Abstract: Several embryonic cellular mechanism including cell
cycle, growth and apoptosis are regulated by phosphatidylinositol-3-
kinase (PI3K)/Akt signaling pathway. The goal of present study is to
determine the effects of annatto (Bixa orellana)-derived δ-tocotrienol
(δ-TCT) on the regulations of PI3K/Akt genes in murine morula.
Twenty four 6-8 week old (23-25g) female balb/c mice were
randomly divided into four groups (G1-G4; n=6). Those groups were
subjected to the following treatments for 7 consecutive days: G1
(control) received tocopherol stripped corn oil, G2 was given 60
mg/kg/day of δ-TCT mixture (contains 90% delta & 10% gamma
isomers), G3 was given 60 mg/kg/day of pure δ-TCT (>98% purity)
and G4 received 60 mg/kg/day α-TOC. On Day 8, females were
superovulated with 5 IU Pregnant Mare’s Serum Gonadotropin
(PMSG) for 48 hours followed with 5 IU human Chorionic
Gonadotropin (hCG) before mated with males at the ratio of 1:1.
Females were sacrificed by cervical dislocation for embryo collection
48 hours post-coitum. About fifty morulas from each group were
used in the gene expression analyses using Affymetrix QuantiGene
Plex 2.0 Assay. Present data showed a significant increase (p
Abstract: These Monolayer and multilayer coatings of CrN and
AlCrN deposited on 100Cr6 (AISI 52100) substrate by PVD
magnetron sputtering system. The microstructures of the coatings
were characterized using atomic force microscopy (AFM). The AFM
analysis revealed the presence of domes and craters that are
uniformly distributed over all surfaces of the various layers.
Nanoindentation measurement of CrN coating showed maximum
hardness (H) and modulus (E) of 14 GPa and 190 GPa, respectively.
The measured H and E values of AlCrN coatings were found to be 30
GPa and 382 GPa, respectively. The improved hardness in both the
coatings was attributed mainly to a reduction in crystallite size and
decrease in surface roughness. The incorporation of Al into the CrN
coatings has improved both hardness and Young’s modulus.
Abstract: The effects of flame-holder position, the ratio of flame
holder diameter to combustion chamber diameter and injection angle
on fuel propulsive droplets sizing and effective mass fraction have
been studied by a cold flow. We named the mass of fuel vapor inside
the flammability limit as the effective mass fraction. An empty
cylinder as well as a flame-holder which are a simulator for duct
combustion has been considered. The airflow comes into the cylinder
from one side and injection operation will be done by four nozzles
which are located on the entrance of cylinder. To fulfill the
calculations a modified version of KIVA-3V code which is a
transient, three-dimensional, multiphase, multi component code for
the analysis of chemically reacting flows with sprays, is used.
Abstract: This study utilizes a frequency domain approach over
the period of 1996 to 2013 to examine the causal relationship between
governance and economic growth in ten Asian countries, which have
different levels of democracy; classified as “Free”, “Partly Free”, and
“Not Free” countries. The empirical results show that there is no
Granger causality running from governance to economic growth in
“Not Free” countries and “Partly Free” countries with the exception of
Singapore. As for “Free” countries such as South Korea and Taiwan,
there is a one-way causality running from governance to economic
growth. The findings of this study indicate that policy makers in South
Korea, Taiwan, and Singapore could use governance index to improve
their predictions of the future economic growth.
Abstract: In this study, to clarify the effectiveness of an
aluminum/chromium/tungsten-based-coated tool for cutting sintered
steel, tool wear was experimentally investigated. The sintered steel
was turned with the (Al60,Cr25,W15)N-, (Al60,Cr25,W15)(C,N)- and
(Al64,Cr28,W8)(C,N)-coated cemented carbide tools according to the
physical vapor deposition (PVD) method. Moreover, the tool wear of
the aluminum/chromium/tungsten-based-coated item was compared
with that of the (Al,Cr)N coated tool. Furthermore, to clarify the tool
wear mechanism of the aluminum/chromium/tungsten-coating film for
cutting sintered steel, Scanning Electron Microscope observation and
Energy Dispersive x-ray Spectroscopy mapping analysis were
conducted on the abraded surface. The following results were
obtained: (1) The wear progress of the (Al64,Cr28,W8)(C,N)-coated
tool was the slowest among that of the five coated tools. (2) Adding
carbon (C) to the aluminum/chromium/tungsten-based-coating film
was effective for improving the wear-resistance. (3) The main wear
mechanism of the (Al60,Cr25,W15)N-, the (Al60,Cr25,W15)(C,N)-
and the (Al64,Cr28,W8)(C,N)-coating films was abrasive wear.
Abstract: High Voltage Direct Current (HVDC) power
transmission is employed to move large amounts of electric power.
There are several possibilities to enhance the transient stability in a
power system. One adequate option is by using the high
controllability of the HVDC if HVDC is available in the system. This
paper presents a control technique for HVDC to enhance the transient
stability. The strategy controls the power through the HVDC to help
make the system more transient stable during disturbances. Loss of
synchronism is prevented by quickly producing sufficient
decelerating energy to counteract accelerating energy gained during.
In this study, the power flow in the HVDC link is modulated with the
addition of an auxiliary signal to the current reference of the rectifier
firing angle controller. This modulation control signal is derived from
speed deviation signal of the generator utilizing a PD controller; the
utilization of a PD controller is suitable because it has the property of
fast response. The effectiveness of the proposed controller is
demonstrated with a SMIB test system.
Abstract: Psyllium gum alone and in combination with
sunflower oil was investigated as a possible alternative edible coating
for improvement of quality and shelf life of fresh-cut papaya.
Different concentrations including 0.5, 1 and 1.5 percent of psyllium
gum were used for coating of fresh-cut papaya. In some samples,
refined sunflower oil was used as a lipid component to increase the
effectiveness of coating in terms of water barrier properties. Soya
lecithin was used as an emulsifier in coatings containing oil.
Pretreatment with 1% calcium chloride was given to maintain the
firmness of fresh-cut papaya cubes. 1% psyllium gum coating was
found to yield better results. Further, addition of oil helped to
maintain the quality and acted as a barrier to water vapour, therefore,
minimizing the weight loss.
Abstract: Native American communities are struggling with unemployment and depressed economies. A major cause is a lack of business knowledge, education, and cultural desire. And yet, in the history of the American West, Native Americans were considered the best traders and negotiators for everything from furs to weapons to buffalo. To improve these economies, there has been an effort to reintroduce that heritage to todays and tomorrows generation of tribal members, such Crow, Cheyenne, and Blackfeet. Professors at the College of Business Montana State University-Billings (MSUB) teach tribal students in Montana to create business plans. These plans have won national small business plan competitions. The teaching and advising method used at MSUB is uniquely successful as theses business students are now five time national champions. This article reviews the environment and the method of learning to achieve a winning small business plan with Native American students. It discusses the five plans that became national champions. And it discusses the problems and solutions discovered in the process of achieving results. Students who participated in this endeavor have graduated and become CPAs, MBAs, and gainfully employed in their chosen professions. They have also worked to improve the economies of their native lands and homes. By educating members of these communities with business strategy and plan development, they are better able to impact their own economies.
Abstract: Amoxicillin is an antibiotic which is widely used to
treat various infections in both human beings and animals. However,
when amoxicillin is released into the environment, it is a major
problem. Amoxicillin causes bacterial resistance to these drugs and
failure of treatment with antibiotics. Liquid membrane is of great
interest as a promising method for the separation and recovery of the
target ions from aqueous solutions due to the use of carriers for the
transport mechanism, resulting in highly selectivity and rapid
transportation of the desired metal ions. The simultaneous processes
of extraction and stripping in a single unit operation of liquid
membrane system are very interesting. Therefore, it is practical to
apply liquid membrane, particularly the HFSLM for industrial
applications as HFSLM is proved to be a separation process with
lower capital and operating costs, low energy and extractant with
long life time, high selectivity and high fluxes compared with solid
membranes. It is a simple design amenable to scaling up for industrial
applications. The extraction and recovery for (Amoxicillin) through
the hollow fiber supported liquid membrane (HFSLM) using
aliquat336 as a carrier were explored with the experimental data. The
important variables affecting on transport of amoxicillin viz.
extractant concentration and operating time were investigated. The
highest AMOX- extraction percentages of 85.35 and Amoxicillin
stripping of 80.04 were achieved with the best condition at 6 mmol/L
[aliquat336] and operating time 100 min. The extraction reaction
order (n) and the extraction reaction rate constant (kf) were found to
be 1.00 and 0.0344 min-1, respectively.
Abstract: This paper presents an application of Artificial Neural
Network (ANN) algorithm for improving power system voltage
stability. The training data is obtained by solving several normal and
abnormal conditions using the Linear Programming technique. The
selected objective function gives minimum deviation of the reactive
power control variables, which leads to the maximization of
minimum Eigen value of load flow Jacobian. The considered reactive
power control variables are switchable VAR compensators, OLTC
transformers and excitation of generators. The method has been
implemented on a modified IEEE 30-bus test system. The results
obtain from the test clearly show that the trained neural network is
capable of improving the voltage stability in power system with a
high level of precision and speed.
Abstract: Evapotranspiration is one of the most important
components of the hydrological cycle. Evapotranspiration (ETo) is an
important variable in water and energy balances on the earth’s
surface, and knowledge of the distribution of ET is a key factor in
hydrology, climatology, agronomy and ecology studies. Many
researchers have a valid relationship, which is a function of climate
factors, to estimate the potential evapotranspiration presented to the
plant water stress or water loss, prevent. The FAO-Penman method
(PM) had been recommended as a standard method. This method
requires many data and these data are not available in every area of
world. So, other methods should be evaluated for these conditions.
When sufficient or reliable data to solve the PM equation are not
available then Hargreaves equation can be used. The Hargreaves
equation (HG) requires only daily mean, maximum and minimum air
temperature extraterrestrial radiation .In this study, Hargreaves
method (HG) were evaluated in 12 stations in the North West region
of Iran. Results of HG and M.HG methods were compared with
results of PM method. Statistical analysis of this comparison showed
that calibration process has had significant effect on efficiency of
Hargreaves method.
Abstract: The crude methanol extracts of five indigenous vegetables namely, Amarathus tricolor, Basella rubra L., Chochurus olitorius L., Ipomea batatas, and Momordica chuchinensis L., were examined for their phytochemical profile and antioxidant activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical. The values for DPPH radical scavenging activity ranged from 7.6-89.53% with B. rubra and I. batatas having the lowest and highest values, respectively. The total flavonoid content of all five indigenous vegetables ranged from 74.65-277.3 mg quercetin equivalent per gram of dried vegetable material while the total phenolic content ranged from 1.93-6.15 mg gallic acid equivalent per gram dried material. Phytochemical screening revealed the presence of steroids, flavonoids, saponins, tannins, carbohydrates and reducing sugars, which may also be associated with the antioxidant activity shown by these indigenous vegetables.
Abstract: It is a well-established fact that terrorism is one of the foremost threats to present-day international security. The creation of tools or mechanisms for confronting it in an effective and efficient manner will only be possible by way of an objective assessment of the phenomenon. In order to achieve this, this paper has the following three main objectives: Firstly, setting out to find the reasons that have prevented the establishment of a universally accepted definition of terrorism, and consequently trying to outline the main features defining the face of the terrorist threat in order to discover the fundamental goals of what is now a serious blight on world society. Secondly, trying to explain the differences between a terrorist movement and a terrorist organisation, and the reasons for which a terrorist movement can be led to transform itself into an organisation. After analysing these motivations and the characteristics of a terrorist organisation, an example of the latter will be succinctly analysed to help the reader understand the ideas expressed. Lastly, discovering and exposing the factors that can lead to the appearance of terrorist tendencies, and discussing the most efficient and effective responses that can be given to this global security threat.
Abstract: Boiling process is characterized by the rapid
formation of vapour bubbles at the solid–liquid interface (nucleate
boiling) with pre-existing vapour or gas pockets. Computational fluid
dynamics (CFD) is an important tool to study bubble dynamics. In
the present study, CFD simulation has been carried out to determine
the bubble detachment diameter and its terminal velocity. Volume of
fluid method is used to model the bubble and the surrounding by
solving single set of momentum equations and tracking the volume
fraction of each of the fluids throughout the domain. In the
simulation, bubble is generated by allowing water-vapour to enter a
cylinder filled with liquid water through an inlet at the bottom. After
the bubble is fully formed, the bubble detaches from the surface and
rises up during which the bubble accelerates due to the net balance
between buoyancy force and viscous drag. Finally when these forces
exactly balance each other, it attains a constant terminal velocity. The
bubble detachment diameter and the terminal velocity of the bubble
are captured by the monitor function provided in FLUENT. The
detachment diameter and the terminal velocity obtained are compared
with the established results based on the shape of the bubble. A good
agreement is obtained between the results obtained from simulation
and the equations in comparison with the established results.
Abstract: In the immunologic sense, clinical infection is a state
of failure of the immune system to combat the pathogenic weapon of
the bacteria invading the host. A motile gram negative vibroid
organism associated with marked mono and poly nuclear cell
responses was traced during the examination of a clinical material
from an infected common carp Cyprinus carpio. On primary plate
culture, growth was shown to be pure, dense population of an
Aeromonas-like colony morphotype. The pure isolate was found to
be; Aerobic, facultatively anaerobic, non-halophilic, grew at 0C, and
37C, oxidase positive utilizes glucose through fermentative pathway,
resist 0/129 and novobiocin, produces alanine and lysine
decarboxylases but non-producing ornithine dehydrolases. Tests for
the in vitro determinants of pathogenicity has shown to be; Betahaemolytic
onto blood agar, gelatinase, casienase and amylase
producer. Three in vivo determinants of pathogenicity were tested as,
the lethal dose fifty, the pathogenesis and pathogenicity. It was
evident that 0.1 milliliter of the causal bacterial cell suspension of a
density 1 x 107 CFU/ml injected intramuscularly into an average of
100gms fish toke five days incubation period, then at the day six
morbidity and mortality were initiated. LD50 was recorded at the day
12 post-infection. Use of an LD50 doses to study the pathogenicity,
reveals mononuclear and polynuclear cell responses, on examining
the stained direct films of the clinical materials from the
experimentally infected fish. Re-isolation tests confirm that the reisolant
is same. The course of the infection in natural case was shown
manifestation of; skin ulceration, haemorrhage and descaling. On
evisceration, the internal organs were shown; congestion in the
intestines, spleen and, air sacs. The induced infection showed a
milder form of these manifestations. The grading of the virulence of
this organism was virulent causing chronic course of infections as
indicated from the pathogenesis and pathogenicity studies. Thus the
infectious bacteria were consistent with Aeromonas hydrophila, and
the infection was chronic.
Abstract: To ensure targeting of apoferritin nanocarrier with
encapsulated doxorubicin drug, we used a peptide linker based on a
protein G with N-terminus affinity towards Fc region of antibodies.
To connect the peptide to the surface of apoferritin, the C-terminus of
peptide was made of cysteine with affinity to gold. The surface of
apoferritin with encapsulated doxorubicin (APODOX) was coated
either with gold nanoparticles (APODOX-Nano) or gold(III) chloride
hydrate reduced with sodium borohydride (APODOX-HAu). The
reduction with sodium borohydride caused a loss of doxorubicin
fluorescent properties and probably accompanied with the loss of its
biological activity. Fluorescent properties of APODOX-Nano were
similar to the unmodified APODOX; therefore it was more suited for
the intended use. To evaluate the specificity of apoferritin modified
with antibodies, ELISA-like method was used with the surface of
microtitration plate wells coated by the antigen (goat anti-human IgG
antibodies). To these wells, the nanocarrier was applied. APODOX
without the modification showed 5× lower affinity to the antigen than
APODOX-Nano modified gold and targeting antibodies (human IgG
antibodies).
Abstract: Roles of the vegetation to mitigate the erosion of the
stream bed or to facilitate the deposition of the fine sediments by the
species of the aquatic plants were presented. Field investigation on the
estimation of the change of the bed level and the estimation of the flow
characteristics were performed. The results showed that Phragmites
japonica has the mitigation function of 0.3m-0.4m of the erosion in the
range of higher than 1.0m/s of flow velocity at the vegetated region.
Phragmites communis has the mitigation function of 0.2m-0.3m of the
erosion in the range of higher than 0.7m/s of flow velocity at the
vegetated region. Salix gracilistyla has greater role than Phragmites
japonica and Phragmites communis to sustain the stable channel. It
has the mitigation function of 0.4m-0.5m of the erosion in the range of
higher than 1.4m/s of flow velocity. Miscanthus sacchariflorus has a
weak role compared with that of Phragmites japonica and Salix
gracilistyla, but it has still function for sustaining the stable bed. From
these results, the vegetation has effective roles to mitigate the erosion
or to facilitate the deposition of the stream bed.
Abstract: Microstructural and electrical properties of
Cu-chromium alloy (Cu-Cr) dispersed with vapor-grown carbon fiber
(VGCF) prepared by powder metallurgy (P/M) process have been
investigated. Cu-0.7 mass% Cr pre-alloyed powder (Cu-Cr) made by
water atomization process was used as raw materials, which contained
solid solute Cr elements in Cu matrix. The alloy powder coated with
un-bundled VGCF by using oil coating process was consolidated at
1223 K in vacuum by spark plasma sintering, and then extruded at
1073 K. The extruded Cu-Cr alloy (monolithic alloy) had 209.3 MPa
YS and 80.4 IACS% conductivity. The extruded Cu-Cr with 0.1
mass% VGCF composites revealed a small decrease of YS compared
to the monolithic Cu-Cr alloy. On the other hand, the composite had a
higher electrical conductivity than that of the monolithic alloy. For
example, Cu-Cr with 0.1 mass% VGCF composite sintered for 5 h
showed 182.7 MPa YS and 89.7 IACS% conductivity. In the case of
Cu-Cr with VGCFs composites, the Cr concentration was observed
around VGCF by SEM-EDS analysis, where Cr23C6 compounds were
detected by TEM observation. The amount of Cr solid solution in the
matrix of the Cu-Cr composites alloy was about 50% compared to the
monolithic Cu-Cr sintered alloy, and resulted in the remarkable
increment of the electrical conductivity.
Abstract: Non-crimp 3D orthogonal fabric composite is one of
the textile-based composite materials that are rapidly developing
light-weight engineering materials. The present paper focuses on
geometric and micromechanical modeling of non-crimp 3D
orthogonal carbon fabric and composites reinforced with it for
aerospace applications. In this research meso-finite element (FE)
modeling employs for stress analysis in different load conditions.
Since mechanical testing of expensive textile carbon composites with
specific application isn't affordable, simulation composite in a virtual
environment is a helpful way to investigate its mechanical properties
in different conditions.
Abstract: Many water desalination technologies have been
developed but in general they are energy intensive and have high cost
and adverse environmental impact. Recently, adsorption technology
for water desalination has been investigated showing the potential of
using low temperature waste heat (50-85oC) thus reducing energy
consumption and CO2 emissions. This work mathematically
compares the performance of an adsorption cycle that produces two
useful effects namely, fresh water and cooling using two different
adsorbents, silica-gel and an advanced zeolite material AQSOA-ZO2,
produced by Mitsubishi plastics. It was found that at low chilled
water temperatures, typically below 20oC, the AQSOA-Z02 is more
efficient than silica-gel as the cycle can produce 5.8 m3 of fresh water
per day and 50.1 Rton of cooling per tonne of AQSOA-ZO2. Above
20oC silica-gel is still better as the cycle production reaches 8.4 m3
per day and 62.4 Rton per tonne of silica-gel. These results show the
potential of using the AQSOA-Z02 at low chilled water temperature
for water desalination and cooling applications.