Abstract: In-vitro mouse co-culture of E14 embryonic stem cells
(ESCs) and OP9 stromal cells can recapitulate the earliest stages of
haematopoietic development, not accessible in human embryos,
supporting both haemogenic precursors and their primitive
haematopoietic progeny. 1α, 25-Dihydroxy-vitamin D3 (VD3) has
been demonstrated to be a powerful differentiation inducer for a wide
variety of neoplastic cells, and could enhance early differentiation of
ESCs into blood cells in E14/OP9 co-culture. This study aims to
ascertain whether VD3 is key in promoting differentiation and
suppressing proliferation, by separately investigating the effects of
VD3 on the proliferation phase of the E14 cell line and on stromal
OP9 cells.The results showed that VD3 inhibited the proliferation of
the cells in a dose-dependent manner, quantitatively by decreased cell
number, and qualitatively by alkaline-phosphatase staining that
revealed significant differences between VD3-treated and untreated
cells, characterised by decreased enzyme expression (colourless
cells). Propidium-iodide cell-cycle analyses showed no significant
percentage change in VD3-treated E14 and OP9 cells within their G
and S-phases, compared to the untreated controls, despite the
increased percentage of G-phase compared to the S-phase in a dosedependent
manner. These results with E14 and OP9 cells indicate that
adequate VD3 concentration enhances cellular differentiation and
inhibits proliferation. The results also suggest that if E14 and OP9
cells were co-cultured andVD3-treated, there would be furtherenhanced
differentiation of ESCs into blood cells.
Abstract: Space exploration is a highly visible endeavour of
humankind to seek profound answers to questions about the origins
of our solar system, whether life exists beyond Earth, and how we
could live on other worlds. Different platforms have been utilized in
planetary exploration missions, such as orbiters, landers, rovers, and
penetrators.
Having low mass, good mechanical contact with the surface,
ability to acquire high quality scientific subsurface data, and ability to
be deployed in areas that may not be conducive to landers or rovers,
Penetrators provide an alternative and complimentary solution that
makes possible scientific exploration of hardly accessible sites (icy
areas, gully sites, highlands etc.).
The Canadian Space Agency (CSA) has put space exploration as
one of the pillars of its space program, and established ExCo program
to prepare Canada for future international planetary exploration.
ExCo sets surface mobility as its focus and priority, and invests
mainly in the development of rovers because of Canada's niche space
robotics technology. Meanwhile, CSA is also investigating how
micro-penetrators can help Canada to fulfill its scientific objectives
for planetary exploration.
This paper presents a review of the micro-penetrator technologies,
past missions, and lessons learned. It gives a detailed analysis of the
technical challenges of micro-penetrators, such as high impact
survivability, high precision guidance navigation and control, thermal
protection, communications, and etc. Then, a Canadian perspective of
a possible micro-penetrator mission is given, including Canadian
scientific objectives and priorities, potential instruments, and flight
opportunities.
Abstract: This paper presents a method for determining the
uniaxial tensile properties such as Young-s modulus, yield strength
and the flow behaviour of a material in a virtually non-destructive
manner. To achieve this, a new dumb-bell shaped miniature
specimen has been designed. This helps in avoiding the removal of
large size material samples from the in-service component for the
evaluation of current material properties. The proposed miniature
specimen has an advantage in finite element modelling with respect
to computational time and memory space. Test fixtures have been
developed to enable the tension tests on the miniature specimen in a
testing machine. The studies have been conducted in a chromium
(H11) steel and an aluminum alloy (AR66). The output from the
miniature test viz. load-elongation diagram is obtained and the finite
element simulation of the test is carried out using a 2D plane stress
analysis. The results are compared with the experimental results. It is
observed that the results from the finite element simulation
corroborate well with the miniature test results. The approach seems
to have potential to predict the mechanical properties of the
materials, which could be used in remaining life estimation of the
various in-service structures.
Abstract: This paper describes new computer vision algorithms
that have been developed to track moving objects as part of a
long-term study into the design of (semi-)autonomous vehicles. We
present the results of a study to exploit variable kernels for tracking in
video sequences. The basis of our work is the mean shift
object-tracking algorithm; for a moving target, it is usual to define a
rectangular target window in an initial frame, and then process the data
within that window to separate the tracked object from the background
by the mean shift segmentation algorithm. Rather than use the
standard, Epanechnikov kernel, we have used a kernel weighted by the
Chamfer distance transform to improve the accuracy of target
representation and localization, minimising the distance between the
two distributions in RGB color space using the Bhattacharyya
coefficient. Experimental results show the improved tracking
capability and versatility of the algorithm in comparison with results
using the standard kernel. These algorithms are incorporated as part of
a robot test-bed architecture which has been used to demonstrate their
effectiveness.
Abstract: Model-based approaches have been applied successfully
to a wide range of tasks such as specification, simulation, testing, and
diagnosis. But one bottleneck often prevents the introduction of these
ideas: Manual modeling is a non-trivial, time-consuming task.
Automatically deriving models by observing and analyzing running
systems is one possible way to amend this bottleneck. To
derive a model automatically, some a-priori knowledge about the
model structure–i.e. about the system–must exist. Such a model
formalism would be used as follows: (i) By observing the network
traffic, a model of the long-term system behavior could be generated
automatically, (ii) Test vectors can be generated from the model,
(iii) While the system is running, the model could be used to diagnose
non-normal system behavior.
The main contribution of this paper is the introduction of a model
formalism called 'probabilistic regression automaton' suitable for the
tasks mentioned above.
Abstract: The presence of cold air with the convergent
topography of the Lut valley over the valley-s sloping terrain can
generate Low Level Jets (LLJ). Moreover, the valley-parallel
pressure gradients and northerly LLJ are produced as a result of the
large-scale processes. In the numerical study the regional MM5
model was run leading to achieve an appropriate dynamical analysis
of flows in the region for summer and winter. The results of this
study show the presence of summer synoptical systems cause the
formation of north-south pressure gradients in the valley which could
be led to the blowing of winds with the velocity more than 14 ms-1
and vulnerable dust and wind storms lasting more than 120 days.
Whereas the presence of cold air masses in the region in winter,
cause the average speed of LLJs decrease. In this time downslope
flows are noticeable in creating the night LLJs.
Abstract: Bioinformatics and computational biology involve
the use of techniques including applied mathematics,
informatics, statistics, computer science, artificial intelligence,
chemistry, and biochemistry to solve biological problems
usually on the molecular level. Research in computational
biology often overlaps with systems biology. Major research
efforts in the field include sequence alignment, gene finding,
genome assembly, protein structure alignment, protein structure
prediction, prediction of gene expression and proteinprotein
interactions, and the modeling of evolution. Various
global rearrangements of permutations, such as reversals and
transpositions,have recently become of interest because of their
applications in computational molecular biology. A reversal is
an operation that reverses the order of a substring of a permutation.
A transposition is an operation that swaps two adjacent
substrings of a permutation. The problem of determining the
smallest number of reversals required to transform a given
permutation into the identity permutation is called sorting by
reversals. Similar problems can be defined for transpositions
and other global rearrangements. In this work we perform a
study about some genome rearrangement primitives. We show
how a genome is modelled by a permutation, introduce some
of the existing primitives and the lower and upper bounds
on them. We then provide a comparison of the introduced
primitives.
Abstract: This paper explores the knowledge and attitude of
women and men in decision making on pap smear screening. This
qualitative study recruited 52 respondents with 44 women and 8 men,
using the purposive sampling with snowballing technique through indepth
interviews. This study demonstrates several key findings:
Female respondents have better knowledge compared to male. Most
of the women perceived that pap smear screening is beneficial and
important, but to proceed with the test is still doubtful. Male
respondents were supportive in terms of sending their spouses to the
health facilities or give more freedom to their wives to choose and
making decision on their own health due to prominent reason that
women know best on their own health. It is expected that the results
from this study will provide useful guideline for healthcare providers
to prepare any action/intervention to provide an extensive education
to improve people-s knowledge and attitude towards pap smear.
Abstract: Support vector machines (SVMs) have shown
superior performance compared to other machine learning techniques,
especially in classification problems. Yet one limitation of SVMs is
the lack of an explanation capability which is crucial in some
applications, e.g. in the medical and security domains. In this paper, a
novel approach for eclectic rule-extraction from support vector
machines is presented. This approach utilizes the knowledge acquired
by the SVM and represented in its support vectors as well as the
parameters associated with them. The approach includes three stages;
training, propositional rule-extraction and rule quality evaluation.
Results from four different experiments have demonstrated the value
of the approach for extracting comprehensible rules of high accuracy
and fidelity.
Abstract: The Portuguese Constitution, in article 22, instituted
the general principle of tort liability of the State and other public law
entities.
Consequently, ordinary legislation established the tort liability of
the State into the Portuguese Legal Order, by means of Decree-Law
48051, of 1967.
This decree, which was criticised extensively, was amended by
virtue of Law 67/2007, of 31st December, establishing the regime for
tort liability arising from losses caused by third parties, due to the
acts of public management in relation to all the functions of the State,
i.e. i) administrative, ii) legislative, and iii) jurisdictional.
Abstract: In this study, the contact problem of a layered composite which consists of two materials with different elastic constants and heights resting on two rigid flat supports with sharp edges is considered. The effect of gravity is neglected. While friction between the layers is taken into account, it is assumed that there is no friction between the supports and the layered composite so that only compressive tractions can be transmitted across the interface. The layered composite is subjected to a uniform clamping pressure over a finite portion of its top surface. The problem is reduced to a singular integral equation in which the contact pressure is the unknown function. The singular integral equation is evaluated numerically and the results for various dimensionless quantities are presented in graphical forms.
Abstract: A generalized Digital Modulation Identification algorithm for adaptive demodulator has been developed and presented in this paper. The algorithm developed is verified using wavelet Transform and histogram computation to identify QPSK and QAM with GMSK and M–ary FSK modulations. It has been found that the histogram peaks simplifies the procedure for identification. The simulated results show that the correct modulation identification is possible to a lower bound of 5 dB and 12 dB for GMSK and QPSK respectively. When SNR is above 5 dB the throughput of the proposed algorithm is more than 97.8%. The receiver operating characteristics (ROC) has been computed to measure the performance of the proposed algorithm and the analysis shows that the probability of detection (Pd) drops rapidly when SNR is 5 dB and probability of false alarm (Pf) is smaller than 0.3. The performance of the proposed algorithm has been compared with existing methods and found it will identify all digital modulation schemes with low SNR.
Abstract: In this paper, a multi-agent robot system is presented. The system consists of four robots. The developed robots are able to automatically enter and patrol a harmful environment, such as the building infected with virus or the factory with leaking hazardous gas. Further, every robot is able to perform obstacle avoidance and search for the victims. Several operation modes are designed: remote control, obstacle avoidance, automatic searching, and so on.
Abstract: In this paper, all-optical signal processors that perform
both microwave mixing and bandpass filtering in a radio-over-fiber
(RoF) link are presented. The key device is a Mach-Zehnder
modulator (MZM) which performs all-optical microwave mixing. An
up-converted microwave signal is obtained and other unwanted
frequency components are suppressed at the end of the fiber span.
Abstract: An integrated Artificial Neural Network- Particle Swarm Optimization (PSO) is presented for analyzing global electricity consumption. To aim this purpose, following steps are done: STEP 1: in the first step, PSO is applied in order to determine world-s oil, natural gas, coal and primary energy demand equations based on socio-economic indicators. World-s population, Gross domestic product (GDP), oil trade movement and natural gas trade movement are used as socio-economic indicators in this study. For each socio-economic indicator, a feed-forward back propagation artificial neural network is trained and projected for future time domain. STEP 2: in the second step, global electricity consumption is projected based on the oil, natural gas, coal and primary energy consumption using PSO. global electricity consumption is forecasted up to year 2040.
Abstract: Video Mosaicing is the stitching of selected frames of
a video by estimating the camera motion between the frames and
thereby registering successive frames of the video to arrive at the
mosaic. Different techniques have been proposed in the literature for
video mosaicing. Despite of the large number of papers dealing with
techniques to generate mosaic, only a few authors have investigated
conditions under which these techniques generate good estimate of
motion parameters. In this paper, these techniques are studied under
different videos, and the reasons for failures are found. We propose
algorithms with incorporation of outlier removal algorithms for better
estimation of motion parameters.
Abstract: In this paper we illuminate a frequency domain based
classification method for video scenes. Videos from certain topical
areas often contain activities with repeating movements. Sports
videos, home improvement videos, or videos showing mechanical
motion are some example areas. Assessing main and side frequencies
of each repeating movement gives rise to the motion type. We
obtain the frequency domain by transforming spatio-temporal motion
trajectories. Further on we explain how to compute frequency features
for video clips and how to use them for classifying. The focus of
the experimental phase is on transforms utilized for our system.
By comparing various transforms, experiments show the optimal
transform for a motion frequency based approach.
Abstract: Ethanol has been known for a long time, being
perhaps the oldest product obtained through traditional biotechnology
fermentation. Agriculture waste as substrate in fermentation is vastly
discussed as alternative to replace edible food and utilization of
organic material. Pineapple peel, highly potential source as substrate
is a by-product of the pineapple processing industry. Bio-ethanol
from pineapple (Ananas comosus) peel extract was carried out by
controlling fermentation without any treatment. Saccharomyces
ellipsoides was used as inoculum in this fermentation process as it is
naturally found at the pineapple skin. In this study, the capability of
Response Surface Methodology (RSM) for optimization of ethanol
production from pineapple peel extract using Saccharomyces
ellipsoideus in batch fermentation process was investigated. Effect of
five test variables in a defined range of inoculum concentration 6-
14% (v/v), pH (4.0-6.0), sugar concentration (14-22°Brix),
temperature (24-32°C) and time of incubation (30-54 hrs) on the
ethanol production were evaluated. Data obtained from experiment
were analyzed with RSM of MINITAB Software (Version 15)
whereby optimum ethanol concentration of 8.637% (v/v) was
determined. The optimum condition of 14% (v/v) inoculum
concentration, pH 6, 22°Brix, 26°C and 30hours of incubation. The
significant regression equation or model at the 5% level with
correlation value of 99.96% was also obtained.
Abstract: The article investigates how 14- to 15- year-olds build informal conceptions of inferential statistics as they engage in a modelling process and build their own computer simulations with dynamic statistical software. This study proposes four primary phases of informal inferential reasoning for the students in the statistical modeling and simulation process. Findings show shifts in the conceptual structures across the four phases and point to the potential of all of these phases for fostering the development of students- robust knowledge of the logic of inference when using computer based simulations to model and investigate statistical questions.
Abstract: In this paper we examine the use of global texture analysis based approaches for the purpose of Persian font recognition in machine-printed document images. Most existing methods for font recognition make use of local typographical features and connected component analysis. However derivation of such features is not an easy task. Gabor filters are appropriate tools for texture analysis and are motivated by human visual system. Here we consider document images as textures and use Gabor filter responses for identifying the fonts. The method is content independent and involves no local feature analysis. Two different classifiers Weighted Euclidean Distance and SVM are used for the purpose of classification. Experiments on seven different type faces and four font styles show average accuracy of 85% with WED and 82% with SVM classifier over typefaces