Abstract: The biomarker for colorectal cancer (CRC) is CEACAM-6 antigen (C6AG). Therefore, this study aims to develop a novel, simple and low-cost CEACAM-6 antigen immumosensor (C6AG-IMS), based on electrical impedance measurement, for precise determination of C6AG. A low-cost screen-printed graphite electrode was constructed and used as the sensor, with CEACAM-6 antibody (C6AB) immobilized on it. The procedures of sensor fabrication and antibody immobilization are simple and low-cost. Measurement of the electrical impedance at a definite frequency ranges (0.43 – 1.26 MHz) showed that the C6AG-IMS has an excellent linear (r2>0.9) response range (8.125 – 65 pg/mL), covering the normal physiological and pathological ranges of blood C6AG levels. Also, the C6AG-IMS has excellent reliability and validity, with the intraclass correlation coefficient being 0.97. In conclusion, a novel, simple, low-cost and reliable C6AG-IMS was designed and developed, being able to accurately determine blood C6AG levels in the range of pathological and normal physiological regions. The C6AG-IMS can provide a point-of-care and immediate screening results to the user at home.
Abstract: The concurrent era is characterised by strengthened interactions among financial markets and increased capital mobility globally. In this frames we examine the effects the international financial integration process has on the European bond markets. We perform a comparative study of the interactions of the European and international bond markets and exploit Cointegration analysis results on the elimination of stochastic trends and the decomposition of the underlying long run equilibria and short run causal relations. Our investigation provides evidence on the relation between the European integration process and that of globalisation, viewed through the bond markets- sector. Additionally the structural formulation applied, offers significant implications of the findings. All in all our analysis offers a number of answers on crucial queries towards the European bond markets integration process.
Abstract: This paper proposes a smart design strategy for a sequential detector to reliably detect the primary user-s signal, especially in fast fading environments. We study the computation of the log-likelihood ratio for coping with a fast changing received signal and noise sample variances, which are considered random variables. First, we analyze the detectability of the conventional generalized log-likelihood ratio (GLLR) scheme when considering fast changing statistics of unknown parameters caused by fast fading effects. Secondly, we propose an efficient sensing algorithm for performing the sequential probability ratio test in a robust and efficient manner when the channel statistics are unknown. Finally, the proposed scheme is compared to the conventional method with simulation results with respect to the average number of samples required to reach a detection decision.
Abstract: Rule Discovery is an important technique for mining knowledge from large databases. Use of objective measures for discovering interesting rules lead to another data mining problem, although of reduced complexity. Data mining researchers have studied subjective measures of interestingness to reduce the volume of discovered rules to ultimately improve the overall efficiency of KDD process. In this paper we study novelty of the discovered rules as a subjective measure of interestingness. We propose a hybrid approach that uses objective and subjective measures to quantify novelty of the discovered rules in terms of their deviations from the known rules. We analyze the types of deviation that can arise between two rules and categorize the discovered rules according to the user specified threshold. We implement the proposed framework and experiment with some public datasets. The experimental results are quite promising.
Abstract: Metal stamping die design is a complex, experiencebased
and time-consuming task. Various artificial intelligence (AI)
techniques are being used by worldwide researchers for stamping die
design to reduce complexity, dependence on human expertise and
time taken in design process as well as to improve design efficiency.
In this paper a comprehensive review of applications of AI
techniques in manufacturability evaluation of sheet metal parts, die
design and process planning of metal stamping die is presented.
Further the salient features of major research work published in the
area of metal stamping are presented in tabular form and scope of
future research work is identified.
Abstract: An advanced Monte Carlo simulation method, called Subset Simulation (SS) for the time-dependent reliability prediction for underground pipelines has been presented in this paper. The SS can provide better resolution for low failure probability level with efficient investigating of rare failure events which are commonly encountered in pipeline engineering applications. In SS method, random samples leading to progressive failure are generated efficiently and used for computing probabilistic performance by statistical variables. SS gains its efficiency as small probability event as a product of a sequence of intermediate events with larger conditional probabilities. The efficiency of SS has been demonstrated by numerical studies and attention in this work is devoted to scrutinise the robustness of the SS application in pipe reliability assessment. It is hoped that the development work can promote the use of SS tools for uncertainty propagation in the decision-making process of underground pipelines network reliability prediction.
Abstract: In Peer-to-Peer service networks, where peers offer any kind of publicly available services or applications, intuitive navigation through all services in the network becomes more difficult as the number of services increases. In this article, a concept is discussed that enables users to intuitively browse and use large scale P2P service networks. The concept extends the idea of creating virtual 3D-environments solely based on Peer-to-Peer technologies. Aside from browsing, users shall have the possibility to emphasize services of interest using their own semantic criteria. The appearance of the virtual world shall intuitively reflect network properties that may be of interest for the user. Additionally, the concept comprises options for load- and traffic-balancing. In this article, the requirements concerning the underlying infrastructure and the graphical user interface are defined. First impressions of the appearance of future systems are presented and the next steps towards a prototypical implementation are discussed.
Abstract: Empty Fruit Bunches (EFB) and Palm Oil Mill
Effluent (POME) are two main wastes from oil palm industries which
contain rich lignocellulose. Degradation of EFB and POME by
microorganisms will produce hydrolytic enzyme which will degrade
cellulose and hemicellulose during composting process. However,
normal composting takes about four to six months to reach maturity.
Hence, application of fungi into compost can shorten the period of
composting. This study identifies the effect of xylanase and cellulase
produced by Aspergillus niger and Trichoderma virens on
composting process using EFB and POME. The degradation of EFB
and POME indicates the lignocellulolytic capacity of Aspergillus
niger and Trichoderma virens with more than 7% decrease in
hemicellulose and more than 25% decrease in cellulose for both
inoculated compost. Inoculation of Aspergillus niger and
Trichoderma virens also increased the enzyme activities during the
composting period compared to the control compost by 21% for both
xylanase and cellulase. Rapid rise in the activities of cellulase and
xylanase was observed by Aspergillus niger with the highest
activities of 14.41 FPU/mg and 3.89 IU/mg, respectively. Increased
activities of cellulase and xylanase also occurred in inoculation of
Trichoderma virens with the highest activities obtained at 13.21
FPU/mg and 4.43 IU/mg, respectively. Therefore, it is evident that
the inoculation of fungi can increase the enzyme activities hence
effectively degrading the EFB and POME.
Abstract: A Wireless sensor network (WSN) consists of a set of battery-powered nodes, which collaborate to perform sensing tasks in a given environment. Each node in WSN should be capable to act for long periods of time with scrimpy or no external management. One requirement for this independent is: in the presence of adverse positions, the sensor nodes must be capable to configure themselves. Hence, the nodes for determine the existence of unusual events in their surroundings should make use of position awareness mechanisms. This work approaches the problem by considering the possible unusual events as diseases, thus making it possible to diagnose them through their symptoms, namely, their side effects. Considering these awareness mechanisms as a foundation for highlevel monitoring services, this paper also shows how these mechanisms are included in the primal plan of an intrusion detection system.
Abstract: The chemical degradation of dieldrin in ferric
sulfide and iron powder aqueous suspension was investigated
in laboratory batch type experiments. To identify the reaction
mechanism, reduced copper was used as reductant. More than
90% of dieldrin was degraded using both reaction systems after
29 days. Initial degradation rate of the pesticide using ferric
sulfide was superior to that using iron powder. The reaction
schemes were completely dissimilar even though the ferric ion
plays an important role in both reaction systems. In the case of
metallic iron powder, dieldrin undergoes partial dechlorination.
This reaction proceeded by reductive hydrodechlorination with
the generation of H+, which arise by oxidation of ferric iron.
This reductive reaction was accelerated by reductant but
mono-dechlorination intermediates were accumulated. On the
other hand, oxidative degradation was observed in the reaction
with ferric sulfide, and the stable chemical structure of dieldrin
was decomposed into water-soluble intermediates. These
reaction intermediates have no chemical structure of drin class.
This dehalogenation reaction assumes to occur via the adsorbed
hydroxyl radial generated on the surface of ferric sulfide.
Abstract: In this paper, an estimation accuracy of multiple moving
talker tracking using a microphone array is improved. The tracking
can be achieved by the adaptive method in which two algorithms are integrated, namely, the PAST (Projection Approximation Subspace
Tracking) algorithm and the IPLS (Interior Point Least Square) algorithm. When either talker begins to speak again after a silent
period, an appropriate feasible region for an evaluation function of
the IPLS algorithm might not be set. Then, the tracking fails due to the incorrect updating. Therefore, if an increment of the number of
active talkers is detected, the feasible region must be reset. Then, a low cost realization is required for the high speed tracking and a high
accuracy realization is desired for the precise tracking. In this paper,
the directions roughly estimated using the delayed-sum-array method
are used for the resetting. Several results of experiments performed in
an actual room environment show the effectiveness of the proposed method.
Abstract: The world economic crises and budget constraints
have caused authorities, especially those in developing countries, to
rationalize water quality monitoring activities. Rationalization
consists of reducing the number of monitoring sites, the number of
samples, and/or the number of water quality variables measured. The
reduction in water quality variables is usually based on correlation. If
two variables exhibit high correlation, it is an indication that some of
the information produced may be redundant. Consequently, one
variable can be discontinued, and the other continues to be measured.
Later, the ordinary least squares (OLS) regression technique is
employed to reconstitute information about discontinued variable by
using the continuously measured one as an explanatory variable. In
this paper, two record extension techniques are employed to
reconstitute information about discontinued water quality variables,
the OLS and the Line of Organic Correlation (LOC). An empirical
experiment is conducted using water quality records from the Nile
Delta water quality monitoring network in Egypt. The record
extension techniques are compared for their ability to predict
different statistical parameters of the discontinued variables. Results
show that the OLS is better at estimating individual water quality
records. However, results indicate an underestimation of the variance
in the extended records. The LOC technique is superior in preserving
characteristics of the entire distribution and avoids underestimation
of the variance. It is concluded from this study that the OLS can be
used for the substitution of missing values, while LOC is preferable
for inferring statements about the probability distribution.
Abstract: The major problem that wireless communication
systems undergo is multipath fading caused by scattering of the
transmitted signal. However, we can treat multipath propagation as
multiple channels between the transmitter and receiver to improve
the signal-to-scattering-noise ratio. While using Single Input
Multiple Output (SIMO) systems, the diversity receivers extract
multiple signal branches or copies of the same signal received from
different channels and apply gain combining schemes such as Root
Mean Square Gain Combining (RMSGC). RMSGC asymptotically
yields an identical performance to that of the theoretically optimal
Maximum Ratio Combining (MRC) for values of mean Signal-to-
Noise-Ratio (SNR) above a certain threshold value without the need
for SNR estimation. This paper introduces an improvement of
RMSGC using two different issues. We found that post-detection and
de-noising the received signals improve the performance of RMSGC
and lower the threshold SNR.
Abstract: This document details the process of developing a
wireless device that captures the basic movements of the foot (plantar
flexion, dorsal flexion, abduction, adduction.), and the knee
movement (flexion). It implements a motion capture system by using
a hardware based on optical fiber sensors, due to the advantages in
terms of scope, noise immunity and speed of data transmission and
reception. The operating principle used by this system is the detection
and transmission of joint movement by mechanical elements and
their respective measurement by optical ones (in this case infrared).
Likewise, Visual Basic software is used for reception, analysis and
signal processing of data acquired by the device, generating a 3D
graphical representation in real time of each movement. The result is
a boot in charge of capturing the movement, a transmission module
(Implementing Xbee Technology) and a receiver module for
receiving information and sending it to the PC for their respective
processing.
The main idea with this device is to help on topics such as
bioengineering and medicine, by helping to improve the quality of
life and movement analysis.
Abstract: Fip-gts, an immunomodulatory protein purified from Ganoderma tsugae, has been reported to possess therapeutic effects in the treatment of cancer and autoimmune disease. For medicinal application, a recombinant Fip-gts was successfully expressed and purified in Sf21 insect cells by our previously work. It is important to evaluate the immunomodulatory activity of the rFip-gts. To assess the immunomodulatory potential of rFip-gts, the T lymphocytes of murine splenocytes were used in the present study. Results revealed that rFip-gts induced cellular aggregation formation. Additionally, the expression of IL-2 and IFN-r were up-regulated after the treatment of rFip-gts, and a corresponding increased production of IL-2 and IFN-r in a dose-dependent manner. The results showed that rFip-gts has an immunomodulatory activity in inducing Th1 lymphocytes from murine splenocytes released IL-2 and IFN-γ, thus suggest that rFip-gts may have therapeutic potential in vivo as an immune modulator.
Abstract: Research on damage of gears and gear pairs using
vibration signals remains very attractive, because vibration signals
from a gear pair are complex in nature and not easy to interpret.
Predicting gear pair defects by analyzing changes in vibration signal
of gears pairs in operation is a very reliable method. Therefore, a
suitable vibration signal processing technique is necessary to extract
defect information generally obscured by the noise from dynamic
factors of other gear pairs.This article presents the value of cepstrum
analysis in vehicle gearbox fault diagnosis. Cepstrum represents the
overall power content of a whole family of harmonics and sidebands
when more than one family of sidebands is present at the same time.
The concept for the measurement and analysis involved in using the
technique are briefly outlined. Cepstrum analysis is used for detection
of an artificial pitting defect in a vehicle gearbox loaded with
different speeds and torques. The test stand is equipped with three
dynamometers; the input dynamometer serves asthe internal
combustion engine, the output dynamometers introduce the load on
the flanges of the output joint shafts. The pitting defect is
manufactured on the tooth side of a gear of the fifth speed on the
secondary shaft. Also, a method for fault diagnosis of gear faults is
presented based on order Cepstrum. The procedure is illustrated with
the experimental vibration data of the vehicle gearbox. The results
show the effectiveness of Cepstrum analysis in detection and
diagnosis of the gear condition.
Abstract: This paper aims to develop an algorithm of finite
capacity material requirement planning (FCMRP) system for a multistage
assembly flow shop. The developed FCMRP system has two
main stages. The first stage is to allocate operations to the first and
second priority work centers and also determine the sequence of the
operations on each work center. The second stage is to determine the
optimal start time of each operation by using a linear programming
model. Real data from a factory is used to analyze and evaluate the
effectiveness of the proposed FCMRP system and also to guarantee a
practical solution to the user. There are five performance measures,
namely, the total tardiness, the number of tardy orders, the total
earliness, the number of early orders, and the average flow-time. The
proposed FCMRP system offers an adjustable solution which is a
compromised solution among the conflicting performance measures.
The user can adjust the weight of each performance measure to
obtain the desired performance. The result shows that the combination
of FCMRP NP3 and EDD outperforms other combinations
in term of overall performance index. The calculation time for the
proposed FCMRP system is about 10 minutes which is practical for
the planners of the factory.
Abstract: In this paper, a novel multi join algorithm to join
multiple relations will be introduced. The novel algorithm is based
on a hashed-based join algorithm of two relations to produce a double index. This is done by scanning the two relations once. But
instead of moving the records into buckets, a double index will be built. This will eliminate the collision that can happen from a complete hash algorithm. The double index will be divided into join
buckets of similar categories from the two relations. The algorithm then joins buckets with similar keys to produce joined buckets. This
will lead at the end to a complete join index of the two relations. without actually joining the actual relations. The time complexity
required to build the join index of two categories is Om log m where m is the size of each category. Totaling time complexity to O n log m
for all buckets. The join index will be used to materialize the joined relation if required. Otherwise, it will be used along with other join
indices of other relations to build a lattice to be used in multi-join operations with minimal I/O requirements. The lattice of the join indices can be fitted into the main memory to reduce time complexity of the multi join algorithm.
Abstract: with increasing circuits- complexity and demand to
use portable devices, power consumption is one of the most
important parameters these days. Full adders are the basic block of
many circuits. Therefore reducing power consumption in full adders
is very important in low power circuits. One of the most powerconsuming
modules in full adders is XOR/XNOR circuit. This paper
presents two new full adders based on two new logic approaches. The
proposed logic approaches use one XOR or XNOR gate to implement
a full adder cell. Therefore, delay and power will be decreased. Using
two new approaches and two XOR and XNOR gates, two new full
adders have been implemented in this paper. Simulations are carried
out by HSPICE in 0.18μm bulk technology with 1.8V supply voltage.
The results show that the ten-transistors proposed full adder has 12%
less power consumption and is 5% faster in comparison to MB12T
full adder. 9T is more efficient in area and is 24% better than similar
10T full adder in term of power consumption. The main drawback of
the proposed circuits is output threshold loss problem.
Abstract: The malfunction of thermal protection system (TPS) caused by aerodynamic heating is a latent trouble to aircraft structure safety. Accurately predicting the structure temperature field is quite important for the TPS design of hypersonic vehicle. Since Thornton’s work in 1988, the coupled method of aerodynamic heating and heat transfer has developed rapidly. However, little attention has been paid to the influence of structural deformation on aerodynamic heating and structural temperature field. In the flight, especially the long-endurance flight, the structural deformation, caused by the aerodynamic heating and temperature rise, has a direct impact on the aerodynamic heating and structural temperature field. Thus, the coupled interaction cannot be neglected. In this paper, based on the method of static aero-thermo-elasticity, considering the influence of aero-thermo-elasticity deformation, the aerodynamic heating and heat transfer coupled results of hypersonic vehicle wing model were calculated. The results show that, for the low-curvature region, such as fuselage or center-section wing, structure deformation has little effect on temperature field. However, for the stagnation region with high curvature, the coupled effect is not negligible. Thus, it is quite important for the structure temperature prediction to take into account the effect of elastic deformation. This work has laid a solid foundation for improving the prediction accuracy of the temperature distribution of aircraft structures and the evaluation capacity of structural performance.