Abstract: Postmenopausal osteoporosis is a disorder
characterized by the progressive bone loss induced by estrogen
deficiency in postmenopausal women. This imbalance affects
calcium–phosphate metabolism and results in secondary
hyperparathyroidism. Purariae Radix (PR), the root of P. lobata
(Wild.) Ohwi, is one of the earliest medicinal herbs employed in
ancient China. PR contains a high quantity of isoflavones and their
glycosides, which are regarded as phytoestrogen. Few investigations
of PR are related to its osteoprotective effects. The present study is
designed to administer PR water extract to ovariectomized (OVX)
female rats, for the investigation of its possibly protective actions on
bone and to delineate the potential mechanisms involved. Our results
demonstrated that long-term treatment of PR could not significantly
improve bone properties, whereas it greatly ameliorated the condition
of secondary hyperparathyroidism induced by ovariectomy in those
animals. PR might be useful as alternative regimen for protecting
against postmenopausal bone loss.