Abstract: Since hyaluronic acid (HA) receptor such as CD44 is
over-expressed at sites of cancer cells, HA can be used as a targeting
vehicles for anti-cancer drugs. The aim of this study is to synthesize
block copolymer composed of hyaluronic acid and
poly(ε-caprolactone) (HAPCL) and to fabricate polymeric micelles for
anticancer drug targeting against CD44 receptor of tumor cells.
Chemical composition of HAPCL was confirmed using 1H NMR
spectroscopy. Doxorubicin (DOX) was incorporated into polymeric
micelles of HAPCL. The diameters of HAPHS polymeric micelles
were changed around 80nm and have spherical shapes. Targeting
potential was investigated using CD44-overexpressing. When
DOX-incorporated polymeric micelles was added to KB cells, they
revealed strong red fluorescence color while blocking of CD44
receptor by pretreatment of free HA resulted in reduced intensity,
indicating that HAPCL polymeric micelles have targetability against
CD44 receptor.
Abstract: Nowadays, HPC, Grid and Cloud systems are evolving
very rapidly. However, the development of infrastructure solutions
related to HPC is lagging behind. While the existing infrastructure is
sufficient for simple cases, many computational problems have more
complex requirements.Such computational experiments use different
resources simultaneously to start a large number of computational
jobs.These resources are heterogeneous. They have different
purposes, architectures, performance and used software.Users need a
convenient tool that allows to describe and to run complex
computational experiments under conditions of HPC environment.
This paper introduces a modularworkflow system called SEGL
which makes it possible to run complex computational experiments
under conditions of a real HPC organization. The system can be used
in a great number of organizations, which provide HPC power.
Significant requirements to this system are high efficiency and
interoperability with the existing HPC infrastructure of the
organization without any changes.
Abstract: The process of laser absorption in the skin during
laser irradiation was a critical point in medical application
treatments. Delivery the correct amount of laser light is a critical
element in photodynamic therapy (PDT). More amounts of laser
light able to affect tissues in the skin and small amount not able to
enhance PDT procedure in skin. The knowledge of the skin tone
laser dependent distribution of 635 nm radiation and its penetration
depth in skin is a very important precondition for the investigation of
advantage laser induced effect in (PDT) in epidermis diseases
(psoriasis). The aim of this work was to estimate an optimum effect
of diode laser (635 nm) on the treatment of epidermis diseases in
different color skin. Furthermore, it is to improve safety of laser in
PDT in epidermis diseases treatment. Advanced system analytical
program (ASAP) which is a new approach in investigating the PDT,
dependent on optical properties of different skin color was used in
present work. A two layered Realistic Skin Model (RSM); stratum
corneum and epidermal with red laser (635 nm, 10 mW) were used
for irradiative transfer to study fluence and absorbance in different
penetration for various human skin colors. Several skin tones very
fair, fair, light, medium and dark are used to irradiative transfer. This
investigation involved the principles of laser tissue interaction when
the skin optically injected by a red laser diode. The results
demonstrated that the power characteristic of a laser diode (635 nm)
can affect the treatment of epidermal disease in various color skins.
Power absorption of the various human skins were recorded and
analyzed in order to find the influence of the melanin in PDT
treatment in epidermal disease. A two layered RSM show that the
change in penetration depth in epidermal layer of the color skin has a
larger effect on the distribution of absorbed laser in the skin; this is
due to the variation of the melanin concentration for each color.
Abstract: Performance appraisal of employee is important in
managing the human resource of an organization. With the change
towards knowledge-based capitalism, maintaining talented
knowledge workers is critical. However, management classification
of “outstanding", “poor" and “average" performance may not be an
easy decision. Besides that, superior might also tend to judge the
work performance of their subordinates informally and arbitrarily
especially without the existence of a system of appraisal. In this
paper, we propose a performance appraisal system using
multifactorial evaluation model in dealing with appraisal grades
which are often express vaguely in linguistic terms. The proposed
model is for evaluating staff performance based on specific
performance appraisal criteria. The project was collaboration with
one of the Information and Communication Technology company in
Malaysia with reference to its performance appraisal process.
Abstract: The main problems of data centric and open source
project are large number of developers and changes of core
framework. Model-View-Control (MVC) design pattern significantly
improved the development and adjustments of complex projects.
Entity framework as a Model layer in MVC architecture has
simplified communication with the database. How often are the new
technologies used and whether they have potentials for designing
more efficient Enterprise Resource Planning (ERP) system that will
be more suited to accountants?
Abstract: Recently, many web services to provide information for public transport are developed and released. They are optimized for mobile devices such a smartphone. We are also developing better path planning system for route buses and trains called “Bus-Net"[1]. However these systems only provide paths and related information before the user start moving. So we propose a context aware navigation to change the way to support public transport users. If we go to somewhere using many kinds of public transport, we have to know how to use them. In addition, public transport is dynamic system, and these have different characteristic by type. So we need information at real-time. Therefore we suggest the system that can support on user-s state. It has a variety of ways to help public transport users by each state, like turn-by-turn navigation. Context aware navigation will be able to reduce anxiety for using public transport.
Abstract: In this article we present a change point detection algorithm based on the continuous wavelet transform. At the beginning of the article we describe a necessary transformation of a signal which has to be made for the purpose of change detection. Then case study related to iron ore sinter production which can be solved using our proposed technique is discussed. After that we describe a probabilistic algorithm which can be used to find changes using our transformed signal. It is shown that our algorithm works well with the presence of some noise and abnormal random bursts.
Abstract: Climate change is one of the greatest environmental,
economic, and social challenges of our time. Urban transportation has
had a major negative impact on our environment—most of our air
pollution comes from transport.
This paper explores ways to move toward a more sustainable
transport system by focusing on creating a more efficient and livable
city and improving the environmental efficiency of transport activity.
The analytical study covers some international examples of applying
sustainable transportation and uses them to suggest a frame work to
develop the transportation system in Egypt to be sustainable and more
intelligent.
Abstract: Air bubbles have been detected in human circulation
of end-stage renal disease patients who are treated by hemodialysis.
The consequence of air embolism, air bubbles, is under recognized
and usually overlooked in daily practice. This paper shows results of
a capacitor based detection method that capable of detecting the
presence of air bubbles in the blood stream in different frequencies.
The method is based on a parallel plates capacitor made of platinum
with an area of 1.5 cm2 and a distance between the two plates is 1cm.
The dielectric material used in this capacitor is Dextran70 solution
which mimics blood rheology. Simulations were carried out using
RC circuit at two frequencies 30Hz and 3 kHz and results compared
with experiments and theory. It is observed that by injecting air
bubbles of different diameters into the device, there were significant
changes in the capacitance of the capacitor. Furthermore, it is
observed that the output voltage from the circuit increased with
increasing air bubble diameter. These results demonstrate the
feasibility of this approach in improving air bubble detection in
Hemodialysis.
Abstract: A method of dynamic mesh based airfoil optimization is proposed according to the drawbacks of surrogate model based airfoil optimization. Programs are designed to achieve the dynamic mesh. Boundary condition is add by integrating commercial software Pointwise, meanwhile the CFD calculation is carried out by commercial software Fluent. The data exchange and communication between the software and programs referred above have been accomplished, and the whole optimization process is performed in iSIGHT platform. A simplified airfoil optimization study case is brought out to show that aerodynamic performances of airfoil have been significantly improved, even save massive repeat operations and increase the robustness and credibility of the optimization result. The case above proclaims that dynamic mesh based airfoil optimization is an effective and high efficient method.
Abstract: Organic Flash Cycle (OFC) has potential of improving
efficiency for recovery of low temperature heat sources mainly due to
reducing temperature mismatch in the heat exchanger. In this work
exergetical performance analysis of ORC is conducted for recovery of
low grade heat source. Effects of system parameters such as flash
evaporation temperature or heating temperature are theoretically
investigated on the exergy destructions (anergies) at various
components of the system as well as exergy efficiency. Results show
that exergy efficiency has a peak with respect to the flash temperature,
and the optimum flash temperature increases with the heating
temperature. The component where the largest exergy destruction
occurs varies with the flash temperature or heating temperature.
Abstract: School leadership is commonly considered to have a
significant influence on school effectiveness and improvement.
Effective school leaders are expected to successfully introduce and
support change and innovation at the school unit. Despite an
abundance of studies on educational leadership, very few studies
have provided evidence on the link between leadership models, and
specific educational and school outcomes. This is true of a popular
contemporary approach to leadership, namely, distributed leadership.
The paper provides an overview of research findings on the effect of
distributed leadership on educational outcomes. The theoretical basis
for this approach to leadership is presented, with reference to
methodological and research limitations. The paper discusses
research findings and draws their implications for educational
research on school leadership.
Abstract: In contrast to existing methods which do not take into account multiconnectivity in a broad sense of this term, we develop mathematical models and highly effective combination (BIEM and FDM) numerical methods of calculation of stationary and quasistationary temperature field of a profile part of a blade with convective cooling (from the point of view of realization on PC). The theoretical substantiation of these methods is proved by appropriate theorems. For it, converging quadrature processes have been developed and the estimations of errors in the terms of A.Ziqmound continuity modules have been received. For visualization of profiles are used: the method of the least squares with automatic conjecture, device spline, smooth replenishment and neural nets. Boundary conditions of heat exchange are determined from the solution of the corresponding integral equations and empirical relationships. The reliability of designed methods is proved by calculation and experimental investigations heat and hydraulic characteristics of the gas turbine first stage nozzle blade.
Abstract: This study is to investigate the electroencephalogram (EEG) differences generated from a normal and Alzheimer-s disease (AD) sources. We also investigate the effects of brain tissue distortions due to AD on EEG. We develop a realistic head model from T1 weighted magnetic resonance imaging (MRI) using finite element method (FEM) for normal source (somatosensory cortex (SC) in parietal lobe) and AD sources (right amygdala (RA) and left amygdala (LA) in medial temporal lobe). Then, we compare the AD sourced EEGs to the SC sourced EEG for studying the nature of potential changes due to sources and 5% to 20% brain tissue distortions. We find an average of 0.15 magnification errors produced by AD sourced EEGs. Different brain tissue distortion models also generate the maximum 0.07 magnification. EEGs obtained from AD sources and different brain tissue distortion levels vary scalp potentials from normal source, and the electrodes residing in parietal and temporal lobes are more sensitive than other electrodes for AD sourced EEG.
Abstract: Imperfect knowledge cannot be avoided all the time. Imperfections may have several forms; uncertainties, imprecision and incompleteness. When we look to classification of methods for the management of imperfect knowledge we see fuzzy set-based techniques. The choice of a method to process data is linked to the choice of knowledge representation, which can be numerical, symbolic, logical or semantic and it depends on the nature of the problem to be solved for example decision support, which will be mentioned in our study. Fuzzy Logic is used for its ability to manage imprecise knowledge, but it can take advantage of the ability of neural networks to learn coefficients or functions. Such an association of methods is typical of so-called soft computing. In this study a new method was used for the management of imprecision for collected knowledge which related to economic analysis of construction industry in Turkey. Because of sudden changes occurring in economic factors decrease competition strength of construction companies. The better evaluation of these changes in economical factors in view of construction industry will made positive influence on company-s decisions which are dealing construction.
Abstract: Advancements in the field of artificial intelligence
(AI) made during this decade have forever changed the way we look
at automating spacecraft subsystems including the electrical power
system. AI have been used to solve complicated practical problems
in various areas and are becoming more and more popular nowadays.
In this paper, a mathematical modeling and MATLAB–SIMULINK
model for the different components of the spacecraft power system is
presented. Also, a control system, which includes either the Neural
Network Controller (NNC) or the Fuzzy Logic Controller (FLC) is
developed for achieving the coordination between the components of
spacecraft power system as well as control the energy flows. The
performance of the spacecraft power system is evaluated by
comparing two control systems using the NNC and the FLC.
Abstract: In this paper, a fast motion compensation algorithm is
proposed that improves coding efficiency for video sequences with
brightness variations. We also propose a cross entropy measure
between histograms of two frames to detect brightness variations. The
framewise brightness variation parameters, a multiplier and an offset
field for image intensity, are estimated and compensated. Simulation
results show that the proposed method yields a higher peak signal to
noise ratio (PSNR) compared with the conventional method, with a
greatly reduced computational load, when the video scene contains
illumination changes.
Abstract: A two dimensional three segments coupled pendulum system that mathematically models human arm configuration was developed along with constructing and solving the equations of motions for this model using the energy (work) based approach of Lagrange. The equations of motion of the model were solved iteratively both as an initial value problem and as a two point boundary value problem. In the initial value problem solutions, both the initial system configuration (segment angles) and initial system velocity (segment angular velocities) were used as inputs, whereas, in the two point boundary value problem solutions initial and final configurations and time were used as inputs to solve for the trajectory of motion. The results suggest that the model solutions are sensitive to small changes in the dynamic forces applied to the system as well as to the initial and boundary conditions used. To overcome the system sensitivity a new approach is suggested.
Abstract: Insect pests are the major source of crop
damage, yield and quality reduction in Pakistan and else
where in the world. Cotton crop is the most hit crop in
Pakistan followed by rice and the second most important
foreign exchange earning crop. A wide variety of staple,
horticultural and cash crops grown, reflect serious problems of
many types of insect pests. To overcome the insect pest
problem, pesticide use in Pakistan has increased substantially
which has now been further intensified. Pesticides worth more
than billions of rupees are imported every year. This paper
reviews the over all pesticide use in Pakistan in relation to
pesticide prices, support price of cotton and rice, pesticide use
in different provinces of Pakistan on different crops and their
impact on crop productivity. The environmental pollution
caused by the use of pesticides, contamination of soil and
water resources and the danger associated with the disposal of
their empty containers is also discussed in detail.
Abstract: Longitudinal data typically have the characteristics of
changes over time, nonlinear growth patterns, between-subjects
variability, and the within errors exhibiting heteroscedasticity and
dependence. The data exploration is more complicated than that of
cross-sectional data. The purpose of this paper is to organize/integrate
of various visual-graphical techniques to explore longitudinal data.
From the application of the proposed methods, investigators can
answer the research questions include characterizing or describing the
growth patterns at both group and individual level, identifying the time
points where important changes occur and unusual subjects, selecting
suitable statistical models, and suggesting possible within-error
variance.