Abstract: Chikungunya virus (CHICKV) is an arboviruses belonging to family Tagoviridae and is transmitted to human through by mosquito (Aedes aegypti and Aedes albopictus) bite. A large outbreak of chikungunya has been reported in India between 2006 and 2007, along with several other countries from South-East Asia and for the first time in Europe. It was for the first time that the CHICKV outbreak has been reported with mortality from Reunion Island and increased mortality from Asian countries. CHICKV affects all age groups, and currently there are no specific drugs or vaccine to cure the disease. The need of antiviral agents for the treatment of CHICKV infection and the success of virtual screening against many therapeutically valuable targets led us to carry out the structure based drug design against Chikungunya nSP2 protease (PDB: 3TRK). Highthroughput virtual screening of publicly available databases, ZINC12 and BindingDB, has been carried out using the Openeye tools and Schrodinger LLC software packages. Openeye Filter program has been used to filter the database and the filtered outputs were docked using HTVS protocol implemented in GLIDE package of Schrodinger LLC. The top HITS were further used for enriching the similar molecules from the database through vROCS; a shape based screening protocol implemented in Openeye. The approach adopted has provided different scaffolds as HITS against CHICKV protease. Three scaffolds: Indole, Pyrazole and Sulphone derivatives were selected based on the docking score and synthetic feasibility. Derivatives of Pyrazole were synthesized and submitted for antiviral screening against CHICKV.
Abstract: DC-DC converters are widely used in regulated switched mode power supplies and in DC motor drive applications. There are several sources of unwanted nonlinearity in practical power converters. In addition, their operation is characterized by switching that gives birth to a variety of nonlinear dynamics. DC-DC buck and boost converters controlled by pulse-width modulation (PWM) have been simulated. The voltage waveforms and attractors obtained from the circuit simulation have been studied. With the onset of instability, the phenomenon of subharmonic oscillations, quasi-periodicity, bifurcations, and chaos have been observed. This paper is mainly motivated by potential contributions of chaos theory in the design, analysis and control of power converters, in particular and power electronics circuits, in general.
Abstract: This paper describes a 3D modeling system in
Augmented Reality environment, named 3DARModeler. It can be
considered a simple version of 3D Studio Max with necessary
functions for a modeling system such as creating objects, applying
texture, adding animation, estimating real light sources and casting
shadows. The 3DARModeler introduces convenient, and effective
human-computer interaction to build 3D models by combining both
the traditional input method (mouse/keyboard) and the tangible input
method (markers). It has the ability to align a new virtual object with
the existing parts of a model. The 3DARModeler targets nontechnical
users. As such, they do not need much knowledge of
computer graphics and modeling techniques. All they have to do is
select basic objects, customize their attributes, and put them together
to build a 3D model in a simple and intuitive way as if they were
doing in the real world. Using the hierarchical modeling technique,
the users are able to group several basic objects to manage them as a
unified, complex object. The system can also connect with other 3D
systems by importing and exporting VRML/3Ds Max files. A
module of speech recognition is included in the system to provide
flexible user interfaces.
Abstract: Surgical site infections (SSIs) are the most common
nosocomial infection in surgical patients resulting in significant
increases in postoperative morbidity and mortality. The commonly
causative bacteria developed resistance to virtually all antibiotics
available. The aim of this study was to isolation and identification the
most common bacteria that cause SSIs in Medical Research Institute,
and to compare their sensitivity to selected group of antibiotics and
natural products (garlic, oregano, olive, and Nigella sativa oils). The
isolated pathogens collected from infected surgical wounds were
identified, and their sensitivities to the antibiotics commonly
available for clinical use, and also to the different concentrations of
the used natural products were investigated. The results indicate to
the potential therapeutic effect of the tested natural products in
treatment of surgical wound infections.
Abstract: In recent years in Kazakhstan, as well as in all countries, we have been talking not only about the professional stress, but also professional Burnout Syndrome of employees. Burnout is essentially a response to chronic emotional stress – manifests itself in the form of chronic fatigue, despondency, unmotivated aggression, anger, and others. This condition is due to mental fatigue among teachers as a sort of payment for overstrain when professional commitments include the impact of “heat your soul", emotional investment. The emergence of professional Burnout among teachers is due to the system of interrelated and mutually reinforcing factors relating to the various levels of the personality: individually-psychological level is psychodynamic special subject characteristics of valuemotivational sphere and formation of skills and habits of selfregulation; the socio-psychological level includes especially the Organization and interpersonal interaction of a teacher. Signs of the Burnout were observed in 15 testees, and virtually a symptom could be observed in every teacher. As a result of the diagnosis 48% of teachers had the signs of stress (phase syndrome), resulting in a sense of anxiety, mood, heightened emotional susceptibility. The following results have also been got:-the fall of General energy potential – 14 pers. -Psychosomatic and psycho vegetative syndrome – 26 pers. -emotional deficit-34 pers. -emotional Burnout Syndrome-6 pers. The problem of professional Burnout of teachers in the current conditions should become not only meaningful, but particularly relevant. The quality of education of the younger generation depends on professional development; teachers- training level, and how “healthy" teachers are. That is why the systematic maintenance of pedagogic-professional development for teachers (including disclosure of professional Burnout Syndrome factors) takes on a special meaning.
Abstract: Simulations play a major role in education not only because they provide realistic models with which students can interact to acquire real world experiences, but also because they constitute safe environments in which students can repeat processes without any risk in order to perceive easier concepts and theories. Virtual reality is widely recognized as a significant technological advance that can facilitate learning process through the development of highly realistic 3D simulations supporting immersive and interactive features. The objective of this paper is to analyze the influence of virtual reality-s use in chemistry instruction as well as to present an integrated web-based learning environment for the simulation of chemical experiments. The proposed application constitutes a cost-effective solution for both schools and universities without appropriate infrastructure and a valuable tool for distance learning and life-long education in chemistry. Its educational objectives are the familiarization of students with the equipment of a real chemical laboratory and the execution of virtual volumetric analysis experiments with the active participation of students.
Abstract: Lean production (or lean management respectively)
gained popularity in several waves. The last three decades have been
filled with numerous attempts to apply these concepts in companies.
However, this has only been partially successful. The roots of lean
production can be traced back to Toyota-s just-in-time production.
This concept, which according to Womack-s, Jones- and Roos-
research at MIT was employed by Japanese car manufacturers,
became popular under its international names “lean production",
“lean-manufacturing" and was termed “Schlanke Produktion" in
Germany. This contribution shows a review about lean production in
Germany over the last thirty years: development, trial & error and
implementation as well.
Abstract: Wireless sensor networks (WSN) consists of many
sensor nodes that are placed on unattended environments such as
military sites in order to collect important information.
Implementing a secure protocol that can prevent forwarding forged
data and modifying content of aggregated data and has low delay
and overhead of communication, computing and storage is very
important. This paper presents a new protocol for concealed data
aggregation (CDA). In this protocol, the network is divided to
virtual cells, nodes within each cell produce a shared key to send
and receive of concealed data with each other. Considering to data
aggregation in each cell is locally and implementing a secure
authentication mechanism, data aggregation delay is very low and
producing false data in the network by malicious nodes is not
possible. To evaluate the performance of our proposed protocol, we
have presented computational models that show the performance
and low overhead in our protocol.
Abstract: To understand life as biological system, evolutionary
understanding is indispensable. Protein interactions data are rapidly
accumulating and are suitable for system-level evolutionary analysis.
We have analyzed yeast protein interaction network by both
mathematical and biological approaches. In this poster presentation,
we inferred the evolutionary birth periods of yeast proteins by
reconstructing phylogenetic profile. It has been thought that hub
proteins that have high connection degree are evolutionary old. But
our analysis showed that hub proteins are entirely evolutionary new.
We also examined evolutionary processes of protein complexes. It
showed that member proteins of complexes were tend to have
appeared in the same evolutionary period. Our results suggested that
protein interaction network evolved by modules that form the
functional unit. We also reconstructed standardized phylogenetic trees
and calculated evolutionary rates of yeast proteins. It showed that
there is no obvious correlation between evolutionary rates and
connection degrees of yeast proteins.
Abstract: Camera calibration is an important step in 3D
reconstruction. Camera calibration may be classified into two major types: traditional calibration and self-calibration. However, a calibration method in using a checkerboard is intermediate between traditional calibration and self-calibration. A self
is proposed based on a square in this paper. Only a square in the planar
template, the camera self-calibration can be completed through the single view. The proposed algorithm is that the virtual circle and straight line are established by a square on planar template, and
circular points, vanishing points in straight lines and the relation
between them are be used, in order to obtain the image of the absolute
conic (IAC) and establish the camera intrinsic parameters. To make
the calibration template is simpler, as compared with the Zhang Zhengyou-s method. Through real experiments and experiments, the experimental results show that this algorithm is
feasible and available, and has a certain precision and robustness.
Abstract: There has been a growing interest in implementing humanoid avatars in networked virtual environment. However, most existing avatar communication systems do not take avatars- social backgrounds into consideration. This paper proposes a novel humanoid avatar animation system to represent personalities and facial emotions of avatars based on culture, profession, mood, age, taste, and so forth. We extract semantic keywords from the input text through natural language processing, and then the animations of personalized avatars are retrieved and displayed according to the order of the keywords. Our primary work is focused on giving avatars runtime instruction from multiple natural languages. Experiments with Chinese, Japanese and English input based on the prototype show that interactive avatar animations can be displayed in real time and be made available online. This system provides a more natural and interesting means of human communication, and therefore is expected to be used for cross-cultural communication, multiuser online games, and other entertainment applications.
Abstract: In this research, the main aim is to investigate the
antimicrobial effectiveness of ammonyx solutions finishing on
Sweatshirt Sport with immersion method. 60 Male healthy subjects
(football player) participated in this study. They were dressed in a
Sweatshirt for 14 days and some microbes found on them were
investigated. The antimicrobial effect of different ammonyx
solutions(1/100, 1/500, 1/1000, 1/2000 v/v solutions of Ammonyx)
on the identified microbes was studied by the zone inhabitation
method in vitro. In the next step the Sweatshirt Sports were treated
with the same different solutions of ammonyx and the antimicrobial
effectiveness was assessed by colony count method in different times
and the results were compared whit untreated ones. Some mechanical
properties of treated cotton/polyester yarn that used in Sweatshirt
Sport were measured after 30 days and were compared with
untreated one. Finally after finishing, scanning electron microscopy
(SEM) was used to compare the surfaces of the finished and
unfinished specimens. The results showed the presence of five
pathogenic microbes on Sweatshirt Sports such as Escherichia coli,
Staphylococcus aureus, Aspergillus, Mucor and Candida. The
inhalation time for treated on Sweatshirt Sports improved. The
amount of colony growth on treated clothes reduced considerably
and moreover the mechanical tests results showed no significant
deterioration effect of studies properties in comparison to the
untreated yarn. The visual examination of the SEM indicated that the
antimicrobial treatments were applied usefully to fabrics.
Abstract: Virtual touch screen using camera is an ordinary screen which uses a camera to imitate the touch screen by taking a picture of an indicator, e.g., finger, which is laid on the screen, converting the indicator tip position on the picture to the position on the screen, and moving the cursor on the screen to that position. In fact, the indicator is not laid on the screen directly, but it is intervened by the cover at some intervals. In spite of this gap, if the eye-indicator-camera angle is not large, the mapping from the indicator tip positions on the image to the corresponding cursor positions on the screen is not difficult and could be done with a little error. However, the larger the angle is, the bigger the error in the mapping occurs. This paper proposes cursor position estimation model for virtual touch screen using camera which could eliminate this kind of error. The proposed model (i) moves the on-screen pilot cursor to the screen position which locates on the screen at the position just behind the indicator tip when the indicator tip has been looked from the camera position, and then (ii) converts that pilot cursor position to the desirable cursor position (the position on the screen when it has been looked from the user-s eye through the indicator tip) by using the bilinear transformation. Simulation results show the correctness of the estimated cursor position by using the proposed model.
Abstract: this paper presents a novel scheme which is capable of reducing the error rate and improves the transmission performance in the asynchronous cooperative MIMO systems. A case study of image transmission is applied to prove the efficient of scheme. The linear dispersion structure is employed to accommodate the cooperative wireless communication network in the dynamic topology of structure, as well as to achieve higher throughput than conventional space–time codes based on orthogonal designs. The LDPC encoder without girth-4 and the STBC encoder with guard intervals are respectively introduced. The experiment results show that the combined coder of LDPC-STBC with guard intervals can be the good error correcting coders and BER performance in the asynchronous cooperative communication. In the case study of image transmission, the results show that in the transmission process, the image quality which is obtained by applied combined scheme is much better than it which is not applied the scheme in the asynchronous cooperative MIMO systems.
Abstract: The purpose of the study was to find out the efficacy
of selected mobility exercises and participation in special games on psychomotor abilities, functional abilities and skill performance
among intellectually disabled children of age group under 14. Thirty male students who were studying in Balar Kalvi Nilayam and YMCA
College Special School, Chennai, acted as subjects for the study.
They were only mild and moderate in intellectual disability. These
students did not undergo any special training or coaching programme apart from their regular routine physical activity classes as a part of
the curriculum in the school. They were attached at random, based on
age in which 30 belonged to under 14 age group, which was divided
into three equal group of ten for each experimental treatment. 10
students (Treatment group I) underwent calisthenics and special
games participation, 10 students (Treatment group II) underwent
aquatics and special games participation, 10 students (Treatment
group III) underwent yoga and special games participation. The subjects were tested on selected criterion variables prior (pre test)
and after twelve weeks of training (post test). The pre and post test
data collected from three groups on functional abilities(self care,
learning, capacity for independent living), psychomotor
variables(static balance, eye hand coordination, simple reaction time
test) and skill performance (bocce skill, badminton skill, table tennis
skill) were statistically examined for significant difference, by
applying the analysis ANACOVA. Whenever an 'F' ratio for
adjusted test was found to be significant for adjusted post test means,
Scheffe-s test was followed as a post-hoc test to determine which of
the paired mean differences was significant. The result of the study
showed that among under 14 age groups there was a significant improvement on selected criterion variables such as, Balance,
Coordination, self-care and learning and also in Bocce, Badminton & Table Tennis skill performance, due to mobility exercises and
participation in special games. However there were no significant
differences among the groups.
Abstract: Appeared toward 1986, the object-oriented databases
management systems had not known successes knew five years after
their birth. One of the major difficulties is the query optimization.
We propose in this paper a new approach that permits to enrich
techniques of query optimization existing in the object-oriented
databases. Seen success that knew the query optimization in the
relational model, our approach inspires itself of these optimization
techniques and enriched it so that they can support the new concepts
introduced by the object databases.
Abstract: An application framework provides a reusable
design and implementation for a family of software systems.
Frameworks are introduced to reduce the cost of a product line
(i.e., family of products that share the common features). Software
testing is a time consuming and costly ongoing activity during the
application software development process. Generating reusable test
cases for the framework applications at the framework
development stage, and providing and using the test cases to test
part of the framework application whenever the framework is used
reduces the application development time and cost considerably.
Framework Interface Classes (FICs) are classes introduced by
the framework hooks to be implemented at the application
development stage. They can have reusable test cases generated at
the framework development stage and provided with the
framework to test the implementations of the FICs at the
application development stage. In this paper, we conduct a case
study using thirteen applications developed using three
frameworks; one domain oriented and two application oriented.
The results show that, in general, the percentage of the number of
FICs in the applications developed using domain frameworks is, on
average, greater than the percentage of the number of FICs in the
applications developed using application frameworks.
Consequently, the reduction of the application unit testing time
using the reusable test cases generated for domain frameworks is,
in general, greater than the reduction of the application unit testing
time using the reusable test cases generated for application
frameworks.
Abstract: For professions of high risk industries, simulation training has always been thought in terms of high degree of fidelity regarding the real operational situation. Due to the recent progress, this way of training is changing, modifying the human-computer and software interactions: the interactions between trainees during simulation training session tend to become virtual, transforming the social-based embodiness (the way subjects integrate social skills for interpersonal relationship with co-workers). On the basis of the analysis of eight different profession trainings, a categorization of interactions has help to produce an analytical tool, the social interactions table. This tool may be very valuable to point out the changes of social interactions when the training sessions are skipping from a high fidelity simulator to a virtual simulator. In this case, it helps the designers of professional training to analyze and to assess the consequences of the potential lack the social-based embodiness.
Abstract: The purpose of this study was to find out the
effectiveness of neurological impress method and repeated reading
technique on reading fluency of children with learning disabilities.
Thirty primary four pupils in three public primary schools
participated in the study. There were two experimental groups and a
control. This research employed a 3 by 2 factorial matrix and the
participants were taught for one session. Two hypotheses were
formulated to guide the research. T-test was used to analyse the data
gathered, and data analysis revealed that pupils exposed to the two
treatment strategies had improvement in their reading fluency. It was
recommended that the two strategies used in the study can be used to
intervene in reading fluency problems in children with learning
disabilities.
Abstract: This paper examines ethical and social issues which
have proved important when initiating and creating educational spaces within a virtual environment. It focuses on one project, identifying the key decisions made, the barriers to new practice
encountered and the impact these had on the project. It demonstrates
the importance of the 'backstage' ethical and social issues involved in
the creation of a virtual education community and offers conclusions,
and questions, which will inform future research and practice in this
area. These ethical issues are considered using Knobel-s framework
of front-end, in-process and back-end concerns, and include
establishing social practices for the islands, allocating access rights,
considering personal safety and supporting researchers appropriately
within this context.