Abstract: 17α-ethynylestradiol (EE2) is a synthetic estrogen
used as a key ingredient in an oral contraceptives pill. EE2 is an
endocrine disrupting compound, high in estrogenic potency.
Although EE2 exhibits low degree of biodegradability with common
microorganisms in wastewater treatment plants (WWTPs), this
compound can be biotransformed by ammonia-oxidizing bacteria
(AOB) via a co-metabolism mechanism in WWTPs. This study
aimed to investigate the effect of real wastewater on
biotransformation of EE2 by AOB. A preliminary experiment on the
effect of nitrite and pH levels on abiotic transformation of EE2
suggested that the abiotic transformation occurred at only pH
Abstract: This article introduces the actual problem that is а
study of proposed by the authors Hydrocele ointment in amino acids’
metabolism of cows’ blood in inflammation of traumatic origin.
Hydrocele ointment has shown a positive effect on inflammatory
process and amino acids’ metabolism of animals treated with the
drug. Amino acid levels reached physiological parameters on the 10th
day after treatment; in the control group this parameter was higher
than normal.
Abstract: Microorganisms isolated from water and soil of
Kazakhstan to identify potential high-effective producers of the
arachidonic acid, exhibiting a wide range of physiological activity
and having practical applications were screened. Based on the results
of two independent tests (the test on the sensitivity of the growth
processes of microorganisms to acetylsalicylic acid - an irreversible
inhibitor of PGH-synthase involved in the metabolism of arachidonic
acid and its derivatives, the test for inhibition of peroxidase activity
of membrane-bounding fraction of PGH - synthase by acetylsalicylic
acid) were selected microbial cultures which are potential highproducer
of arachidonic acid. They are characterized by a stable
strong growth in the laboratory conditions. Identification of
microorganism cultures based on morphological, physiological,
biochemical and molecular genetic characteristics was performed.
Abstract: A lot of recent research have spoken on the relation
between the increase of the homocysteinemia and some kinds of
cancer . For that, our study was based on the research of a possible
relation between the increase of the concentration of this amino-acid
in the plasma and the appearance of the disease of the Acute
Lymphoblastic Leukaemia in a part of Algerian children with Berber
origin in the East of Algeria . The study has done on 47 ill persons
with an average age of (09±06 ) years , with whom the disease has
diagnosed by blood and marrow examination in the hospital of blood
diseases in the CHU of Batna, and on 194 healthy witnesses of the
same age. The two groups were benefited by a dosage of the
concentration of the homocysteine vitamin B9 ,vitamin B12 , and
also of the study of special polymorphisms of indispensable enzymes
in the metabolism of this acid , and that by the use of the method (
Light cycler ) Real time PCR , on the following enzymes : MS (
C2756G ), MSR ( A66G ) ,MTHFR1 ( C677T ) and MTHFR2
(A1298C). The obtained results have revealed that the rate of the
homozygote muted genotype is the less frequent in the two groups ,
and that exist at list one genotype of each enzyme in the ill group and
in which the percentage exceed with remarkable way the same
genotype in the healthy group and we notice specially the muted
genotype GG of -the methionine synthetase-and the form TT of the
enzyme – methyline tetra hydrofolate reductase – We notice the
existence of considerable number of genotypes in the ill group lied
with characteristic increase of this Amino-acid ,and that for the
reduction of the biologic activity of these enzymes which become
inefficient in the transfer of the homocysteine into the methionine
and cause the diminution of the biologic activity of these enzymes
and with consequence the reduction of the percentage of methylic
radicals in the DNA of studied genes and that lead to the increase of
the activity and the capacity of transcription , and it-s so probably
that this last one is one of the factors of this disease especially if we
know that the specific check-up of vitamins is normal and similar in
the two groups , which ovoid the hypothesis of the reduction of
vitamins . We notice also that the heterozygote genotype is the less in
the sick category except the MTHFR2. Wild genotype is more
frequent in the witness group except MSR. Even these results are
partials; they open a new way in the genetic diagnosis of this
malicious disease which allow a precocious diagnosis and the use of
an effective and appropriated treatment in the same time.
Abstract: Hospitals in southern Hualien teamed with the
Hypertension Joint Care Network. Working with the network, the
team provided a special designed health education to the individual
who had been identified as a hypertension patient in the outpatient
department. Some metabolism improvements achieved. This is a
retrospective study by purposively taking 106 patients from a hospital
between 2008 and 2010. Records of before and after education
intervention of the objects was collected and analyzed to see the how
the intervention affected the patients- hypertension control via clinical
parameter monitoring. The results showed that the clinical indicators,
the LDL-C, the cholesterol and the systolic blood pressure were
significantly improved. The study provides evidence for the
effectiveness of the network in controlling hypertension.
Abstract: This paper describes the optimization of a complex
dairy farm simulation model using two quite different methods of
optimization, the Genetic algorithm (GA) and the Lipschitz
Branch-and-Bound (LBB) algorithm. These techniques have been
used to improve an agricultural system model developed by Dexcel
Limited, New Zealand, which describes a detailed representation of
pastoral dairying scenarios and contains an 8-dimensional parameter
space. The model incorporates the sub-models of pasture growth and
animal metabolism, which are themselves complex in many cases.
Each evaluation of the objective function, a composite 'Farm
Performance Index (FPI)', requires simulation of at least a one-year
period of farm operation with a daily time-step, and is therefore
computationally expensive. The problem of visualization of the
objective function (response surface) in high-dimensional spaces is
also considered in the context of the farm optimization problem.
Adaptations of the sammon mapping and parallel coordinates
visualization are described which help visualize some important
properties of the model-s output topography. From this study, it is
found that GA requires fewer function evaluations in optimization
than the LBB algorithm.