Abstract: carbonylation of methanol in homogenous phase is
one of the major routesfor production of acetic acid. Amongst group
VIII metal catalysts used in this process iridium has displayed the
best capabilities. To investigate effect of operating parameters like:
temperature, pressure, methyl iodide, methyl acetate, iridium,
ruthenium, and water concentrations on the reaction rate,
experimental design for this system based upon central composite
design (CCD) was utilized. Statistical rate equation developed by this
method contained individual, interactions and curvature effects of
parameters on the reaction rate. The model with p-value less than
0.0001 and R2 values greater than 0.9; confirmeda satisfactory fitness
of the experimental and theoretical studies. In other words, the
developed model and experimental data obtained passed all
diagnostic tests establishing this model as a statistically significant.