Abstract: Microparticles carrier systems made from naturally occurring polymers based on chitosan/casein system appears to be a promising carrier for the sustained release of orally and parenteral administered drugs. In the current study we followed a microencapsulation technique based aqueous coacervation method to prepare chitosan/casein microparticles of compositions 1:1, 1:2 and 1:5 incorporated with chloramphenicol. Glutaraldehyde was used as a chemical cross-linking agent. The microparticles were prepared by aerosol method and studied by optical microscopy, infrared spectroscopy, thermo gravimetric analysis, swelling studies and drug release studies at various pH. The percentage swelling of the polymers are found to be in the order pH 4 > pH 10 > pH 7 and the increase in casein composition decrease the swelling percentage. The drug release studies also follow the above order.
Abstract: The main objective of Automatic Generation Control (AGC) is to balance the total system generation against system load losses so that the desired frequency and power interchange with neighboring systems is maintained. Any mismatch between generation and demand causes the system frequency to deviate from its nominal value. Thus high frequency deviation may lead to system collapse. This necessitates a very fast and accurate controller to maintain the nominal system frequency. This paper deals with a novel approach of artificial intelligence (AI) technique called Hybrid Neuro-Fuzzy (HNF) approach for an (AGC). The advantage of this controller is that it can handle the non-linearities at the same time it is faster than other conventional controllers. The effectiveness of the proposed controller in increasing the damping of local and inter area modes of oscillation is demonstrated in a two area interconnected power system. The result shows that intelligent controller is having improved dynamic response and at the same time faster than conventional controller.
Abstract: Oxidative stress makes up common incidents in
eukaryotic metabolism. The presence of diverse components
disturbing the equilibrium during oxygen metabolism increases
oxidative damage unspecifically in living cells. Body´s own
ubiquinone (Q10) seems to be a promising drug in defending the
heightened appearance of reactive oxygen species (ROS). Though, its
lipophilic properties require a new strategy in drug formulation to
overcome their low bioavailability. Consequently, the manufacture of
heterogeneous nanodispersions is in focus for medical applications.
The composition of conventional nanodispersions is made up of a
drug-consisting core and a surfactive agent, also named as surfactant.
Long-termed encapsulation of the surfactive components into tissues
might be the consequence of the use during medical therapeutics. The
potential of provoking side-effects is given by their nonbiodegradable
properties. Further improvements during fabrication
process use the incorporation of biodegradable components such as
modified γ-polyglutamic acid which decreases the potential of
prospective side-effects.
Abstract: This paper presents a hybrid approach for solving nqueen problem by combination of PSO and SA. PSO is a population based heuristic method that sometimes traps in local maximum. To solve this problem we can use SA. Although SA suffer from many iterations and long time convergence for solving some problems, By good adjusting initial parameters such as temperature and the length of temperature stages SA guarantees convergence. In this article we use discrete PSO (due to nature of n-queen problem) to achieve a good local maximum. Then we use SA to escape from local maximum. The experimental results show that our hybrid method in comparison of SA method converges to result faster, especially for high dimensions n-queen problems.
Abstract: Protection and proper management of archaeological heritage are an essential process of studying and interpreting the generations present and future. Protecting the archaeological heritage is based upon multidiscipline professional collaboration. This study aims to gather data by different sources (Photogrammetry and Geographic Information System (GIS)) integrated for the purpose of documenting one the of significant archeological sites (Ahl-Alkahf, Jordan). 3D modeling deals with the actual image of the features, shapes and texture to represent reality as realistically as possible by using texture. The 3D coordinates that result of the photogrammetric adjustment procedures are used to create 3D-models of the study area. Adding Textures to the 3D-models surfaces gives a 'real world' appearance to the displayed models. GIS system combined all data, including boundary maps, indicating the location of archeological sites, transportation layer, digital elevation model and orthoimages. For realistic representation of the study area, 3D - GIS model prepared, where efficient generation, management and visualization of such special data can be achieved.
Abstract: In this paper we consider a one-dimensional random
geometric graph process with the inter-nodal gaps evolving according
to an exponential AR(1) process. The transition probability matrix
and stationary distribution are derived for the Markov chains concerning
connectivity and the number of components. We analyze the
algorithm for hitting time regarding disconnectivity. In addition to
dynamical properties, we also study topological properties for static
snapshots. We obtain the degree distributions as well as asymptotic
precise bounds and strong law of large numbers for connectivity
threshold distance and the largest nearest neighbor distance amongst
others. Both exact results and limit theorems are provided in this
paper.
Abstract: Tubular linear induction motor (TLIM) can be used as a capsule pump in a large pneumatic capsule pipeline (PCP) system. Parametric performance evaluation of the designed 1-meter diameter PCP-TLIM system yields encouraging results for practical implementation. The capsule thrust and speed inside the TLIM pump can be calculated from the combination of the PCP fluid mechanics and the TLIM equations. The TLIM equivalent circuits derived from those of the conventional three-phase induction motor are used as a model to predict the static test results of a small-scale PCP-TLIM system. In this paper, additional dynamic tests are performed on the same small-scale PCP-TLIM system with two capsules of different diameters. The behaviors of the capsule inside the pump are observed and analyzed. The dynamic performances from the dynamic tests are compared with the theoretical predictions based on the TLIM equivalent circuit model.
Abstract: In this study, a nickel film with nano-crystalline grains,
high hardness and smooth surface was electrodeposited using a post
supercritical carbon dioxide (CO2) mixed Watts electrolyte. Although
the hardness was not as high as its Sc-CO2 counterpart, the thin coating
contained significantly less number of nano-sized pinholes. By
measuring the escape concentration of the dissolved CO2 in post
Sc-CO2 mixed electrolyte with the elapsed time, it was believed that
the residue of dissolved CO2 bubbles should closely relate to the
improvement in hardness and surface roughness over its conventional
plating counterpart. Therefore, shortening the duration of
electroplating with the raise of current density up to 0.5 A/cm2 could
effectively retain more post Sc-CO2 mixing effect. This study not only
confirms the roles of dissolved CO2 bubbles in electrolyte but also
provides a potential process to overcome most issues associated with
the cost in building high-pressure chamber for large size products and
continuous plating using supercritical method.
Abstract: The SOM has several beneficial features which make
it a useful method for data mining. One of the most important
features is the ability to preserve the topology in the projection.
There are several measures that can be used to quantify the goodness
of the map in order to obtain the optimal projection, including the
average quantization error and many topological errors. Many
researches have studied how the topology preservation should be
measured. One option consists of using the topographic error which
considers the ratio of data vectors for which the first and second best
BMUs are not adjacent. In this work we present a study of the
behaviour of the topographic error in different kinds of maps. We
have found that this error devaluates the rectangular maps and we
have studied the reasons why this happens. Finally, we suggest a new
topological error to improve the deficiency of the topographic error.
Abstract: The paper examines the performance of bit-interleaved parity (BIP) methods in error rate monitoring, and in declaration and clearing of alarms in those transport networks that employ automatic protection switching (APS). The BIP-based error rate monitoring is attractive for its simplicity and ease of implementation. The BIP-based results are compared with exact results and are found to declare the alarms too late, and to clear the alarms too early. It is concluded that the standards development and systems implementation should take into account the fact of early clearing and late declaration of alarms. The window parameters defining the detection and clearing thresholds should be set so as to build sufficient hysteresis into the system to ensure that BIP-based implementations yield acceptable performance results.
Abstract: Software maintenance, which involves making enhancements, modifications and corrections to existing software systems, consumes more than half of developer time. Specification comprehensibility plays an important role in software maintenance as it permits the understanding of the system properties more easily and quickly. The use of formal notation such as B increases a specification-s precision and consistency. However, the notation is regarded as being difficult to comprehend. Semi-formal notation such as the Unified Modelling Language (UML) is perceived as more accessible but it lacks formality. Perhaps by combining both notations could produce a specification that is not only accurate and consistent but also accessible to users. This paper presents an experiment conducted on a model that integrates the use of both UML and B notations, namely UML-B, versus a B model alone. The objective of the experiment was to evaluate the comprehensibility of a UML-B model compared to a traditional B model. The measurement used in the experiment focused on the efficiency in performing the comprehension tasks. The experiment employed a cross-over design and was conducted on forty-one subjects, including undergraduate and masters students. The results show that the notation used in the UML-B model is more comprehensible than the B model.
Abstract: Using a force balanced translational-radial dynamics,
phase space of the moving single bubble sonoluminescence (m-
SBSL) in 85% wt sulfuric acid has been numerically calculated. This
phase space is compared with that of single bubble sonoluminescence
(SBSL) in pure water which has been calculated by using the mere
radial dynamics. It is shown that in 85% wt sulfuric acid, in a general
agreement with experiment, the bubble-s positional instability
threshold lays under the shape instability threshold. At the onset of
spatial instability of moving sonoluminescing (SL) bubble in 85%
wt sulfuric acid, temporal effects of the hydrodynamic force on the
bubble translational-radial dynamics have been investigated. The
appearance of non-zero history force on the moving SL bubble is
because of proper condition which was produced by high viscosity of
acid. Around the moving bubble collapse due to the rapid contraction
of the bubble wall, the inertial based added mass force overcomes the
viscous based history force and induces acceleration on the bubble
translational motion.
Abstract: In this paper we present the modeling, design, and
experimental testing of a nerve cuff multi-electrode system for
diameter-selective vagus nerve stimulation.
The multi-electrode system contained ninety-nine platinum
electrodes embedded within a self-curling spiral silicone sheet. The
electrodes were organized in a matrix having nine parallel groups,
each containing eleven electrodes.
Preliminary testing of the nerve cuff was performed in an isolated
segment of a swinish left cervical vagus nerve. For selective vagus
nerve stimulation, precisely defined current quasitrapezoidal,
asymmetric and biphasic stimulating pulses were applied to
preselected locations along the left vagus segment via appointed
group of three electrodes within the cuff. Selective stimulation was
obtained by anodal block. However, these pulses may not be safe for
a long-term application because of a frequently used high imbalance
between the cathodic and anodic part of the stimulating pulse.
Preliminary results show that the cuff was capable of exciting A
and B-fibres, and, that for a certain range of parameters used in
stimulating pulses, the contribution of A-fibres to the CAP was
slightly reduced and the contribution of B-fibres was slightly larger.
Results also showed that measured CAPs are not greatly
influenced by the imbalance between a charge Qc injected in cathodic
and Qa in anodic phase of quasitrapezoidal, asymmetric and biphasic
pulses.
Abstract: This paper describes the development of a WLAN
propagation model, using Spectral Analyzer measurements. The
signal is generated by two Access Points (APs) on the base floor at
the administrative Communication School of ESPOL building. In
general, users do not have a Q&S reference about a wireless network;
however, this depends on the level signal as a function of frequency,
distance and other path conditions between receiver and transmitter.
Then, power density of the signal decrease as it propagates through
space and data transfer rate is affected. This document evaluates and
implements empirical mathematical formulation for the
characterization of WLAN radio wave propagation on two aisles of
the building base floor.
Abstract: The main objective of this study was to demonstrate that differentiation of infected and vaccinated animals (DIVA) strategy using different ELISA tests is possible when a subunit vaccine (Haemagglutinin protein) is used to prevent Avian influenza. Special emphasis was placed on the differentiation in the serological response to different components of the AIV (Nucleoprotein, Neuraminidase, Haemagglutinin, Nucleocapsid) between chickens that were vaccinated with a whole virus kill vaccine and recombinant vaccine. Furthermore, the potential use of this DIVA strategy using ELISA assays to detect Neuraminidase 1 (N1) was analyzed as strategy in countries where the field virus is H5N1 and the vaccine used is formulated with H5N2. Detection of AIV-s antibodies to any component in serum was negative for all animals on the study days 0-13. At study day 14 the titers of antibodies against Nucleoprotein (NP) and Nucleocapsid (NC) rose in the experimental groups vaccinated with Volvac® AI KV and were negatives during all the trial in the experimental groups vaccinated with a subunit H5; significant statistically differences were observed between these groups (p < 0.05). The seroconversion either Haemagglutinin or Neuraminidase was evident after 21 days post-vaccination in the experimental groups vaccinated with the respective viral fraction. Regarding the main aim of this study and according with the results that were obtained, use a combination of different ELISA test as a DIVA strategy is feasible when the vaccination is carry out with a subunit H5 vaccine. Also is possible to use the ELISA kit to detect Neuraminidase (either N1 or N2) as a DIVA concept in countries where H5N1 is present and the vaccination programs are done with H5N2 vaccine.
Abstract: In this paper, with the purpose of further reducing the
complexity of the system, while keeping its temporal and spatial
focusing performance, we investigate the possibility of using optimal
one bit time reversal (TR) system for impulse radio ultra wideband
multi-user wireless communications. The results show that, by optimally
selecting the number of used taps in the pre-filter the optimal
one bit TR system can outperform the full one bit TR system. In
some cases, the temporal and spatial focusing performance of the
optimal one bit TR system appears to be compatible with that of the
original TR system. This is a significant result as the overhead cost
is much lower than it is required in the original TR system.
Abstract: Delay-Tolerant Networks (DTNs) are sparse, wireless
networks where disconnections are common due to host mobility and
low node density. The Message Ferrying (MF) scheme is a mobilityassisted
paradigm to improve connectivity in DTN-like networks. A
ferry or message ferry is a special node in the network which has
a per-determined route in the deployed area and relays messages
between mobile hosts (MHs) which are intermittently connected.
Increased contact opportunities among mobile hosts and the ferry
improve the performance of the network, both in terms of message
delivery ratio and average end-end delay. However, due to the inherent
mobility of mobile hosts and pre-determined periodicity of the
message ferry, mobile hosts may often -miss- contact opportunities
with a ferry. In this paper, we propose the combination of stationary
ferry access points (FAPs) with MF routing to increase contact
opportunities between mobile hosts and the MF and consequently
improve the performance of the DTN. We also propose several
placement models for deploying FAPs on MF routes. We evaluate the
performance of the FAP placement models through comprehensive
simulation. Our findings show that FAPs do improve the performance
of MF-assisted DTNs and symmetric placement of FAPs outperforms
other placement strategies.
Abstract: Cluster analysis is the name given to a diverse collection of techniques that can be used to classify objects (e.g. individuals, quadrats, species etc). While Kohonen's Self-Organizing Feature Map (SOFM) or Self-Organizing Map (SOM) networks have been successfully applied as a classification tool to various problem domains, including speech recognition, image data compression, image or character recognition, robot control and medical diagnosis, its potential as a robust substitute for clustering analysis remains relatively unresearched. SOM networks combine competitive learning with dimensionality reduction by smoothing the clusters with respect to an a priori grid and provide a powerful tool for data visualization. In this paper, SOM is used for creating a toroidal mapping of two-dimensional lattice to perform cluster analysis on results of a chemical analysis of wines produced in the same region in Italy but derived from three different cultivators, referred to as the “wine recognition data" located in the University of California-Irvine database. The results are encouraging and it is believed that SOM would make an appealing and powerful decision-support system tool for clustering tasks and for data visualization.
Abstract: This paper focuses on a novel method for semantic
searching and retrieval of information about learning materials.
Metametadata encapsulate metadata instances by using the properties
and attributes provided by ontologies rather than describing learning
objects. A novel metametadata taxonomy has been developed which
provides the basis for a semantic search engine to extract, match and
map queries to retrieve relevant results. The use of ontological views
is a foundation for viewing the pedagogical content of metadata
extracted from learning objects by using the pedagogical attributes
from the metametadata taxonomy. Using the ontological approach
and metametadata (based on the metametadata taxonomy) we present
a novel semantic searching mechanism.These three strands – the
taxonomy, the ontological views, and the search algorithm – are
incorporated into a novel architecture (OMESCOD) which has been
implemented.
Abstract: Does the spatial perspective provide a common thread for rural sociology? Have rural sociologists succeeded in bringing order to their data using spatial analysis models and techniques? A trial answer to such questions, as touchstones of theoretical and applied sociological studies in rural areas, is the point at issue in the present paper. Spatial analyses have changed the way rural sociologists approach scientific problems. Rural sociology is spatial by nature because much, if not most, of its research topics has a spatial “awareness." However, such spatial awareness is not quite the same as spatial analysis because it is not typically associated with underlying theories and hypotheses about spatial patterns that are designed to be tested for their specific spatial content. This paper presents pressing issues for future research to reintroduce mainstream rural sociology to the concept of space.