Abstract: Tuberculosis (TB) is a bacterial infectious disease caused by the obligate human pathogen, Mycobacterium tuberculosis. Multidrug-resistant tuberculosis (MDR-TB) is a global reality that threatens tuberculosis control. Resistance to antibiotic Rifampicin, occurs in 95% of cases through nucleotide substitutions in an 81-bp core region of the rpoB i.e; beta subunit of DNA dependant RNA polymerase. In this paper, we studied the Rifampicin-rpoB receptor interactions In silico. First, homology modeling was performed to obtain the three dimensional structure of Mycobacterium rpoB. Sixty analogs of Rifampicin were prepared using Marvin sketch software. Both original Rifampicin and the analogs were docked with rpoB and energy values were obtained. Out of sixty analogs, 43 analogs had lesser energy values than conventional Rifampicin and hence are predicted to have greater binding affinity to rpoB. Thus, this study offers a route for the development of Rifampicin analogs against multi drug resistant Mycobacterium rpoB.
Abstract: In this paper, we propose an easily computable proximity index for predicting voltage collapse of a load bus using only measured values of the bus voltage and power; Using these measurements a polynomial of fourth order is obtained by using LES estimation algorithms. The sum of the absolute values of the polynomial coefficient gives an idea of the critical bus. We demonstrate the applicability of our proposed method on 6 bus test system. The results obtained verify its applicability, as well as its accuracy and the simplicity. From this indicator, it is allowed to predict the voltage instability or the proximity of a collapse. Results obtained by the PV curve are compared with corresponding values by QV curves and are observed to be in close agreement.
Abstract: To improve the characterization of blood flows, we propose a method which makes it possible to use the spectral analysis
of the Doppler signals. Our calculation induces a reasonable approximation, the error made on estimated speed reflects the fact
that speed depends on the flow conditions as well as on measurement parameters like the bore and the volume flow rate. The estimate of the Doppler signal frequency enables us to determine the maximum Doppler frequencie Fd max as well as the maximum flow speed. The
results show that the difference between the estimated frequencies
( Fde ) and the Doppler frequencies ( Fd ) is small, this variation tends to zero for important θ angles and it is proportional to the diameter D. The description of the speed of friction and the
coefficient of friction justify the error rate obtained.
Abstract: Virtualization-based server consolidation has been
proven to be an ideal technique to solve the server sprawl problem by
consolidating multiple virtualized servers onto a few physical servers
leading to improved resource utilization and return on investment. In
this paper, we solve this problem by using existing servers, which are
heterogeneous and diversely preferred by IT managers. Five practical
consolidation rules are introduced, and a decision model is proposed to
optimally allocate source services to physical target servers while
maximizing the average resource utilization and preference value. Our
model can be regarded as a multi-objective multi-dimension
bin-packing (MOMDBP) problem with constraints, which is strongly
NP-hard. An improved grouping generic algorithm (GGA) is
introduced for the problem. Extensive simulations were performed and
the results are given.
Abstract: In terms of total online audience, newspapers are the most successful form of online content to date. The online audience for newspapers continues to demand higher-quality services, including personalized news services. News providers should be able to offer suitable users appropriate content. In this paper, a news article recommender system is suggested based on a user-s preference when he or she visits an Internet news site and reads the published articles. This system helps raise the user-s satisfaction, increase customer loyalty toward the content provider.
Abstract: Nowadays, fluidized bed plays an important part in industry. The design of this kind of reactor requires knowing the interfacial area between two phases and this interfacial area leads to calculate the solid holdup in the bed. Consequently achieving interfacial area between gas and solid in the bed experimentally is so significant. On interfacial area measurement in fluidized bed with gas has been worked, but light transmission technique has been used less. Therefore, in the current research the possibility of using of this technique and its accuracy are investigated. Measuring, a fluidized bed was designed and the problems were averted as far as possible. By using fine solid with equal shape and diameter and installing an optical system, the absorption of light during the time of fluidization has been measured. Results indicate that this method that its validity has been proved in the gas-liquid system, by different reasons have less application in gas-solid system. One important reason could be non-uniformity in such systems.
Abstract: Traditional optical networks are gradually evolving towards intelligent optical networks due to the need for faster bandwidth provisioning, protection and restoration of the network that can be accomplished with devices like optical switch, add drop multiplexer and cross connects. Since dense wavelength multiplexing forms the physical layer for intelligent optical networking, the roll of high speed all optical switch is important. This paper analyzes such an ultra-high speed polymer electro-optic switch. The performances of the 2x2 optical waveguide switch with rectangular, triangular and trapezoidal grating profiles on various device parameters are analyzed. The simulation result shows that trapezoidal grating is the optimized structure which has the coupling length of 81μm and switching voltage of 11V for the operating wavelength of 1550nm. The switching time for this proposed switch is 0.47 picosecond. This makes the proposed switch to be an important element in the intelligent optical network.
Abstract: Active vibration isolation systems are less commonly
used than passive systems due to their associated cost and power
requirements. In principle, semi-active isolation systems can deliver
the versatility, adaptability and higher performance of fully active
systems for a fraction of the power consumption. Various semi-active
control algorithms have been suggested in the past. This paper
studies the 4DOF model of semi-active suspension performance
controlled by on–off and continuous skyhook damping control
strategy. The frequency and transient responses of model are
evaluated in terms of body acceleration, roll angle and tire deflection
and are compared with that of a passive damper. The results show
that the semi-active system controlled by skyhook strategy always
provides better isolation than a conventional passively damped
system except at tire natural frequencies.
Abstract: The Minimum Vertex Cover (MVC) problem is a classic
graph optimization NP - complete problem. In this paper a competent
algorithm, called Vertex Support Algorithm (VSA), is designed to
find the smallest vertex cover of a graph. The VSA is tested on a
large number of random graphs and DIMACS benchmark graphs.
Comparative study of this algorithm with the other existing methods
has been carried out. Extensive simulation results show that the VSA
can yield better solutions than other existing algorithms found in the
literature for solving the minimum vertex cover problem.
Abstract: A synchronous network-on-chip using wormhole packet switching
and supporting guaranteed-completion best-effort with low-priority (LP)
and high-priority (HP) wormhole packet delivery service is presented in
this paper. Both our proposed LP and HP message services deliver a good
quality of service in term of lossless packet completion and in-order message
data delivery. However, the LP message service does not guarantee minimal
completion bound. The HP packets will absolutely use 100% bandwidth of
their reserved links if the HP packets are injected from the source node with
maximum injection. Hence, the service are suitable for small size messages
(less than hundred bytes). Otherwise the other HP and LP messages, which
require also the links, will experience relatively high latency depending on the
size of the HP message. The LP packets are routed using a minimal adaptive
routing, while the HP packets are routed using a non-minimal adaptive routing
algorithm. Therefore, an additional 3-bit field, identifying the packet type,
is introduced in their packet headers to classify and to determine the type
of service committed to the packet. Our NoC prototypes have been also
synthesized using a 180-nm CMOS standard-cell technology to evaluate the
cost of implementing the combination of both services.
Abstract: Linear stability analysis of wake-shear layers in twophase
shallow flows is performed in the present paper. Twodimensional
shallow water equations are used in the analysis. It is
assumed that the fluid contains uniformly distributed solid particles.
No dynamic interaction between the carrier fluid and particles is
expected in the initial moment. The stability calculations are
performed for different values of the particle loading parameter and
two other parameters which characterize the velocity ratio and the
velocity deficit. The results show that the particle loading parameter
has a stabilizing effect on the flow while the increase in the velocity
ratio or in the velocity deficit destabilizes the flow.
Abstract: Retinoic acid is like a steroid hormone that plays a
role in embryo formation, proliferation of spermatogonia cells,
ephitelial cells differentiation and organogenesis. Retinoic acid can
influences seminiferous tubule formation during embryonic testis
development and also play a role in the regulation of ovarian function
and female reproductive tract by suppressing the hormones FSH
receptor expression. The excessive use of retinoic acid caused
abnormalities in the fetus. The result showed that there is the
influence of retinoic acid on the developmet of mice fetal testes, for
examples disruption of the formation of seminiferous tubules and
tubules seemed to be hollow, spermatogonia cells are relatively few
in number and caused Leydig cells count relatively more. While in
the female fetus does not caused the formation of primordial follicles
and disrupted the development of germinal ephitelial cells of fetal
ovaries of female mice (mus musculus) Swiss Webster.
Abstract: The line sleeves on power transmission line connects
two conductors while the transmission line is constructing. However,
the line sleeves sometimes cause transmission line break down,
because the line sleeves are deteriorated and decayed by acid rain.
When the transmission line is broken, the economical loss is huge.
Therefore the line sleeves on power transmission lines should be
inspected periodically to prevent power failure. In this paper, Korea
Electric Power Research Institute reviewed several robots to inspect
line status and proposes a robot to inspect line sleeve by measuring
magnetic field on line sleeve. The developed inspection tool can
reliable to move along transmission line and overcome several
obstacles on transmission line. The developed system is also applied
on power transmission line and verified the efficiency of the robot.
Abstract: Software-as-a-Service (SaaS) is a form of cloud
computing that relieves the user of the burden of hardware and
software installation and management. SaaS can be used at the course
level to enhance curricula and student experience. When cloud
computing and SaaS are included in educational literature, the focus
is typically on implementing administrative functions. Yet, SaaS can
make more immediate and substantial contributions to the technical
course content in educational offerings. This paper explores cloud
computing and SaaS, provides examples, reports on experiences
using SaaS to offer specialized software in courses, and analyzes the
advantages and disadvantages of using SaaS at the course level. The
paper contributes to the literature in higher education by analyzing
the major technical concepts, potential, and constraints for using
SaaS to deliver specialized software at the course level. Further it
may enable more educators and students to benefit from this
emerging technology.
Abstract: Microarrays have become the effective, broadly used tools in biological and medical research to address a wide range of problems, including classification of disease subtypes and tumors. Many statistical methods are available for analyzing and systematizing these complex data into meaningful information, and one of the main goals in analyzing gene expression data is the detection of samples or genes with similar expression patterns. In this paper, we express and compare the performance of several clustering methods based on data preprocessing including strategies of normalization or noise clearness. We also evaluate each of these clustering methods with validation measures for both simulated data and real gene expression data. Consequently, clustering methods which are common used in microarray data analysis are affected by normalization and degree of noise and clearness for datasets.
Abstract: In this paper, we propose an effective relay
communication for layered video transmission as an alternative to
make the most of limited resources in a wireless communication
network where loss often occurs. Relaying brings stable multimedia
services to end clients, compared to multiple description coding
(MDC). Also, retransmission of only parity data about one or more
video layer using channel coder to the end client of the relay device is
paramount to the robustness of the loss situation. Using these
methods in resource-constrained environments, such as real-time user
created content (UCC) with layered video transmission, can provide
high-quality services even in a poor communication environment.
Minimal services are also possible. The mathematical analysis shows
that the proposed method reduced the probability of GOP loss rate
compared to MDC and raptor code without relay. The GOP loss rate
is about zero, while MDC and raptor code without relay have a GOP
loss rate of 36% and 70% in case of 10% frame loss rate.
Abstract: Microarrays technique allows the simultaneous measurements of the expression levels of thousands of mRNAs. By mining this data one can identify the dynamics of the gene expression time series. By recourse of principal component analysis, we uncover the circadian rhythmic patterns underlying the gene expression profiles from Cyanobacterium Synechocystis. We applied PCA to reduce the dimensionality of the data set. Examination of the components also provides insight into the underlying factors measured in the experiments. Our results suggest that all rhythmic content of data can be reduced to three main components.
Abstract: One of the mayor problems of programming a cruise
circuit is to decide which destinations to include and which don-t.
Thus a decision problem emerges, that might be solved using a linear
and goal programming approach. The problem becomes more
complex if several boats in the fleet must be programmed in a limited
schedule, trying their capacity matches best a seasonal demand and
also attempting to minimize the operation costs. Moreover, the
programmer of the company should consider the time of the
passenger as a limited asset, and would like to maximize its usage.
The aim of this work is to design a method in which, using linear and
goal programming techniques, a model to design circuits for the
cruise company decision maker can achieve an optimal solution
within the fleet schedule.
Abstract: We study the problem of decision making with Dempster-Shafer belief structure. We analyze the previous work developed by Yager about using the ordered weighted averaging (OWA) operator in the aggregation of the Dempster-Shafer decision process. We discuss the possibility of aggregating with an ascending order in the OWA operator for the cases where the smallest value is the best result. We suggest the introduction of the ordered weighted geometric (OWG) operator in the Dempster-Shafer framework. In this case, we also discuss the possibility of aggregating with an ascending order and we find that it is completely necessary as the OWG operator cannot aggregate negative numbers. Finally, we give an illustrative example where we can see the different results obtained by using the OWA, the Ascending OWA (AOWA), the OWG and the Ascending OWG (AOWG) operator.
Abstract: A simple approach is demonstrated for growing large
scale, nearly vertically aligned ZnO nanowire arrays by thermal
oxidation method. To reveal effect of temperature on growth and
physical properties of the ZnO nanowires, gold coated zinc substrates
were annealed at 300 °C and 400 °C for 4 hours duration in air. Xray
diffraction patterns of annealed samples indicated a set of well
defined diffraction peaks, indexed to the wurtzite hexagonal phase of
ZnO. The scanning electron microscopy studies show formation of
ZnO nanowires having length of several microns and average of
diameter less than 500 nm. It is found that the areal density of wires
is relatively higher, when the annealing is carried out at higher
temperature i.e. at 400°C. From the field emission studies, the values
of the turn-on and threshold field, required to draw emission current
density of 10 μA/cm2 and 100 μA/cm2 are observed to be 1.2 V/μm
and 1.7 V/μm for the samples annealed at 300 °C and 2.9 V/μm and
3.7 V/μm for that annealed at 400 °C, respectively. The field
emission current stability, investigated over duration of more than 2
hours at the preset value of 1 μA, is found to be fairly good in both
cases. The simplicity of the synthesis route coupled with the
promising field emission properties offer unprecedented advantage
for the use of ZnO field emitters for high current density
applications.