Abstract: This study presents design of a carbon silicon electrode
for iontophorsis treatment towards alopecia. The alopecia is a medical
description means loss of hair from the body. For solving this problem,
the drug need to be delivered into the scalp, therefore, the
iontophoresis was chosen to use in this treatment. However, almost
common electrodes of iontophoresis device are made with metal
material, the electrodes could give patients hurt when they using it, and
it is hard to avoid the hair for attaching the hair. For this reason, an
electrode is made with silicon material to decrease the hurt from the
electrodes, and the carbon material is mixed in it for increasing
conductance. The several cones with stainless material on the
electrode make the electrode is able to void hair to attach the affected
part. According to the results of a vivo-experiment, the carbon silicon
electrode showed a good performance and in treatment comfortably.
Abstract: In the 1980s, companies began to feel the effect of three major influences on their product development: newer and innovative technologies, increasing product complexity and larger organizations. And therefore companies were forced to look for new product development methods. This paper tries to focus on the two of new product development methods (DFM and CE). The aim of this paper is to see and analyze different product development methods specifically on Design for Manufacturability and Concurrent Engineering. Companies can achieve and be benefited by minimizing product life cycle, cost and meeting delivery schedule. This paper also presents simplified models that can be modified and used by different companies based on the companies- objective and requirements. Methodologies that are followed to do this research are case studies. Two companies were taken and analysed on the product development process. Historical data, interview were conducted on these companies in addition to that, Survey of literatures and previous research works on similar topics has been done during this research. This paper also tries to show the implementation cost benefit analysis and tries to calculate the implementation time. From this research, it has been found that the two companies did not achieve the delivery time to the customer. Some of most frequently coming products are analyzed and 50% to 80 % of their products are not delivered on time to the customers. The companies are following the traditional way of product development that is sequentially design and production method, which highly affect time to market. In the case study it is found that by implementing these new methods and by forming multi disciplinary team in designing and quality inspection; the company can reduce the workflow steps from 40 to 30.
Abstract: The Mobile IP Standard has been developed to support mobility over the Internet. This standard contains several drawbacks as in the cases where packets are routed via sub-optimal paths and significant amount of signaling messages is generated due to the home registration procedure which keeps the network aware of the current location of the mobile nodes. Recently, a dynamic hierarchical mobility management strategy for mobile IP networks (DHMIP) has been proposed to reduce home registrations costs. However, this strategy induces a packet delivery delay and increases the risk of packet loss. In this paper, we propose an enhanced version of the dynamic hierarchical strategy that reduces the packet delivery delay and minimizes the risk of packet loss. Preliminary results obtained from simulations are promising. They show that the enhanced version outperforms the original dynamic hierarchical mobility management strategy version.
Abstract: While to minimize the overall project cost is always
one of the objectives of construction managers, to obtain the
maximum economic return is definitely one the ultimate goals of the
project investors. As there is a trade-off relationship between the
project time and cost, and the project delivery time directly affects the
timing of economic recovery of an investment project, to provide a
method that can quantify the relationship between the project delivery
time and cost, and identify the optimal delivery time to maximize
economic return has always been the focus of researchers and
industrial practitioners. Using genetic algorithms, this study
introduces an optimization model that can quantify the relationship
between the project delivery time and cost and furthermore, determine
the optimal delivery time to maximize the economic return of the
project. The results provide objective quantification for accurately
evaluating the project delivery time and cost, and facilitate the
analysis of the economic return of a project.
Abstract: Total weighted tardiness is a measure of customer
satisfaction. Minimizing it represents satisfying the general
requirement of on-time delivery. In this research, we consider an ant
colony optimization (ACO) algorithm to solve the problem of
scheduling unrelated parallel machines to minimize total weighted
tardiness. The problem is NP-hard in the strong sense. Computational
results show that the proposed ACO algorithm is giving promising
results compared to other existing algorithms.
Abstract: A new and cost effective RP-HPLC method was
developed and validated for simultaneous analysis of non steroidal
anti inflammatory dugs Diclofenac sodium (DFS), Flurbiprofen
(FLP) and an opioid analgesic Tramadol (TMD) in advanced drug
delivery systems (Liposome and Microcapsules), marketed brands
and human plasma. Isocratic system was employed for the flow of
mobile phase consisting of 10 mM sodium dihydrogen phosphate
buffer and acetonitrile in molar ratio of 67: 33 with adjusted pH of
3.2. The stationary phase was hypersil ODS column (C18, 250×4.6
mm i.d., 5 μm) with controlled temperature of 30 C°. DFS in
liposomes, microcapsules and marketed drug products was
determined in range of 99.76-99.84%. FLP and TMD in
microcapsules and brands formulation were 99.78 - 99.94 % and
99.80 - 99.82 %, respectively. Single step liquid-liquid extraction
procedure using combination of acetonitrile and trichloroacetic acid
(TCA) as protein precipitating agent was employed. The detection
limits (at S/N ratio 3) of quality control solutions and plasma samples
were 10, 20, and 20 ng/ml for DFS, FLP and TMD, respectively.
The Assay was acceptable in linear dynamic range. All other
validation parameters were found in limits of FDA and ICH method
validation guidelines. The proposed method is sensitive, accurate and
precise and could be applicable for routine analysis in
pharmaceutical industry as well as in human plasma samples for
bioequivalence and pharmacokinetics studies.
Abstract: The radius-of-curvature (ROC) defines the degree of
curvature along the centerline of a roadway whereby a travelling
vehicle must follow. Roadway designs must encompass ROC in
mitigating the cost of earthwork associated with construction while
also allowing vehicles to travel at maximum allowable design speeds.
Thus, a road will tend to follow natural topography where possible,
but curvature must also be optimized to permit fast, but safe vehicle
speeds. The more severe the curvature of the road, the slower the
permissible vehicle speed. For route planning, whether for urban
settings, emergency operations, or even parcel delivery, ROC is a
necessary attribute of road arcs for computing travel time.
It is extremely rare for a geo-spatial database to contain ROC. This
paper will present a procedure and mathematical algorithm to
calculate and assign ROC to a segment pair and/or polyline.
Abstract: Nano fibers produced by electrospinning are of industrial and scientific attention due to their special characteristics such as long length, small diameter and high surface area. Applications of electrospun structures in nanotechnology are included tissue scaffolds, fibers for drug delivery, composite reinforcement, chemical sensing, enzyme immobilization, membrane-based filtration, protective clothing, catalysis, solar cells, electronic devices and others. Many polymer and ceramic precursor nano fibers have been successfully electrospun with diameters in the range from 1 nm to several microns. The process is complex so that fiber diameter is influenced by various material, design and operating parameters. The objective of this work is to apply genetic algorithm on the parameters of electrospinning which have the most significant effect on the nano fiber diameter to determine the optimum parameter values before doing experimental set up. Effective factors including initial polymer concentration, initial jet radius, electrical potential, relaxation time, initial elongation, viscosity and distance between nozzle and collector are considered to determine finest diameter which is selected by user.
Abstract: This paper presents a case study that uses processoriented
simulation to identify bottlenecks in the service delivery
system in an emergency department of a hospital in the United Arab
Emirates. Using results of the simulation, response surface models
were developed to explain patient waiting time and the total time
patients spend in the hospital system. Results of the study could be
used as a service improvement tool to help hospital management in
improving patient throughput and service quality in the hospital
system.
Abstract: The purpose of this work was to inspect the potential
of vincristine-dextran complex loaded solid lipid nanoparticles for
drug delivery to the brain.
The nanoparticles were stained with a fluorescence dye and their
plasma pharmacokinetic and brain concentrations were investigated
following injection to rats.
The result revealed a significant improvement in the plasma
concentration profile of the SLN injected animals as well as a sharp
increased concentration in the brains.
Abstract: This article demonstrated development of
controlled release system of an NSAID drug, Diclofenac
sodium employing different ratios of Ethyl cellulose.
Diclofenac sodium and ethyl cellulose in different proportions
were processed by microencapsulation based on phase
separation technique to formulate microcapsules. The
prepared microcapsules were then compressed into tablets to
obtain controlled release oral formulations. In-vitro evaluation
was performed by dissolution test of each preparation was
conducted in 900 ml of phosphate buffer solution of pH 7.2
maintained at 37 ± 0.5 °C and stirred at 50 rpm. At predetermined
time intervals (0, 0.5, 1.0, 1.5, 2, 3, 4, 6, 8, 10, 12,
16, 20 and 24 hrs). The drug concentration in the collected
samples was determined by UV spectrophotometer at 276 nm.
The physical characteristics of diclofenac sodium
microcapsules were according to accepted range. These were
off-white, free flowing and spherical in shape. The release
profile of diclofenac sodium from microcapsules was found to
be directly proportional to the proportion of ethylcellulose and
coat thickness. The in-vitro release pattern showed that with
ratio of 1:1 and 1:2 (drug: polymer), the percentage release of
drug at first hour was 16.91 and 11.52 %, respectively as
compared to 1:3 which is only 6.87 % with in this time. The
release mechanism followed higuchi model for its release
pattern. Tablet Formulation (F2) of present study was found
comparable in release profile the marketed brand Phlogin-SR,
microcapsules showed an extended release beyond 24 h.
Further, a good correlation was found between drug release
and proportion of ethylcellulose in the microcapsules.
Microencapsulation based on coacervation found as good
technique to control release of diclofenac sodium for making
the controlled release formulations.
Abstract: Problem-based learning (PBL) is one of the student
centered approaches and has been considered by a number of higher
educational institutions in many parts of the world as a method of
delivery. This paper presents a creative thinking approach for
implementing Problem-based Learning in Mechanics of Structure
within a Malaysian Polytechnics environment. In the learning
process, students learn how to analyze the problem given among the
students and sharing classroom knowledge into practice. Further,
through this course-s emphasis on problem-based learning, students
acquire creative thinking skills and professional skills as they tackle
complex, interdisciplinary and real-situation problems. Once the
creative ideas are generated, there are useful additional techniques
for tender ideas that will grow into a productive concept or solution.
The combination of creative skills and technical abilities will enable
the students to be ready to “hit-the-ground-running" and produce in
industry when they graduate.
Abstract: Solar power plants(SPPs) have shown a lot of good outcomes
in providing a various functions depending on industrial expectations by
deploying ad-hoc networking with helps of light loaded and battery powered
sensor nodes. In particular, it is strongly requested to develop an algorithm to
deriver the sensing data from the end node of solar power plants to the sink node
on time. In this paper, based on the above observation we have proposed an
IEEE802.15.4 based self routing scheme for solar power plants. The proposed
beacon based priority routing Algorithm (BPRA) scheme utilizes beacon
periods in sending message with embedding the high priority data and thus
provides high quality of service(QoS) in the given criteria. The performance
measures are the packet Throughput, delivery, latency, total energy
consumption. Simulation results under TinyOS Simulator(TOSSIM) have
shown the proposed scheme outcome the conventional Ad hoc On-Demand
Distance Vector(AODV) Routing in solar power plants.
Abstract: Requirements management is critical to software
delivery success and project lifecycle. Requirements management
and their traceability provide assistance for many software
engineering activities like impact analysis, coverage analysis,
requirements validation and regression testing. In addition
requirements traceability is the recognized component of many
software process improvement initiatives. Requirements traceability
also helps to control and manage evolution of a software system.
This paper aims to provide an evaluation of current requirements
management and traceability tools. Management and test managers
require an appropriate tool for the software under test. We hope,
evaluation identified here will help to select the efficient and
effective tool.
Abstract: Mobile ad hoc network is a collection of mobile
nodes communicating through wireless channels without any existing
network infrastructure or centralized administration. Because of the
limited transmission range of wireless network interfaces, multiple
"hops" may be needed to exchange data across the network. In order
to facilitate communication within the network, a routing protocol is
used to discover routes between nodes. The primary goal of such an
ad hoc network routing protocol is correct and efficient route
establishment between a pair of nodes so that messages may be
delivered in a timely manner. Route construction should be done
with a minimum of overhead and bandwidth consumption. This paper
examines two routing protocols for mobile ad hoc networks– the
Destination Sequenced Distance Vector (DSDV), the table- driven
protocol and the Ad hoc On- Demand Distance Vector routing
(AODV), an On –Demand protocol and evaluates both protocols
based on packet delivery fraction, normalized routing load, average
delay and throughput while varying number of nodes, speed and
pause time.
Abstract: Two optimized strategies were successfully established
to develop biomolecule-based magnetic nanoassemblies.
Streptavidin-coated and amine-coated magnetic nanoparticles were
chosen as model scaffolds onto which double-stranded DNA and
human immunoglobulin G were specifically conjugated in succession,
using biotin-streptavidin interaction or covalent cross-linkers. The
success of this study opens the prospect of developing selective and
sensitive nanoparticle-based structures for diagnostics or drug
delivery.
Abstract: Due to the rise of aging population, effective utilization
of healthcare resources has become an important issue. With the
advance of ICT technology, the application of tele-healthcare service
has received more attention than ever. The main purpose of this
research is to investigate how to conduct innovative design for
tele-healthcare service based on user-s perspectives. First, the
healthcare service blueprint was used to describe the processes
of tele-healthcare service delivery, and then construct PZB service
quality gap model based on the literature and practitioners-
interviews. Next, TRIZ theory is applied to implement service
innovation. We found the proposed service innovation procedures can
effectively improve the quality of service design.
Abstract: Nowadays pharmaceutical care departments located in
hospitals are amongst the important pillars of the healthcare system.
The aim of this study was to evaluate quality of hospital drugstores
affiliated with Kermanshah University of Medical Sciences.
In this cross-sectional study a validated questionnaire was used.
The questionnaire was filled in by the one of the researchers in all
seventeen hospital drugstores located in the teaching and nonteaching
hospitals affiliated with Kermanshah University of Medical
Sciences. The results shows that in observed hospitals,24% of
pharmacy environments, 25% of pharmacy store and storage
conditions, 49% of storage procedure, 25% of ordering drugs and
supplies, 73% of receiving supplies (proper procedure are fallowed
for receiving supplies), 35% of receiving supplies (prompt action
taken if deterioration of drugs received is suspected), 23.35% of
drugs delivery to patients and finally 0% of stock cards are used for
proper inventory control have full compliance with standards.
Abstract: Customer-supplier collaboration enables firms to
achieve greater success than acting independently. Nevertheless, not
many firms have fully utilized the potential of collaboration. This
paper presents organizational and human related success factors for
collaboration in manufacturing supply chains in casting industry. Our
research approach was a case study including multiple cases. Data
was gathered by interviews and group discussions in two different
research projects. In the first research project we studied seven firms
and in the second five. It was found that the success factors are
interrelated, in other words, organizational and human factors
together enable success but not any of them alone. Some of the found
success factors are a culture of following agreements, and a speed of
informing the partner about changes affecting to the product or the
delivery chain.
Abstract: Does a communication modality matter in delivering e-learning information? With the recent growth of broadcasting systems, media technologies and e-learning contents, various systems with different communication modalities have been introduced. In accordance with these trends, this study examines the effects of the information delivery modality on psychology of students. Findings from an experiment indicated that the delivering information which includes a video modality elicited higher degrees of credibility, quality, representativeness of content, and perceived suitability for delivering information than those of auditory information. However, there is no difference between content liking and attitude. The Implications of the findings and the limitations are discussed.