Abstract: The psychological and physical trauma associated with the loss of a human limb can severely impact on the quality of life of an amputee rendering even the most basic of tasks very difficult. A prosthetic device can be of great benefit to the amputee in the performance of everyday human tasks. This paper outlines a proposed mechanical design of a 12 degree-of-freedom SMA actuated artificial hand. It is proposed that the SMA wires be embedded intrinsically within the hand structure which will allow for significant flexibility for use either as a prosthetic hand solution, or as part of a complete lower arm prosthetic solution. A modular approach is taken in the design facilitating ease of manufacture and assembly, and more importantly, also allows the end user to easily replace SMA wires in the event of failure. A biomimetric approach has been taken during the design process meaning that the artificial hand should replicate that of a human hand as far as is possible with due regard to functional requirements. The proposed design has been exposed to appropriate loading through the use of finite element analysis (FEA) to ensure that it is structurally sound. Theoretical analysis of the mechanical framework was also carried out to establish the limits of the angular displacement and velocity of the finger tip as well finger tip force generation. A combination of various polymers and Titanium, which are suitably lightweight, are proposed for the manufacture of the design.
Abstract: Human skull is shown to exhibit numerous sexually dimorphic traits. Estimation of sex is a challenging task especially when a part of skull is brought for medicolegal investigation. The present research was planned to evaluate the sexing potential of the dimensions of foramen magnum in forensic identification by craniometric analysis. Length and breadth of the foramen magnum was measured using Vernier calipers and the area of foramen magnum was calculated. The length, breadth, and area of foramen magnum were found to be larger in males than females. Sexual dimorphism index was calculated to estimate the sexing potential of each variable. The study observations are suggestive of the limited utility of the craniometric analysis of foramen magnum during the examination of skull and its parts in estimation of sex.
Abstract: This paper proposes new enhancement models to the
methods of nonlinear anisotropic diffusion to greatly reduce speckle
and preserve image features in medical ultrasound images. By
incorporating local physical characteristics of the image, in this case
scatterer density, in addition to the gradient, into existing tensorbased
image diffusion methods, we were able to greatly improve the
performance of the existing filtering methods, namely edge
enhancing (EE) and coherence enhancing (CE) diffusion. The new
enhancement methods were tested using various ultrasound images,
including phantom and some clinical images, to determine the
amount of speckle reduction, edge, and coherence enhancements.
Scatterer density weighted nonlinear anisotropic diffusion
(SDWNAD) for ultrasound images consistently outperformed its
traditional tensor-based counterparts that use gradient only to weight
the diffusivity function. SDWNAD is shown to greatly reduce
speckle noise while preserving image features as edges, orientation
coherence, and scatterer density. SDWNAD superior performances
over nonlinear coherent diffusion (NCD), speckle reducing
anisotropic diffusion (SRAD), adaptive weighted median filter
(AWMF), wavelet shrinkage (WS), and wavelet shrinkage with
contrast enhancement (WSCE), make these methods ideal
preprocessing steps for automatic segmentation in ultrasound
imaging.
Abstract: Sensitive and predictive DILI (Drug Induced Liver
Injury) biomarkers are needed in drug R&D to improve early
detection of hepatotoxicity. The discovery of DILI biomarkers that
demonstrate the predictive power to identify individuals at risk to
DILI would represent a major advance in the development of
personalized healthcare approaches. In this healthy volunteer
acetaminophen study (4g/day for 7 days, with 3 monitored nontreatment
days before and 4 after), 450 serum samples from 32
subjects were analyzed using protein profiling by antibody
suspension bead arrays. Multiparallel protein profiles were generated
using a DILI target protein array with 300 antibodies, where the
antibodies were selected based on previous literature findings of
putative DILI biomarkers and a screening process using pre dose
samples from the same cohort. Of the 32 subjects, 16 were found to
develop an elevated ALT value (2Xbaseline, responders). Using the
plasma profiling approach together with multivariate statistical
analysis some novel findings linked to lipid metabolism were found
and more important, endogenous protein profiles in baseline samples
(prior to treatment) with predictive power for ALT elevations were
identified.
Abstract: An important problem in speech research is the automatic extraction of information about the shape and dimensions of the vocal tract during real-time speech production. We have previously developed Southampton dynamic magnetic resonance imaging (SDMRI) as an approach to the solution of this problem.However, the SDMRI images are very noisy so that shape extraction is a major challenge. In this paper, we address the problem of tongue shape extraction, which poses difficulties because this is a highly deforming non-parametric shape. We show that combining active shape models with the dynamic Hough transform allows the tongue shape to be reliably tracked in the image sequence.
Abstract: This paper focuses on analyzing medical diagnostic data using classification rules in data mining and context reduction in formal concept analysis. It helps in finding redundancies among the various medical examination tests used in diagnosis of a disease. Classification rules have been derived from positive and negative association rules using the Concept lattice structure of the Formal Concept Analysis. Context reduction technique given in Formal Concept Analysis along with classification rules has been used to find redundancies among the various medical examination tests. Also it finds out whether expensive medical tests can be replaced by some cheaper tests.
Abstract: This paper presents the application of a signal intensity independent registration criterion for non-rigid body registration of medical images. The criterion is defined as the weighted ratio image of two images. The ratio is computed on a voxel per voxel basis and weighting is performed by setting the ratios between signal and background voxels to a standard high value. The mean squared value of the weighted ratio is computed over the union of the signal areas of the two images and it is minimized using the Chebyshev polynomial approximation. The geometric transformation model adopted is a local cubic B-splines based model.
Abstract: In Mauritius, much emphasis is put on measures to
combat the high prevalence of non-communicable diseases (NCDs).
Health promotion campaigns for the adoption of healthy behaviors
and screening programs are done regularly by local authorities and
NCD surveys are carried out at intervals. However, the health
behaviors of the poor have not been investigated so far. This study
aims to give an insight on the perceptions of health status and
lifestyle health behaviors of poor people in Mauritius. A crosssectional
study among 83 persons benefiting from social aid in a
selected urban district was carried out. Results showed that 51.8% of
respondents perceived that they had good health status. 57.8% had no
known NCD whilst 25.3% had hypertension, followed by diabetes
(16.9%), asthma (9.6%) and heart disease (7.2%).They had low
smoking (10.8%) and alcohol consumption (6.0%) as well as high
physical activity prevalence (54.2%). These results were significantly
different from the NCD survey carried out in the general population.
Consumption of vegetables in the study was high. Overweight and
obesity trends were however similar to the NCD survey report 2009.
These findings contrast with other international studies showing poor
people having poor perceptions of health status and unhealthy
behavioral choices. Whether these positive health behaviors of poor
people in Mauritius arise out of choice or whether it is because the
alternative behavior is too costly remains to be investigated further.
Abstract: A personal estimate of a health risk may not
correspond to a scientific assessment of the health risk. Hence, there
is a need to investigate perceived health risks in the public. In this
study, a young, educated and healthy group of people from a tertiary
institute were questioned about their health concerns. Ethics
clearance was obtained and data was collected by means of a
questionnaire. 362 students participated in the study. Tobacco use,
heavy alcohol drinking, illicit drugs, unsafe sex and potential
carcinogens were perceived to be the five greatest threats to health in
this cohort. On the other hand natural health products,
unemployment, unmet contraceptive needs, family violence and
homelessness were felt to be the least perceived health risks.
Nutrition-related health risks as well as health risks due to physical
inactivity and obesity were not perceived as major health threats.
Such a study of health perceptions may guide health promotion
campaigns.
Abstract: Along with the advances in medicine, providing medical information to individual patient is becoming more important. In Japan such information via Braille is hardly provided to blind and partially sighted people. Thus we are researching and developing a Web-based automatic translation program “eBraille" to translate Japanese text into Japanese Braille. First we analyzed the Japanese transcription rules to implement them on our program. We then added medical words to the dictionary of the program to improve its translation accuracy for medical text. Finally we examined the efficacy of statistical learning models (SLMs) for further increase of word segmentation accuracy in braille translation. As a result, eBraille had the highest translation accuracy in the comparison with other translation programs, improved the accuracy for medical text and is utilized to make hospital brochures in braille for outpatients and inpatients.
Abstract: We report a computational study of the spreading
dynamics of a viral infection in a complex (scale-free) network. The
final epidemic size distribution (FESD) was found to be unimodal or
bimodal depending on the value of the basic reproductive
number R0 . The FESDs occurred on time-scales long enough for
intermediate-time epidemic size distributions (IESDs) to be important
for control measures. The usefulness of R0 for deciding on the
timeliness and intensity of control measures was found to be limited
by the multimodal nature of the IESDs and by its inability to inform
on the speed at which the infection spreads through the population. A
reduction of the transmission probability at the hubs of the scale-free
network decreased the occurrence of the larger-sized epidemic events
of the multimodal distributions. For effective epidemic control, an
early reduction in transmission at the index cell and its neighbors was
essential.
Abstract: Case based reasoning (CBR) methodology presents a foundation for a new technology of building intelligent computeraided diagnoses systems. This Technology directly addresses the problems found in the traditional Artificial Intelligence (AI) techniques, e.g. the problems of knowledge acquisition, remembering, robust and maintenance. This paper discusses the CBR methodology, the research issues and technical aspects of implementing intelligent medical diagnoses systems. Successful applications in cancer and heart diseases developed by Medical Informatics Research Group at Ain Shams University are also discussed.
Abstract: Breast skin-line estimation and breast segmentation is an important pre-process in mammogram image processing and computer-aided diagnosis of breast cancer. Limiting the area to be processed into a specific target region in an image would increase the accuracy and efficiency of processing algorithms. In this paper we are presenting a new algorithm for estimating skin-line and breast segmentation using fast marching algorithm. Fast marching is a partial-differential equation based numerical technique to track evolution of interfaces. We have introduced some modifications to the traditional fast marching method, specifically to improve the accuracy of skin-line estimation and breast tissue segmentation. Proposed modifications ensure that the evolving front stops near the desired boundary. We have evaluated the performance of the algorithm by using 100 mammogram images taken from mini-MIAS database. The results obtained from the experimental evaluation indicate that this algorithm explains 98.6% of the ground truth breast region and accuracy of the segmentation is 99.1%. Also this algorithm is capable of partially-extracting nipple when it is available in the profile.
Abstract: Oxidative stress is considered to be the cause for onset
and the progression of type 2 diabetes mellitus (T2DM) and
complications including neuropathy. It is a deleterious process that
can be an important mediator of damage to cell structures: protein,
lipids and DNA. Data suggest that in patients with diabetes and
diabetic neuropathy DNA repair is impaired, which prevents effective
removal of lesions. Objective: The aim of our study was to evaluate
the association of the hOGG1 (326 Ser/Cys) and XRCC1 (194
Arg/Trp, 399 Arg/Gln) gene polymorphisms whose protein is
involved in the BER pathway with DNA repair efficiency in patients
with diabetes type 2 and diabetic neuropathy compared to the healthy
subjects. Genotypes were determined by PCR-RFLP analysis in 385
subjects, including 117 with type 2 diabetes, 56 with diabetic
neuropathy and 212 with normal glucose metabolism. The
polymorphisms studied include codon 326 of hOGG1 and 194, 399
of XRCC1 in the base excision repair (BER) genes. Comet assay was
carried out using peripheral blood lymphocytes from the patients and
controls. This test enabled the evaluation of DNA damage in cells
exposed to hydrogen peroxide alone and in the combination with the
endonuclease III (Nth). The results of the analysis of polymorphism
were statistically examination by calculating the odds ratio (OR) and
their 95% confidence intervals (95% CI) using the ¤ç2-tests. Our data
indicate that patients with diabetes mellitus type 2 (including those
with neuropathy) had higher frequencies of the XRCC1 399Arg/Gln
polymorphism in homozygote (GG) (OR: 1.85 [95% CI: 1.07-3.22],
P=0.3) and also increased frequency of 399Gln (G) allele (OR: 1.38
[95% CI: 1.03-1.83], P=0.3). No relation to other polymorphisms
with increased risk of diabetes or diabetic neuropathy. In T2DM
patients complicated by neuropathy, there was less efficient repair of
oxidative DNA damage induced by hydrogen peroxide in both the
presence and absence of the Nth enzyme. The results of our study
suggest that the XRCC1 399 Arg/Gln polymorphism is a significant
risk factor of T2DM in Polish population. Obtained data suggest a
decreased efficiency of DNA repair in cells from patients with
diabetes and neuropathy may be associated with oxidative stress.
Additionally, patients with neuropathy are characterized by even
greater sensitivity to oxidative damage than patients with diabetes,
which suggests participation of free radicals in the pathogenesis of
neuropathy.
Abstract: Recently, there has been a considerable increase in the
number of procedures carried out under regional anesthesia.
However, percutaneous nephrolithotomy (PCNL) procedures are
usually performed under general anesthesia. The aim of this study
was to assess the safety and efficacy of PCNL under spinal anesthesia
in patients with renal calculi. We describe our 9 years experience of
performing PCNL under spinal anesthesia for 387 patients with large
stones of the upper urinary tract, with regard to the effectiveness and
side effects. All patients received spinal anesthetics (Lidocain 5%, or
Bupivacaine 0.75%) and underwent PCNL in prone position. The
success rate was 94.1%. The incidence of complications was 11.6%.
PCNL under spinal anesthesia is feasible, safe, and well-tolerated in
management of patients with renal stones.
Abstract: COPD is characterized by loss of elastic fibers from
small airways and alveolar walls, with the decrease in elastin
increasing with disease severity. It is unclear why there is a lack of
repair of elastic fibers. We have examined fibroblasts cultured from
lung tissue from normal and COPD subjects to determine if the
secretory profile explains lack of tissue repair. In this study,
fibroblasts were cultured from lung parenchyma of bronchial
carcinoma patients with varying degrees of COPD; controls
(non-COPD, n=5), mild COPD (GOLD 1, n=5) and moderate-severe
COPD (GOLD 2-3, n=12). Measurements were made of proliferation,
senescence-associated beta-galactosidase-1, mRNA expression of
IL-6, IL-8, MMP-1, tropoelastin and versican, and protein levels for
IL-6, IL-8, PGE2, tropoelastin, insoluble elastin, and versican. It was
found that GOLD 2-3 fibroblasts proliferated more slowly (p
Abstract: Chitosan is an attractive polysaccharide obtained by
deacetylation of an abundant natural biopolymer called chitin. Chitin
and chitosan are excellent materials. To improve the potential of
chitin and chitosan modification is needed. In the present study,
grafting of maleic acid on to chitosan by cerium ammonium nitrate in
acetic acid solution was investigated with use of a microwave and
reflux system. The grafted chitosan was characterized by using a
Fourier-transform infrared spectrometry. The solubility and swelling
behavior of grafted chitosans were determined in acetate buffer (pH
3.6), citrophosphate buffer (pH 5.6 and pH 7.0), and boric buffer (pH
9.2) solutions. The sample obtained by microwave system with use of
a chitosan/maleic anhydride/ceric ammonium nitrate 0.2/3.922/0.99
gram of raw material within 30 minute showed the maximum
swelling ratio (13.6) in boric buffer solution.
Abstract: A typical definition of the Computer Aided Diagnosis
(CAD), found in literature, can be: A diagnosis made by a radiologist
using the output of a computerized scheme for automated image
analysis as a diagnostic aid. Often it is possible to find the expression
Computer Aided Detection (CAD or CADe): this definition
emphasizes the intent of CAD to support rather than substitute the
human observer in the analysis of radiographic images. In this article
we will illustrate the application of CAD systems and the aim of
these definitions.
Commercially available CAD systems use computerized
algorithms for identifying suspicious regions of interest. In this paper
are described the general CAD systems as an expert system
constituted of the following components: segmentation / detection,
feature extraction, and classification / decision making.
As example, in this work is shown the realization of a Computer-
Aided Detection system that is able to assist the radiologist in
identifying types of mammary tumor lesions. Furthermore this
prototype of station uses a GRID configuration to work on a large
distributed database of digitized mammographic images.
Abstract: The aim of this retrospective study was to evaluate the
parameters of dental implants such as patient gender, number of
implant, failed implant before prosthetic restorations and failed
implant after implantation and failed implant after prosthetic
restorations. 135 male and 99 female patients, total 234 implant
patients which have been treated with 450 implant between 2005-
2009 years in GATA Haydarpasa Training Hospital Dental Service.
Twelve implants were failed before prosthetic restorations. Four
implant were failed after fixed prosthetic restorations. Cumulative
survival rate after prostheses were 97.56 % during 6 years period.
Abstract: Increased physical fitness participation has been
paralleled by increasedoveruse injuries such as insertional Achilles
tendinosis (AT). Treatment has provided inconsistentresults. The use
of extracorporeal shockwave therapy (ECSWT) offers a new
treatment consideration.The purpose of this study was to assess the
effects of ECSWTon pain, function, range of motion (ROM), joint
mobility and strength in patients with AT. Thirty subjects were
treated with ECSWT and measures were takenbefore and three
months after treatment. There was significant differences in visual
analog scale (VAS) scores for pain at rest (p=0.002); after activity
(p= 0.0001); overall improvement(p=0.0001); Lower Extremity
Functional Scale (LEFS) scores (p=0.002); dorsiflexion range of
motion (ROM) (p=0.0001); plantarflexion strength (p=0.025);
talocrural joint anterior glide (p=0.046); and subtalar joint medial and
lateral glide (p=0.025).ECSWT offers a new intervention that may
limit the progression of the disorder and the long term healthcare
costs associated with AT.