Abstract: Currently, many types of no-reversible compressed
sound source, represented by MP3 (MPEG Audio Layer-3) are
popular in the world and they are widely used to make the music file
size smaller. The sound data created in this way has less information as
compared to pre-compressed data. The objective of this study is by
analyzing EEG to determine if people can recognize such difference as
differences in sound. A measurement system that can measure and
analyze EEG when a subject listens to music were experimentally
developed. And ten subjects were studied with this system. In this
experiment, a WAVE formatted music data and a MP3 compressed
music data that is made from the WAVE formatted data were
prepared. Each subject was made to hear these music sources at the
same volume. From the results of this experiment, clear differences
were confirmed between two wound sources.
Abstract: The plant world is the source of many medicines.
Recently, researchers have estimated that there are approximately
400,000 plant species worldwide, of which about a quarter or a third
have been used by societies for medicinal purposes. The human uses
of plants for thousands of years to treat various ailments, in many
developing countries, much of the population trust in traditional
doctors and their collections of medicinal plants to treat them.
Essential oils have many therapeutic properties. In herbal medicine,
they are used for their antiseptic properties against infectious
diseases of fungal origin, against dermatophytes, those of bacterial
origin. The aim of our study is to determine the antimicrobial effect
of essential oils of the plant Trigonella focnum greacum on some
pathogenic bacteria, it is a medicinal plant used in traditional
therapy. The test adopted is based on the diffusion method on solid
medium (Antibiogram), this method determines the sensitivity or
resistance of a microorganism vis-à-vis the extract studied. Our study
reveals that the essential oil of the plant Trigonella focnum greacum
has a different effect on the resistance of germs. For staphiloccocus
Pseudomonnas aeroginosa and Krebsilla, are moderately sensitive
strains, also Escherichia coli and Candida albicans represents a high
sensitivity. By against Proteus is a strain that represents a weak
sensitivity.
Abstract: Presence of phytosterol compound in Durian seed
(Durio zibethinus) or known as King of fruits has been discovered
from screening work using reagent test. Further analysis work has
been carried out using mass spectrometer in order to support the
priliminary finding. Isolation and purification of the major
phytosterol has been carried out using an open column
chromatography. The separation was monitored using thin layer
chromatography (TLC). Major isolated compounds and purified
phytosterol were identified using mass spectrometer and nuclear
magnetic resonance (NMR). This novel finding could promote
utilization of durian seeds as a functional ingredient in food products
through production of standardized extract based on phytosterol
content.
Abstract: Acetaminophen (Paracetamol) tablets are popular OTC products among patients as analgesics and antipyretics. Paracetamol is marketed by a lot of suppliers around the world. The aim of the present investigation was to compare between many types of paracetamol tablets obtained from different suppliers (six brands produced by different pharmaceutical companies in middle east countries, and Panadol® manufactured in Ireland), by different quality control tests according to USP pharmacopeia.Using Non official tests-hardness and friability; official tests- disintegration, dissolution, and drug content. Additionally, evaluate the influence of temperatures 4°C, 25°C and 40°C at 75% relative humidity on the stability of the same brands in their original packaging has been conducted for two months. The results revealed that all paracetamol tablet brands complied with the official USP specifications. In conclusion, paracetamol tablets preferred to be stored at 25°C. All the tested brands being biopharmaceutically and chemically equivalent.
Abstract: Size based filtration is one of the common methods
employed to isolate circulating tumor cells (CTCs) from whole
blood. It is well known that this method suffers from isolation
efficiency to purity tradeoff. However, this tradeoff is poorly
understood. In this paper, we present the design and manufacturing
of a special rectangular slit filter. The filter was designed to retain
maximal amounts of nucleated cells, while minimizing the pressure
on cells, thereby preserving their morphology. The key parameter,
namely, input pressure, was optimized to retain the maximal number
of tumor cells, whilst maximizing the depletion of normal blood cells
(red and white blood cells and platelets). Our results indicate that for
a slit geometry of 5 × 40 μm on a 13 mm circular membrane with a
fill factor of 21%, a pressure of 6.9 mBar yields the optimum for
maximizing isolation of MCF-7 and depletion of normal blood cells.
Abstract: NFκB is a transcription factor regulating many
function of the vessel wall. In the normal condition , NFκB is
revealed diffuse cytoplasmic expressionsuggesting that the system is
inactive. The presence of activation NFκB provide a potential
pathway for the rapid transcriptional of a variety of genes encoding
cytokines, growth factors, adhesion molecules and procoagulatory
factors. It is likely to play an important role in chronic inflamatory
disease involved atherosclerosis. There are many stimuli with the
potential to active NFκB, including hyperlipidemia. We used 24 mice
which was divided in 6 groups. The HFD given by et libitum
procedure during 2, 4, and 6 months. The parameters in this study
were the amount of NFKB activation ,H2O2 as ROS and VCAM-1 as
a product of NFKB activation. H2O2 colorimetryc assay performed
directly using Anti Rat H2O2 ELISA Kit. The NFKB and VCAM-1
detection obtained from aorta mice, measured by ELISA kit and
imunohistochemistry. There was a significant difference activation of
H2O2, NFKB and VCAM-1 level at induce HFD after 2, 4 and 6
months. It suggest that HFD induce ROS formation and increase the
activation of NFKB as one of atherosclerosis marker that caused by
hyperlipidemia as classical atheroschlerosis risk factor.
Abstract: We present a dextran modified silicon microring
resonator sensor for high density antibody immobilization. An array
of sensors consisting of three sensor rings and a reference ring was
fabricated and its surface sensitivity and the limit of detection were
obtained using polyelectrolyte multilayers. The mass sensitivity and
the limit of detection of the fabricated sensor ring are 0.35 nm/ng
mm-2 and 42.8 pg/mm2 in air, respectively. Dextran modified sensor
surface was successfully prepared by covalent grafting of oxidized
dextran on 3-aminopropyltriethoxysilane (APTES) modified silicon
sensor surface. The antibody immobilization on hydrogel dextran
matrix improves 40% compared to traditional antibody
immobilization method via APTES and glutaraldehyde linkage.
Abstract: The objective of the present study was to evaluate the
potential of hollow microneedles for enhancing the transdermal
delivery of Bovine Serum Albumin (MW~66,000 Da)-Fluorescein
Isothiocyanate (BSA-FITC) conjugate, a hydrophilic large molecular
compound. Moreover, the effect of different formulations was
evaluated. The series of binary mixtures composed of propylene
glycol (PG) and pH 7.4 phosphate buffer solution (PBS) was
prepared and used as a medium for BSA-FITC. The results showed
that there was no permeation of BSA-FITC solution across the
neonatal porcine skin without using hollow microneedles, whereas
the cumulative amount of BSA-FITC released at 8 h through the
neonatal porcine skin was about 60-70% when using hollow
microneedles. Furthermore, the results demonstrated that the higher
volume of PG in binary mixtures injected, the lower cumulative
amount of BSA-FITC released and release rate of BSA-FITC from
skin. These release profiles of BSA-FITC in binary mixtures were
expressed by Fick-s law of diffusion. These results suggest the
utilization of hollow microneedle to enhance transdermal delivery of
protein and provide useful information for designing an effective
hollow microneedle system.
Abstract: Sensory nerves in the foot play an important part in the diagnosis of various neuropathydisorders, especially in diabetes mellitus.However, a detailed description of the anatomical distribution of the nerves is currently lacking. A computationalmodel of the afferent nerves inthe foot may bea useful tool for the study of diabetic neuropathy. In this study, we present the development of an anatomically-based model of various major sensory nerves of the sole and dorsal sidesof the foot. In addition, we presentan algorithm for generating synthetic somatosensory nerve networks in the big-toe region of a right foot model. The algorithm was based on a modified version of the Monte Carlo algorithm, with the capability of being able to vary the intra-epidermal nerve fiber density in differentregionsof the foot model. Preliminary results from the combinedmodel show the realistic anatomical structure of the major nerves as well as the smaller somatosensory nerves of the foot. The model may now be developed to investigate the functional outcomes of structural neuropathyindiabetic patients.
Abstract: SEMG (Surface Electromyogram) is one of the
bio-signals and is generated from the muscle. And there are many
research results that use forearm EMG to detect hand motions. In this
paper, we will talk about our developed the robot hand system that can
control grasping power by SEMG. In our system, we suppose that
muscle power is proportional to the amplitude of SEMG. The power is
estimated and the grip power of a robot hand is able to be controlled
using estimated muscle power in our system. In addition, to perform a
more precise control can be considered to build a closed loop feedback
system as an object to a subject to pressure from the edge of hand. Our
objectives of this study are the development of a method that makes
perfect detection of the hand grip force possible using SEMG patterns,
and applying this method to the man-machine interface.
Abstract: We present a label-free biosensor based on
electrochemical impedance spectroscopy for the detection of proinflammatory
cytokine Tumor Necrosis Factor (TNF-α). Secretion of
TNF-α has been correlated to the onset of various diseases including
rheumatoid arthritis, Crohn-s disease etc. Gold electrodes were
patterned on a silicon substrate and self assembled monolayer of
dithiobis-succinimidyl propionate was used to develop the biosensor
which achieved a detection limit of ~57fM. A linear relationship was
also observed between increasing TNF-α concentrations and chargetransfer
resistance within a dynamic range of 1pg/ml – 1ng/ml.
Abstract: This paper presents the design of a ring-shaped tri-axial fore sensor that can be incorporated into the tip of a guidewire for use in minimally invasive surgery (MIS). The designed sensor comprises a ring-shaped structure located at the center of four cantilever beams. The ringdesign allows surgical tools to be easily passed through which largely simplified the integration process. Silicon nanowires (SiNWs) are used aspiezoresistive sensing elementsembeddedon the four cantilevers of the sensor to detect the resistance change caused by the applied load.An integration scheme with new designed guidewire tip structure having two coils at the distal end is presented. Finite element modeling has been employed in the sensor design to find the maximum stress location in order to put the SiNWs at the high stress regions to obtain maximum output. A maximum applicable force of 5 mN is found from modeling. The interaction mechanism between the designed sensor and a steel wire has been modeled by FEM. A linear relationship between the applied load on the steel wire and the induced stress on the SiNWs were observed.