Abstract: The 1:1 cocrystal of 2-amino-4-chloro-6-
methylpyrimidine (2A4C6MP) with 4-methylbenzoic acid (4MBA)
(I) has been prepared by slow evaporation method in methanol,
which was crystallized in monoclinic C2/c space group, Z = 8, and a
= 28.431 (2) Å, b = 7.3098 (5) Å, c = 14.2622 (10) Å and β =
109.618 (3)°. The presence of unionized –COOH functional group in
cocrystal I was identified both by spectral methods (1H and 13C
NMR, FTIR) and X-ray diffraction structural analysis. The
2A4C6MP molecule interact with the carboxylic group of the
respective 4MBA molecule through N—H⋯O and O—H⋯N
hydrogen bonds, forming a cyclic hydrogen–bonded motif R2
2(8).
The crystal structure was stabilized by Npyrimidine—H⋯O=C and
C=O—H⋯Npyrimidine types hydrogen bonding interactions.
Theoretical investigations have been computed by HF and density
function (B3LYP) method with 6–311+G (d,p)basis set. The
vibrational frequencies together with 1H and 13C NMR chemical
shifts have been calculated on the fully optimized geometry of
cocrystal I. Theoretical calculations are in good agreement with the
experimental results. Solvent–free formation of this cocrystal I is
confirmed by powder X-ray diffraction analysis.
Abstract: The application of ESS (Energy Storage Systems) in
the future grids has been the solution of the microgrid. However, high
investment costs necessitate accurate modeling and control strategy of
ESS to justify its economic viability and further underutilization.
Therefore, the reasonable control strategy for ESS which is subjected
to generator and usage helps to curtail the cost of investment and
operation costs. The rated frequency in power system is decreased
when the load is increasing unexpectedly; hence the thermal power is
operated at the capacity of only its 95% for the Governor Free (GF) to
adjust the frequency as reserve (5%) in practice. The ESS can be
utilized with governor at the same time for the frequency response due
to characteristic of its fast response speed and moreover, the cost of
ESS is declined rapidly to the reasonable price. This paper presents the
ESS control strategy to extend usage of the ESS taken account into
governor’s ramp rate and reduce the governor’s intervention as well.
All results in this paper are simulated by MATLAB.
Abstract: It is very important for a developing nation to
developing their infrastructure on the prime priority because their
infrastructure particularly their roads and transportation functions as a
blood in the system. Almost 1.1 billion populations share the travel
and transportation industry in India. On the other hand, the Pakistan
transportation industry is also extensive and elevating about 170
million users of transportation. Indian and Pakistani specifically
within bus industry are well connected within and between the urban
and rural areas. The transportation industry is radically helping the
economic alleviation of both countries. Due to high economic
instability, unemployment and poverty rate both countries
governments are very serious and committed to help for boosting
their economy. They believe that any form of transportation
development would play a vital role in the development of land,
infrastructure which could indirectly support many other industries’
developments, such as tourism, freighting and shipping businesses,
just to mention a few. However, it seems that their previous
transportation planning in the due course has failed to meet the fast
growing demand. As with the span of time, both the countries are
looking forward to a long-term, and economical solutions, because
the demand is from time to time keep appreciating and reacting
according to other key economic drivers. Content analysis method
and case study approach is used in this paper and secondary data
from the bureau of statistic is used for case analysis. The paper
focused on the mobility concerns of the lower and middle-income
people in India and Pakistan. The paper is aimed to highlight the
weaknesses, opportunities and limitations resulting from low priority
industry for a government, which is making the either country's
public suffer. The paper has concluded that the main issue is
identified as the slow, inappropriate, and unfavorable decisions which
are not in favor of long-term country’s economic development and
public interest. The paper also recommends to future research
avenues for public and private transportation, which is continuously
failing to meet the public expectations.
Abstract: A theoretical study of a humidification
dehumidification solar desalination unit has been carried out to
increase understanding the effect of weather conditions on the unit
productivity. A humidification-dehumidification (HD) solar
desalination unit has been designed to provide fresh water for
population in remote arid areas. It consists of solar water collector
and air collector; to provide the hot water and air to the desalination
chamber. The desalination chamber is divided into humidification
and dehumidification towers. The circulation of air between the two
towers is maintained by the forced convection. A mathematical
model has been formulated, in which the thermodynamic relations
were used to study the flow, heat and mass transfer inside the
humidifier and dehumidifier. The present technique is performed in
order to increase the unit performance. Heat and mass balance has
been done and a set of governing equations has been solved using the
finite difference technique. The unit productivity has been calculated
along the working day during the summer and winter sessions and
has compared with the available experimental results. The average
accumulative productivity of the system in winter has been ranged
between 2.5 to 4 (kg/m2)/day, while the average summer productivity
has been found between 8 to 12 (kg/m2)/day.
Abstract: Background: Breast milk may impact early brain
development, with potentially important biological, medical and
social implications. There is an important discussion on which is the
adequate breastfeeding extension to the development consolidation
and how the children breastfeeding affects their psychomotor
development, in the first year of life, and in following periods as
well. Some special fats (LC PUFA) contained in breast milk play a
key role in the brain’s maturation and cognitive development or
social skills. These capacities created during breastfeeding time
would be unfolded throughout all lifespan. Aim of the study: In our research, we have studied the effect of
breastfeeding in preschooler's psychomotor assessment.
Method: This study was conducted in a sample of 158 preschool
children in Vlorë, Albania. We have measured the psychometric
parameters of preschoolers with ASQ-3 (Age&Stage Questionnaires-
3). The studied sample was divided in three groups according to their
breastfeeding duration (3, 6 and 12 months). Results: Children breastfed for only 3 months have definitely
lower psychometric scores compared to the ones with 6 or more
months of breastfeeding (respectively 217 to 239 ASQ-3 scores). Six
and twelvemonth breastfed children have progressively more odds to
have high levels of psychomotor development comparing to those
with only 3 months of breastfeeding. The most affected psychometric
domains by shortness of breastfeeding are Communication and
Global motor. Conclusion: This leads to conclusion that to ensure high
psychomotor parameters during childhood is necessary breastfeeding
for at least 6 months.
Abstract: Within this paper, latest results on processing of energetic nanomaterials by means of the Spray Flash Evaporation technique are presented. This technology constitutes a highly effective and continuous way to prepare fascinating materials on the nano- and micro-scale. Within the process, a solution is set under high pressure and sprayed into an evacuated atomization chamber. Subsequent ultrafast evaporation of the solvent leads to an aerosol stream, which is separated by cyclones or filters. No drying gas is required, so the present technique should not be confused with spray dying. Resulting nanothermites, insensitive explosives or propellants and compositions are foreseen to replace toxic (according to REACH) and very sensitive matter in military and civil applications. Diverse examples are given in detail: nano-RDX (n-Cyclotrimethylentrinitramin) and nano-aluminum based systems, mixtures (n-RDX/n-TNT - trinitrotoluene) or even cocrystalline matter like n-CL-20/HMX (Hexanitrohexaazaisowurtzitane/ Cyclotetra-methylentetranitramin). These nanomaterials show reduced sensitivity by trend without losing effectiveness and performance. An analytical study for material characterization was performed by using Atomic Force Microscopy, X-Ray Diffraction, and combined techniques as well as spectroscopic methods. As a matter of course, sensitivity tests regarding electrostatic discharge, impact, and friction are provided.
Abstract: The research on thermoelectric has been a blooming field of research for the latest decade, owing to large amount of heat source available to be harvested, being eco-friendly and static in operation. This paper provides the performance of thermoelectric generator (TEG) with bulk material of bismuth telluride, Bi2Te3. Later, the performance of the TEGs is evaluated by considering attaching the TEGs on a plastic (polyethylene sheet) in contrast to the common method of attaching the TEGs on the metal surface.
Abstract: Anaerobic digestion is a well-known technique for
sustainable energy recovery from sewage sludge. However, sewage
sludge digestion is restricted due to certain factors. Pre-treatment
methods have been established in various publications as a promising
technique to improve the digestibility of the sewage sludge and to
enhance the biogas generated which can be used for energy recovery.
In this study, continuous flow microwave (MW) pre-treatment with
different intensities were compared by using 5 L semi-continuous
digesters at a hydraulic retention time of 27 days. We focused on the
effects of MW at different intensities on the sludge solubilization,
sludge digestibility, and biogas production of the untreated and MW
pre-treated sludge. The MW pre-treatment demonstrated an increase
in the ratio of soluble chemical oxygen demand to total chemical
oxygen demand (sCOD/tCOD) and volatile fatty acid (VFA)
concentration. Besides that, the total volatile solid (TVS) removal
efficiency and tCOD removal efficiency also increased during the
digestion of the MW pre-treated sewage sludge compared to the
untreated sewage sludge. Furthermore, the biogas yield also
subsequently increases due to the pre-treatment effect. A higher MW
power level and irradiation time generally enhanced the biogas
generation which has potential for sustainable energy recovery from
sewage treatment plant. However, the net energy balance tabulation
shows that the MW pre-treatment leads to negative net energy production.
Abstract: The post-rain puddles problem that occurs in the first
yard of Prambanan Temple are often disturbing visitor activity. A
poodle layer and a drainage system had ever built to avoid such a
problem, but puddles still did not stop appearing after rain.
Permeability parameter needs to be determined by using a simpler
procedure to find exact method of solution. The instrument modelling
was proposed according to the development of field permeability
testing instrument. This experiment used a proposed Constant
Discharge method. Constant Discharge method used a tube poured
with constant water flow from unsaturated until saturated soil
condition. Volumetric water content (θ) were monitored by soil
moisture measurement device. The results were correlations between
k and θ which were drawn by numerical approach from Van
Genutchen model. Parameters θr optimum value obtained from the
test was at very dry soil. Coefficient of permeability with a density of
19.8 kN/m3 for unsaturated conditions was in range of 3 x 10-6
cm/sec (Sr=68%) until 9.98 x 10-4 cm/sec (Sr=82%). The equipment
and testing procedure developed in this research was quite effective,
simple and easy to be implemented on determining field soil
permeability coefficient value of sandy soil. Using constant discharge
method in proposed permeability test, value of permeability
coefficient under unsaturated condition can be obtained without
establish soil water characteristic curve.
Abstract: In order to investigate the prebiotic potential of
oligosaccharides prepared by chemical hydrolysis of water-soluble
polysaccharides (WSP) from Zizyphus lotus leaves, the effect of
oligosaccharides on bacterial growth was studied. The chemical
composition of WSP was evaluated by colorimetric assays revealed
the average values: 7.05±0.73% proteins and 86.21±0.74%
carbohydrates, among them 64.81±0.42% is neutral sugar and the rest
16.25±1.62% is uronic acids. The characterization of
monosaccharides was determined by high performance anion
exchange chromatography with pulsed amperometric detection
(HPAEC-PAD) was found to be composed of galactose (23.95%),
glucose (21.30%), rhamnose (20.28%), arabinose (9.55%), and
glucuronic acid (22.95%). The effects of oligosaccharides on the
growth of lactic acid bacteria were compared with those of fructooligosaccharide
(RP95). The oligosaccharides concentration was
1g/L of Man, Rogosa, Sharpe broth. Bacterial growth was assessed
during 2, 4.5, 6.5, 9, 12, 16 and 24 h by measuring the optical density
of the cultures at 600 nm (OD600) and pH values. During
fermentation, pH in broth cultures decreased from 6.7 to 5.87±0.15.
The enumeration of lactic acid bacteria indicated that
oligosaccharides led to a significant increase in bacteria (P≤0.05)
compared to the control. The fermentative metabolism appeared to be
faster on RP95 than on oligosaccharides from Zizyphus lotus leaves.
Both RP95 and oligosaccharides showed clear prebiotic effects, but
had differences in fermentation kinetics because of to the different
degree of polymerization. This study shows the prebiotic
effectiveness of oligosaccharides, and provides proof for the selection
of leaves of Zizyphus lotus for use as functional food ingredients.
Abstract: Diets high in processed foods have been found to lack
essential micro-nutrients for optimum human development and
overall health. Some micro-nutrients such as copper (Cu) have been
found to enhance the inflammatory response through its oxidative
functions, thereby having a role in cardiovascular disease, metabolic
syndrome, diabetes and related complications. This research study
was designed to determine if food crops could be bio-fortified with
micro-nutrients by growing sprouts on mineral fortified fiber mats. In
the feasibility study described in this contribution, recycled cellulose
fibers and clay, saturated with either micro-nutrient copper ions or
copper nanoparticles, were converted to a novel mineral-cellulose
fiber carrier of essential micro-nutrient and of antimicrobial
properties. Seeds of Medicago sativa (alfalfa), purchased from a
commercial, organic supplier were germinated on engineered
cellulose fiber mats. After the appearance of the first leaves, the
sprouts were dehydrated and analyzed for Cu content. Nutrient
analysis showed ~2 increase in Cu of the sprouts grown on the fiber
mats with copper particles, and ~4 increase on mats with ionic copper
as compared to the control samples. This study illustrates the
potential for the use of engineered mats as a viable way to increase
the micro-nutrient composition of locally-grown food crops and the
need for additional research to determine the uptake, nutritional
implications and risks of micro-nutrient bio-fortification.
Abstract: Nature constantly changes as a result of human
necessities. This change mostly feels in natural water sources which
are reconstructed with an effect of dams and motorways. In other
respects, visual quality of the landscape gets a new and different
character during and after the construction of dams and motorways.
Changing and specialization new landscapes will be very important
to protection-usage balance to explore sustainable usage facilities.
The main cause of the selection of Artvin city is that it has very
important geographical location and one of the most attraction points
in the World with its biodiversity, conservation areas and natural
landscape characteristics. Many hydroelectric station and 7 dams are
situated, 3 of them have already been built on the Çoruh River in the
province of Artvin. As a result of dams, motorways route were reshaped
and the ways which have already changed because of
elevation is directly affected several of natural destruction. In
contrast, many different reservoirs in Coruh Basin provide new vista
point that has high visual quality. In this study, we would like to
evaluate with sustainable landscape design in 76 km river corridor,
which is mainly based on Deriner, Borçka and Muratlı Dams and
determination of their basin-lakes recreational potential and
opportunities. Lastly, we are going to give some suggestion about the
potential of the corridor.
Abstract: The objective of this work is to carryout critical
comparison of different actuation mechanisms like electrostatic,
thermal, piezoelectric, and magnetic with reference to a micro
cantilever. The relevant parameters like force generated,
displacement are compared in actuation methods. With these results,
helps in choosing the best actuation method for a particular
application. In this study, Comsol/Multiphysics software is used.
Modeling and simulation is done by considering the micro cantilever
of same dimensions as an actuator using all the above mentioned
actuation techniques. In addition to their small size, micro actuators
consume very little power and are capable of accurate results. In this
work, a comparison of actuation mechanisms is done to decide the
efficient system in micro domain.
Abstract: The paper discusses the problem of load transport
using farm tractors and road tractor units. This type of carriage of
goods is often done with farm vehicles. The tests were performed
with the PEMS equipment (Portable Emission Measurement System)
under actual traffic conditions. The vehicles carried a load of 20000
kg. This research method is one of the most desired because it
provides reliable information on the actual vehicle emissions and fuel
consumption (carbon balance method). For the tests, a route was
selected that simulated a trip from a small town to a food-processing
facility located in a city. The analysis of the obtained results gave a
clear answer as to what vehicles need to be used for carriage of this
type of cargo in terms of exhaust emissions and fuel consumption.
Abstract: Within Rapid Prototyping technologies are used many
types of materials. Many of them are recyclable but there are still as
plastic like, so practically they do not degrade in the landfill.
Polylactic acid (PLA) is one of the special plastic materials, which
are biodegradable and available for 3D printing within Fused
Deposition Modeling (FDM) technology. The question is, if the
mechanical properties of produced models are comparable to similar
technical plastic materials which are usual for prototype production.
Presented paper shows the experiments results for tensile strength
measurements for specimens prepared with different 3D printer
settings and model orientation. Paper contains also the comparison of
tensile strength values with values measured on specimens produced
by conventional technologies as injection moulding.
Abstract: Reduction of energy consumption in built
infrastructure, through the installation of energy-efficient
technologies, is a major approach to achieving sustainability. In
practice, the viability of energy efficiency projects strongly depends
on the cost reimbursement and profitability. These projects are
subject to failure if the actual cost savings do not reimburse the
project cost promptly. In such cases, refinancing could be a solution
to benefit from the long-term returns of the project, if implemented
wisely. However, very little is still known about the effect of
refinancing options on financial performance of energy efficiency
projects. In order to fill this gap, the present study investigates the
financial behavior of energy efficiency projects with focus on
refinancing options, such as Leveraged Loans. A System Dynamics
(SD) model is introduced, and the model application is presented
using an actual case-study data. The case study results indicate that
while high-interest start-ups make using Leveraged Loan inevitable,
refinancing can rescue the project and bring about profitability. This
paper also presents some managerial implications of refinancing
energy efficiency projects based on the case-study analysis. Results
of this study help to implement financially viable energy efficiency
projects so that the community could benefit from their
environmental advantages widely.
Abstract: Given the increase in the number of e-commerce sites,
the number of competitors has become very important. This means
that companies have to take appropriate decisions in order to meet the
expectations of their customers and satisfy their needs. In this paper,
we present a case study of applying LRFM (length, recency,
frequency and monetary) model and clustering techniques in the
sector of electronic commerce with a view to evaluating customers’
values of the Moroccan e-commerce websites and then developing
effective marketing strategies. To achieve these objectives, we adopt
LRFM model by applying a two-stage clustering method. In the first
stage, the self-organizing maps method is used to determine the best
number of clusters and the initial centroid. In the second stage, kmeans
method is applied to segment 730 customers into nine clusters
according to their L, R, F and M values. The results show that the
cluster 6 is the most important cluster because the average values of
L, R, F and M are higher than the overall average value. In addition,
this study has considered another variable that describes the mode of
payment used by customers to improve and strengthen clusters’
analysis. The clusters’ analysis demonstrates that the payment method is
one of the key indicators of a new index which allows to assess the
level of customers’ confidence in the company's Website.
Abstract: Lagos urban mini bus drivers play a critical role in the
transportation sector. The current major mode of transportation
within Lagos metropolis remains road transportation and this
confirms the relevance of urban mini-bus drivers in transporting the
populace to their various destinations. Other modes of transportation
such as the train and waterways are currently inadequate. Various
threats to the well-being of urban bus drivers include congested
traffic typical of modern day lifestyles, dwindling financial returns
due to long hours in traffic, fewer hours of sleep, inadequate diet,
time pressure, and assaults related to fare disputes. Several healthrelated
problems have been documented to be associated with urban
bus driving. For instance, greater rates of hypertension, obesity and
cholesterol level have been reported. Research studies are yet to
identify the influence of age and marital status on the well-being of
urban mini-bus drivers in Lagos metropolis. A study of this nature is
necessary as it is culturally perceived in Nigeria that older and
married people are especially influenced by family affiliation and
would behave in ways that would project positive outcomes. The
study sample consisted of 150 urban mini-bus drivers who were
conveniently sampled from six (6) different terminuses where their
journey begins and terminates. The well-being questionnaire was
administered to participants. The criteria for inclusion in the study
included the ability to read in English language and the confirmation
that interested participants were on duty and suited to be driving
mini-buses. Due to the nature of the job of bus driving, the researcher
administered the questionnaires on participants who were free and
willing to respond to the survey. All participants were males of
various age groups and of different marital statuses. Results of
analyses conducted revealed no significant influence of age and
marital status on the well-being of urban mini-bus drivers. This
indicates that the well-being of urban mini bus drivers is not
influenced by age or marital status. The findings of this study have
cultural implications. It negates the popularly held belief that older
and married people care more about their well-being than younger
and single people. It brings to fore the need to also identify and
consider other factors when certifying people for the job of urban bus
driving.
Abstract: Various nanomaterials can be used as a drug delivery
vehicles in nanomedicine, called nanocarriers. They can either be
organic or inorganic, synthetic or natural-based. Although synthetic
nanocarriers are easier to produce, they can often be toxic for the
organism and thus not suitable for use in treatment. From naturalbased
nanocarriers, the most commonly used are protein cages or
viral capsids. In this work, virus bacteriophage λ was used for
delivery of different cytotoxic drugs (cisplatin, carboplatin,
oxaliplatin and doxorubicin). Large quantities of phage λ were
obtained from phage λ-producing strain of E. coli cultivated in
medium with 0.2% maltose. After killing of E. coli with chloroform
and its removal by centrifugation, the phage was concentrated by
ultracentrifugation at 130 000×g and 4°C for 3 h. The encapsulation
of the drugs was performed by infusion method and four different
concentrations of the drugs were encapsulated (200; 100; 50; 25
μg·mL-1). Free drug molecules were removed by filtration. The
encapsulation was verified using the absorbance for doxorubicin and
atomic absorption spectrometry for platinum cytostatics. The amount
of encapsulated drug linearly increased with the increasing
concentration of applied drug with the determination coefficient
R2=0.989 for doxorubicin; R2=0.967 for cisplatin; R2=0.989 for
carboplatin and R2=0.996 for oxaliplatin. The overall encapsulation
efficiency was calculated as 50% for doxorubicin; 8% for cisplatin;
6% for carboplatin and 10% for oxaliplatin.
Abstract: Chatter vibrations, occurring during cutting process,
cause vibration between the cutting tool and workpiece, which
deteriorates surface roughness and reduces tool life. The purpose of
this study is to investigate the influence of cutting parameters and
tool construction on surface roughness and vibration in turning of
aluminum alloy AA2024. A new design of cutting tool is proposed,
which is filled up with epoxy granite in order to improve damping
capacity of the tool. Experiments were performed at the lathe using
carbide cutting insert coated with TiC and two different cutting tools
made of AISI 5140 steel. Taguchi L9 orthogonal array was applied to
design of experiment and to optimize cutting conditions. By the help
of signal-to-noise ratio and analysis of variance the optimal cutting
condition and the effect of the cutting parameters on surface
roughness and vibration were determined. Effectiveness of Taguchi
method was verified by confirmation test. It was revealed that new
cutting tool with epoxy granite has reduced vibration and surface
roughness due to high damping properties of epoxy granite in
toolholder.