, aimed to fill a gap by being
among the pioneering research that tries to study the effectiveness of
adopting Facebook as a learning platform across other cultural
settings, namely Malaysia. Structural equation modeling was
employed for data analysis and hypothesis testing. This study finding
has provided some insights that would likely affect students’
awareness towards using Facebook as an alternative learning
platform in the Malaysian higher learning institutions. At the end,
future direction is proposed.
Abstract: Prosperity of electronic equipment in photocopying
environment not only has improved work efficiency, but also has
changed indoor air quality. Considering the number of photocopying
employed, indoor air quality might be worse than in general office
environments. Determining the contribution from any type of
equipment to indoor air pollution is a complex matter. Non-methane
hydrocarbons are known to have an important role on air quality due
to their high reactivity. The presence of hazardous pollutants in
indoor air has been detected in one photocopying shop in Novi Sad,
Serbia. Air samples were collected and analyzed for five days, during
8-hr working time in three time intervals, whereas three different
sampling points were determined. Using multiple linear regression
model and software package STATISTICA 10 the concentrations of
occupational hazards and microclimates parameters were mutually
correlated. Based on the obtained multiple coefficients of
determination (0.3751, 0.2389 and 0.1975), a weak positive
correlation between the observed variables was determined. Small
values of parameter F indicated that there was no statistically
significant difference between the concentration levels of nonmethane
hydrocarbons and microclimates parameters. The results
showed that variable could be presented by the general regression
model: y = b0 + b1xi1+ b2xi2. Obtained regression equations allow to
measure the quantitative agreement between the variables and thus
obtain more accurate knowledge of their mutual relations.
Abstract: The purpose of this study was to develop a descriptive
profile of the adapted physical activity research using single subject
experimental designs. All research articles using single subject
experimental designs published in the journal of Adapted Physical
Activity Quarterly from 1984 to 2013 were employed as the data
source. Each of the articles was coded in a subcategory of seven
categories: (a) the size of sample; (b) the age of participants; (c) the
type of disabilities; (d) the type of data analysis; (e) the type of
designs, (f) the independent variable, and (g) the dependent variable.
Frequencies, percentages, and trend inspection were used to analyze
the data and develop a profile. The profile developed characterizes a
small portion of research articles used single subject designs, in
which most researchers used a small sample size, recruited children
as subjects, emphasized learning and behavior impairments, selected
visual inspection with descriptive statistics, preferred a multiple
baseline design, focused on effects of therapy, inclusion, and
strategy, and measured desired behaviors more often, with a
decreasing trend over years.
Abstract: The growth in the volume of text data such as books
and articles in libraries for centuries has imposed to establish
effective mechanisms to locate them. Early techniques such as
abstraction, indexing and the use of classification categories have
marked the birth of a new field of research called "Information
Retrieval". Information Retrieval (IR) can be defined as the task of
defining models and systems whose purpose is to facilitate access to
a set of documents in electronic form (corpus) to allow a user to find
the relevant ones for him, that is to say, the contents which matches
with the information needs of the user. This paper presents a new
semantic indexing approach of a documentary corpus. The indexing
process starts first by a term weighting phase to determine the
importance of these terms in the documents. Then the use of a
thesaurus like Wordnet allows moving to the conceptual level.
Each candidate concept is evaluated by determining its level of
representation of the document, that is to say, the importance of the
concept in relation to other concepts of the document. Finally, the
semantic index is constructed by attaching to each concept of the
ontology, the documents of the corpus in which these concepts are
found.
Abstract: The relationship between the state and the religion is
different based on the fact that how powerful is the religion faith in a
state and of the influences that affected the views of the constitution
drafters according to the constitutional system they were based to
draft their constitution. This paper aims at providing, through a
comparative methodology, how it is regulated by the constitution the
relationship between the state and the religion. The object of this
study are the constitutions of Italy as a nation with catholic religious
tradition, Greece as a nation with orthodox religion tradition, and
Turkey as a nation which represents Muslim religion, while Albania
as a nation known for its religious plurality. In particular, the analysis
will be focused on the secular or religious principle provided in the
constitution of each respective state. This comparative overview
intends to discern which of the states analyzed is more tolerant and
fully respects the freedom of religion. It results that most of the states
subject of this study, despite their religious tradition have chosen the
secular principle in their constitutions, but the religious freedom is
differently guaranteed.
Abstract: Microscopic simulation tool kits allow for
consideration of the two processes of railway operations and the
previous timetable production. Block occupation conflicts on both
process levels are often solved by using defined train priorities. These
conflict resolutions (dispatching decisions) generate reactionary
delays to the involved trains. The sum of reactionary delays is
commonly used to evaluate the quality of railway operations, which
describes the timetable robustness. It is either compared to an
acceptable train performance or the delays are appraised
economically by linear monetary functions. It is impossible to
adequately evaluate dispatching decisions without a well-founded
objective function. This paper presents a new approach for the
evaluation of dispatching decisions. The approach uses mode choice
models and considers the behaviour of the end-customers. These
models evaluate the reactionary delays in more detail and consider
other competing modes of transport. The new approach pursues the
coupling of a microscopic model of railway operations with the
macroscopic choice mode model. At first, it will be implemented for
railway operations process but it can also be used for timetable
production. The evaluation considers the possibility for the customer
to interchange to other transport modes. The new approach starts to
look at rail and road, but it can also be extended to air travel. The
result of mode choice models is the modal split. The reactions by the
end-customers have an impact on the revenue of the train operating
companies. Different purposes of travel have different payment
reserves and tolerances towards late running. Aside from changes to
revenues, longer journey times can also generate additional costs.
The costs are either time- or track-specific and arise from required
changes to rolling stock or train crew cycles. Only the variable values
are summarised in the contribution margin, which is the base for the
monetary evaluation of delays. The contribution margin is calculated
for different possible solutions to the same conflict. The conflict
resolution is optimised until the monetary loss becomes minimal. The
iterative process therefore determines an optimum conflict resolution
by monitoring the change to the contribution margin. Furthermore, a
monetary value of each dispatching decision can also be derived.
Abstract: A mathematical model of the additional effects of the
liquid in the hydrodynamic gap is presented in the paper. An
incompressible viscous fluid is considered. Based on computational
modeling are determined the matrices of mass, stiffness and damping.
The mathematical model is experimentally verified.
Abstract: High density electrical prospecting has been widely
used in groundwater investigation, civil engineering and
environmental survey. For efficient inversion, the forward modeling
routine, sensitivity calculation, and inversion algorithm must be
efficient. This paper attempts to provide a brief summary of the past
and ongoing developments of the method. It includes reviews of the
procedures used for data acquisition, processing and inversion of
electrical resistivity data based on compilation of academic literature.
In recent times there had been a significant evolution in field survey
designs and data inversion techniques for the resistivity method. In
general 2-D inversion for resistivity data is carried out using the
linearized least-square method with the local optimization technique
.Multi-electrode and multi-channel systems have made it possible to
conduct large 2-D, 3-D and even 4-D surveys efficiently to resolve
complex geological structures that were not possible with traditional
1-D surveys. 3-D surveys play an increasingly important role in very
complex areas where 2-D models suffer from artifacts due to off-line
structures. Continued developments in computation technology, as
well as fast data inversion techniques and software, have made it
possible to use optimization techniques to obtain model parameters to
a higher accuracy. A brief discussion on the limitations of the
electrical resistivity method has also been presented.
Abstract: In the Hierarchical Temporal Memory (HTM) paradigm
the effect of overlap between inputs on the activation of columns in
the spatial pooler is studied. Numerical results suggest that similar
inputs are represented by similar sets of columns and dissimilar inputs
are represented by dissimilar sets of columns. It is shown that the
spatial pooler produces these results under certain conditions for
the connectivity and proximal thresholds. Following the discussion
of the initialization of parameters for the thresholds, corresponding
qualitative arguments about the learning dynamics of the spatial
pooler are discussed.
Abstract: In order to produce lead free piezoceramics with
optimum piezoelectric and dielectric properties, KNN modified with
Li+ (as an A site dopant) and Sb5+ (as a B site dopant)
(K0.49Na0.49Li0.02) (Nb0.96Sb0.04) O3 (referred as KNLNS in this paper)
have been synthesized using solid state reaction method and
conventional sintering technique. The ceramics were sintered in the
narrow range of 1050°C-1090°C for 2-3 h to get precise information
about sintering parameters. Detailed study of dependence of
microstructural, dielectric and piezoelectric properties on sintering
conditions was then carried out. The study suggests that the volatility
of the highly hygroscopic KNN ceramics is not only sensitive to
sintering temperatures but also to sintering durations. By merely
reducing the sintering duration for a given sintering temperature we
saw an increase in the density of the samples which was supported by
the increase in dielectric constants of the ceramics. And since density
directly or indirectly affects almost all the associated properties, other
dielectric and piezoelectric properties were also enhanced as we
approached towards the most suitable sintering temperature and
duration combination. The detailed results are reported in this paper.
Abstract: Quick adoption of e-business and emerging influence
of “Electronic Word of Mouth e-WOM” communication on guests
made leading hotel brands successful examples of electronic guest
relationship management. Main reasons behind such success are well
established procedures in collection, analysis and usage of highly
valuable data available on the Internet, generated through some form
of e-GRM programme. E-GRM is more than just a technology
solution. It’s a system which balance respective guest demands, hotel
technological capabilities and organizational culture of employees,
discharging the universal approach in guest relations “same for all”.
The purpose of this research derives from the necessity of
determining the importance of monitoring and applying e-WOM
communication as one of the methods used in managing guest
relations. This paper analyses and compares different hotelier’s
opinions on e-WOM communication.
Abstract: In this work, two fermentations at different
temperatures (25 and 30ºC), with cell recycling, were accomplished
to produce ethanol, using a mix of commercial substrates, xylose
(70%) and glucose (30%), as organic source for Scheffersomyces
stipitis. Five consecutive fermentations of 80 g L-1 (1º, 2º and 3º
recycles), 96 g L-1 (4º recycle) and 120 g L-1 (5º recycle)reduced
sugars led to a final maximum ethanol concentration of 17.2 and 34.5
g L-1, at 25 and 30ºC, respectively. Glucose was the preferred
substrate; moreover xylose startup degradation was initiated after a
remaining glucose presence in the medium. Results showed that yeast
acid treatment, performed before each cycle, provided improvements
on cell viability, accompanied by ethanol productivity of 2.16 g L-1 h-
1 at 30ºC. A maximum 36% of xylose was retained in the
fermentation medium and after five-cycle fermentation an ethanol
yield of 0.43 g ethanol/g sugars was observed. S. stipitis fermentation
capacity and tolerance showed better results at 30ºC with 83.4% of
theoretical yield referenced on initial biomass.
Abstract: An efficient remanufacturing network lead to an
efficient design of sustainable manufacturing enterprise. In
remanufacturing network, products are collected from the customer
zone, disassembled and remanufactured at a suitable remanufacturing
facility. In this respect, another issue to consider is how the returned
product to be remanufactured, in other words, what is the best layout
for such facility. In order to achieve a sustainable manufacturing
system, Cellular Manufacturing System (CMS) designs are highly
recommended, CMSs combine high throughput rates of line layouts
with the flexibility offered by functional layouts (job shop).
Introducing the CMS while designing a remanufacturing network will
benefit the utilization of such a network. This paper presents and
analyzes a comprehensive mathematical model for the design of
Dynamic Cellular Remanufacturing Systems (DCRSs). In this paper,
the proposed model is the first one to date that considers CMS and
remanufacturing system simultaneously. The proposed DCRS model
considers several manufacturing attributes such as multi period
production planning, dynamic system reconfiguration, duplicate
machines, machine capacity, available time for workers, worker
assignments, and machine procurement, where the demand is totally
satisfied from a returned product. A numerical example is presented
to illustrate the proposed model.
Abstract: Hypersonic flows around spatial vehicles during their reentry phase in planetary atmospheres are characterized by intense aerothermodynamics phenomena. The aim of this work is to analyze high temperature flows around an axisymmetric blunt body taking into account chemical and vibrational non-equilibrium for air mixture species and the no slip condition at the wall. For this purpose, the Navier-Stokes equations system is resolved by the finite volume methodology to determine the flow parameters around the axisymmetric blunt body especially at the stagnation point and in the boundary layer along the wall of the blunt body. The code allows the capture of shock wave before a blunt body placed in hypersonic free stream. The numerical technique uses the Flux Vector Splitting method of Van Leer. CFL coefficient and mesh size level are selected to ensure the numerical convergence.
Abstract: We investigated the structure and electronic properties
of the compound Mg1-xBixO with varying concentrations of 0, ¼, ½,
and ¾ x bismuth in the the cesium chloride (CsCl), zinc-blende
(ZnS), nickel arsenide (NiAs) NaCl (rock-salt) and WZ (wurtzite)
phases. We calculated. The calculations were performed using the
first-principles pseudo-potential method within the framework of spin
density functional theory (DFT).
Abstract: This paper presents the development of a robot car
that can track the motion of an object by detecting its color through
an Android device. The employed computer vision algorithm uses the
OpenCV library, which is embedded into an Android application of a
smartphone, for manipulating the captured image of the object. The
captured image of the object is subjected to color conversion and is
transformed to a binary image for further processing after color
filtering. The desired object is clearly determined after removing
pixel noise by applying image morphology operations and contour
definition. Finally, the area and the center of the object are
determined so that object’s motion to be tracked. The smartphone
application has been placed on a robot car and transmits by Bluetooth
to an Arduino assembly the motion directives so that to follow
objects of a specified color. The experimental evaluation of the
proposed algorithm shows reliable color detection and smooth
tracking characteristics.