Abstract: Introduction: The process to build a better safety
culture, methods of error analysis, and preventive measures, starts
with an understanding of the effects when human factors engineering
refer to remote microscopic diagnosis in surgery and specially in
organ transplantation for the remote evaluation of the grafts. It has
been estimated that even in well-organized transplant systems an
average of 8% to 14% of the grafts (G) that arrive at the recipient
hospitals may be considered as diseased, injured, damaged or
improper for transplantation. Digital microscopy adds information on
a microscopic level about the grafts in Organ Transplant (OT), and
may lead to a change in their management. Such a method will
reduce the possibility that a diseased G, will arrive at the recipient
hospital for implantation. Aim: Ergonomics of Digital Microscopy
(DM) based on virtual slides, on Telemedicine Systems (TS) for
Tele-Pathological (TPE) evaluation of the grafts (G) in organ
transplantation (OT). Material and Methods: By experimental
simulation, the ergonomics of DM for microscopic TPE of Renal
Graft (RG), Liver Graft (LG) and Pancreatic Graft (PG) tissues is
analyzed. In fact, this corresponded to the ergonomics of digital
microscopy for TPE in OT by applying Virtual Slide (VS) system for
graft tissue image capture, for remote diagnoses of possible
microscopic inflammatory and/or neoplastic lesions. Experimentation
included: a. Development of an OTE-TS similar Experimental
Telemedicine System (Exp.-TS), b. Simulation of the integration of
TS with the VS based microscopic TPE of RG, LG and PG applying
DM. Simulation of the DM based TPE was performed by 2
specialists on a total of 238 human Renal Graft (RG), 172 Liver Graft
(LG) and 108 Pancreatic Graft (PG) tissues digital microscopic
images for inflammatory and neoplastic lesions on four electronic
spaces of the four used TS. Results: Statistical analysis of specialist‘s
answers about the ability to diagnose accurately the diseased RG, LG
and PG tissues on the electronic space among four TS (A,B,C,D)
showed that DM on TS for TPE in OT is elaborated perfectly on the
ES of a Desktop, followed by the ES of the applied Exp.-TS. Tablet
and Mobile-Phone ES seem significantly risky for the application of
DM in OT (p
Abstract: Background: To improve the delivery of paediatric
healthcare in low resource settings, Community Health Workers
(CHW) have been provided with a paper-based set of protocols
known as Community Case Management (CCM). Yet research has
shown that CHW adherence to CCM guidelines is poor, ultimately
impacting health service delivery. Digitising the CCM guidelines via
mobile technology is argued in extant literature to improve CHW
adherence. However, little research exist which outlines how (a) this
process can be digitised and (b) adherence could be improved as a
result. Aim: To explore how an electronic mobile version of CCM
(eCCM) can overcome issues associated with the paper-based CCM
protocol (inadequate adherence to guidelines) vis-à-vis service
blueprinting. This service blueprint will outline how (a) the CCM
process can be digitised using mobile Clinical Decision Support
Systems software to support clinical decision-making and (b)
adherence can be improved as a result. Method: Development of a
single service blueprint for a standalone application which visually
depicts the service processes (eCCM) when supporting the CHWs,
using an application known as Supporting LIFE (SL eCCM app) as
an exemplar. Results: A service blueprint is developed which
illustrates how the SL eCCM app can be utilised by CHWs to assist
with the delivery of healthcare services to children. Leveraging
smartphone technologies can (a) provide CHWs with just-in-time
data to assist with their decision making at the point-of-care and (b)
improve CHW adherence to CCM guidelines. Conclusions: The
development of the eCCM opens up opportunities for the CHWs to
leverage the inherent benefit of mobile devices to assist them with
health service delivery in rural settings. To ensure that benefits are
achieved, it is imperative to comprehend the functionality and form
of the eCCM service process. By creating such a service blueprint for
an eCCM approach, CHWs are provided with a clear picture
regarding the role of the eCCM solution, often resulting in buy-in
from the end-users.
Abstract: Lateral torsional buckling is a global buckling mode
which should be considered in design of slender structural members
under flexure about their strong axis. It is possible to compute the
load which causes lateral torsional buckling of a beam by finite
element analysis, however, closed form equations are needed in
engineering practice for calculation ease which can be obtained by
using energy method. In lateral torsional buckling applications of
energy method, a proper function for the critical lateral torsional
buckling mode should be chosen which can be thought as the
variation of twisting angle along the buckled beam. Accuracy of the
results depends on how close is the chosen function to the exact
mode. Since critical lateral torsional buckling mode of the cantilever
I-beams varies due to material properties, section properties and
loading case, the hardest step is to determine a proper mode function
in application of energy method. This paper presents an approximate function for critical lateral
torsional buckling mode of doubly symmetric cantilever I-beams.
Coefficient matrices are calculated for concentrated load at free end,
uniformly distributed load and constant moment along the beam
cases. Critical lateral torsional buckling modes obtained by presented
function and exact solutions are compared. It is found that the modes
obtained by presented function coincide with differential equation
solutions for considered loading cases.
Abstract: In this study, a general approach to the reliability
based limit analysis of laterally loaded piles is presented. In
engineering practice the uncertainties play a very important role. The
aim of this study is to evaluate the lateral load capacity of free-head
and fixed-head long pile when plastic limit analysis is considered. In
addition to the plastic limit analysis to control the plastic behaviour
of the structure, uncertain bound on the complementary strain energy
of the residual forces is also applied. This bound has significant effect
for the load parameter. The solution to reliability-based problems is
obtained by a computer program which is governed by the reliability
index calculation.
Abstract: Cancer is still one of the serious diseases threatening
the lives of human beings. How to have an early diagnosis and
effective treatment for tumors is a very important issue. The animal
carcinoma model can provide a simulation tool for the studies of
pathogenesis, biological characteristics, and therapeutic effects.
Recently, drug delivery systems have been rapidly developed to
effectively improve the therapeutic effects. Liposome plays an
increasingly important role in clinical diagnosis and therapy for
delivering a pharmaceutic or contrast agent to the targeted sites.
Liposome can be absorbed and excreted by the human body, and is
well known that no harm to the human body. This study aimed to
compare the therapeutic effects between encapsulated (doxorubicin
liposomal, Lipodox) and un-encapsulated (doxorubicin, Dox)
anti-tumor drugs using magnetic resonance imaging (MRI).
Twenty-four New Zealand rabbits implanted with VX2 carcinoma at
left thighs were classified into three groups: control group (untreated),
Dox-treated group, and LipoDox-treated group, 8 rabbits for each
group. MRI scans were performed three days after tumor implantation.
A 1.5T GE Signa HDxt whole body MRI scanner with a high
resolution knee coil was used in this study. After a 3-plane localizer
scan was performed, three-dimensional (3D) fast spin echo (FSE)
T2-weighted Images (T2WI) was used for tumor volumetric
quantification. Afterwards, two-dimensional (2D) spoiled gradient
recalled echo (SPGR) dynamic contrast-enhanced (DCE) MRI was
used for tumor perfusion evaluation. DCE-MRI was designed to
acquire four baseline images, followed by contrast agent Gd-DOTA
injection through the ear vein of rabbit. A series of 32 images were
acquired to observe the signals change over time in the tumor and
muscle. The MRI scanning was scheduled on a weekly basis for a
period of four weeks to observe the tumor progression longitudinally.
The Dox and LipoDox treatments were prescribed 3 times in the first
week immediately after the first MRI scan; i.e. 3 days after VX2 tumor
implantation. ImageJ was used to quantitate tumor volume and time
course signal enhancement on DCE images. The changes of tumor size
showed that the growth of VX2 tumors was effectively inhibited for
both LipoDox-treated and Dox-treated groups. Furthermore, the tumor
volume of LipoDox-treated group was significantly lower than that of
Dox-treated group, which implies that LipoDox has better therapeutic effect than Dox. The signal intensity of LipoDox-treated group is
significantly lower than that of the other two groups, which implies
that targeted therapeutic drug remained in the tumor tissue. This study
provides a radiation-free and non-invasive MRI method for
therapeutic monitoring of targeted liposome on an animal tumor
model.
Abstract: Fires is one of the main types of disturbances that
shape ecosystems in the Mediterranean region. However nowadays,
climate alterations towards higher temperatures result on increased
levels of fire intensity, frequency and spread as well as difficulties for
natural regeneration to occur. Thasos Island is one of the Greek
islands that has experienced those problems. Since 1984, a series of
wildfires led to the reduction of forest cover from 61.6% to almost
20%. The negative impacts were devastating in many different
aspects for the island. The absence of plant cover, post-wildfire
precipitation and steep slopes were the major factors that induced
severe soil erosion and intense floods. That also resulted to serious
economic problems to the local communities and the inability of the
burnt areas to regenerate naturally. Despite the substantial amount of
published work regarding Thasos wildfires, there is no information
related to post-wildfire effects on factors such as soil erosion. More
research related to post-fire effects should help to an overall
assessment of the negative impacts of wildfires on land degradation
through processes such as soil erosion and flooding.
Abstract: The garment manufacturing industry involves
sequential processes that are subjected to uncontrollable variations.
The industry depends on the skill of labour in handling the varieties
of fabrics and accessories, machines, as well as complicated sewing
operation. Due to these reasons, garment manufacturers have created
systems to monitor and to control the quality of the products on a
regular basis by conducting quality approaches to minimize variation.
With that, the aim of this research has been to ascertain the quality
approaches deployed by Malaysian garment manufacturers in three
key areas - quality systems and tools; quality control and types of
inspection; as well as sampling procedures chosen for garment
inspection. Besides, the focus of this research was to distinguish the
quality approaches adopted by companies that supplied finished
garments to both domestic and international markets. Feedback from
each company representative has been obtained via online survey,
which comprised of five sections and 44 questions on the
organizational profile and the quality approaches employed in the
garment industry. As a result, the response rate was 31%. The results
revealed that almost all companies have established their own
mechanism of process control by conducting a series of quality
inspections for daily production, either it was formally set up or
otherwise. In addition, quality inspection has been the predominant
quality control activity in the garment manufacturing, while the level
of complexity of these activities was substantially dictated by the
customers. Moreover, AQL-based sampling was utilized by
companies dealing with exports, whilst almost all the companies that
only concentrated on the domestic market were comfortable using
their own sampling procedures for garment inspection. Hence, this
research has provided insights into the implementation of a number
of quality approaches that were perceived as important and useful in
the garment manufacturing sector, which is truly labour-intensive.
Abstract: South Africa is in its post-industrial era moving from
the primary and secondary sector to the tertiary sector. The study
investigated the impact of the disaggregated energy consumption
(coal, oil, and electricity) on the primary, secondary and tertiary
sectors of the economy between 1980 and 2012 in South Africa.
Using vector error correction model, it was established that South
Africa is an energy dependent economy, and that energy (especially
electricity and oil) is a limiting factor of growth. This implies that
implementation of energy conservation policies may hamper
economic growth. Output growth is significantly outpacing energy
supply, which has necessitated load shedding. To meet up the excess
energy demand, there is a need to increase the generating capacity
which will necessitate increased investment in the electricity sector as
well as strategic steps to increase oil production. There is also need to
explore more renewable energy sources, in order to meet the growing
energy demand without compromising growth and environmental
sustainability. Policy makers should also pursue energy efficiency
policies especially at sectoral level of the economy.
Abstract: Hypertension is a common condition causing cardio
and cerebrovascular complications. Portugal has one of the highest
mortality rates from stroke and a high prevalence of hypertension.
Systolic Blood Pressure (SBP) is an important risk factor for
cardiovascular events (myocardial infarction and stroke) and
premature mortality, particularly in the elderly population. The
present study aims to estimate the prevalence of hypertension in a
Portuguese population living in a coastal city and to identify some of
its determinants (namely gender, age, the body mass index and
physical activity frequency). A total of 91 adults who attended three pharmacies of a coastal
city in the center of Portugal, between May and August of 2013 were
evaluated. Attendants who reported to have diabetes or taking
antihypertensive drugs in the 2 previous weeks were excluded from
the study. Sociodemographic factors, BMI, habits of exercise and BP
were assessed. Hypertension was defined as blood pressure ≥140/90
mmHg. The majority of the studied population was constituted by women
(75.8%), with a mean age of 54.2±1.6 years old, married or living in
civil union and that had completed secondary school or had higher
education (40%). They presented a mean BMI of 26.2±4.76 Kg/m2.,
and were sedentary. The mean BP was 127.0±17.77mmHg- 74.69 ±
9.53. In this population we found 4.3% of people with hypertension
and 16.1% with normal high blood pressure. Men exhibit a tendency to present higher systolic blood pressure
values than women. Of all the factors considered, SBP values also
tended to be higher with age and higher BMI values.
Despite the fact that the mean values of SBP did not present values
higher than 140 mmHg we must be concerned because the studied
population is undiagnosed for hypertension. Although this is a preliminary study, it might be a prelude to the
upcoming research about the underlying factors responsible for the
occurrence of SBP.
Abstract: The aim of this study is to empirically investigate the
mediating impact of export performance (EP) between technological
advancement capabilities and business performance (BP) of
Malaysian manufacturing micro, small and medium sized enterprises
(MSME’s). Firm’s technological advancement resources are
hypothesized as a platform to enhance both exports and BP of
manufacturing MSMEs in Malaysia. This study is twofold, primary it
has investigated that technological advancement capabilities helps to
appreciates main performance measures noted in terms of EP and
Secondly, it investigates that how efficiently and effectively
technological advancement capabilities can contribute in overall
Malaysian MSME’s BP. Smart PLS-3 statistical software is used to
know the association between technological advancement
capabilities, MSME’s EP and BP. In this study, the data was
composed from Malaysian manufacturing MSME’s in east coast
industrial zones known as the manufacturing hub of MSMEs. Seven
hundred and fifty (750) questionnaires were distributed, but only 148
usable questionnaires are returned. The finding of this study indicated
that technological advancement capabilities helps to strengthen the
export in term of time and cost efficient and it plays a significant role
in appreciating their BP. This study is helpful for small and medium
enterprise owners who intend to expand their business overseas and
though smart technological advancement resources they can achieve
their business competitiveness and excellence both at local and
international markets.
Abstract: Hydraulic fracturing is one of the most important
stimulation techniques available to the petroleum engineer to extract
hydrocarbons in tight gas sandstones. It allows more oil and gas
production in tight reservoirs as compared to conventional means.
The main aim of the study is to optimize the hydraulic fracturing as
technique and for this purpose three multi-zones layer formation is
considered and fractured contemporaneously. The three zones are
named as Zone1 (upper zone), Zone2 (middle zone) and Zone3
(lower zone) respectively and they all occur in shale rock. Simulation was performed with Mfrac integrated software which
gives a variety of 3D fracture options. This simulation process
yielded an average fracture efficiency of 93.8%for the three
respective zones and an increase of the average permeability of the
rock system. An average fracture length of 909 ft with net height
(propped height) of 210 ft (average) was achieved. Optimum
fracturing results was also achieved with maximum fracture width of
0.379 inches at an injection rate of 13.01 bpm with 17995 Mscf of
gas production.
Abstract: Mixed-use development is one of the most important
trends in new island house transformation along southeast coastal area
in China. Unique island geographical environment and profound
fishing village culture coexist for a long time in this. With artistic
creation for the purpose of the "live-work" houses are in a large
number of emergence, however, still lack of systematic strategy.
Based on space effect from marine resources to regional human
settlements, this article teases out the evolution regularity of island
settlement context and architectural form, then, puts forward the
formation mechanism and construction model of art island houses.
Thereby, to further explore space design method and site creation
strategy of mixed-use development.
Abstract: Detecting changes in multiple images of the same
scene has recently seen increased interest due to the many
contemporary applications including smart security systems, smart
homes, remote sensing, surveillance, medical diagnosis, weather
forecasting, speed and distance measurement, post-disaster forensics
and much more. These applications differ in the scale, nature, and
speed of change. This paper presents an application of image
processing techniques to implement a real-time change detection
system. Change is identified by comparing the RGB representation of
two consecutive frames captured in real-time. The detection threshold
can be controlled to account for various luminance levels. The
comparison result is passed through a filter before decision making to
reduce false positives, especially at lower luminance conditions. The
system is implemented with a MATLAB Graphical User interface
with several controls to manage its operation and performance.
Abstract: An early diagnosis of bone metastasis is very
important for making a right decision on a subsequent therapy. One
of the most important steps to be taken initially, for developing a new
radiopharmaceutical is the measurement of organ radiation exposure
dose. In this study, the dosimetric studies of a novel agent for
SPECT-imaging of the bone metastasis, 111In-(4-
{[(bis(phosphonomethyl))carbamoyl]methyl}7,10bis(carboxymethyl)
-1,4,7,10-tetraazacyclododec-1-yl) acetic acid (111In-BPAMD)
complex, have been carried out to estimate the dose in human organs
based on the data derived from mice. The radiolabeled complex was
prepared with high radiochemical purity in the optimal conditions.
Biodistribution studies of the complex was investigated in the male
Syrian mice at the selected times after injection (2, 4, 24 and 48 h).
The human absorbed dose estimation of the complex was made based
on data derived from the mice by the radiation absorbed dose
assessment resource (RADAR) method. 111In-BPAMD complex was prepared with high radiochemical
purity >95% (ITLC) and specific activities of 2.85 TBq/mmol. Total
body effective absorbed dose for 111In-BPAMD was 0.205
mSv/MBq. This value is comparable to the other 111In clinically used
complexes. The results show that the dose with respect to the critical
organs is satisfactory within the acceptable range for diagnostic
nuclear medicine procedures. Generally, 111In-BPAMD has
interesting characteristics and it can be considered as a viable agent
for SPECT-imaging of the bone metastasis in the near future.
Abstract: Cesium molybdates with general formula
CsMIII(MoO4)2, where MIII = Bi, Dy, Pr, Er, exhibit rich
polymorphism, and crystallize in a layered structure. These properties
cause intensive studies on cesium molybdates. CsBi(MoO4)2 was synthesized by microwave method by using
cerium sulphate, bismuth oxide and molybdenum (VI) oxide in an
appropriate molar ratio. Characterizations were done by x-ray
diffraction (XRD), fourier transform infrared (FTIR) spectroscopy,
scanning electron microscopy/energy dispersive analyze (SEM/EDS),
thermo gravimetric/differantial thermal analysis (TG/DTA).
Abstract: Cost overruns are a persistent problem in oil and gas
megaprojects. Whilst the extant literature is filled with studies on
incidents and causes of cost overruns, underlying theories to explain
their emergence in oil and gas megaprojects are few. Yet, a way to
contain the syndrome of cost overruns is to understand the bases of
‘how and why’ they occur. Such knowledge will also help to develop
pragmatic techniques for better overall management of oil and gas
megaprojects. The aim of this paper is to explain the development of
cost overruns in hydrocarbon megaprojects through the perspective of
chaos theory. The underlying principles of chaos theory and its
implications for cost overruns are examined and practical
recommendations proposed. In addition, directions for future research
in this fertile area provided.
Abstract: Adequate and reliable estimates of aquifer parameters
are of utmost importance for proper management of vital
groundwater resources. At present scenario, the ground water is
polluted because of industrial waste disposed over the land and the
contaminants are transported in the aquifer from one area to another
area, which is depending on the characteristics of the aquifer and
contaminants. To know the contaminant transport, the accurate
estimation of aquifer properties is highly needed. Conventionally,
these properties are estimated through pumping tests carried out on
water wells. The occurrence and movement of ground water in the
aquifer are characteristically defined by the aquifer parameters. The
pumping (aquifer) test is the standard technique for estimating
various hydraulic properties of aquifer systems, viz., transmissivity
(T), hydraulic conductivity (K), storage coefficient (S) etc., for which
the graphical method is widely used. The study area for conducting
pumping test is Pydibheemavaram Industrial area near the coastal
belt of Srikulam, AP, India. The main objective of the present work is
to estimate the aquifer properties for developing contaminant
transport model for the study area.
Abstract: Graphene, a single-atom sheet, has been considered as
the most promising material for making future nanoelectromechanical
systems as well as purely electrical switching with graphene
transistors. Graphene-based devices have advantages in scaled-up
device fabrication due to the recent progress in large area graphene
growth and lithographic patterning of graphene nanostructures. Here
we investigated its mechanical responses of circular graphene
nanoflake under the nanoindentation using classical molecular
dynamics simulations. A correlation between the load and the
indentation depth was constructed. The nanoindented force in this
work was applied to the center point of the circular graphene nanoflake
and then, the resonance frequency could be tuned by a nanoindented
depth. We found the hardening or the softening of the graphene
nanoflake during its nanoindented-deflections, and such properties
were recognized by the shift of the resonance frequency. The
calculated mechanical parameters in the force-vs-deflection plot were
in good agreement with previous experimental and theoretical works.
This proposed schematics can detect the pressure via the deflection
change or/and the resonance frequency shift, and also have great
potential for versatile applications in nanoelectromechanical systems.
Abstract: One of the challenges that higher education faces is to
find how to approach the sustainability in an inclusive way to the
student within all the different academic areas, how to move the
sustainable development from the abstract field to the operational
field. This research comes from the ecoliteracy and the pedagogical
praxis as tools for rebuilding the teaching processes inside of
universities. The purpose is to determine and describe which are the
factors involved in the process of learning particularly in the
Greenhouse-School Siembra UV. In the Greenhouse-School Siembra UV, of the University of
Veracruz, are cultivated vegetables, medicinal plants and small
cornfields under the usage of eco-technologies such as hydroponics,
Wickingbed and Hugelkultur, which main purpose is the saving of
space, labor and natural resources, as well as function as agricultural
production alternatives in the urban and periurban zones. The sample was formed with students from different academic
areas and who are actively involved in the greenhouse, as well as
institutes from the University of Veracruz and governmental and nongovernmental
departments. This project comes from a pedagogic praxis approach, from filling
the needs that the different professional profiles of the university
students have. All this with the purpose of generate a pragmatic
dialogue with the sustainability. It also comes from the necessity to
understand the factors that intervene in the students’ praxis. In this
manner is how the students are the fundamental unit in the sphere of
sustainability. As a result, it is observed that those University of Veracruz
students who are involved in the Greenhouse-school, Siembra UV,
have enriched in different levels the sense of urban and periurban
agriculture because of the diverse academic approaches they have
and the interaction between them. It is concluded that the ecotechnologies
act as fundamental tools for ecoliteracy in society,
where it is strengthen the nutritional and food security from a
sustainable development approach.
Abstract: Background: To compare the thinning patterns of the
ganglion cell-inner plexiform layer (GCIPL) and peripapillary retinal
nerve fiber layer (pRNFL) as measured using Cirrus high-definition
optical coherence tomography (HD-OCT) in patients with visual field
(VF) defects that respect the vertical meridian. Methods: Twenty eyes of eleven patients with VF defects that
respect the vertical meridian were enrolled retrospectively. The
thicknesses of the macular GCIPL and pRNFL were measured using
Cirrus HD-OCT. The 5% and 1% thinning area index (TAI) was
calculated as the proportion of abnormally thin sectors at the 5% and
1% probability level within the area corresponding to the affected VF.
The 5% and 1% TAI were compared between the GCIPL and pRNFL
measurements. Results: The color-coded GCIPL deviation map showed a
characteristic vertical thinning pattern of the GCIPL, which is also
seen in the VF of patients with brain lesions. The 5% and 1% TAI
were significantly higher in the GCIPL measurements than in the
pRNFL measurements (all P < 0.01). Conclusions: Macular GCIPL analysis clearly visualized a
characteristic topographic pattern of retinal ganglion cell (RGC) loss
in patients with VF defects that respect the vertical meridian, unlike
pRNFL measurements. Macular GCIPL measurements provide more
valuable information than pRNFL measurements for detecting the
loss of RGCs in patients with retrograde degeneration of the optic
nerve fibers.