Quantitative Analysis of Carcinoembryonic Antigen (CEA) Using Micromechanical Piezoresistive Cantilever

In this work, we have used arrays of micromechanical piezoresistive cantilever with different geometries to detect carcinoembryonic antigen (CEA), which is known as an important biomarker associated with various cancers such as colorectal, lung, breast, pancreatic, and bladder cancer. The sensing principle is based on the surface stress changes induced by antigen–antibody interaction on the microcantilevers surfaces. Different concentrations of CEA in a human serum albumin (HSA) solution were detected as a function of deflection of the beams. According to the experiments, it was revealed that microcantilevers have surface stress sensitivities in the order of 8 (mJ/m). This matter allows them to detect CEA concentrations as low as 3 ng/mL or 18 pM. This indicates the fact that the self-sensing microcantilevers approach is beneficial for pathological tests.

Soil Compaction in Tropical Organic Farming Systems and Its Impact on Natural Soil-Borne Disease Suppression: Challenges for Management

Organic farming systems still depend on intensive, mechanical soil tillage. Frequent passes by machinery traffic cause substantial soil compaction that threatens soil health. Adopting practices as reduced tillage and organic matter retention on the soil surface are considered effective ways to control soil compaction. In tropical regions, however, the acceleration of soil organic matter decomposition and soil carbon turnover on the topsoil layer is influenced more rapidly by the oscillation process of drying and wetting. It is hypothesized therefore, that rapid reduction in soil organic matter hastens the potential for compaction to occur in organic farming systems. Compaction changes soil physical properties and as a consequence it has been implicated as a causal agent in the inhibition of natural disease suppression in soils. Here we describe relationships between soil management in organic vegetable systems, soil compaction, and declining soil capacity to suppress pathogenic microorganisms.

Characterising the Effects of Sand Blasting on Formed Steel Samples

The present research study focuses on the investigation of the influence of sand blasting on formed mild steel samples. The investigation involved the examinations on the parent material and a sand blasted material. The results were compared to the mechanically formed materials (sand and non-sand blasted) as well as a laser formed material (sand and non-sand blasted). Each material was characterized for the grain sizes and hardness. The percentage change in the grain sizes was quantified and correlation to the microhardness values was established. The Ultimate Tensile Strength (UTS) of the materials was also quantified using the obtained hardness values. The investigations revealed that the sand blasting causes an increase in the Vickers microhardness values of all the materials which also led to an increase in the UTS. After the forming operation, the microstructure revealed elongated grains as compared to almost equiaxed obtained from the parent non-sand blasted materials.

A Model for Collaborative COTS Software Acquisition (COSA)

Acquiring commercial off-the-shelf (COTS) software applications is becoming routine in organizations. However, eliciting user requirements, finding the candidate COTS products and making the decision is a complex task, especially for SMEs who do not have the time and knowledge needed to do the task properly. The existing models intended to help the decision makers are originally designed for professional use. SMEs are obligated to rely on the software vendor’s ability to solve the problem with the systems provided.  In this paper, we develop a model for SMEs for the acquisition of Commercial Off-The-Shelf (COTS) software products. A leading idea of the model is that the ICT investment is basically a change initiative and therefore it should also be taken as a process of organizational learning. The model is designed bearing three objectives in mind: 1) business orientation, 2) agility, and 3) Learning and knowledge management orientation. The model can be applied to ICT investments in SMEs which have a professional team leader with basic business and IT knowledge.   

Implementing ALD in Product Development: The Effect of Geometrical Dimensions on Tubular Member Deformation

The product development process has undergone many changes concomitant with world progress in order to produce products that meet customer needs quickly and inexpensively. Analysis-Led Design (ALD) is one of the latest methods in the product development process. It focuses more on up-front engineering, a product quality optimization process that starts early in the conceptual design stage. Product development and manufacturing through ALD utilizes digital tools extensively for design, analysis and product optimization. This study uses computer-aided design (CAD) and finite element method (FEM) simulation to examine the modes of deformation of tubular members under axial loading. A multiple-combination impact absorption tubular member, referred to as a compress–expand member, is proposed as a substitute for the conventional thin-walled cylindrical tube to be used as a vehicle’s crash box. The study of deformation modes is crucial for evaluating the geometrical dimension limits by which a member can absorb energy efficiently.

Socio-Demographic Effects on Digital Libraries Preference and Use: A Case Study at Higher Learning Institutions

Explosion in information management and information system technology has brought dramatic changes in learning and library system environments. The use of academic digital libraries does witness the spectacular impact on academic societies’ way of performing their study in Malaysia, a country with a multi-racial people. This paper highlights a research on examining the socio-demographic differences on the preference and use of academic digital libraries as compared to physical libraries at higher learning institutions. Findings indicate that preference towards digital libraries differed between ethnicity, gender and university. However none of the socio-demographic factors is statistically significant in terms of the use of digital libraries.

Determination of Alkali Treatment Conditions Effects Which Influence the Variability of Kenaf Fiber Mean Cross Sectional Area

Fiber cross sectional area value is a crucial factor in determining the strength properties of natural fiber. Furthermore, unlike synthetic fiber, a diameter and cross sectional area of natural fiber has a large variation along and between the fibers. This study aims to determine the main and interaction effects of alkali treatment conditions which influence kenaf bast fiber mean cross sectional area. Three alkali treatment conditions at two different levels were selected. The conditions setting were alkali concentrations at 2 and 10 w/v %; fiber immersed temperature at room temperature and 1000C; and fiber immersed duration for 30 and 480 minutes. Untreated kenaf fiber was used as a control unit. Kenaf bast fiber bundle mounting tab was prepared according to ASTM C1557-03. Cross sectional area was measured using a Leica video analyzer. The study result showed that kenaf fiber bundle mean cross sectional area was reduced 6.77% to 29.88% after alkali treatment. From analysis of variance, it shows that interaction of alkali concentration and immersed time has a higher magnitude at 0.1619 compared to alkali concentration and immersed temperature interaction which was 0.0896. For the main effect, alkali concentration factor contributes to the higher magnitude at 0.1372 which indicated are decrease pattern of variability when the level was change from lower to higher level. Then, it was followed by immersed temperature at 0.1261 and immersed time at 0.0696 magnitudes.

Ethnic Andean Concepts of Health and Illness in the Post-Colombian World and Its Relevance Today

—‘MEDICINE’ is a new project funded under the EC Horizon 2020 Marie-Sklodowska Curie Actions, to determine concepts of health and healing from a culturally specific indigenous context, using a framework of interdisciplinary methods which integrates archaeological-historical, ethnographic and modern health sciences approaches. The study will generate new theoretical and methodological approaches to model how peoples survive and adapt their traditional belief systems in a context of alien cultural impacts. In the immediate wake of the conquest of Peru by invading Spanish armies and ideology, native Andeans responded by forming the Taki Onkoy millenarian movement, which rejected European philosophical and ontological teachings, claiming “you make us sick”. The study explores how people’s experience of their world and their health beliefs within it, is fundamentally shaped by their inherent beliefs about the nature of being and identity in relation to the wider cosmos. Cultural and health belief systems and related rituals or behaviors sustain a people’s sense of identity, wellbeing and integrity. In the event of dislocation and persecution these may change into devolved forms, which eventually inter-relate with ‘modern’ biomedical systems of health in as yet unidentified ways. The development of new conceptual frameworks that model this process will greatly expand our understanding of how people survive and adapt in response to cultural trauma. It will also demonstrate the continuing role, relevance and use of TM in present-day indigenous communities. Studies will first be made of relevant pre-Colombian material culture, and then of early colonial period ethnohistorical texts which document the health beliefs and ritual practices still employed by indigenous Andean societies at the advent of the 17th century Jesuit campaigns of persecution - ‘Extirpación de las Idolatrías’. Core beliefs drawn from these baseline studies will then be used to construct a questionnaire about current health beliefs and practices to be taken into the study population of indigenous Quechua peoples in the northern Andean region of Ecuador. Their current systems of knowledge and medicine have evolved within complex historical contexts of both the conquest by invading Inca armies in the late 15th century, followed a generation later by Spain, into new forms. A new model will be developed of contemporary  Andean concepts of health, illness and healing demonstrating  the way these have changed through time. With this, a ‘policy tool’ will be constructed as a bridhging facility into contemporary global scenarios relevant to other Indigenous, First Nations, and migrant peoples to provide a means through which their traditional health beliefs and current needs may be more appropriately understood and met. This paper presents findings from the first analytical phases of the work based upon the study of the literature and the archaeological records. The study offers a novel perspective and methods in the development policies sensitive to indigenous and minority people’s health needs.

Digital Privacy Legislation Awareness

Privacy is regarded as a fundamental human right and it is clear that the study of digital privacy is an important field. Digital privacy is influenced by new and constantly evolving technologies and this continuous change makes it hard to create legislation to protect people’s privacy from being exploited by misuse of these technologies. This study aims to benefit digital privacy legislation efforts by evaluating the awareness and perceived importance of digital privacy legislation among computer science students. The chosen fixed variables for the population are study year and gamer classification. The use of location based services in mobile applications and games are a concern for digital privacy. For this reason the study focused on computer science students as they have a high likelihood to use and develop this type of software. Surveys were used to evaluate awareness and perceived importance of digital privacy legislation. The results of the study show that privacy legislation and awareness of privacy legislation are important to people. The perception of the importance of privacy legislation increases with academic experience. Awareness of privacy legislation increases from non-gamers to pro gamers. 

The Effects of Weather Anomalies on the Quantitative and Qualitative Parameters of Maize Hybrids of Different Genetic Traits in Hungary

Hybrid selection and the application of hybrid specific production technologies are important in terms of the increase of the yield and crop safety of maize. The main explanation for this is climate change, since weather extremes are going on and seem to accelerate in Hungary too. The biological bases, the selection of appropriate hybrids will be of greater importance in the future. The issue of the adaptability of hybrids will be considerably appreciated. Its good agronomical traits and stress bearing against climatic factors and agrotechnical elements (e.g. different types of herbicides) will be important. There have been examples of 3-4 consecutive droughty years in the past decades, e.g. 1992-1993-1994 or 2009-2011-2012, which made the results of crop production critical. Irrigation cannot be the solution for the problem since currently only the 2% of the arable land is irrigated. Temperatures exceeding the multi-year average are characteristic mainly to the July and August in Hungary, which significantly increase the soil surface evaporation, thus further enhance water shortage. In terms of the yield and crop safety of maize, the weather of these two months is crucial, since the extreme high temperature in July decreases the viability of the pollen and the pistil of maize, decreases the extent of fertilization and makes grain-filling tardy. Consequently, yield and crop safety decrease.

Lime-Pozzolan Plasters with Enhanced Thermal Capacity

A new type of lightweight plaster with the thermal capacity enhanced by PCM (Phase Change Material) addition is analyzed. The basic physical characteristics, namely the bulk density, matrix density, total open porosity, and pore size distribution are measured at first. For description of mechanical properties, compressive strength measurements are done. The thermal properties are characterized by transient impulse techniques as well as by DSC analysis that enables determination of the specific heat capacity as a function of temperature. The resistivity against the liquid water ingress is described by water absorption coefficient measurement. The experimental results indicate a good capability of the designed plaster to moderate effectively the interior climate of buildings.

Education and Assessment of Civil Employees in e-Government: The Case of a Moodle Based Platform

One of the most important factors for the success of e-government is training and preparing the workforce of the public sector. As changes and innovation in the public sector progress at a very slow pace and more slowly than in the private sector, issues related to human resources require special care. This is because the workforce will eventually seize the opportunities of the technological solutions used in e-Government. Thus, the central administration should provide employees with continuous and focused training not only on new technologies but also on a wide range of subjects and also improve interdepartmental interaction. To achieve all this, new methods and training tools need to be implemented in addition to assessment of the employees. In this spirit, we propose the development of an educational platform with user personalization features. We propose the development of this platform using Moodle as the basic tool. Incorporating a personalization mechanism is very important since different employees have different backgrounds, education levels, computer skills, or different capability to develop further. Key features of the proposed platform include, besides typical e-learning tools, communities organized in order to exchange experiences and knowledge, groups of users based on certain criteria, automatic evaluation of users and potential self-education and self-assessment. In its fully developed form, this platform can be part of a more comprehensive knowledge management system for the public sector.

The Impact of Crop Rotation and N Fertilization on the Leaf Area Index, Leaf Disease and Yield of Winter Wheat

The research focused on the effects of previous cropping and fertilizers on the LAI, rhythm of the dry matter, leaf disease intensity and amount of yield. Long term field experiments’ results proved that the previous crop fundamentally determines size, rate and dynamics of the dry matter formation in the spring time vegetation period. The LAI index and crop results of winter wheat can be influenced mainly by raising the fertilizer amount. N fertilization has an outstanding role in the changes in leaf area index (LAI), weight of dry matter and yield of winter wheat. According to our results, the interaction effect of leaf area index, weight of dry matter and fertilization resulted in the maximum yield in biculture and triculture.

Effect of Different Tillage Systems on Soil Properties and Production on Wheat, Maize and Soybean Crop

Soil tillage systems can be able to influence soil compaction, water dynamics, soil temperature and crop yield. These processes can be expressed as changes of soil microbiological activity, soil respiration and sustainability of agriculture. Objectives of this study were: 1 - to assess the effects of tillage systems (Conventional System (CS), Minimum Tillage (MT), No-Tillage (NT)) on soil compaction, soil temperature, soil moisture and soil respiration and 2- to establish the effect of the changes on the production of wheat, maize and soybean. Five treatments were installed: CS-plough; MT-paraplow, chisel, rotary grape; NT-direct sowing. The study was conducted on an Argic-Stagnic Faeoziom. The MT and NT applications reduce or completely eliminate the soil mobilization, due to this; soil is compacted in the first year of application. The degree of compaction is directly related to soil type and its state of degradation. The state of soil compaction diminished over time, tending toward a specific type of soil density. Soil moisture was higher in NT and MT at the time of sowing and in the early stages of vegetation and differences diminished over time. Moisture determinations showed statistically significant differences. The MT and NT applications reduced the thermal amplitude in the first 15cm of soil depth and increased the soil temperature by 0.5-2.20C. Water dynamics and soil temperature showed no differences on the effect of crop yields. The determinations confirm the effect of soil tillage system on soil respiration; the daily average was lower at NT (315-1914 mmoli m-2s-1) and followed by MT (318-2395 mmoli m-2s-1) and is higher in the CS (321-2480 mmol m-2s-1). Comparing with CS, all the four conservation tillage measures decreased soil respiration, with the best effects of no-tillage. Although wheat production at MT and NT applications, had no significant differences soybean production was significantly affected from MT and NT applications. The differences in crop yields are recorded at maize and can be a direct consequence of loosening, mineralization and intensive mobilization of soil fertility.

A Review of the Theoretical Context of the Role of Innovation in Economic Development

It is the aim of this paper to place the role of innovation in economic development in its theoretical context through a literature review. The review compares classical economic theory and the neoclassical theories of “equilibrium in the markets” and “perfectly competitive markets” with the Schumpeterian theory. It was found that Schumpeter’s role in contributing towards economic development theories, and by creating awareness of the role of innovation in these theories is of immeasurable importance. His contribution led to a change in economic thinking, although this was only realized much later than when his theories were first published. The neo-Schumpeterian thinking expanded on the Schumpeterian theory by studying innovation within a system of interaction among different role players. Studies on innovation should be founded in the neo-Schumpeterian school of thought in order to accommodate the complexity of the innovation system concept.

Pulse Oximeter Concept for Vascular Occlusion Test

Microcirculatory dysfunction is very common in sepsis and may results in organ failure and increased risk of death. Analyzing oxygen utilization can potentially assess microcirculation function of an individual. In this study, a modified pulse oximeter is used to extract information signals due to absorption of red (R) and infrared (IR) light. IR and R signal are related to the overall blood volume and reduced hemoglobin, respectively. Differences between these two signals thus represent the amount of oxygenated hemoglobin. Avascular occlusion test has been conducted on healthy individuals to validate the pulse oximeter concept. In this test, both R and IR signals rapidly changed according to the occlusion process. The pulse oximeter concept presented is capable of extracting valuable information to assess microcirculation condition. Implementing this concept on ICU patients has the potential to aid sepsis diagnosis and provide more accurate tracking of patient state and sepsis status.

A Study on Changing of Energy-Saving Performance of GHP Air Conditioning System with Time-Series Variation

This paper deals the energy saving performance of GHP (Gas engine heat pump) air conditioning system has improved with time-series variation. There are two types of air conditioning systems, VRF (Variable refrigerant flow) and central cooling and heating system. VRF is classified as EHP (Electric driven heat pump) and GHP. EHP drives the compressor with electric motor. GHP drives the compressor with the gas engine. The electric consumption of GHP is less than one tenth of EHP does. In this study, the energy consumption data of GHP installed the junior high schools was collected. An annual and monthly energy consumption per rated thermal output power of each apparatus was calculated, and then their energy efficiency was analyzed. From these data, we investigated improvement of the energy saving of the GHP air conditioning system by the change in the generation.

Adaptive Dynamic Time Warping for Variable Structure Pattern Recognition

Pattern discovery from time series is of fundamental importance. Particularly, when information about the structure of a pattern is not complete, an algorithm to discover specific patterns or shapes automatically from the time series data is necessary. The dynamic time warping is a technique that allows local flexibility in aligning time series. Because of this, it is widely used in many fields such as science, medicine, industry, finance and others. However, a major problem of the dynamic time warping is that it is not able to work with structural changes of a pattern. This problem arises when the structure is influenced by noise, which is a common thing in practice for almost every application. This paper addresses this problem by means of developing a novel technique called adaptive dynamic time warping.

Influence of Overfeeding on Productive Performance Traits, Foie Gras Production, Blood Parameters, Internal Organs, Carcass Traits, and Mortality Rate in Two Breeds of Ducks

A total of 60 male mule ducks and 60 male Muscovy ducks were allotted into three groups (n = 20) to estimate the effects of overfeeding (two and four meals) versus ad libitum feeding on productive performance traits, foie gras production, internal organs, and blood parameters. The results show that force-feeding four meals significantly increased (P < 0.01) body weight, weight gain, and gain percentage compared to force-feeding two meals. Both force-feeding regimes (two or four meals) induced significantly higher body weight, weight gain, gain percentage, and absolute carcass weight than ad libitum feeding; however, carcass percentage was significantly higher in ad libitum feeding. Mule ducks had significantly higher weight gain and weight gain percentages than Muscovy ducks. Feed consumption per kilogram of foie gras and per kilogram weight gain was lower for the four-meal than for the two-meal forced feeding regime. Force-feeding four meals induced significantly higher liver weight and percentage (488.96 ± 25.78g, 7.82 ± 0.40%) than force-feeding two meals (381.98 ± 13.60g, 6.42 ± 0.21%). Moreover, feed conversion was significantly higher under forced feeding than under ad libitum feeding (77.65 ± 3.41g, 1.72 ± 0.05%; P < 0.01). Forced feeding (two or four meals) increased all organ weights (intestine, proventriculus, heart, spleen, and pancreas) over ad libitum feeding weights, except for the gizzard; however intestinal and abdominal fat values were higher for four-meal forced feeding than for two-meal forced feeding. Overfeeding did not change blood parameters significantly compared to ad libitum feeding; however, four-meal forced feeding improved the quality of foie gras since it significantly increased the percentage of grade A foie gras (62.5%) at the expense of grades B (33.33%) and C (4.17%) compared with the two-meal forced feeding. The mortality percentage among Muscovy ducks during the forced feeding period was 22.5%, compared to 0% in mule ducks. Liver weight was highly significantly correlated with life weight after overfeeding and certain blood plasma traits.

Integrated Simulation and Optimization for Carbon Capture and Storage System

CO2 capture and storage/sequestration (CCS) is a key technology for addressing the global warming issue. This paper proposes an integrated model for the whole chain of CCS, from a power plant to a reservoir. The integrated model is further utilized to determine optimal operating conditions and study responses to various changes in input variables.