Abstract: Development of a method to estimate gene functions is
an important task in bioinformatics. One of the approaches for the
annotation is the identification of the metabolic pathway that genes are
involved in. Since gene expression data reflect various intracellular
phenomena, those data are considered to be related with genes’
functions. However, it has been difficult to estimate the gene function
with high accuracy. It is considered that the low accuracy of the
estimation is caused by the difficulty of accurately measuring a gene
expression. Even though they are measured under the same condition,
the gene expressions will vary usually. In this study, we proposed a
feature extraction method focusing on the variability of gene
expressions to estimate the genes' metabolic pathway accurately. First,
we estimated the distribution of each gene expression from replicate
data. Next, we calculated the similarity between all gene pairs by KL
divergence, which is a method for calculating the similarity between
distributions. Finally, we utilized the similarity vectors as feature
vectors and trained the multiclass SVM for identifying the genes'
metabolic pathway. To evaluate our developed method, we applied the
method to budding yeast and trained the multiclass SVM for
identifying the seven metabolic pathways. As a result, the accuracy
that calculated by our developed method was higher than the one that
calculated from the raw gene expression data. Thus, our developed
method combined with KL divergence is useful for identifying the
genes' metabolic pathway.
Abstract: In this paper, an effective non-destructive, noninvasive
approach for leak detection was proposed. The process relies
on analyzing thermal images collected by an IR viewer device that
captures thermo-grams. In this study a statistical analysis of the
collected thermal images of the ground surface along the expected
leak location followed by a visual inspection of the thermo-grams
was performed in order to locate the leak. In order to verify the
applicability of the proposed approach the predicted leak location
from the developed approach was compared with the real leak
location. The results showed that the expected leak location was
successfully identified with an accuracy of more than 95%.
Abstract: Human leukocyte antigen (HLA) typing from next
generation sequencing (NGS) data has the potential for applications in
clinical laboratories and population genetic studies. Here we introduce
a novel technique for HLA typing from NGS data based on
read-mapping using a comprehensive reference panel containing all
known HLA alleles and de novo assembly of the gene-specific short
reads. An accurate HLA typing at high-digit resolution was achieved
when it was tested on publicly available NGS data, outperforming
other newly-developed tools such as HLAminer and PHLAT.
Abstract: Experimental & numeral study of temperature
distribution during milling process, is important in milling quality
and tools life aspects. In the present study the milling cross-section
temperature is determined by using Artificial Neural Networks
(ANN) according to the temperature of certain points of the work
piece and the point specifications and the milling rotational speed of
the blade. In the present work, at first three-dimensional model of the
work piece is provided and then by using the Computational Heat
Transfer (CHT) simulations, temperature in different nods of the
work piece are specified in steady-state conditions. Results obtained
from CHT are used for training and testing the ANN approach. Using
reverse engineering and setting the desired x, y, z and the milling
rotational speed of the blade as input data to the network, the milling
surface temperature determined by neural network is presented as
output data. The desired points temperature for different milling
blade rotational speed are obtained experimentally and by
extrapolation method for the milling surface temperature is obtained
and a comparison is performed among the soft programming ANN,
CHT results and experimental data and it is observed that ANN soft
programming code can be used more efficiently to determine the
temperature in a milling process.
Abstract: Micro-alloyed steel components are used in
automotive industry for the necessity to make the manufacturing
process cycles shorter when compared to conventional steel by
eliminating heat treatment cycles, so an important saving of costs and
energy can be reached by reducing the number of operations. Microalloying
elements like vanadium, niobium or titanium have been
added to medium carbon steels to achieve grain refinement with or
without precipitation strengthening along with uniform
microstructure throughout the matrix. Present study reports the
applicability of medium carbon vanadium micro-alloyed steel in hot
forging. Forgeability has been determined with respect to different
cooling rates, after forging in a hydraulic press at 50% diameter
reduction in temperature range of 900-11000C. Final microstructures,
hardness, tensile strength, and impact strength have been evaluated.
The friction coefficients of different lubricating conditions, viz.,
graphite in hydraulic oil, graphite in furnace oil, DF 150 (Graphite,
Water-Based) die lubricant and dry or without any lubrication were
obtained from the ring compression test for the above micro-alloyed
steel. Results of ring compression tests indicate that graphite in
hydraulic oil lubricant is preferred for free forging and dry lubricant
is preferred for die forging operation. Exceptionally good forgeability
and high resistance to fracture, especially for faster cooling rate has
been observed for fine equiaxed ferrite-pearlite grains, some amount
of bainite and fine precipitates of vanadium carbides and
carbonitrides. The results indicated that the cooling rate has a
remarkable effect on the microstructure and mechanical properties at
room temperature.
Abstract: Unmanned Aircraft Systems (UAS) become
indispensable parts of modern airpower as force multiplier. One of
the main advantages of UAS is long endurance. UAS have to take
extra payloads to accomplish different missions but these payloads
decrease endurance of aircraft because of increasing drag. There are
continuing researches to increase the capability of UAS. There are
some vertical thermal air currents, which can cause climb and
increase endurance, in nature. Birds and gliders use thermals to gain
altitude with no effort. UAS have wide wings which can use
thermals like birds and gliders. Thermal regions, which is area of
2000-3000 meter (1 NM), exist all around the world. It is natural and
infinite source. This study analyses if thermal regions can be adopted
and implemented as an assistant tool for UAS route planning. First
and second part of study will contain information about the thermal
regions and current applications about UAS in aviation and climbing
performance with a real example. Continuing parts will analyze the
contribution of thermal regions to UAS endurance. Contribution is
important because planning declaration of UAS navigation rules will
be in 2015.
Abstract: The concept of technology as well as itself has
evolved continuously over time, such that, nowadays, this concept is
still marked by myths and realities. Even the concept of science is
frequently misunderstood as technology. In this way, this paper
presents different forms of interpretation of the concept of technology
in the course of history, as well as the social and cultural aspects
associated with it, through an analysis made by means of insights
from sociological studies of science and technology and its multiple
relations with society. Through the analysis of contents, the paper
presents a classification of how technology is interpreted in the social
sphere and search channel efforts to show how a broader
understanding can contribute to better interpretations of how
scientific and technological development influences the environment
in which we operate. The text also presents a particular point of view
for the interpretation of the concept from the analysis throughout the
whole work.
Abstract: The goal of image segmentation is to cluster pixels
into salient image regions. Segmentation could be used for object
recognition, occlusion boundary estimation within motion or stereo
systems, image compression, image editing, or image database lookup.
In this paper, we present a color image segmentation using
support vector machine (SVM) pixel classification. Firstly, the pixel
level color and texture features of the image are extracted and they
are used as input to the SVM classifier. These features are extracted
using the homogeneity model and Gabor Filter. With the extracted
pixel level features, the SVM Classifier is trained by using FCM
(Fuzzy C-Means).The image segmentation takes the advantage of
both the pixel level information of the image and also the ability of
the SVM Classifier. The Experiments show that the proposed method
has a very good segmentation result and a better efficiency, increases
the quality of the image segmentation compared with the other
segmentation methods proposed in the literature.
Abstract: The objectives of study are the following: To study
the way of life in terms of one hundred years co-existence of the
Muslim and local community in this area 2) To analyze factors affect
to this community with happy co-existence. The study requires
quantitative research to study a history together with the study of
humanity. The result of this study showed that the area of Petchburi
7 community is an ancient area which has owned by the Muslim for
almost 100 years. There is a sanctuary as & center of unity. Later
Bangkok becomes developed and provides more infrastructures like
motorway and other transportation: however, the owners of lands in
this community still keep their lands and build many buildings to run
business. With this purpose, there are many non-Muslim people come
to live here with co-existence. Not only are they convenient to work
but also easy to transport by sky train. There are factors that make
them live harmonious as following: 1) All Muslims in this area are
strict to follow their rules and allocate their community for business.
2) All people, who come and live here, are middle-aged and working
men and women. They, rent rooms closed to their work. 3) There are
Muslim food and desserts, especially Roti, the popular fried flour,
and local Chachak, tea originated from the south of Thailand. All
these food and desserts are famous for working men and women to
home and join after work 4) All Muslim in this area are independent
to lead their own lives although a society changes rapidly.
Abstract: Doxorubicin, also known as Adriamycin, is an
anthracycline class of drug used in cancer chemotherapy. It is used in
the treatment of non-Hodgkin’s lymphoma, multiple myeloma, acute
leukemia, breast cancer, lung cancer, endometrium cancer and ovary
cancers. It functions via intercalating DNA and ultimately killing
cancer cells. The major side effects of doxorubicin are hair loss,
myelosuppression, nausea & vomiting, oesophagitis, diarrhea, heart
damage and liver dysfunction. The minor modifications in the
structure of compound exhibit large variation in the biological
activity, has prompted us to carry out the synthesis of sulfonamide
derivatives. Sulfonamide is an important feature with broad spectrum
of biological activity such as antiviral, antifungal, diuretics, antiinflammatory,
antibacterial and anticancer activities. Structure of the
synthesized compound N-(1-methyl-2-oxo-2-N-methyl anilinoethyl)
benzene sulfonamide confirmed by proton nuclear magnetic
resonance (1H NMR),13C NMR, Mass and FTIR spectroscopic tools
to assure the position of all protons and hence stereochemistry of the
molecule. Further we have reported the binding potential of
synthesized sulfonamide analogues in comparison to doxorubicin
drug using Auto Dock 4.2 software. Computational binding energy
(B.E.) and inhibitory constant (Ki) has been evaluated for the
synthesized compound in comparison of doxorubicin against Poly
(dA-dT).Poly (dA-dT) and Poly (dG-dC).Poly (dG-dC) sequences.
The in vitro cytotoxic study against human breast cancer cell lines
confirms the better anticancer activity of the synthesized compound
over currently in use anticancer drug doxorubicin. The IC50 value of
the synthesized compound is 7.12 μM whereas for doxorubicin is 7.2
μM.
Abstract: Formal verification is proposed to ensure the
correctness of the design and make functional verification more
efficient. As cache plays a vital role in the design of System on Chip
(SoC), and cache with Memory Management Unit (MMU) and cache
memory unit makes the state space too large for simulation to verify,
then a formal verification is presented for such system design. In the
paper, a formal model checking verification flow is suggested and a
new cache memory model which is called “exhaustive search model”
is proposed. Instead of using large size ram to denote the whole cache
memory, exhaustive search model employs just two cache blocks. For
cache system contains data cache (Dcache) and instruction cache
(Icache), Dcache memory model and Icache memory model are
established separately using the same mechanism. At last, the novel
model is employed to the verification of a cache which is module of a
custom-built SoC system that has been applied in practical, and the
result shows that the cache system is verified correctly using the
exhaustive search model, and it makes the verification much more
manageable and flexible.
Abstract: The purpose of this presentation is to describe an interdisciplinary teaching program that integrates physical education concepts using a philosophical approach. The presentation includes a review of: a) the philosophy of American education, b) the philosophy of sports and physical education, c) the interdisciplinary physical education program, d) professional development programs, (e) the Success of this physical education program, f) future of physical education. This unique interdisciplinary program has been implemented in an urban school physical education discipline in East Orange, New Jersey for over 10 years.
During the program the students realize that the bodies go through different experiences. The body becomes a place where a child can recognize in an enjoyable way to express and perceive particular feelings or mental states. Children may distinguish themselves to have high abilities in the social or other domains but low abilities in the field of athletics.
The goal of this program for the individuals is to discover new skills, develop and demonstrate age appropriate mastery level at different tasks, therefore the program consists of 9 to 12 sports, including many game. Each successful experience increases the awareness ability. Engaging in sports and physical activities are social movements involving groups of children in situations such as teams, friends, and recreational settings, which serve as a primary socializing agent for teaching interpersonal skills. As a result of this presentation the audience will reflect and explore how to structure a physical education program to integrate interdisciplinary subjects with philosophical concepts.
Abstract: The decision-making process is theoretically clearly
defined. Generally, it includes the problem identification and
analysis, data gathering, goals and criteria setting, alternatives
development and optimal alternative choice and its implementation.
In practice however, various modifications of the theoretical
decision-making process can occur. The managers can consider some
of the phases to be too complicated or unfeasible and thus they do not
carry them out and conversely some of the steps can be
overestimated.
The aim of the paper is to reveal and characterize the perception of
the individual phases of decision-making process by the managers.
The research is concerned with managers in the military environment
– commanders. Quantitative survey is focused cross-sectionally in the
individual levels of management of the Ministry of Defence of the
Czech Republic. On the total number of 135 respondents the analysis
focuses on which of the decision-making process phases are
problematic or not carried out in practice and which are again
perceived to be the easiest. Then it is examined the reasons of the
findings.
Abstract: This paper proposes a mathematical model and
examines the performance of an exact algorithm for a location–
transportation problems in humanitarian relief. The model determines
the number and location of distribution centers in a relief network,
the amount of relief supplies to be stocked at each distribution center
and the vehicles to take the supplies to meet the needs of disaster
victims under capacity restriction, transportation and budgetary
constraints. The computational experiments are conducted on the
various sizes of problems that are generated. Branch and bound
algorithm is applied for these problems. The results show that this
algorithm can solve problem sizes of up to three candidate locations
with five demand points and one candidate location with up to twenty
demand points without premature termination.
Abstract: In reference to the legal state in the Thai legal system,
most people understand the minor principles of the legal state form,
which are the principles that can be explained and understood easily
and the results can be seen clearly, especially in the legitimacy of
administrative acts. Therefore, there is no awareness of justice, which
is the fundamental value of Thai law. The legitimacy of administrative
acts requires the administration to adhere to the constitution and
legislative laws in enforcement of the laws. If it appears that the
administrative acts are illegitimate, the administrative court, as the
court of justice, will revoke those acts as if they had never been set in
the legal system, this will affect people’s trust as they are unaware as
to whether the administrative acts that appoint their lives are
legitimate or not. Regarding the revocation of administrative orders
by the administrative court as if those orders had never existed, the
common individual surely cannot be expected to comprehend the
security of their juristic position. Therefore, the legal state does not
require a revocation of the government’s acts to terminate its legal
results merely because those acts are illegitimate, but there should be
considerations and realizations regarding the “The Principle of the
Protection of Legitimate Expectation,” which is a minor principle in
the legal state’s content that focuses on supporting and protecting
legitimate expectations of the juristic position of an individual and
maintaining justice, which is the fundamental value of Thai law.
Abstract: In this paper, we consider the vehicle routing problem
with mixed fleet of conventional and heterogenous electric vehicles
and time dependent charging costs, denoted VRP-HFCC, in which
a set of geographically scattered customers have to be served by a
mixed fleet of vehicles composed of a heterogenous fleet of Electric
Vehicles (EVs), having different battery capacities and operating
costs, and Conventional Vehicles (CVs). We include the possibility
of charging EVs in the available charging stations during the routes
in order to serve all customers. Each charging station offers charging
service with a known technology of chargers and time dependent
charging costs. Charging stations are also subject to operating time
windows constraints. EVs are not necessarily compatible with all
available charging technologies and a partial charging is allowed.
Intermittent charging at the depot is also allowed provided that
constraints related to the electricity grid are satisfied.
The objective is to minimize the number of employed vehicles and
then minimize the total travel and charging costs.
In this study, we present a Mixed Integer Programming Model and
develop a Charging Routing Heuristic and a Local Search Heuristic
based on the Inject-Eject routine with different insertion methods. All
heuristics are tested on real data instances.
Abstract: In order to detect and quantify the phenolic contents
of a wastewater with biosensors, two working electrodes based on
modified Poly(Pyrrole) films were fabricated. Enzyme horseradish
peroxidase was used as biomolecule of the prepared electrodes.
Various phenolics were tested at the biosensor. Phenol detection was
realized by electrochemical reduction of quinones produced by
enzymatic activity. Analytical parameters were calculated and the
results were compared with each other.
Abstract: In urban area, several landmarks may affect housing
price and rents, and hedonic analysis should employ distance variables
corresponding to each landmarks. Unfortunately, the effects of
distances to landmarks on housing prices are generally not consistent
with the true price. These distance variables may cause magnitude
error in regression, pointing a problem of spatial multicollinearity. In
this paper, we provided some approaches for getting the samples with
less bias and method on locating the specific sampling area to avoid
the multicollinerity problem in two specific landmarks case.
Abstract: Fluid viscous damping systems are well suited for
many air vehicles subjected to shock and vibration. These damping
system work with the principle of viscous fluid throttling through the
orifice to create huge pressure difference between compression and
rebound chamber and obtain the required damping force. One
application of such systems is its use in aircraft door system to
counteract the door’s velocity and safely stop it. In exigency
situations like crash or emergency landing where the door doesn’t
open easily, possibly due to unusually tilting of fuselage or some
obstacles or intrusion of debris obstruction to move the parts of the
door, such system can be combined with other systems to provide
needed force to forcefully open the door and also securely stop it
simultaneously within the required time i.e. less than 8 seconds. In
the present study, a hydraulic system called snubber along with other
systems like actuator, gas bottle assembly which together known as
emergency power assist system (EPAS) is designed, built and
experimentally studied to check the magnitude of angular velocity,
damping force and time required to effectively open the door.
Whenever needed, the gas pressure from the bottle is released to
actuate the actuator and at the same time pull the snubber’s piston to
operate the emergency opening of the door. Such EPAS installed in
the suspension arm of the aircraft door is studied explicitly changing
parameters like orifice size, oil level, oil viscosity and bypass valve
gap and its spring of the snubber at varying temperature to generate
the optimum design case. Comparative analysis of the EPAS at
several cases is done and conclusions are made. It is found that
during emergency condition, the system opening time and angular
velocity, when snubber with 0.3mm piston and shaft orifice and
bypass valve gap of 0.5 mm with its original spring is used, shows
significant improvement over the old ones.
Abstract: Precise capture of plantar 3D surface of the foot at the
loading gait phases on rigid substrates was found to be valuable for
the assessment of the physiology, health and problems of the feet.
Photogrammetry, a precision 3D spatial data capture technique is
suitable for this type of dynamic application. In this research, the
technique is utilised to study the plantar deformation as a result of
having a strip of kinesiology tape on the plantar surface during the
loading phase of gait. For this pilot study, one healthy adult male
subject was recruited under the University’s human research ethics
guidelines for this preliminary study. The 3D plantar deformation
data with and without applying the tape were analysed. The results
and analyses are presented together with detailed findings.