Abstract: Tumour suppressors are key participants in the
prevention of cancer. Regulation of their expression through
miRNAs is important for comprehensive translation inhibition of
tumour suppressors and elucidation of carcinogenesis mechanisms.
We studies the possibility of 1521 miRNAs to bind with 873 mRNAs
of human tumour suppressors using RNAHybrid 2.1 and ERNAhybrid
programmes. Only 978 miRNAs were found to be
translational regulators of 812 mRNAs, and 61 mRNAs did not have
any miRNA binding sites. Additionally, 45.9% of all miRNA binding
sites were located in coding sequences (CDSs), 33.8% were located
in 3' untranslated region (UTR), and 20.3% were located in the
5'UTR. MiRNAs binding with more than 50 target mRNAs and
mRNAs binding with several miRNAs were selected. Hsa-miR-5096
had 15 perfectly complementary binding sites with mRNAs of 14
tumour suppressors. These newly indentified miRNA binding sites
can be used in the development of medicines (anti-sense therapies)
for cancer treatment.
Abstract: Since large power transformers are the most
expensive and strategically important components of any power
generator and transmission system, their reliability is crucially
important for the energy system operation. Also, Circuit breakers are
very important elements in the power transmission line so monitoring
the events gives a knowledgebase to determine time to the next
maintenance. This paper deals with the introduction of the
comparative method of the state estimation of transformers and
Circuit breakers using continuous monitoring of voltage, current.
This paper gives details a new method based on wavelet to apparatus
insulation monitoring. In this paper to insulation monitoring of
transformer, a new method based on wavelet transformation and
neutral point analysis is proposed. Using the EMTP tools, fault in
transformer winding and the detailed transformer winding model
were simulated. The current of neutral point of winding was analyzed
by wavelet transformation. It is shown that the neutral current of the
transformer winding has useful information about fault in insulation
of the transformer.
Abstract: A novel concept to balance and tradeoff between
make-to-stock and make-to-order has been hybrid MTS/MTO production context. One of the most important decisions involved in
the hybrid MTS/MTO environment is determining whether a product
is manufactured to stock, to order, or hybrid MTS/MTO strategy. In this paper, a model based on analytic network process is developed to tackle the addressed decision. Since the regarded decision deals with
the uncertainty and ambiguity of data as well as experts- and
managers- linguistic judgments, the proposed model is equipped with
fuzzy sets theory. An important attribute of the model is its generality due to diverse decision factors which are elicited from the
literature and developed by the authors. Finally, the model is validated by applying to a real case study to reveal how the proposed
model can actually be implemented.
Abstract: Among all geo-hydrological relationships, rainfallrunoff
relationship is of utmost importance in any hydrological
investigation and water resource planning. Spatial variation, lag time
involved in obtaining areal estimates for the basin as a whole can
affect the parameterization in design stage as well as in planning
stage. In conventional hydrological processing of data, spatial aspect
is either ignored or interpolated at sub-basin level. Temporal
variation when analysed for different stages can provide clues for its
spatial effectiveness. The interplay of space-time variation at pixel
level can provide better understanding of basin parameters.
Sustenance of design structures for different return periods and their
spatial auto-correlations should be studied at different geographical
scales for better management and planning of water resources.
In order to understand the relative effect of spatio-temporal
variation in hydrological data network, a detailed geo-hydrological
analysis of Betwa river catchment falling in Lower Yamuna Basin is
presented in this paper. Moreover, the exact estimates about the
availability of water in the Betwa river catchment, especially in the
wake of recent Betwa-Ken linkage project, need thorough scientific
investigation for better planning. Therefore, an attempt in this
direction is made here to analyse the existing hydrological and
meteorological data with the help of SPSS, GIS and MS-EXCEL
software. A comparison of spatial and temporal correlations at subcatchment
level in case of upper Betwa reaches has been made to
demonstrate the representativeness of rain gauges. First, flows at
different locations are used to derive correlation and regression
coefficients. Then, long-term normal water yield estimates based on
pixel-wise regression coefficients of rainfall-runoff relationship have
been mapped. The areal values obtained from these maps can
definitely improve upon estimates based on point-based
extrapolations or areal interpolations.
Abstract: The Kowsar dam supply water for different usages
such as drinking, industrial, agricultural and aquaculture farms
usages and located next to the city of Dehdashat in Kohgiluye and
Boyerahmad province in southern Iran. There are some towns and
villages on the Kowsar dam watersheds, which Dehdasht and Choram
are the most important and populated cities in this area. The study
was undertaken to assess the status of water quality in the urban areas
of the Kowsar dam. A total of 28 water samples were collected from
6 stations on surface water and 1 station from groundwater on the
watershed of the Kowsar dam. All the samples were analyzed for Ni
concentration using standard procedures. The results were compared
with other national and international standards. Among the analyzed
samples, as the maximum value of Nickel (0.01 mg/L) was observed
on the station 2 at the autumn 2010, all the samples analyzed were
within the maximum admissible limits by the United States
Environmental Protection Agency, EU, WHO and the Iranian. In
general results of the present study have shown that a Ni mean value
of station No. 2 with 0.006 mg/L is higher than the other stations. Ni
level of all samples and stations have had normal values and this is an
indication of pollution potential and hazards because of human
activity and waste water of towns in the areas, which can effect on
human health implications in future. This research, therefore,
recommends the government and other responsible authorities to take
suitable improving measures in the Kowsar dam watersheds.
Abstract: In a state-of-the-art industrial production line of
photovoltaic products the handling and automation processes are of
particular importance and implication. While processing a fully
functional crystalline solar cell an as-cut photovoltaic wafer is subject
to numerous repeated handling steps. With respect to stronger
requirements in productivity and decreasing rejections due to defects
the mechanical stress on the thin wafers has to be reduced to a
minimum as the fragility increases by decreasing wafer thicknesses.
In relation to the increasing wafer fragility, researches at the
Fraunhofer Institutes IPA and CSP showed a negative correlation
between multiple handling processes and the wafer integrity. Recent
work therefore focused on the analysis and optimization of the dry
wafer stack separation process with compressed air. The achievement
of a wafer sensitive process capability and a high production
throughput rate is the basic motivation in this research.
Abstract: Low temperature (LT) is one of the most abiotic
stresses causing loss of yield in wheat (T. aestivum). Four major
genes in wheat (Triticum aestivum L.) with the dominant alleles
designated Vrn–A1,Vrn–B1,Vrn–D1 and Vrn4, are known to have
large effects on the vernalization response, but the effects on cold
hardiness are ambiguous. Poor cold tolerance has restricted winter
wheat production in regions of high winter stress [9]. It was known
that nearly all wheat chromosomes [5] or at least 10 chromosomes of
21 chromosome pairs are important in winter hardiness [15]. The
objective of present study was to clarify the role of each chromosome
in cold tolerance. With this purpose we used 20 isogenic lines of
wheat. In each one of these isogenic lines only a chromosome from
‘Bezostaya’ variety (a winter habit cultivar) was substituted to
‘Capple desprez’ variety. The plant materials were planted in
controlled conditions with 20º C and 16 h day length in moderately
cold areas of Iran at Karaj Agricultural Research Station in 2006-07
and the acclimation period was completed for about 4 weeks in a
cold room with 4º C. The cold hardiness of these isogenic lines was
measured by LT50 (the temperature in which 50% of the plants are
killed by freezing stress).The experimental design was completely
randomized block design (RCBD)with three replicates. The results
showed that chromosome 5A had a major effect on freezing
tolerance, and then chromosomes 1A and 4A had less effect on this
trait. Further studies are essential to understanding the importance of
each chromosome in controlling cold hardiness in wheat.
Abstract: Defining strategic position of the organizations within
the industry environment is one of the basic and most important
phases of strategic planning to which extent that one of the
fundamental schools of strategic planning is the strategic positioning
school. In today-s knowledge-based economy and dynamic
environment, it is essential for universities as the centers of
education, knowledge creation and knowledge worker evolvement.
Till now, variant models with different approaches to strategic
positioning are deployed in defining the strategic position within the
various industries. Balanced Scorecard as one of the powerful models
for strategic positioning, analyzes all aspects of the organization
evenly. In this paper with the consideration of BSC strength in
strategic evaluation, it is used for analyzing the environmental
position of the best-s Iranian Business Schools. The results could be
used in developing strategic plans for these schools as well as other
Iranian Management and Business Schools.
Abstract: Bicycle usage for exercise, recreation, and commuting
to work in Australia shows that pedal cycling is the fourth most
popular activity with 10.6% increase in participants between 2001
and 2007. As with other means of transport, accident and injury
becomes common although mandatory bicycle helmet wearing has
been introduced. The research aims to develop a face surrogate made
of sandwich of rigid foam and rubber sheets to represent human
facial bone under blunt impact. The facial surrogate will serve as an
important test device for further development of facial-impact
protection for cyclist. A test procedure was developed to simulate the
energy of impact and record data to evaluate the effect of impact on
facial bones. Drop tests were performed to establish a suitable
combination of materials. It was found that the sandwich structure of
rigid extruded-polystyrene foam (density of 40 kg/m3 with a pattern
of 6-mm-holes), Neoprene rubber sponge, and Abrasaflex rubber
backing, had impact characteristics comparable to that of human
facial bone. In particular, the foam thickness of 30 mm and 25 mm
was found suitable to represent human zygoma (cheekbone) and
maxilla (upper-jaw bone), respectively.
Abstract: Modern civilization has come in recent decades into a new phase in its development, called the information society. The concept of "information society" has become one of the most common. Therefore, the attempt to understand what exactly the society we live in, what are its essential features, and possible future scenarios, is important to the social and philosophical analysis. At the heart of all these deep transformations is more increasing, almost defining role knowledge and information as play substrata of «information society». The mankind opened for itself and actively exploits a new resource – information. Information society puts forward on the arena new type of the power, at the heart of which activity – mastering by a new resource: information and knowledge. The password of the new power – intelligence as synthesis of knowledge, information and communications, the strength of mind, fundamental sociocultural values. In a postindustrial society, the power of knowledge and information is crucial in the management of the company, pushing into the background the influence of money and state coercion.
Abstract: Kernel function, which allows the formulation of nonlinear variants of any algorithm that can be cast in terms of dot products, makes the Support Vector Machines (SVM) have been successfully applied in many fields, e.g. classification and regression. The importance of kernel has motivated many studies on its composition. It-s well-known that reproducing kernel (R.K) is a useful kernel function which possesses many properties, e.g. positive definiteness, reproducing property and composing complex R.K by simple operation. There are two popular ways to compute the R.K with explicit form. One is to construct and solve a specific differential equation with boundary value whose handicap is incapable of obtaining a unified form of R.K. The other is using a piecewise integral of the Green function associated with a differential operator L. The latter benefits the computation of a R.K with a unified explicit form and theoretical analysis, whereas there are relatively later studies and fewer practical computations. In this paper, a new algorithm for computing a R.K is presented. It can obtain the unified explicit form of R.K in general reproducing kernel Hilbert space. It avoids constructing and solving the complex differential equations manually and benefits an automatic, flexible and rigorous computation for more general RKHS. In order to validate that the R.K computed by the algorithm can be used in SVM well, some illustrative examples and a comparison between R.K and Gaussian kernel (RBF) in support vector regression are presented. The result shows that the performance of R.K is close or slightly superior to that of RBF.
Abstract: R&D risk management has been suggested as one of
the management approaches for accomplishing the goals of public
R&D investment. The investment in basic science and core technology
development is the essential roles of government for securing the
social base needed for continuous economic growth. And, it is also an
important role of the science and technology policy sectors to generate
a positive environment in which the outcomes of public R&D can be
diffused in a stable fashion by controlling the uncertainties and risk
factors in advance that may arise during the application of such
achievements to society and industry. Various policies have already
been implemented to manage uncertainties and variables that may
have negative impact on accomplishing public R& investment goals.
But we may derive new policy measures for complementing the
existing policies and for exploring progress direction by analyzing
them in a policy package from the viewpoint of R&D risk
management.
Abstract: The present paper develops and validates a numerical procedure for the calculation of turbulent combustive flow in converging and diverging ducts and throuh simulation of the heat transfer processes, the amount of production and spread of Nox pollutant has been measured. A marching integration solution procedure employing the TDMA is used to solve the discretized equations. The turbulence model is the Prandtl Mixing Length method. Modeling the combustion process is done by the use of Arrhenius and Eddy Dissipation method. Thermal mechanism has been utilized for modeling the process of forming the nitrogen oxides. Finite difference method and Genmix numerical code are used for numerical solution of equations. Our results indicate the important influence of the limiting diverging angle of diffuser on the coefficient of recovering of pressure. Moreover, due to the intense dependence of Nox pollutant to the maximum temperature in the domain with this feature, the Nox pollutant amount is also in maximum level.
Abstract: The purpose of this study was primarily assessing how important economic factors namely: The Thai export price of white rice, the exchange rate, and the world rice consumption affect the overall Thai white rice export, using historical data during the period 1989-2013 from the Thai Rice Exporters Association, and Food and Agricultural Organization of the United Nations. The co-integration method, regression analysis, and error correction model were applied to investigate the econometric model. The findings indicated that in the long-run, the world rice consumption, the exchange rate, and the Thai export price of white rice were the important factors affecting the export quantity of Thai white rice respectively, as indicated by their significant coefficients. Meanwhile, the rice export price was an important factor affecting the export quantity of Thai white rice in the short-run. This information is useful in the business, export opportunities, price competitiveness, and policymaker in Thailand.
Abstract: This paper argues that a product development exercise
involves in addition to the conventional stages, several decisions
regarding other aspects. These aspects should be addressed
simultaneously in order to develop a product that responds to the
customer needs and that helps realize objectives of the stakeholders
in terms of profitability, market share and the like. We present a
framework that encompasses these different development
dimensions. The framework shows that a product development
methodology such as the Quality Function Deployment (QFD) is the
basic tool which allows definition of the target specifications of a
new product. Creativity is the first dimension that enables the
development exercise to live and end successfully. A number of
group processes need to be followed by the development team in
order to ensure enough creativity and innovation. Secondly,
packaging is considered to be an important extension of the product.
Branding strategies, quality and standardization requirements,
identification technologies, design technologies, production
technologies and costing and pricing are also integral parts to the
development exercise. These dimensions constitute the proposed
framework. The paper also presents a mathematical model used to
calculate the design targets based on the target costing principle. The
framework is used to study a case of a new product development in
the telecommunications services sector.
Abstract: This paper discusses a new, systematic approach to
the synthesis of a NP-hard class of non-regenerative Boolean
networks, described by FON[FOFF]={mi}[{Mi}], where for every
mj[Mj]∈{mi}[{Mi}], there exists another mk[Mk]∈{mi}[{Mi}], such
that their Hamming distance HD(mj, mk)=HD(Mj, Mk)=O(n), (where
'n' represents the number of distinct primary inputs). The method
automatically ensures exact minimization for certain important selfdual
functions with 2n-1 points in its one-set. The elements meant for
grouping are determined from a newly proposed weighted incidence
matrix. Then the binary value corresponding to the candidate pair is
correlated with the proposed binary value matrix to enable direct
synthesis. We recommend algebraic factorization operations as a post
processing step to enable reduction in literal count. The algorithm
can be implemented in any high level language and achieves best
cost optimization for the problem dealt with, irrespective of the
number of inputs. For other cases, the method is iterated to
subsequently reduce it to a problem of O(n-1), O(n-2),.... and then
solved. In addition, it leads to optimal results for problems exhibiting
higher degree of adjacency, with a different interpretation of the
heuristic, and the results are comparable with other methods.
In terms of literal cost, at the technology independent stage, the
circuits synthesized using our algorithm enabled net savings over
AOI (AND-OR-Invert) logic, AND-EXOR logic (EXOR Sum-of-
Products or ESOP forms) and AND-OR-EXOR logic by 45.57%,
41.78% and 41.78% respectively for the various problems.
Circuit level simulations were performed for a wide variety of
case studies at 3.3V and 2.5V supply to validate the performance of
the proposed method and the quality of the resulting synthesized
circuits at two different voltage corners. Power estimation was
carried out for a 0.35micron TSMC CMOS process technology. In
comparison with AOI logic, the proposed method enabled mean
savings in power by 42.46%. With respect to AND-EXOR logic, the
proposed method yielded power savings to the tune of 31.88%, while
in comparison with AND-OR-EXOR level networks; average power
savings of 33.23% was obtained.
Abstract: Food mileage is one of the important issues concerning environmental sustainability. In this research we have utilized a prototype platform with iterative user-centered testing. With these findings we successfully demonstrate the use of the context of persuasive methods to influence users- attitudes towards the sustainable concept.
Abstract: Assessment of IEP (Individual Education Plan) is an
important stage in the area of special education. This paper deals
with this problem by introducing computer software which process
the data gathered from application of IEP. The software is intended
to be used by special education institution in Turkey and allows
assessment of school and family trainings. The software has a user
friendly interface and its design includes graphical developer tools.
Abstract: The dynamics of Min proteins plays a center role in
accurate cell division. Although the nucleoids may presumably play
an important role in prokaryotic cell division, there is a lack of
models to account for its participation. In this work, we apply the
lattice Boltzmann method to investigate protein oscillation based on a
mesoscopic model that takes into account the nucleoid-s role. We
found that our numerical results are in reasonably good agreement
with the previous experimental results On comparing with the other
computational models without the presence of nucleoids, the
highlight of our finding is that the local densities of MinD and MinE
on the cytoplasmic membrane increases, especially along the cell
width, when the size of the obstacle increases, leading to a more
distinct cap-like structure at the poles. This feature indicated the
realistic pattern and reflected the combination of Min protein
dynamics and nucleoid-s role.
Abstract: Water is the main component of biological processes.
Water management is important to obtain higher productivity. In this
study, some of the yield components were investigated together with
different drought levels. Four chickpea genotypes (CDC Frontier,
CDC Luna, Sawyer and Sierra) were grown in pots with 3 different
irrigation levels (a dose of 17.5 ml, 35 ml and 70 ml for each pot per
day) after three weeks from sowing. In the research, flowering, pod
set, pod per plant, fertile pod, double seed/pod, stem diameter, plant
weight, seed per plant, 1000 seed weight, seed diameter, vegetation
length and weekly plant height were measured. Consequently,
significant differences were observed on all the investigated
characteristics owing to genotypes (except double seed/pod and stem
diameter), water levels (except first pod, seed weight and height on
3rd week) and genotype x water level interaction (except first pod,
double seed/pod, seed weight and height).