Abstract: The aim of the present study was to evaluate the
mucoadhesion and the release of nicotinamide gel formulations using
in vitro methods. An agar plate technique was used to investigate the
adhesiveness of the gels whereas a diffusion apparatus was employed
to determine the release of nicotinamide from the gels. In this
respect, 10% w/w nicotinamide gels containing bioadhesive
polymers: Carbopol 934P (0.5-2% w/w), hydroxypropylmethyl
cellulose (HPMC) (4-10% w/w), sodium carboxymethyl cellulose
(SCMC) (4-6% w/w) and methylcellulose 4000 (MC) (3-5% w/w)
were prepared. The gel formulations had pH values in the range of
7.14 - 8.17, which were considered appropriate to oral mucosa
application. In general, the rank order of pH values appeared to be
SCMC > MC4000 > HPMC > Carbopol 934P. Types and
concentrations of polymers used somewhat affected the
adhesiveness. It was found that anionic polymers (Carbopol 934 and
SCMC) adhered more firmly to the agar plate than the neutral
polymers (HPMC and MC 4000). The formulation containing 0.5%
Carbopol 934P (F1) showed the highest release rate. With the
exception of the formulation F1, the neutral polymers tended to give
higher relate rates than the anionic polymers. For oral tissue
treatment, the optimum has to be balanced between the residence
time (adhesiveness) of the formulations and the release rate of the
drug. The formulations containing the anionic polymers: Carbopol
934P or SCMC possessed suitable physical properties (appearance,
pH and viscosity). In addition, for anionic polymer formulations,
justifiable mucoadhesive properties and reasonable release rates of
nicotinamide were achieved. Accordingly, these gel formulations
may be applied for the treatment of oral mucosal lesions.
Abstract: As increasing importance of symbiosis and cooperation among mobile communication industries, the mobile ecosystem has been especially highlighted in academia and practice. The structure of mobile ecosystem is quite complex and the ecological role of actors is important to understand that structure. In this respect, this study aims to explore structure of mobile ecosystem in the case of Korea using inter-industry network analysis. Then, the ecological roles in mobile ecosystem are identified using centrality measures as a result of network analysis: degree of centrality, closeness, and betweenness. The result shows that the manufacturing and service industries are separate. Also, the ecological roles of some actors are identified based on the characteristics of ecological terms: keystone, niche, and dominator. Based on the result of this paper, we expect that the policy makers can formulate the future of mobile industry and healthier mobile ecosystem can be constructed.
Abstract: The common practice of operating S-rotor is in an
open environment; however there are times when the rotor is
installed in a bounded environment and there might be changes in the
performance of the rotor. This paper presents the changes in the
performance of S-rotor when operated in bounded flows. The
investigation was conducted experimentally to compare the
performance of the rotors in bounded environment against open
environment. Three different rotors models were designed, fabricated
and subjected to experimental measurements. All of the three models
were having 600 mm height and 300 mm Diameter. They were tested
in three different flow environments; namely: partially bounded
environment, fully bounded environment and open environment.
Rotors were found to have better starting up capabilities when
operated in bounded environment. Apart from that, all rotors manage
to achieve higher Power and Torque Coefficients at a higher Tip
Speed Ratio as compared to the open environment.
Abstract: The disaster from functional gastrointestinal disorders has detrimental impact on the quality of life of the effected population and imposes a tremendous social and economic burden. There are, however, rare diagnostic methods for the functional gastrointestinal disorders. Our research group identified recently that the gastrointestinal tract well in the patients with the functional gastrointestinal disorders becomes more rigid than healthy people when palpating the abdominal regions overlaying the gastrointestinal tract. Objective of current study is, therefore, identify feasibility of a diagnostic system for the functional gastrointestinal disorders based on ultrasound technique, which can quantify the characteristics above. Two-dimensional finite difference (FD) models (one normal and two rigid model) were developed to analyze the reflective characteristic (displacement) on each soft-tissue layer responded after application of ultrasound signals. The FD analysis was then based on elastic ultrasound theory. Validation of the model was performed via comparison of the characteristic of the ultrasonic responses predicted by FD analysis with that determined from the actual specimens for the normal and rigid conditions. Based on the results from FD analysis, ultrasound system for diagnosis of the functional gastrointestinal disorders was developed and clinically tested via application of it to 40 human subjects with/without functional gastrointestinal disorders who were assigned to Normal and Patient Groups. The FD models were favorably validated. The results from FD analysis showed that the maximum displacement amplitude in the rigid models (0.12 and 0.16) at the interface between the fat and muscle layers was explicitly less than that in the normal model (0.29). The results from actual specimens showed that the maximum amplitude of the ultrasonic reflective signal in the rigid models (0.2±0.1Vp-p) at the interface between the fat and muscle layers was explicitly higher than that in the normal model (0.1±0.2 Vp-p). Clinical tests using our customized ultrasound system showed that the maximum amplitudes of the ultrasonic reflective signals near to the gastrointestinal tract well for the patient group (2.6±0.3 Vp-p) were generally higher than those in normal group (0.1±0.2 Vp-p). Here, maximum reflective signals was appeared at 20mm depth approximately from abdominal skin for all human subjects, corresponding to the location of the boundary layer close to gastrointestinal tract well. These findings suggest that our customized ultrasound system using the ultrasonic reflective signal may be helpful to the diagnosis of the functional gastrointestinal disorders.
Abstract: This paper presents a novel approach to assessing textile porosity by the application of the image analysis techniques. The images of different types of sample fabrics, taken through a microscope when the fabric is placed over a constant light source,transfer the problem into the image analysis domain. Indeed, porosity can thus be expressed in terms of a brightness percentage index calculated on the digital microscope image. Furthermore, it is meaningful to compare the brightness percentage index with the air permeability and the tightness indices of each fabric type. We have experimentally shown that there exists an approximately linear relation between brightness percentage and air permeability indices.
Abstract: Availability of raw materials is important for
Indonesia as a furniture exporting country. Teak log as raw materials
is supplied to the furniture industry by Perum Perhutani (PP). PP
needs to involve carbon trading for nature conservation. PP also has
an obligation in the Corporate Social Responsibility program. PP and
furniture industry also must prosecute the regulations related to
ecological issues and labor rights. This study has the objective to
create the relationship model between supplier and manufacturer to
fulfill teak log demand that involving teak forest carbon
sequestration. A model is formulated as Goal Programming to get the
favorable solution for teak log procurement and support carbon
sequestration that considering economical, ecological, and social
aspects of both supplier and manufacturer. The results show that the
proposed model can be used to determine the teak log quantity
involving carbon trading to achieve the seven goals to be satisfied the
sustainability considerations.
Abstract: In this study, we consider a special situation that only a pair of hydrophone on a moving underwater vehicle is available to localize a fixed acoustic source of far distance. The trigonometry can be used in this situation by using two different DOA of different locations. Notice that the distance between the two locations should be measured. Therefore, we assume that the vehicle is sailing straightly and the moving distance for each unit time is measured continuously. However, the accuracy of the localization using the trigonometry is highly dependent to the accuracy of DOAs and measured moving distances. Therefore, we proposed another method based on the extended Kalman filter that gives more robust and accurate localization result.
Abstract: As a primitive assumption, if a new information
system is able to remind users their old work habits, it should have a
better opportunity to be accepted, adopted and finally, utilized. In
this paper some theoretical concepts borrowed from psychodynamic
theory e.g. ego defenses are discussed to show how such resemblance
can be made without necessarily affecting the performance of the
new system. The main assertion is a new system should somehow
imitate old work habits, not literally, but through following their
paces in terms of the order of habitual tensional states including
stimulation, defensive actions and satisfactions.
Abstract: This paper presents a method for the detection of OD in the retina which takes advantage of the powerful preprocessing techniques such as the contrast enhancement, Gabor wavelet transform for vessel segmentation, mathematical morphology and Earth Mover-s distance (EMD) as the matching process. The OD detection algorithm is based on matching the expected directional pattern of the retinal blood vessels. Vessel segmentation method produces segmentations by classifying each image pixel as vessel or nonvessel, based on the pixel-s feature vector. Feature vectors are composed of the pixel-s intensity and 2D Gabor wavelet transform responses taken at multiple scales. A simple matched filter is proposed to roughly match the direction of the vessels at the OD vicinity using the EMD. The minimum distance provides an estimate of the OD center coordinates. The method-s performance is evaluated on publicly available DRIVE and STARE databases. On the DRIVE database the OD center was detected correctly in all of the 40 images (100%) and on the STARE database the OD was detected correctly in 76 out of the 81 images, even in rather difficult pathological situations.
Abstract: Brassinosteroids (BRs) regulate cell elongation,
vascular differentiation, senescence, and stress responses. BRs signal
through the BES1/BZR1 family of transcription factors, which
regulate hundreds of target genes involved in this pathway. In this
research a comprehensive genome-wide analysis was carried out in
BES1/BZR1 gene family in Arabidopsis thaliana, Cucumis sativus,
Vitis vinifera, Glycin max and Brachypodium distachyon.
Specifications of the desired sequences, dot plot and hydropathy plot
were analyzed in the protein and genome sequences of five plant
species. The maximum amino acid length was attributed to protein
sequence Brdic3g with 374aa and the minimum amino acid length
was attributed to protein sequence Gm7g with 163aa. The maximum
Instability index was attributed to protein sequence AT1G19350
equal with 79.99 and the minimum Instability index was attributed to
protein sequence Gm5g equal with 33.22. Aliphatic index of these
protein sequences ranged from 47.82 to 78.79 in Arabidopsis
thaliana, 49.91 to 57.50 in Vitis vinifera, 55.09 to 82.43 in Glycin
max, 54.09 to 54.28 in Brachypodium distachyon 55.36 to 56.83 in
Cucumis sativus. Overall, data obtained from our investigation
contributes a better understanding of the complexity of the
BES1/BZR1 gene family and provides the first step towards directing
future experimental designs to perform systematic analysis of the
functions of the BES1/BZR1 gene family.
Abstract: In this paper we present the deep study about the Bio-
Medical Images and tag it with some basic extracting features (e.g.
color, pixel value etc). The classification is done by using a nearest
neighbor classifier with various distance measures as well as the
automatic combination of classifier results. This process selects a
subset of relevant features from a group of features of the image. It
also helps to acquire better understanding about the image by
describing which the important features are. The accuracy can be
improved by increasing the number of features selected. Various
types of classifications were evolved for the medical images like
Support Vector Machine (SVM) which is used for classifying the
Bacterial types. Ant Colony Optimization method is used for optimal
results. It has high approximation capability and much faster
convergence, Texture feature extraction method based on Gabor
wavelets etc..
Abstract: Biological sequences from different species are called or-thologs if they evolved from a sequence of a common ancestor species and they have the same biological function. Approximations of Kolmogorov complexity or entropy of biological sequences are already well known to be useful in extracting similarity information between such sequences -in the interest, for example, of ortholog detection. As is well known, the exact Kolmogorov complexity is not algorithmically computable. In prac-tice one can approximate it by computable compression methods. How-ever, such compression methods do not provide a good approximation to Kolmogorov complexity for short sequences. Herein is suggested a new ap-proach to overcome the problem that compression approximations may notwork well on short sequences. This approach is inspired by new, conditional computations of Kolmogorov entropy. A main contribution of the empir-ical work described shows the new set of entropy-based machine learning attributes provides good separation between positive (ortholog) and nega-tive (non-ortholog) data - better than with good, previously known alter-natives (which do not employ some means to handle short sequences well).Also empirically compared are the new entropy based attribute set and a number of other, more standard similarity attributes sets commonly used in genomic analysis. The various similarity attributes are evaluated by cross validation, through boosted decision tree induction C5.0, and by Receiver Operating Characteristic (ROC) analysis. The results point to the conclu-sion: the new, entropy based attribute set by itself is not the one giving the best prediction; however, it is the best attribute set for use in improving the other, standard attribute sets when conjoined with them.
Abstract: Selected Mapping (SLM) is a PAPR reduction technique, which converts the OFDM signal into several independent signals by multiplication with the phase sequence set and transmits one of the signals with lowest PAPR. But it requires the index of the selected signal i.e. side information (SI) to be transmitted with each OFDM symbol. The PAPR reduction capability of the SLM scheme depends on the selection of phase sequence set. In this paper, we have proposed a new phase sequence set generation scheme based on M-ary chaotic sequence and a mapping scheme to map quaternary data to concentric circle constellation (CCC) is used. It is shown that this method does not require SI and provides better SER performance with good PAPR reduction capability as compared to existing SLMOFDM methods.
Abstract: Alzheimer is known as the loss of mental functions
such as thinking, memory, and reasoning that is severe enough to
interfere with a person's daily functioning. The appearance of
Alzheimer Disease symptoms (AD) are resulted based on which part
of the brain has a variety of infection or damage. In this case, the
MRI is the best biomedical instrumentation can be ever used to
discover the AD existence. Therefore, this paper proposed a fusion
method to distinguish between the normal and (AD) MRIs. In this
combined method around 27 MRIs collected from Jordanian
Hospitals are analyzed based on the use of Low pass -morphological
filters to get the extracted statistical outputs through intensity
histogram to be employed by the descriptive box plot. Also, the
artificial neural network (ANN) is applied to test the performance of
this approach. Finally, the obtained result of t-test with confidence
accuracy (95%) has compared with classification accuracy of ANN
(100 %). The robust of the developed method can be considered
effectively to diagnose and determine the type of AD image.
Abstract: Neural processors have shown good results for
detecting a certain character in a given input matrix. In this paper, a
new idead to speed up the operation of neural processors for character
detection is presented. Such processors are designed based on cross
correlation in the frequency domain between the input matrix and the
weights of neural networks. This approach is developed to reduce the
computation steps required by these faster neural networks for the
searching process. The principle of divide and conquer strategy is
applied through image decomposition. Each image is divided into
small in size sub-images and then each one is tested separately by
using a single faster neural processor. Furthermore, faster character
detection is obtained by using parallel processing techniques to test the
resulting sub-images at the same time using the same number of faster
neural networks. In contrast to using only faster neural processors, the
speed up ratio is increased with the size of the input image when using
faster neural processors and image decomposition. Moreover, the
problem of local subimage normalization in the frequency domain is
solved. The effect of image normalization on the speed up ratio of
character detection is discussed. Simulation results show that local
subimage normalization through weight normalization is faster than
subimage normalization in the spatial domain. The overall speed up
ratio of the detection process is increased as the normalization of
weights is done off line.
Abstract: The RK5GL3 method is a numerical method for solving
initial value problems in ordinary differential equations, and is based
on a combination of a fifth-order Runge-Kutta method and 3-point
Gauss-Legendre quadrature. In this paper we describe the propagation
of local errors in this method, and show that the global order of
RK5GL3 is expected to be six, one better than the underlying Runge-
Kutta method.
Abstract: In this paper, we are going to determine the threshold levels of adaptive modulation in a burst by burst CDMA system by a suboptimum method so that the above method attempts to increase the average bit per symbol (BPS) rate of transceiver system by switching between the different modulation modes in variable channel condition. In this method, we choose the minimum values of average bit error rate (BER) and maximum values of average BPS on different values of average channel signal to noise ratio (SNR) and then calculate the relative threshold levels of them, so that when the instantaneous SNR increases, a higher order modulation be employed for increasing throughput and vise-versa when the instantaneous SNR decreases, a lower order modulation be employed for improvement of BER. In transmission step, by this adaptive modulation method, in according to comparison between obtained estimation of pilot symbols and a set of above suboptimum threshold levels, above system chooses one of states no transmission, BPSK, 4QAM and square 16QAM for modulation of data. The expected channel in this paper is a slow Rayleigh fading.
Abstract: In this paper a genetic algorithms approach for solving the linear and quadratic fuzzy equations Ãx̃=B̃ and Ãx̃2 + B̃x̃=C̃ , where Ã, B̃, C̃ and x̃ are fuzzy numbers is proposed by genetic algorithms. Our genetic based method initially starts with a set of random fuzzy solutions. Then in each generation of genetic algorithms, the solution candidates converge more to better fuzzy solution x̃b . In this proposed method the final reached x̃b is not only restricted to fuzzy triangular and it can be fuzzy number.
Abstract: An inverse geometry problem is solved to predict an
unknown irregular boundary profile. The aim is to minimize the
objective function, which is the difference between real and
computed temperatures, using three different versions of Conjugate
Gradient Method. The gradient of the objective function, considered
necessary in this method, obtained as a result of solving the adjoint
equation. The abilities of three versions of Conjugate Gradient
Method in predicting the boundary profile are compared using a
numerical algorithm based on the method. The predicted shapes show
that due to its convergence rate and accuracy of predicted values, the
Powell-Beale version of the method is more effective than the
Fletcher-Reeves and Polak –Ribiere versions.
Abstract: To motivate users to adopt and use information
systems effectively, the nature of motivation should be carefully
investigated. People are usually motivated within ongoing processes
which include a chain of states such as perception, stimulation,
motivation, actions and reactions and finally, satisfaction. This study
assumes that the relevant motivation processes should be executed in
a proper and continuous manner to be able to persistently motivate
and re-motivate people in organizational settings and towards
information systems. On this basis, the study attempts to propose
possible relationships between this process-nature view of
motivation in terms of the common chain of states and the nearly
unique properties of information systems as is perceived by users in
the sense of a knowledgeable and authoritative entity. In the
conclusion section, some guidelines for practitioners are suggested to
ease their tasks for motivating people to adopt and use information
systems.