Abstract: Many inherited diseases and non-hereditary disorders are common in the development of renal cystic diseases. Polycystic kidney disease (PKD) is a disorder developed within the kidneys in which grouping of cysts filled with water like fluid. PKD is responsible for 5-10% of end-stage renal failure treated by dialysis or transplantation. New experimental models, application of molecular biology techniques have provided new insights into the pathogenesis of PKD. Researchers are showing keen interest for developing an automated system by applying computer aided techniques for the diagnosis of diseases. In this paper a multilayered feed forward neural network with one hidden layer is constructed, trained and tested by applying back propagation learning rule for the diagnosis of PKD based on physical symptoms and test results of urinalysis collected from the individual patients. The data collected from 50 patients are used to train and test the network. Among these samples, 75% of the data used for training and remaining 25% of the data are used for testing purpose. Further, this trained network is used to implement for new samples. The output results in normality and abnormality of the patient.
Abstract: Supersaturation of drugs in the gastrointestinal tract is one approach to increase the absorption of poorly water-soluble drugs. The stabilization of a supersaturated state was achieved by adding precipitation inhibitors that may act through a variety of mechanisms. In this study, the effect of the natural gums, acacia, gelatin, pectin and tragacanth on curcumin supersaturation in simulated gastric fluid (SGF) (pH 1.2), fasted state simulated gastric fluid (FaSSGF) (pH 1.6), and simulated intestinal fluid (SIF) (pH 6.8) was investigated. The results indicated that all natural gums significantly increased the curcumin solubility (about 1.2-6-fold) when compared to the absence of gum, and assisted in maintaining the supersaturated drug solution. Among the tested gums, pectin at 3% w/w was the best precipitation inhibitor with a significant increase in the degree of supersaturation about 3-fold in SGF, 2.4-fold in FaSSGF and 2-fold in SIF.
Abstract: Novel solid lipid nanoparticles (SLNs) were developed to improve oral bioavailability of oxyresveratrol (OXY). The SLNs were prepared by a high speed homogenization technique, at an effective speed and time, using Compritol® 888 ATO (5% w/w) as the solid lipid. The appropriate weight proportions (0.3% w/w) of OXY affected the physicochemical properties of blank SLNs. The effects of surfactant types on the properties of the formulations such as particle size and entrapment efficacy were also investigated. Conclusively, Tween 80 combined with soy lecithin was the most appropriate surfactant to stabilize OXY-loaded SLNs. The mean particle size of the optimized formulation was 134.40 ± 0.57 nm. In vitro drug release study, the selected S2 formulation showed a retarded release profile for OXY with no initial burst release compared to OXY suspension in the simulated gastrointestinal fluids. Therefore, these SLNs could provide a suitable system to develop for the oral OXY delivery.
Abstract: Some of the major concerns regarding sewer overflows to receiving water bodies include serious environmental, aesthetic and public health problems. A noble self-cleansing sewer overflow screening device having a sewer overflow chamber, a rectangular tank and a slotted ogee weir to capture the gross pollutants has been investigated. Computational Fluid Dynamics (CFD) techniques are used to simulate the flow phenomena with two different inlet orientations; parallel and perpendicular to the weir direction. CFD simulation results are compared with analytical results. Numerical results show that the flow is not uniform (across the width of the inclined surface) near the top of the inclined surface. The flow becomes uniform near the bottom of the inclined surface, with significant increase of shear stress. The simulation results promises for an effective and efficient self-cleansing sewer overflow screening device by comparing hydrodynamic results.
Abstract: The present study is carried out to investigate the magneto-viscous effects on incompressible ferrofluid flow over a porous rotating disc with suction or injection on the surface of the disc subjected to a magnetic field. The flow under consideration is axi-symmetric steady ferrofluid flow of electrically non-conducting fluid. Karman’s transformation is used to convert the governing boundary layer equations involved in the problem to a system of non linear coupled differential equations. The solution of this system is obtained by using power series approximation. The flow characteristics i.e. radial, tangential, axial velocities and boundary layer displacement thickness are calculated for various values of MFD (magnetic field dependent) viscosity and for different values of suction injection parameter. Besides this, skin friction coefficients are also calculated on the surface of the disk. The results thus obtained are presented numerically and graphically in the paper.
Abstract: An attempt has been made to study the effect of rotation on incompressible, electrically non-conducting ferrofluid in porous medium on Axi-symmetric steady flow over a rotating disk excluding thermal effects. Here, we solved the boundary layer equations with boundary conditions using Neuringer-Rosensweig model considering the z-axis as the axis of rotation. The non linear boundary layer equations involved in the problem are transformed to the non linear coupled ordinary differential equations by Karman's transformation and solved by power series approximations. Besides numerically calculating the velocity components and pressure for different values of porosity parameter with the variation of Karman's parameter we have also calculated the displacement thickness of boundary layer, the total volume flowing outward the z-axis and angle between wall and ferrofluid. The results for all above variables are obtained numerically and discussed graphically.
Abstract: A solar powered air heating system using parabolic trough collector was experimentally investigated. In this experimental setup, the reflected solar radiations were focused on absorber tube which was placed at focal length of the parabolic trough. In this setup, air was used as working fluid which collects the heat from absorber tube. To enhance the performance of parabolic trough, collector with different type of reflectors were used. It was observed For Aluminum sheet maximum temperature is 52.3ºC, which 24.22% more than steel sheet as reflector and 8.5% more than Aluminum foil as reflector, also efficiency by using Aluminum sheet as reflector compared to steel sheet as reflector is 61.18% more. Efficiency by using Aluminum sheet as reflector compared to Aluminum foil as reflector is 18.98% more.
Abstract: An unsteady mixed free convection MHD flow of elastic-viscous incompressible fluid past an infinite vertical porous flat plate is investigated when the presence of heat Source/sink, temperature and concentration are assumed to be oscillating with time and hall effect. The governing equations are solved by complex variable technique. The expressions for the velocity field, temperature field and species concentration are demonstrated in graphs. The effects of the Prandtl number, the Grashof number, modified Grashof number, the Schimidt number, the Hall parameter, Elastic parameter & Magnetic parameter are discussed.
Abstract: Metal working fluids were used in the preparation of oil in water emulsions. The size of oil droplets were evaluated by using the analysis of video images taken from the zeta potential measurements. The evaluated size distributions for emulsions were also tested by microscopic analysis. In addition, emulsion stabilities were discussed depending on electrolyte concentration and pH. The results showed that the stability of oil emulsions was strongly related to pH and the concentration of CaCl2. However, the same dependency was not observed for NaCl.
Abstract: The performance of airlift bioreactors are closely related with their geometry, especially the gas-liquid separator design. In this study, the influence of the gas-liquid separator geometry on oxygen transfer and gas hold-up was evaluated in 10-L concentric-tube airlift bioreactor operating with distilled water and xanthan gum solution. The specific airflow rate (ɸAIR) exhibited the higher effect on the oxygen transfer coefficient (kLa) for both fluids. While the gas-liquid separator openness angle (α) and liquid volume fraction on the gas-liquid separator (VGLS) have presented opposite effects on oxygen mass transfer, they affected negatively the global gas hold-up of distilled water system. The best degassing zone geometry corresponded to a 90° openness angle with 10% of the liquid on it.
Abstract: In water pipeline systems, the flow control is an integrated part of the operation, for instance, opening and closing the valves, starting and stopping the pumps, when these operations very quickly performed, they shall cause the hydraulic transient phenomena, which may cause pump and, valve failures and catastrophic pipe ruptures. Fluid transient analysis is one of the more challenging and complicated flow problems in the design and the operation of water pipeline systems. Transient control has become an essential requirement for ensuring safe operation of water pipeline systems. An accurate analysis and suitable protection devices should be used to protect water pipeline systems. The fourth-order Runge-Kutta method has been used to solve the dynamic and continuity equations in the rigid column method, while the characteristics method used to solve these equations in the full elastic methods. This paper presents the problem of modeling and simulating of transient phenomena in conveying pipeline systems based on the rigid column and full elastic methods. Also, it provides the influence of using the protection devices to protect the pipeline systems from damaging due to the gain pressure which occur in the transient state. The results obtained provide that the model is an efficient tool for flow transient analysis and provide approximately identical results by using these two methods. Moreover; using the closed surge tank reduces the unfavorable effects of transients.
Abstract: The objective of this paper is to develop a computational model of human nasal cavity from computed tomography (CT) scans using MIMICS software. Computational fluid dynamic techniques were employed to understand nasal airflow. Gambit and Fluent software was used to perform CFD simulation. Velocity profiles, iteration plots, pressure distribution, streamline and pathline patterns for steady, laminar airflow inside the human nasal cavity of healthy and also infected persons are presented in detail. The implications for olfaction are visualized. Results are validated with the available numerical and experimental data. The graphs reveal that airflow varies with different anatomical nasal structures and only fraction of the inspired air reaches the olfactory region. The Deviations in the results suggest that the treatment of infected volunteers will improve the olfactory function.
Abstract: The atomization effect is an important factor of the heat transfer of liquid nitrogen spray. In this paper, two kinds of internal-mixing twin-fluid atomizers were design. According to the fracture theory and fluid mechanics, the model is established to simulate atomization effect. The results showed that: Internal-mixing atomizers, with the liquid nitrogen atomization size from 20um to 40um, have superior performance. Y-jet atomizer spray speed is greater than Multi-jet atomizer, and it can improve the efficiency of heat transfer between the liquid nitrogen and its spray object. Multi-jet atomizer atomization cone angle is about 30°, Y-jet atomizer atomization cone angle is about 20°. During atomizer selection, the size of the heat transfer area should be considered.
Abstract: This article aims to investigate the performance of a magnetic fluid based squeeze film between rotating transversely rough curved porous annular plates incorporating the effect of elastic deformation. The associated stochastically averaged Reynolds type equation is solved to obtain the pressure distribution leading to the calculation of the load carrying capacity. The results suggest that the transverse roughness of the bearing surfaces affects the performance adversely although the bearing systems register a relatively improved performance due to the magnetization. The deformation causes reduced the load carrying capacity while the curvature parameters tend to nominally increase the load carrying capacity. Besides, the adverse effect of porosity, deformation and standard deviation can be minimized to some extent by the positive effect of the magnetization and the curvature parameters in the case of negatively skewed roughness by suitably choosing the rotational inertia and the aspect ratio, which becomes significant when negative variance occurs.
Abstract: Present study numerically investigates the flow field and heat transfer of water in two dimensional sinusoidal and rectangular corrugated wall channels. Simulations are performed for fully developed flow conditions at inlet sections of the channels that have 12 waves. The temperature of the input fluid is taken to be less than that temperature of wavy walls. The governing continuity, momentum and energy equations are numerically solved using finite volume method based on SIMPLE technique. The investigation covers Reynolds number in the rage of 100-1000. The effects of the distance between upper and lower corrugated walls are studied by varying Hmin/Hmax ratio from 0.3 to 0.5 for keeping wave length and wave amplitude values fixed for both geometries. The effects of the wall geometry, Reynolds number and the distance between walls on the flow characteristics, the local Nusselt number and heat transfer are studied. It is found that heat transfer enhancement increases by usage of corrugated horizontal walls in an appropriate Reynolds number regime and channel height.
Abstract: Numerical investigation on the generality of nanoparticle velocity equation had been done on the previous published work. The three dimensional governing equations (continuity, momentum and energy) were solved using finite volume method (FVM). Parametric study of thermal performance between pure water-cooled and nanofluid-cooled are evaluated for volume fraction in the range of 1% to 4%, and nanofluid type of gamma-Al2O3 at Reynolds number range of 67.41 to 286.77. The nanofluid is modeled using single and two phase approach. Three different existing Brownian motion velocities are applied in comparing the generality of the equation for a wide parametric condition. Deviation in between the Brownian motion velocity is identified to be due to the different means of mean free path and constant value used in diffusion equation.
Abstract: The mixture between two fluids of different salinity has been proven to capable of producing electricity in an ocean salinity energy conversion system known as hydrocratic generator. The system relies on the difference between the salinity of the incoming fresh water and the surrounding sea water in the generator. In this investigation, additional parameter is introduced which is the temperature difference between the two fluids; hence the system is known as Ocean Salinity and Temperature Energy Conversion System (OSTEC). The investigation is divided into two papers. This first paper of Part 1 presents the theoretical formulation by considering the effect of fluid dynamic viscosity known as Viscosity Model and later compares with the conventional formulation which is Density Model. The dynamic viscosity model is used to predict the dynamic of the fluids in the system which in turns gives the analytical formulation of the potential power output that can be harvested.
Abstract: The characteristics of physiological blood flow in human carotid arterial bifurcation model have been numerically studied using a fully coupled fluid-structure interaction (FSI) analysis. This computational model with the fluid-structure interaction is constructed to investigate the flow characteristics and wall shear stress in the carotid artery. As the flow begins to decelerate after the peak flow, a large recirculation zone develops at the non-divider wall of both internal carotid artery (ICA) and external carotid artery (ECA) in FSI model due to the elastic energy stored in the expanding compliant wall. The calculated difference in wall shear stress (WSS) in both Non-FSI and FSI models is a range of between 5 and 11% at the mean WSS. The low WSS corresponds to regions of carotid artery that are more susceptible to atherosclerosis.
Abstract: A theoretical investigation on the effects of both
steady-state and dynamic deformations of the foils on the dynamic
performance characteristics of a self-acting air foil journal bearing
operating under small harmonic vibrations is proposed. To take into
account the dynamic deformations of foils, the perturbation method is
used for determining the gas-film stiffness and damping coefficients
for given values of excitation frequency, compressibility number, and
compliance factor of the bump foil. The nonlinear stationary
Reynolds’ equation is solved by means of the Galerkins’ finite
element formulation while the finite differences method are used to
solve the first order complex dynamic equations resulting from the
perturbation of the nonlinear transient compressible Reynolds’
equation. The stiffness of a bump is uniformly distributed throughout
the bearing surface (generation I bearing). It was found that the
dynamic properties of the compliant finite length journal bearing are
significantly affected by the compliance of foils especially whenthe
dynamic deformation of foils is considered in addition to the static
one by applying the principle of superposition.
Abstract: A numerical investigation is performed for non Newtonian fluids flow between two concentric cylinders. The D2Q9 lattice Boltzmann model developed from the Bhatangar-Gross-Krook (LBGK) approximation is used to obtain the flow field for fluids obeying to the power-law model. The inner and outer cylinders rotate in the same and the opposite direction while the end walls are maintained at rest. The combined effects of the Reynolds number (Re) of the inner and outer cylinders, the radius ratio (η) as well as the power-law index (n) on the flow characteristics are analyzed for an annular space of a finite aspect ratio (Γ). Two flow modes are obtained: a primary mode (laminar stable regime) and a secondary mode (laminar unstable regime). The so obtained flow structures are different from one mode to another. The transition critical Reynolds number Rec from the primary to the secondary mode is analyzed for the co-courant and counter-courant flows. This critical value increases as n increases. The prediction of the swirling flow of non Newtonians fluids in axisymmetric geometries is shown in the present work.