Abstract: Anthocyanins are natural pigments with effective UV
protection but their topical use could be limited due to their
physicochemical characteristics. An attempt to overcome such
limitations by complexation of 2 major anthocyanin-rich sources, C.
ternatea and Z. mays, has potentiated its use as topical antiinflammatory.
Cell studies indicate no cytotoxicity of the
anthocyanin complex (AC) up to 1 mg/ml tested in HaCaT and
human fore head fibroblasts by MTT. Croton oil-induced ear edema
in Wistar rats suggests an effective dose of 5 mg/cm2 of AC as a
topical anti-inflammatory in comparison to 0.5 mg/cm2 of
fluocinolone acetonide. Niosomal encapsulation of the AC
significantly prolonged the anti-inflammatory activity particularly at
8 h after topical application (p = 0.0001). The AC was not cytotoxic
and its anti-inflammatory and activity was dose-dependent and
prolonged by niosomal encapsulation. It has also shown to promote
collagen type 1 production in cell culture. Thus, AC could be a
potential candidate for topical anti-inflammatory agent from natural
resources.
Abstract: Liver disorders are one of the major problems of the
world. Despite its frequent occurrence, high morbidity and high
mortality, its medical management is currently inadequate. This study
was designed to evaluate the hepatoprotective effect of saponin
extract of the root of Garcinia kola on the integrity of the liver of
paracetamol induced wistar albino rats. Twenty five (25) male adult
wistar albino rats were divided into five (5) groups. Group I was the
Control group that received distilled water only, group II was the
negative control that received 2 g/kg of paracetamol on the 13th day,
and group III, IV and V were pre-treated with 100, 200 and
400mg/kg of the saponin extract before inducing the liver damage on
the 13th day with 2 g/kg of paracetamol. Twenty four (24) h after
administration, the rats were sacrificed and blood samples were
collected. The serum Alanine Transaminase (ALT), Aspartate
Transaminase (AST), Alkaline Phosphatase (ALP) activities,
Bilirubin and conjugated bilirubin, glucose and protein
concentrations were evaluated. The liver was fixed immediately in
Formalin and was processed and stained in Haematoxylin and Eosin
(H&E). Administration of saponin extract from the root of Garcinia
kola significantly decreased paracetamol induced elevated enzymes
in the test group. Also histological observations showed that saponin
extract of the root of Garcinia kola exhibited a significant liver
protection against the toxicant as evident by the cells trying to return
to normal. Saponin extract from the root of Garcinia kola indicated a
protection of structural integrity of the hepatocytic cell membrane
and regeneration of the damaged liver.
Abstract: This paper proposed a silicon controller rectifier (SCR)
based ESD protection device to protect low voltage ESD for integrated
circuit. The proposed ESD protection device has low trigger voltage
and high holding voltage compared with conventional SCR-based
ESD protection devices. The proposed ESD protection circuit is
verified and compared by TCAD simulation. This paper verified
effective low voltage ESD characteristics with low trigger voltage of
5.79V and high holding voltage of 3.5V through optimization
depending on design variables (D1, D2, D3 and D4).
Abstract: This paper impart the design and testing of
Nanotechnology based sequential circuits using multiplexer
conservative QCA (MX-CQCA) logic gates, which is easily testable
using only two vectors. This method has great prospective in the
design of sequential circuits based on reversible conservative logic
gates and also smashes the sequential circuits implemented in
traditional gates in terms of testability. Reversible circuits are similar
to usual logic circuits except that they are built from reversible gates.
Designs of multiplexer conservative QCA logic based two vectors
testable double edge triggered (DET) sequential circuits in VHDL
language are also accessible here; it will also diminish intricacy in
testing side. Also other types of sequential circuits such as D, SR, JK
latches are designed using this MX-CQCA logic gate. The objective
behind the proposed design methodologies is to amalgamate
arithmetic and logic functional units optimizing key metrics such as
garbage outputs, delay, area and power. The projected MX-CQCA
gate outshines other reversible gates in terms of the intricacy, delay.
Abstract: Liposome plays an important role in medical and
pharmaceutical science as e.g. nano scale drug carriers. Liposomes
are vesicles of varying size consisting of a spherical lipid bilayer and
an aqueous inner compartment. Magnet-driven liposome used for the
targeted delivery of drugs to organs and tissues. These liposome
preparations contain encapsulated drug components and finely
dispersed magnetic particles.
Liposomes are vesicles of varying size consisting of a spherical
lipid bilayer and an aqueous inner compartment that are generated in
vitro. These are useful in terms of biocompatibility, biodegradability,
and low toxicity, and can control biodistribution by changing the size,
lipid composition, and physical characteristics. Furthermore,
liposomes can entrap both hydrophobic and hydrophilic drugs and are
able to continuously release the entrapped substrate, thus being useful
drug carriers. Magnetic liposomes (MLs) are phospholipid vesicles
that encapsulate magneticor paramagnetic nanoparticles. They are
applied as contrast agents for magnetic resonance imaging (MRI).
The biological synthesis of nanoparticles using plant extracts plays
an important role in the field of nanotechnology. Green-synthesized
magnetite nanoparticles-protein hybrid has been produced by treating
Iron (III) / Iron (II) chloride with the leaf extract of Datura inoxia.
The phytochemicals present in the leaf extracts act as a reducing as
well stabilizing agents preventing agglomeration, which include
flavonoids, phenolic compounds, cardiac glycosides, proteins and
sugars.
The magnetite nanoparticles-protein hybrid has been trapped
inside the aqueous core of the liposome prepared by reversed phase
evaporation (REV) method using oleic and linoleic acid which has
been shown to be driven under magnetic field confirming the
formation magnetic liposome (ML). Chemical characterization of
stealth magnetic liposome has been performed by breaking the
liposome and release of magnetic nanoparticles. The presence iron
has been confirmed by colour complex formation with KSCN and
UV-Vis study using spectrophotometer Cary 60, Agilent.
This magnet driven liposome using nanoparticles-protein hybrid
can be a smart vesicles for the targeted drug delivery.
Abstract: The paper examines the interaction between the
environmental taxation, size of government spending on
environmental protection and greenhouse gas emissions and gross
inland energy consumption. The aim is to analyze the effects of
environmental taxation and government spending on environmental
protection as an environmental policy instruments on greenhouse gas
emissions and gross inland energy consumption in the EU15. The
empirical study is performed using a VAR approach with the
application of aggregated data of EU15 over the period 1995 to 2012.
The results provide the evidence that the reactions of greenhouse gas
emission and gross inland energy consumption to the shocks of
environmental policy instruments are strong, mainly in the short term
and decay to zero after about 8 years. Further, the reactions of the
environmental policy instruments to the shocks of greenhouse gas
emission and gross inland energy consumption are also strong in the
short term, however with the deferred effects. In addition, the results
show that government spending on environmental protection together
with gross inland energy consumption has stronger effect on
greenhouse gas emissions than environmental taxes in EU15 over the
examined period.
Abstract: The tomato is a very important crop, whose
cultivation in the Mediterranean basin is severely affected by the
phytoparasitic weed Phelipanche ramosa. The semiarid regions of
the world are considered the main areas where this parasitic weed is
established causing heavy infestation as it is able to produce high
numbers of seeds (up to 500,000 per plant), which remain viable for
extended period (more than 20 years). In this paper the results
obtained from eleven treatments in order to control this parasitic
weed including chemical, agronomic, biological and biotechnological
methods compared with the untreated test under two plowing depths
(30 and 50 cm) are reported. The split-plot design with 3 replicates
was adopted. In 2014 a trial was performed in Foggia province
(southern Italy) on processing tomato (cv Docet) grown in the field
infested by Phelipanche ramosa. Tomato seedlings were transplant
on May 5, on a clay-loam soil. During the growing cycle of the
tomato crop, at 56-78 and 92 days after transplantation, the number
of parasitic shoots emerged in each plot was detected. At tomato
harvesting, on August 18, the major quantity-quality yield parameters
were determined (marketable yield, mean weight, dry matter, pH,
soluble solids and color of fruits). All data were subjected to analysis
of variance (ANOVA) and the means were compared by Tukey's test.
Each treatment studied did not provide complete control against
Phelipanche ramosa. However, among the different methods tested,
some of them which Fusarium, gliphosate, radicon biostimulant and
Red Setter tomato cv (improved genotypes obtained by Tilling
technology) under deeper plowing (50 cm depth) proved to mitigate
the virulence of the Phelipanche ramose attacks. It is assumed that
these effects can be improved combining some of these treatments
each other, especially for a gradual and continuing reduction of the
“seed bank” of the parasite in the soil.
Abstract: The paper describes a Chinese shadow play animation
system based on Kinect. Users, without any professional training, can
personally manipulate the shadow characters to finish a shadow play
performance by their body actions and get a shadow play video
through giving the record command to our system if they want. In our
system, Kinect is responsible for capturing human movement and
voice commands data. Gesture recognition module is used to control
the change of the shadow play scenes. After packaging the data from
Kinect and the recognition result from gesture recognition module,
VRPN transmits them to the server-side. At last, the server-side uses
the information to control the motion of shadow characters and video
recording. This system not only achieves human-computer interaction,
but also realizes the interaction between people. It brings an
entertaining experience to users and easy to operate for all ages. Even
more important is that the application background of Chinese shadow
play embodies the protection of the art of shadow play animation.
Abstract: The paper involves a chain of activities from
synthesis, establishment of the methodology for characterization and
testing of novel protective materials through the pilot production and
application on model supports.
It summarizes the results regarding the development of the pilot
production protocol for newly developed self-cleaning materials. The
optimization of the production parameters was completed in order to
improve the most important functional properties (mineralogy
characteristics, particle size, self-cleaning properties and
photocatalytic activity) of the newly designed nanocomposite
material.
Abstract: Safety is one of the most important considerations
when buying a new car. While active safety aims at avoiding
accidents, passive safety systems such as airbags and seat belts
protect the occupant in case of an accident. In addition to legal
regulations, organizations like Euro NCAP provide consumers with
an independent assessment of the safety performance of cars and
drive the development of safety systems in automobile industry.
Those ratings are mainly based on injury assessment reference values
derived from physical parameters measured in dummies during a car
crash test.
The components and sub-systems of a safety system are designed
to achieve the required restraint performance. Sled tests and other
types of tests are then carried out by car makers and their suppliers
to confirm the protection level of the safety system. A Knowledge
Discovery in Databases (KDD) process is proposed in order to
minimize the number of tests. The KDD process is based on the
data emerging from sled tests according to Euro NCAP specifications.
About 30 parameters of the passive safety systems from different data
sources (crash data, dummy protocol) are first analysed together with
experts opinions. A procedure is proposed to manage missing data
and validated on real data sets. Finally, a procedure is developed to
estimate a set of rough initial parameters of the passive system before
testing aiming at reducing the number of tests.
Abstract: The paper presents a plastic analysis procedure based
on the energy balance concept for performance based seismic retrofit
of multi-story multi-bay masonry infilled reinforced concrete (R/C)
frames with a ‘soft’ ground story using passive energy dissipation
(PED) devices with the objective of achieving a target performance
level of the retrofitted R/C frame for a given seismic hazard level at
the building site. The proposed energy based plastic analysis
procedure was employed for developing performance based design
(PBD) formulations for PED devices for a simulated application in
seismic retrofit of existing frame structures designed in compliance
with the prevalent standard codes of practice. The PBD formulations
developed for PED devices were implemented for simulated seismic
retrofit of a representative code-compliant masonry infilled R/C
frame with a ‘soft’ ground story using friction dampers as the PED
device. Non-linear dynamic analyses of the retrofitted masonry
infilled R/C frames is performed to investigate the efficacy and
accuracy of the proposed energy based plastic analysis procedure in
achieving the target performance level under design level
earthquakes. Results of non-linear dynamic analyses demonstrate that
the maximum inter-story drifts in the masonry infilled R/C frames
with a ‘soft’ ground story that is retrofitted with the friction dampers
designed using the proposed PBD formulations are controlled within
the target drifts under near-field as well far-field earthquakes.
Abstract: Carbon nanotube is one of the most attractive materials
for the potential applications of nanotechnology due to its excellent
mechanical, thermal, electrical and optical properties. In this paper we
report a supercapacitor made of nickel foil electrodes, coated with
multiwall carbon nanotubes (MWCNTs) thin film using
electrophoretic deposition (EPD) method. Chemical vapor deposition
method was used for the growth of MWCNTs and ethanol was used as
a hydrocarbon source. High graphitic multiwall carbon nanotube was
found at 750oC analyzing by Raman spectroscopy. We observed the
electrochemical performance of supercapacitor by cyclic
voltammetry. The electrodes of supercapacitor fabricated from
MWCNTs exhibit considerably small equivalent series resistance
(ESR), and a high specific power density. Electrophoretic deposition
is an easy method in fabricating MWCNT electrodes for high
performance supercapacitor.
Abstract: Brown seaweeds are abundant in Portuguese coastline
and represent an almost unexploited marine economic resource. One
of the most common species, easily available for harvesting in the
northwest coast, is Saccorhiza polyschides grows in the lowest shore
and costal rocky reefs. It is almost exclusively used by local farmers
as natural fertilizer, but contains a substantial amount of valuable
compounds, particularly alginates, natural biopolymers of high
interest for many industrial applications.
Alginates are natural polysaccharides present in cell walls of
brown seaweed, highly biocompatible, with particular properties that
make them of high interest for the food, biotechnology, cosmetics
and pharmaceutical industries. Conventional extraction processes are
based on thermal treatment. They are lengthy and consume high
amounts of energy and solvents. In recent years, microwave-assisted
extraction (MAE) has shown enormous potential to overcome major
drawbacks that outcome from conventional plant material extraction
(thermal and/or solvent based) techniques, being also successfully
applied to the extraction of agar, fucoidans and alginates. In the
present study, acid pretreatment of brown seaweed Saccorhiza
polyschides for subsequent microwave-assisted extraction (MAE) of
alginate was optimized. Seaweeds were collected in Northwest
Portuguese coastal waters of the Atlantic Ocean between May and
August, 2014. Experimental design was used to assess the effect of
temperature and acid pretreatment time in alginate extraction.
Response surface methodology allowed the determination of the
optimum MAE conditions: 40 mL of HCl 0.1 M per g of dried
seaweed with constant stirring at 20ºC during 14h. Optimal acid
pretreatment conditions have enhanced significantly MAE of
alginates from Saccorhiza polyschides, thus contributing for the
development of a viable, more environmental friendly alternative to
conventional processes.
Abstract: The extermination and proper disposal of
pharmaceutical wastes from expired and unused medications remains
a disputable issue due to their specific nature and characteristics.
Even though the hazards from these wastes are already well known in
terms of environment and human health, people still treat them as
usual wastes. At a national level, in many countries the management
of pharmaceutical and medical wastes has been one of the main
objectives in order to protect people’s health and the environment.
Even though many legal regulations exist in this respect, there has not
been a single law that would clearly explain the procedures of
returning medicines, ways of selection, treatment and extermination
of pharmaceutical wastes. This paper aims at analyzing the practices
of pharmaceutical waste management and treatment in some
European countries as well as a review of the legislation and official
guidelines in managing these kinds of wastes and protecting the
environment and human health. A suitable treatment and
management of expired medications and other similar wastes would
be in the interest of public health in the first place, as well as in the
interest of healthcare institutions and other bodies engaged in
environment protection.
Abstract: The financial crises caused a collapse in prices of
most asset classes, raising the attention on alternative investments
such as sukuk, a smaller, fast growing but often misunderstood
market. We study diversification benefits of sukuk, their correlation
with other asset classes and the effects of their inclusion in
investment portfolios of institutional and retail investors, through a
comprehensive comparison of their risk/return profiles during and
after the financial crisis.
We find a beneficial performance adjusted for the specific
volatility together with a lower correlation especially during the
financial crisis. The distribution of sukuk returns is positively skewed
and leptokurtic, with a risk/return profile similarly to high yield
bonds. Overall, our results suggest that sukuk present diversification
opportunities, a significant volatility-adjusted performance and lower
correlations especially during the financial crisis.
Our findings are relevant for a number of institutional investors.
Long term investors, such as life insurers would benefit from sukuk’s
protective features during financial crisis yet keeping return and
growth opportunities, whereas banks would gain due to their role of
placers, advisors, market makers or underwriters.
Abstract: Due to the determination of the pollution status of
fresh resources in the Egyptian territorial waters is very important for
public health; this study was carried out to reveal the levels of heavy
metals in the shellfish and their environment and its relation to the
highly developed industrial activities in those areas. A total of 100
shellfish samples from the Rosetta, Edku, El-Maadiya, Abo-Kir and
El-Max coasts [10 crustaceans (shrimp) and 10 mollusks (oysters)]
were randomly collected from each coast. Additionally, 10 samples
from both the water and the sediment were collected from each coast.
Each collected sample was analyzed for cadmium, chromium,
copper, lead and zinc residues using a Perkin Elmer atomic
absorption spectrophotometer (AAS). The results showed that the
levels of heavy metals were higher in the water and sediment from
Abo-Kir. The heavy metal levels decreased successively for the
Rosetta, Edku, El-Maadiya, and El-Max coasts, and the
concentrations of heavy metals, except copper and zinc, in shellfish
exhibited the same pattern. For the concentration of heavy metals in
shellfish tissue, the highest was zinc and the concentrations decreased
successively for copper, lead, chromium and cadmium for all coasts,
except the Abo-Kir coast, where the chromium level was highest and
the other metals decreased successively for zinc, copper, lead and
cadmium. In Rosetta, chromium was higher only in the mollusks,
while the level of this metal was lower in the crustaceans; this trend
was observed at the Edku, El-Maadiya and El-Max coasts as well.
Herein, we discuss the importance of such contamination for public
health and the sources of shellfish contamination with heavy metals.
We suggest measures to minimize and prevent these pollutants in the
aquatic environment and, furthermore, how to protect humans from
excessive intake.
Abstract: Artificial Immune Systems (AIS), inspired by the
human immune system, are algorithms and mechanisms which are
self-adaptive and self-learning classifiers capable of recognizing and
classifying by learning, long-term memory and association. Unlike
other human system inspired techniques like genetic algorithms and
neural networks, AIS includes a range of algorithms modeling on
different immune mechanism of the body. In this paper, a mechanism
of a human immune system based on apoptosis is adopted to build an
Intrusion Detection System (IDS) to protect computer networks.
Features are selected from network traffic using Fisher Score. Based
on the selected features, the record/connection is classified as either
an attack or normal traffic by the proposed methodology. Simulation
results demonstrates that the proposed AIS based on apoptosis
performs better than existing AIS for intrusion detection.
Abstract: Marine Protected Areas can benefit from nature based
tourism, monitoring environmental impacts and also become target
for human presence. From more than 3 million tourists visiting
Cozumel Island every year, an average of 2,8 million arrive by cruise
ship, and 41% are estimated to have motivation for water activities.
The destination is relying so much on the tourism activity, that scuba
diving and snorkeling in the National Park Reef of Cozumel sustain
the major economic activity. In order to achieve the sustainable
development indicator designed for regional environmental
development, the PNAC offers a training course to tourism providers
to access the protected area. This way, the update of the last 5 years
of such training is directed to diving staff, boat crew and
professionals, making them able to assist in managing the natural
resource. Moreover, the case study is an example to be used for
raising awareness among tourists visiting protected areas.
Abstract: Climate change would cause mean sea level to rise +1
m by 2100. To prevent coastal floods resulting from the sea level
rising, different flood control structures have been built, with
acceptable protection levels. Gothenburg with the River Göta älv
located on the southwest coast of Sweden is a vulnerable city to the
accelerated rises in mean sea level. We evaluated using a sea barrage
in the River Göta älv to protect Gothenburg during this century. The
highest sea level was estimated to 2.95 m above the current mean sea
level by 2100. To verify flood protection against such high sea levels,
both barriers have to be closed. To prevent high water level in the
River Göta älv reservoir, the barriers would be open when the sea
level is low. The suggested flood control structures would
successfully protect the city from flooding events during this century.
Abstract: Food contamination occurs during post process
handling. This leads to spoilage and growth of pathogenic
microorganisms in the food, thereby reducing its shelf life or
spreading of food borne diseases. Several methods are tried and one
of which is use of antimicrobial packaging. Here, papain, a protease
enzyme, is covalently immobilized with the help of glutarldehyde on
polyurethane and used as a food wrap to protect food from microbial
contamination. Covalent immobilization of papain was achieved at a
pH of 7.4; temperature of 4°C; glutaraldehyde concentration of 0.5%;
incubation time of 24h; and 50mg of papain. The formation of -C=Nobserved
in the Fourier transform infrared spectrum confirmed the
immobilization of the enzyme on the polymer. Immobilized enzyme
retained higher activity than the native free enzyme. The modified
polyurethane showed better reduction of Staphylococcus aureus
biofilm than bare polymer film (eight folds reduction in live colonies,
two times reduction in protein and 6 times reduction in
carbohydrates). The efficacy of this was studied by wrapping it over
S. aureus contaminated cottage cheese (paneer) and cheese and
stored at a temperature of 4°C for 7days. The modified film reduced
the bacterial contamination by eight folds when compared to the bare
film. FTIR also indicated reduction in lipids, sugars and proteins in
the biofilm.