Abstract: Kidney cancer is the most lethal urological cancer
accounting for 3% of adult malignancies. VHL, a tumor-suppressor
gene, is best known to be associated with renal cell carcinoma
(RCC). The VHL functions as negative regulator of hypoxia inducible
factors. Recent sequencing efforts have identified several novel
frequent mutations of histone modifying and chromatin remodeling
genes in ccRCC (clear cell RCC) including PBRM1 and SETD2. The
PBRM1 gene encodes the BAF180 protein, which involved in
transcriptional activation and repression of selected genes. SETD2
encodes a histone methyltransferase, which may play a role in
suppressing tumor development. In this study, RNAs of 30 paired
tumor and normal samples that were grouped according to the types
of kidney cancer and clinical characteristics of patients, including
gender and average age were examined by RT-PCR, SSCP and
sequencing techniques. VHL, PBRM1 and SETD2 expressions were
relatively down-regulated. However, statistically no significance was
found (Wilcoxon signed rank test, p>0.05). Interestingly, no mutation
was observed on the contrary of previous studies. Understanding the
molecular mechanisms involved in the pathogenesis of RCC has
aided the development of molecular-targeted drugs for kidney cancer.
Further analysis is required to identify the responsible genes rather
than VHL, PBRM1 and SETD2 in kidney cancer.
Abstract: The changes of the optical and structural properties of
Bismuth-Boro-Tellurite glasses pre and post gamma irradiation were
studied. Six glass samples, with different composition [(TeO2)0.7
(B2O3)0.3]1-x (Bi2O3)x prepared by melt quenching method were
irradiated with 25kGy gamma radiation at room temperature. The
Fourier Transform Infrared Spectroscopy (FTIR) was used to explore
the structural bonding in the prepared glass samples due to exposure,
while UV-VIS Spectrophotometer was used to evaluate the changes
in the optical properties before and after irradiation. Gamma
irradiation causes profound changes in the peak intensity as shown by
FTIR spectra which is due to the breaking of the network bonding.
Before gamma irradiation, the optical band gap, Eg value decreased
from 2.44 eV to 2.15 eV with the addition of Bismuth content. The
value kept decreasing (from 2.18 eV to 2.00 eV) following exposure
to gamma radiation due to the increase of non-bridging oxygen
(NBO) and the increase of defect in the glass. In conclusion, the glass
with high content of Bi2O3 (0.30Bi) give smallest Eg and show less
changes in FTIR spectra after gamma irradiation which indicate that
this glass is more resistant to gamma radiation compared to other
glasses.
Abstract: In Hungary, the society has changed a lot for the past
25 years, and these changes could be detected in educational
situations as well. The number and the intensity of conflicts have
been increased in most fields of life, as well as at schools. Teachers
have difficulties to be able to handle school conflicts. What is more,
the new net generation, generation Z has values and behavioural
patterns different from those of the previous one, which might
generate more serious conflicts at school, especially with teachers
who were mainly socialising in a traditional teacher – student
relationship.
In Hungary, the bill CCIV of 2011 declared the foundation of
Institutes of Teacher Training in higher education institutes. One of
the tasks of the Institutes is to survey the competences and needs of
teachers working in public education and to provide further trainings
and services for them according to their needs and requirements. This
job is supported by the Social Renewal Operative Programs 4.1.2.B.
The professors of a college carried out a questionnaire and surveyed
the needs and the requirements of teachers working in the region.
Based on the results, the professors of the Institute of Teacher
Training decided to meet the requirements of teachers and to launch
short teacher further training courses in spring 2015. One of the
courses is going to focus on school conflict management through
mediation.
The aim of the pilot course is to provide conflict management
techniques for teachers and to present different mediation techniques
to them. The theoretical part of the course (5 hours) will enable
participants to understand the main points and the advantages of
mediation, while the practical part (10 hours) will involve teachers in
role plays to learn how to cope with conflict situations applying
mediation. We hope if conflicts could be reduced, it would influence
school atmosphere in a positive way and the teaching – learning
process could be more successful and effective.
Abstract: The problems arising from unbalanced data sets
generally appear in real world applications. Due to unequal class
distribution, many researchers have found that the performance of
existing classifiers tends to be biased towards the majority class. The
k-nearest neighbors’ nonparametric discriminant analysis is a method
that was proposed for classifying unbalanced classes with good
performance. In this study, the methods of discriminant analysis are
of interest in investigating misclassification error rates for classimbalanced
data of three diabetes risk groups. The purpose of this
study was to compare the classification performance between
parametric discriminant analysis and nonparametric discriminant
analysis in a three-class classification of class-imbalanced data of
diabetes risk groups. Data from a project maintaining healthy
conditions for 599 employees of a government hospital in Bangkok
were obtained for the classification problem. The employees were
divided into three diabetes risk groups: non-risk (90%), risk (5%),
and diabetic (5%). The original data including the variables of
diabetes risk group, age, gender, blood glucose, and BMI were
analyzed and bootstrapped for 50 and 100 samples, 599 observations
per sample, for additional estimation of the misclassification error
rate. Each data set was explored for the departure of multivariate
normality and the equality of covariance matrices of the three risk
groups. Both the original data and the bootstrap samples showed nonnormality
and unequal covariance matrices. The parametric linear
discriminant function, quadratic discriminant function, and the
nonparametric k-nearest neighbors’ discriminant function were
performed over 50 and 100 bootstrap samples and applied to the
original data. Searching the optimal classification rule, the choices of
prior probabilities were set up for both equal proportions (0.33: 0.33:
0.33) and unequal proportions of (0.90:0.05:0.05), (0.80: 0.10: 0.10)
and (0.70, 0.15, 0.15). The results from 50 and 100 bootstrap samples
indicated that the k-nearest neighbors approach when k=3 or k=4 and
the defined prior probabilities of non-risk: risk: diabetic as 0.90:
0.05:0.05 or 0.80:0.10:0.10 gave the smallest error rate of
misclassification. The k-nearest neighbors approach would be
suggested for classifying a three-class-imbalanced data of diabetes
risk groups.
Abstract: In this work, we explore the capability of the mean
shift algorithm as a powerful preprocessing tool for improving the
quality of spatial data, acquired from airborne scanners, from densely
built urban areas. On one hand, high resolution image data corrupted
by noise caused by lossy compression techniques are appropriately
smoothed while at the same time preserving the optical edges and, on
the other, low resolution LiDAR data in the form of normalized
Digital Surface Map (nDSM) is upsampled through the joint mean
shift algorithm. Experiments on both the edge-preserving smoothing
and upsampling capabilities using synthetic RGB-z data show that the
mean shift algorithm is superior to bilateral filtering as well as to
other classical smoothing and upsampling algorithms. Application of
the proposed methodology for 3D reconstruction of buildings of a
pilot region of Athens, Greece results in a significant visual
improvement of the 3D building block model.
Abstract: Prosperity of electronic equipment in photocopying
environment not only has improved work efficiency, but also has
changed indoor air quality. Considering the number of photocopying
employed, indoor air quality might be worse than in general office
environments. Determining the contribution from any type of
equipment to indoor air pollution is a complex matter. Non-methane
hydrocarbons are known to have an important role on air quality due
to their high reactivity. The presence of hazardous pollutants in
indoor air has been detected in one photocopying shop in Novi Sad,
Serbia. Air samples were collected and analyzed for five days, during
8-hr working time in three time intervals, whereas three different
sampling points were determined. Using multiple linear regression
model and software package STATISTICA 10 the concentrations of
occupational hazards and microclimates parameters were mutually
correlated. Based on the obtained multiple coefficients of
determination (0.3751, 0.2389 and 0.1975), a weak positive
correlation between the observed variables was determined. Small
values of parameter F indicated that there was no statistically
significant difference between the concentration levels of nonmethane
hydrocarbons and microclimates parameters. The results
showed that variable could be presented by the general regression
model: y = b0 + b1xi1+ b2xi2. Obtained regression equations allow to
measure the quantitative agreement between the variables and thus
obtain more accurate knowledge of their mutual relations.
Abstract: The purpose of this study was to develop a descriptive
profile of the adapted physical activity research using single subject
experimental designs. All research articles using single subject
experimental designs published in the journal of Adapted Physical
Activity Quarterly from 1984 to 2013 were employed as the data
source. Each of the articles was coded in a subcategory of seven
categories: (a) the size of sample; (b) the age of participants; (c) the
type of disabilities; (d) the type of data analysis; (e) the type of
designs, (f) the independent variable, and (g) the dependent variable.
Frequencies, percentages, and trend inspection were used to analyze
the data and develop a profile. The profile developed characterizes a
small portion of research articles used single subject designs, in
which most researchers used a small sample size, recruited children
as subjects, emphasized learning and behavior impairments, selected
visual inspection with descriptive statistics, preferred a multiple
baseline design, focused on effects of therapy, inclusion, and
strategy, and measured desired behaviors more often, with a
decreasing trend over years.
Abstract: The growth in the volume of text data such as books
and articles in libraries for centuries has imposed to establish
effective mechanisms to locate them. Early techniques such as
abstraction, indexing and the use of classification categories have
marked the birth of a new field of research called "Information
Retrieval". Information Retrieval (IR) can be defined as the task of
defining models and systems whose purpose is to facilitate access to
a set of documents in electronic form (corpus) to allow a user to find
the relevant ones for him, that is to say, the contents which matches
with the information needs of the user. This paper presents a new
semantic indexing approach of a documentary corpus. The indexing
process starts first by a term weighting phase to determine the
importance of these terms in the documents. Then the use of a
thesaurus like Wordnet allows moving to the conceptual level.
Each candidate concept is evaluated by determining its level of
representation of the document, that is to say, the importance of the
concept in relation to other concepts of the document. Finally, the
semantic index is constructed by attaching to each concept of the
ontology, the documents of the corpus in which these concepts are
found.
Abstract: Microscopic simulation tool kits allow for
consideration of the two processes of railway operations and the
previous timetable production. Block occupation conflicts on both
process levels are often solved by using defined train priorities. These
conflict resolutions (dispatching decisions) generate reactionary
delays to the involved trains. The sum of reactionary delays is
commonly used to evaluate the quality of railway operations, which
describes the timetable robustness. It is either compared to an
acceptable train performance or the delays are appraised
economically by linear monetary functions. It is impossible to
adequately evaluate dispatching decisions without a well-founded
objective function. This paper presents a new approach for the
evaluation of dispatching decisions. The approach uses mode choice
models and considers the behaviour of the end-customers. These
models evaluate the reactionary delays in more detail and consider
other competing modes of transport. The new approach pursues the
coupling of a microscopic model of railway operations with the
macroscopic choice mode model. At first, it will be implemented for
railway operations process but it can also be used for timetable
production. The evaluation considers the possibility for the customer
to interchange to other transport modes. The new approach starts to
look at rail and road, but it can also be extended to air travel. The
result of mode choice models is the modal split. The reactions by the
end-customers have an impact on the revenue of the train operating
companies. Different purposes of travel have different payment
reserves and tolerances towards late running. Aside from changes to
revenues, longer journey times can also generate additional costs.
The costs are either time- or track-specific and arise from required
changes to rolling stock or train crew cycles. Only the variable values
are summarised in the contribution margin, which is the base for the
monetary evaluation of delays. The contribution margin is calculated
for different possible solutions to the same conflict. The conflict
resolution is optimised until the monetary loss becomes minimal. The
iterative process therefore determines an optimum conflict resolution
by monitoring the change to the contribution margin. Furthermore, a
monetary value of each dispatching decision can also be derived.
Abstract: In more complex systems, such as automotive
gearbox, a rigorous treatment of the data is necessary because there
are several moving parts (gears, bearings, shafts, etc.), and in this
way, there are several possible sources of errors and also noise. The
basic objective of this work is the detection of damage in automotive
gearbox. The detection methods used are the wavelet method, the
bispectrum; advanced filtering techniques (selective filtering) of
vibrational signals and mathematical morphology. Gearbox vibration
tests were performed (gearboxes in good condition and with defects)
of a production line of a large vehicle assembler. The vibration
signals are obtained using five accelerometers in different positions
of the sample. The results obtained using the kurtosis, bispectrum,
wavelet and mathematical morphology showed that it is possible to
identify the existence of defects in automotive gearboxes.
Abstract: The aim of this exploratory research is to understand
further how organisations can evaluate their activities, which
generate knowledge creation, to meet changing stakeholder
expectations. A Scale of Knowledge (SoK) Framework is proposed
which links knowledge management and organisational activities to
changing stakeholder expectations. The framework was informed by
the knowledge management literature, as well as empirical work
conducted via a single case study of a multi-site hospital organisation
in Saudi Arabia. Eight in-depth semi-structured interviews were
conducted with managers from across the organisation regarding
current and future stakeholder expectations, organisational
strategy/activities and knowledge management. Data were analysed
using thematic analysis and a hierarchical value map technique to
identify activities that can produce further knowledge and
consequently impact on how stakeholder expectations are met.
The SoK Framework developed may be useful to practitioners as
an analytical aid to determine if current organisational activities
produce organisational knowledge which helps them meet
(increasingly higher levels of) stakeholder expectations. The
limitations of the research and avenues for future development of the
proposed framework are discussed.
Abstract: In the Hierarchical Temporal Memory (HTM) paradigm
the effect of overlap between inputs on the activation of columns in
the spatial pooler is studied. Numerical results suggest that similar
inputs are represented by similar sets of columns and dissimilar inputs
are represented by dissimilar sets of columns. It is shown that the
spatial pooler produces these results under certain conditions for
the connectivity and proximal thresholds. Following the discussion
of the initialization of parameters for the thresholds, corresponding
qualitative arguments about the learning dynamics of the spatial
pooler are discussed.
Abstract: In order to produce lead free piezoceramics with
optimum piezoelectric and dielectric properties, KNN modified with
Li+ (as an A site dopant) and Sb5+ (as a B site dopant)
(K0.49Na0.49Li0.02) (Nb0.96Sb0.04) O3 (referred as KNLNS in this paper)
have been synthesized using solid state reaction method and
conventional sintering technique. The ceramics were sintered in the
narrow range of 1050°C-1090°C for 2-3 h to get precise information
about sintering parameters. Detailed study of dependence of
microstructural, dielectric and piezoelectric properties on sintering
conditions was then carried out. The study suggests that the volatility
of the highly hygroscopic KNN ceramics is not only sensitive to
sintering temperatures but also to sintering durations. By merely
reducing the sintering duration for a given sintering temperature we
saw an increase in the density of the samples which was supported by
the increase in dielectric constants of the ceramics. And since density
directly or indirectly affects almost all the associated properties, other
dielectric and piezoelectric properties were also enhanced as we
approached towards the most suitable sintering temperature and
duration combination. The detailed results are reported in this paper.
Abstract: In this study, we proposed two techniques to track the
maximum power point (MPPT) of a photovoltaic system. The first is
an intelligent control technique, and the second is robust used for
variable structure system. In fact the characteristics I-V and P–V of
the photovoltaic generator depends on the solar irradiance and
temperature. These climate changes cause the fluctuation of
maximum power point; a maximum power point tracking technique
(MPPT) is required to maximize the output power. For this we have
adopted a control by fuzzy logic (FLC) famous for its stability and
robustness. And a Siding Mode Control (SMC) widely used for
variable structure system. The system comprises a photovoltaic panel
(PV), a DC-DC converter, which is considered as an adaptation stage
between the PV and the load. The modelling and simulation of the
system is developed using MATLAB/Simulink. SMC technique
provides a good tracking speed in fast changing irradiation and when
the irradiation changes slowly or it is constant the panel power of
FLC technique presents a much smoother signal with less
fluctuations.
Abstract: This paper is aimed to the use of different types of
industrial wastes in concrete production. From examined waste
(crushed concrete waste) our tested concrete samples with dimension
150 mm were prepared. In these samples, fractions 4/8 mm and 8/16
mm by recycled concrete aggregate with a range of variation from 0
to 100% were replaced. Experiment samples were tested for
compressive strength after 2, 7, 14 and 28 days of hardening.
From obtained results it is evident that all samples prepared with
washed recycled concrete aggregates met the requirement of standard
for compressive strength of 20 MPa already after 14 days of
hardening. Sample prepared with recycled concrete aggregates (4/8
mm: 100% and 8/16 mm: 60%) reached 101% of compressive
strength value (34.7 MPa) after 28 days of hardening in comparison
with the reference sample (34.4 MPa). The lowest strength after 28
days of hardening (27.42 MPa) was obtained for sample consisting of
recycled concrete in proportion of 40% for 4/8 fraction and 100% for
8/16 fraction of recycled concrete.
Abstract: Evolutionary optimization methods such as genetic
algorithms have been used extensively for the construction site layout
problem. More recently, ant colony optimization algorithms, which
are evolutionary methods based on the foraging behavior of ants,
have been successfully applied to benchmark combinatorial
optimization problems. This paper proposes a formulation of the site
layout problem in terms of a sequencing problem that is suitable for
solution using an ant colony optimization algorithm.
In the construction industry, site layout is a very important
planning problem. The objective of site layout is to position
temporary facilities both geographically and at the correct time such
that the construction work can be performed satisfactorily with
minimal costs and improved safety and working environment. During
the last decade, evolutionary methods such as genetic algorithms
have been used extensively for the construction site layout problem.
This paper proposes an ant colony optimization model for
construction site layout. A simple case study for a highway project is
utilized to illustrate the application of the model.
Abstract: Quick adoption of e-business and emerging influence
of “Electronic Word of Mouth e-WOM” communication on guests
made leading hotel brands successful examples of electronic guest
relationship management. Main reasons behind such success are well
established procedures in collection, analysis and usage of highly
valuable data available on the Internet, generated through some form
of e-GRM programme. E-GRM is more than just a technology
solution. It’s a system which balance respective guest demands, hotel
technological capabilities and organizational culture of employees,
discharging the universal approach in guest relations “same for all”.
The purpose of this research derives from the necessity of
determining the importance of monitoring and applying e-WOM
communication as one of the methods used in managing guest
relations. This paper analyses and compares different hotelier’s
opinions on e-WOM communication.
Abstract: This study investigated the behavior of improved soft soils through the vibro replacement technique by considering their settlements and consolidation rates and the applicability of this technique in various types of soils and settlement and bearing capacity calculations.
Abstract: In this work, two fermentations at different
temperatures (25 and 30ºC), with cell recycling, were accomplished
to produce ethanol, using a mix of commercial substrates, xylose
(70%) and glucose (30%), as organic source for Scheffersomyces
stipitis. Five consecutive fermentations of 80 g L-1 (1º, 2º and 3º
recycles), 96 g L-1 (4º recycle) and 120 g L-1 (5º recycle)reduced
sugars led to a final maximum ethanol concentration of 17.2 and 34.5
g L-1, at 25 and 30ºC, respectively. Glucose was the preferred
substrate; moreover xylose startup degradation was initiated after a
remaining glucose presence in the medium. Results showed that yeast
acid treatment, performed before each cycle, provided improvements
on cell viability, accompanied by ethanol productivity of 2.16 g L-1 h-
1 at 30ºC. A maximum 36% of xylose was retained in the
fermentation medium and after five-cycle fermentation an ethanol
yield of 0.43 g ethanol/g sugars was observed. S. stipitis fermentation
capacity and tolerance showed better results at 30ºC with 83.4% of
theoretical yield referenced on initial biomass.
Abstract: The use of engineered nanomaterials has increased as
a result of their positive impact on many sectors of the economy,
including agriculture. Silver nanoparticles (AgNPs) are now used to
enhance seed germination, plant growth, and photosynthetic quantum
efficiency and as antimicrobial agents to control plant diseases. In
this study, we examined the effect of AgNP dosage on the seed
germination of three plant species: corn (Zea mays L.), watermelon
(Citrullus lanatus [Thunb.] Matsum. & Nakai) and zucchini
(Cucurbita pepo L.). This experiment was designed to study the
effect of AgNPs on germination percentage, germination rate, mean
germination time, root length and fresh and dry weight of seedlings
for the three species. Seven concentrations (0.05, 0.1, 0.5, 1, 1.5, 2
and 2.5 mg/ml) of AgNPs were examined at the seed germination
stage. The three species had different dose responses to AgNPs in
terms of germination parameters and the measured growth
characteristics. The germination rates of the three plants were
enhanced in response to AgNPs. Significant enhancement of the
germination percentage values was observed after treatment of the
watermelon and zucchini plants with AgNPs in comparison with
untreated seeds. AgNPs showed a toxic effect on corn root
elongation, whereas watermelon and zucchini seedling growth were
positively affected by certain concentrations of AgNPs. This study
showed that exposure to AgNPs caused both positive and negative
effects on plant growth and germination.