Abstract: The ability to distinguish missense nucleotide
substitutions that contribute to harmful effect from those that do not
is a difficult problem usually accomplished through functional in
vivo analyses. In this study, instead current biochemical methods, the
effects of missense mutations upon protein structure and function
were assayed by means of computational methods and information
from the databases. For this order, the effects of new missense
mutations in exon 5 of PTEN gene upon protein structure and
function were examined. The gene coding for PTEN was identified
and localized on chromosome region 10q23.3 as the tumor
suppressor gene. The utilization of these methods were shown that
c.319G>A and c.341T>G missense mutations that were recognized in
patients with breast cancer and Cowden disease, could be pathogenic.
This method could be use for analysis of missense mutation in others
genes.
Abstract: In a world worried about water resources with the
shadow of drought and famine looming all around, the quality of
water is as important as its quantity. The source of all concerns is the
constant reduction of per capita quality water for different uses.
Iran With an average annual precipitation of 250 mm compared to
the 800 mm world average, Iran is considered a water scarce country
and the disparity in the rainfall distribution, the limitations of
renewable resources and the population concentration in the margins
of desert and water scarce areas have intensified the problem.
The shortage of per capita renewable freshwater and its poor
quality in large areas of the country, which have saline, brackish or
hard water resources, and the profusion of natural and artificial
pollutant have caused the deterioration of water quality.
Among methods of treatment and use of these waters one can refer
to the application of membrane technologies, which have come into
focus in recent years due to their great advantages. This process is
quite efficient in eliminating multi-capacity ions; and due to the
possibilities of production at different capacities, application as
treatment process in points of use, and the need for less energy in
comparison to Reverse Osmosis processes, it can revolutionize the
water and wastewater sector in years to come. The article studied the
different capacities of water resources in the Persian Gulf and Oman
Sea watershed basins, and processes the possibility of using
nanofiltration process to treat brackish and non-conventional waters
in these basins.
Abstract: Macrobenthos distribution along the coastal waters of
Penang National Park was studid to estimate the effect of different
environmental parameters at three stations, during six sampling
months, from June 2010 to April 2011. The aim of this survey was to
investigate different environment stress over soft bottom polychaete
community along Teluk Ketapang and Pantai Acheh (Penang
National Park) over a year period. Variations in the polychaete
community were evaluated using univariate and multivariate
methods. A total of 604 individuals were examined which was
grouped into 23 families. Family Nereidae was the most abundant
(22.68%), followed by Spionidae (22.02%), Hesionidae (12.58%),
Nephtylidae (9.27%) and Orbiniidae (8.61%). It is noticeable that
good results can only be obtained on the basis of good taxonomic
resolution. The maximum Shannon-Wiener diversity (H'=2.16) was
recorded at distance 200m and 1200m (August 2010) in Teluk
Ketapang and lowest value of diversity was found at distance 1200m
(December 2010) in Teluk Ketapang.
Abstract: Using a methodology grounded in business process
change theory, we investigate the critical success factors that affect
ERP implementation success in United States and India.
Specifically, we examine the ERP implementation at two case study
companies, one in each country. Our findings suggest that certain
factors that affect the success of ERP implementations are not
culturally bound, whereas some critical success factors depend on the
national culture of the country in which the system is being
implemented. We believe that the understanding of these critical
success factors will deepen the understanding of ERP
implementations and will help avoid implementation mistakes,
thereby increasing the rate of success in culturally different contexts.
Implications of the findings and future research directions for both
academicians and practitioners are also discussed.
Abstract: Testing accounts for the major percentage of technical
contribution in the software development process. Typically, it
consumes more than 50 percent of the total cost of developing a
piece of software. The selection of software tests is a very important
activity within this process to ensure the software reliability
requirements are met. Generally tests are run to achieve maximum
coverage of the software code and very little attention is given to the
achieved reliability of the software. Using an existing methodology,
this paper describes how to use Bayesian Belief Networks (BBNs) to
select unit tests based on their contribution to the reliability of the
module under consideration. In particular the work examines how the
approach can enhance test-first development by assessing the quality
of test suites resulting from this development methodology and
providing insight into additional tests that can significantly reduce
the achieved reliability. In this way the method can produce an
optimal selection of inputs and the order in which the tests are
executed to maximize the software reliability. To illustrate this
approach, a belief network is constructed for a modern software
system incorporating the expert opinion, expressed through
probabilities of the relative quality of the elements of the software,
and the potential effectiveness of the software tests. The steps
involved in constructing the Bayesian Network are explained as is a
method to allow for the test suite resulting from test-driven
development.
Abstract: Cancer becomes one of the leading cause of death in
many countries over the world. Fourier-transform infrared (FTIR)
spectra of human lung cancer cells (A549) treated with PMF (natural
product extracted from PM 701) for different time intervals were
examined. Second derivative and difference method were taken in
comparison studies. Cesium (Cs) and Rubidium (Rb) nanoparticles in
PMF were detected by Energy Dispersive X-ray attached to Scanning
Electron Microscope SEM-EDX. Characteristic changes in protein
secondary structure, lipid profile and changes in the intensities of
DNA bands were identified in treated A549 cells spectra. A
characteristic internucleosomal ladder of DNA fragmentation was
also observed after 30 min of treatment. Moreover, the pH values
were significantly increases upon treatment due to the presence of Cs
and Rb nanoparticles in the PMF fraction. These results support the
previous findings that PMF is selective anticancer agent and can
produce apoptosis to A549 cells.
Abstract: The past decade has witnessed a good opportunities
for city development schemes in UK. The government encouraged
restoration of city centers to comprise mixed use developments with
high density residential apartments. Investments in regeneration areas
were doing well according to the analyses of Property Databank
(IPD). However, more recent analysis by IPD has shown that since
2007, property in regeneration areas has been more vulnerable to the
market downturn than other types of investment property. The early
stages of a property market downturn may be felt most in
regeneration where funding, investor confidence and occupier
demand would dissipate because the sector was considered more
marginal or risky when development costs rise. Moreover, the Bank
of England survey shows that lenders have sequentially tightened the
availability of credit for commercial real estate since mid-2007. A
sharp reduction in the willingness of banks to lend on commercial
property was recorded. The credit crunch has already affected
commercial property but its impact has been particularly severe in
certain kinds of properties where residential developments are
extremely difficult, in particular city centre apartments and buy-to-let
markets. Commercial property – retail, industrial leisure and mixed
use were also pressed, in Birmingham; tens of mixed use plots were
built to replace old factories in the heart of the city. The purpose of
these developments was to enable young professionals to work and
live in same place. Thousands of people lost their jobs during the
recession, moreover lending was more difficult and the future of
many developments is unknown. The recession casts its shadow upon
the society due to cuts in public spending by government, Inflation,
rising tuition fees and high rise in unemployment generated anger and
hatred was spreading among youth causing vandalism and riots in
many cities. Recent riots targeted many mixed used development in
the UK where banks, shops, restaurants and big stores were robbed
and set into fire leaving residents with horror and shock. This paper
examines the impact of the recession and riots on mixed use
development in UK.
Abstract: Polyurethane foam (PUF) were prepared by
reacting polyols synthesized from soy-oil into mixture of 2,4-
Toluene diisocyanate (TDI) with 4,4--Methylene Diamine
Isocyanate (MDI) with ratio of 70:30. The polyols obtained
via esterification reaction were categorize into different
temperature of reaction and by used of varied concentration
of phosphoric acid catalyst. The purpose of catalysts is to
shifting selectivity to a desired and value added of product.
The effect of stoichiometric balance (molar ratio of
epoxide/ethylene glycol) to the concentration of the catalyst
on the final properties was evaluated.
Abstract: The influence of viscosity on droplet diameter for
water-in-crude oil (w/o) emulsion with two different ratios; 20-80 %
and 50-50 % w/o emulsion was examined in the Brookfield
Rotational Digital Rheometer. The emulsion was prepared with
sorbitan sesquiolate (Span 83) act as emulsifier at varied temperature
and stirring speed in rotation per minute (rpm). Results showed that
the viscosity of w/o emulsion was strongly augmented by increasing
volume of water and decreased the temperature. The changing of
viscosity also altered the droplet size distribution. Changing of
droplet diameter was depends on the viscosity and the behavior of
emulsion either Newtonian or non-Newtonian.
Abstract: The purpose of this study is to examine the self and
decision making levels of students receiving education in schools of
physical training and sports. The population of the study consisted
258 students, among which 152 were male and 106 were female
( X age=19,3713 + 1,6968), that received education in the schools of
physical education and sports of Selcuk University, Inonu University,
Gazi University and Karamanoglu Mehmetbey University. In order to
achieve the purpose of the study, the Melbourne Decision Making
Questionnary developed by Mann et al. (1998) [1] and adapted to
Turkish by Deniz (2004) [2] and the Self-Esteem Scale developed by
Aricak (1999) [3] was utilized. For analyzing and interpreting data
Kolmogorov-Smirnov test, t-test and one way anova test were used,
while for determining the difference between the groups Tukey test
and Multiple Linear Regression test were employed and significance
was accepted at P
Abstract: This paper presents the use of anti-sway angle control
approaches for a two-dimensional gantry crane with disturbances
effect in the dynamic system. Delayed feedback signal (DFS) and
proportional-derivative (PD)-type fuzzy logic controller are the
techniques used in this investigation to actively control the sway
angle of the rope of gantry crane system. A nonlinear overhead
gantry crane system is considered and the dynamic model of the
system is derived using the Euler-Lagrange formulation. A complete
analysis of simulation results for each technique is presented in time
domain and frequency domain respectively. Performances of both
controllers are examined in terms of sway angle suppression and
disturbances cancellation. Finally, a comparative assessment of the
impact of each controller on the system performance is presented and
discussed.
Abstract: The damage tolerance behavior of integrally and
conventional stiffened panel is investigated based on the fracture
mechanics and finite element analysis. The load bearing capability
and crack growth characteristic of both types of the stiffened panels
having same configuration subjected to distributed tensile load is
examined in this paper. A fourteen-stringer stiffened panel is
analyzed for a central skin crack propagating towards the adjacent
stringers. Stress intensity factors and fatigue crack propagation rates
of both types of the stiffened panels are then compared. The analysis
results show that integral stiffening causes higher stress intensity
factor than conventional stiffened panel as the crack tip passes
through the stringer and the integrally stiffened panel has less load
bearing capability than the riveted stiffened panel.
Abstract: In this research it is aimed that the effect of some demographic factors on Turkish Adolescents' subjective well being is investigated. 432 adolescents who are 247 girls and 185 boys are participated in this study. They are ages 15-17, and also are high school students. The Positive and Negative Affect Scale and Life Satisfaction Scale are used for measuring adolescents' subjective well being. The ANOVA method is used in order to examine the effect of ages. For gender differences, independent t-test method is used, and finally the Pearson Correlation method is used so as to examine the effect of socio economic statues of adolescents' parents. According to results, there is no gender difference on adolescents' subjective well being. On the other hand, SES and age are effect significantly lover level on adolescents' subjective well being.
Abstract: Recently, it has been suggested that thought control strategies aimed at controlling unwanted thoughts may be used to cope with paranoid thoughts in both clinical and nonclinical samples. The current study aims to examine the type of thought control strategies that were associated with the frequency of paranoid thoughts in nonclinical samples. A total of 159 Japanese undergraduate students completed the two scales–the Paranoia Checklist and the Thought Control Questionnaire. A hierarchical multiple regression analysis demonstrated that worry-based control strategies were associated with paranoid thoughts, whereas distraction- and social-based control strategies were inversely associated with paranoid thoughts. Our findings suggest that in a nonclinical population, worry-based strategies may be especially maladaptive, whereas distraction- and social-based strategies may be adaptive to paranoid thoughts.
Abstract: In this paper, Tobephobia (TBP) alludes to the fear of
failure experienced by teachers to manage curriculum change. TBP is
an emerging concept and it extends the boundaries of research in
terms of how we view achievement and failure in education.
Outcomes-based education (OBE) was introduced fifteen years ago
in South African schools without simultaneously upgrading teachers-
professional competencies. This exploratory research, therefore
examines a simple question: What is the impact of TBP and OBE on
teachers? Teacher ineptitude to cope with the OBE curriculum in the
classroom is a serious problem affecting large numbers of South
African teachers. This exploratory study sought to determine the
perceived negative impact of OBE and TBP on teachers. A survey
was conducted amongst 311 teachers in Port Elizabeth and Durban,
South Africa. The results confirm the very negative impact of TBP
and OBE on teachers. This exploratory study authenticates the
existence of TBP.
Abstract: Experimental data are presented to show the influence of different types of chemical demulsifier on the stability and demulsification of emulsions. Three groups of demulsifier with different functional groups were used in this work namely amines, alcohol and polyhydric alcohol. The results obtained in this study have exposed the capability of chemical breaking agents in destabilization of water in crude oil emulsions. From the present study, found that molecular weight of the demulsifier were influent the capability of the emulsion to separate.
Abstract: Cancers could normally be marked by a number of
differentially expressed genes which show enormous potential as
biomarkers for a certain disease. Recent years, cancer classification
based on the investigation of gene expression profiles derived by
high-throughput microarrays has widely been used. The selection of
discriminative genes is, therefore, an essential preprocess step in
carcinogenesis studies. In this paper, we have proposed a novel gene
selector using information-theoretic measures for biological
discovery. This multivariate filter is a four-stage framework through
the analyses of feature relevance, feature interdependence, feature
redundancy-dependence and subset rankings, and having been
examined on the colon cancer data set. Our experimental result show
that the proposed method outperformed other information theorem
based filters in all aspect of classification errors and classification
performance.
Abstract: Current research has explored the impact of
instructional immediacy, defined as those behaviors that help build
close relationships or feelings of closeness, both on cognition and
motivation in the traditional classroom and online classroom;
however, online courses continue to suffer from higher dropout rates.
Based on Albert Bandura-s Social Cognitive Theory, four primary
relationships or interactions in an online course will be explored in
light of how they can provide immediacy thereby reducing student
attrition and improving cognitive learning. The four relationships are
teacher-student, student-student, and student-content, and studentcomputer.
Results of a study conducted with inservice teachers
completing a 14-week online professional development technology
course will be examined to demonstrate immediacy strategies that
improve cognitive learning and reduce student attrition. Results of
the study reveal that students can be motivated through various
interactions and instructional immediacy behaviors which lead to
higher completion rates, improved self-efficacy, and cognitive
learning.
Abstract: As nanotechnology advances, the use of nanotechnology for medical purposes in the field of nanomedicine seems more promising; the rise of nanorobots for medical diagnostics and treatments could be arriving in the near future. This study proposes a swarm intelligence based control mechanism for swarm nanorobots that operate as artificial platelets to search for wounds. The canonical particle swarm optimization algorithm is employed in this study. A simulation in the circulatory system is constructed and used for demonstrating the movement of nanorobots with essential characteristics to examine the performance of proposed control mechanism. The effects of three nanorobot capabilities including their perception range, maximum velocity and respond time are investigated. The results show that canonical particle swarm optimization can be used to control the early version nanorobots with simple behaviors and actions.
Abstract: The aim of this paper is to present a new method
which can be used for progressive transmission of electrocardiogram
(ECG). The idea consists in transforming any ECG signal to an
image, containing one beat in each row. In the first step, the beats are
synchronized in order to reduce the high frequencies due to inter-beat
transitions. The obtained image is then transformed using a discrete
version of Radon Transform (DRT). Hence, transmitting the ECG,
leads to transmit the most significant energy of the transformed
image in Radon domain. For decoding purpose, the receptor needs to
use the inverse Radon Transform as well as the two synchronization
frames.
The presented protocol can be adapted for lossy to lossless
compression systems. In lossy mode we show that the compression
ratio can be multiplied by an average factor of 2 for an acceptable
quality of reconstructed signal. These results have been obtained on
real signals from MIT database.