Abstract: Purpose: The study aimed to assess the depressant or
antidepressant effects of several Nonsteroidal Anti-Inflammatory
Drugs (NSAIDs) in mice: the selective cyclooxygenase-2 (COX-2)
inhibitor meloxicam, and the non-selective COX-1 and COX-2
inhibitors lornoxicam, sodium metamizole, and ketorolac. The
current literature data regarding such effects of these agents are
scarce.
Materials and methods: The study was carried out on NMRI mice
weighing 20-35 g, kept in a standard laboratory environment. The
study was approved by the Ethics Committee of the University of
Medicine and Pharmacy „Carol Davila”, Bucharest. The study agents
were injected intraperitoneally, 10 mL/kg body weight (bw) 1 hour
before the assessment of the locomotor activity by cage testing (n=10
mice/ group) and 2 hours before the forced swimming tests (n=15).
The study agents were dissolved in normal saline (meloxicam,
sodium metamizole), ethanol 11.8% v/v in normal saline (ketorolac),
or water (lornoxicam), respectively. Negative and positive control
agents were also given (amitryptilline in the forced swimming test).
The cage floor used in the locomotor activity assessment was divided
into 20 equal 10 cm squares. The forced swimming test involved
partial immersion of the mice in cylinders (15/9cm height/diameter)
filled with water (10 cm depth at 28C), where they were left for 6
minutes. The cage endpoint used in the locomotor activity assessment
was the number of treaded squares. Four endpoints were used in the
forced swimming test (immobility latency for the entire 6 minutes,
and immobility, swimming, and climbing scores for the final 4
minutes of the swimming session), recorded by an observer that was
„blinded” to the experimental design. The statistical analysis used the
Levene test for variance homogeneity, ANOVA and post-hoc
analysis as appropriate, Tukey or Tamhane tests.
Results: No statistically significant increase or decrease in the
number of treaded squares was seen in the locomotor activity
assessment of any mice group. In the forced swimming test,
amitryptilline showed an antidepressant effect in each experiment, at
the 10 mg/kg bw dosage. Sodium metamizole was depressant at 100
mg/kg bw (increased the immobility score, p=0.049, Tamhane test),
but not in lower dosages as well (25 and 50 mg/kg bw). Ketorolac
showed an antidepressant effect at the intermediate dosage of 5
mg/kg bw, but not so in the dosages of 2.5 and 10 mg/kg bw,
respectively (increased the swimming score, p=0.012, Tamhane test).
Meloxicam and lornoxicam did not alter the forced swimming
endpoints at any dosage level.
Discussion: 1) Certain NSAIDs caused changes in the forced
swimming patterns without interfering with locomotion. 2) Sodium
metamizole showed a depressant effect, whereas ketorolac proved
antidepressant. Conclusion: NSAID-induced mood changes are not
class effects of these agents and apparently are independent of the
type of inhibited cyclooxygenase (COX-1 or COX-2).
Disclosure: This paper was co-financed from the European Social
Fund, through the Sectorial Operational Programme Human Resources Development 2007-2013, project number POSDRU /159
/1.5 /S /138907 "Excellence in scientific interdisciplinary research,
doctoral and postdoctoral, in the economic, social and medical fields
-EXCELIS", coordinator The Bucharest University of Economic
Studies.
Abstract: The present research work investigates the seismic
response of reinforced concrete (RC) frame building considering the
effect of modeling masonry infill (MI) walls. The seismic behavior of
a residential 6-storey RC frame building, considering and ignoring
the effect of masonry, is numerically investigated using response
spectrum (RS) analysis. The considered herein building is designed
as a moment resisting frame (MRF) system following the Egyptian
code (EC) requirements. Two developed models in terms of bare
frame and infill walls frame are used in the study. Equivalent
diagonal strut methodology is used to represent the behavior of infill
walls, whilst the well-known software package ETABS is used for
implementing all frame models and performing the analysis. The
results of the numerical simulations such as base shear,
displacements, and internal forces for the bare frame as well as the
infill wall frame are presented in a comparative way. The results of
the study indicate that the interaction between infill walls and frames
significantly change the responses of buildings during earthquakes
compared to the results of bare frame building model. Specifically,
the seismic analysis of RC bare frame structure leads to
underestimation of base shear and consequently damage or even
collapse of buildings may occur under strong shakings. On the other
hand, considering infill walls significantly decrease the peak floor
displacements and drifts in both X and Y-directions.
Abstract: The paper is focused on the identification of limiting
environmental factors of individual industrial floors on which newly
developed polymer protection and repair systems with the use of
secondary raw materials will be used. These mainly include floors
with extreme stresses and special requirements for materials used. In
relation to the environment of a particular industrial floor, it is
necessary to ensure, for example, chemical stability, resistance to
higher temperatures, resistance to higher mechanical stress, etc. for
developed materials, which is reflected in the demands for the
developed material systems. The paper describes individual
environments and, in relation to them, also requirements for
individual components of the developed materials and for the
developed materials as a whole.
Abstract: An innovative flooring underlayment was produced
and tested. The composite system is made of common OSB boards
and a layer of eco-friendly non-cement gypsum based material
(GeoGypTM). It was found that the shear bond between the two
materials is sufficient to secure the composite interaction between the
two. The very high compressive strength and relatively high tensile
strength of the non-cement based component together with its high
modulus of elasticity provides enough strength and stiffness for the
composite product to cover wider spacing between the joists. The
initial findings of this study indicate that with joist spacing as wide as
800 mm, the flooring system provides enough strength without
compromising the serviceability requirements of the building codes.
Abstract: Applications of the Hausdorff space and its mappings
into tangent spaces are outlined, including their fractal dimensions
and self-similarities. The paper details this theory set up and further
describes virtualizations and atomization of manufacturing processes.
It demonstrates novel concurrency principles that will guide
manufacturing processes and resources configurations. Moreover,
varying levels of details may be produced by up folding and breaking
down of newly introduced generic models. This choice of layered
generic models for units and systems aspects along specific aspects
allows research work in parallel to other disciplines with the same
focus on all levels of detail. More credit and easier access are granted
to outside disciplines for enriching manufacturing grounds. Specific
mappings and the layers give hints for chances for interdisciplinary
outcomes and may highlight more details for interoperability
standards, as already worked on the international level. The new rules
are described, which require additional properties concerning all
involved entities for defining distributed decision cycles, again on the
base of self-similarity. All properties are further detailed and assigned
to a maturity scale, eventually displaying the smartness maturity of a
total shopfloor or a factory. The paper contributes to the intensive
ongoing discussion in the field of intelligent distributed
manufacturing and promotes solid concepts for implementations of
Cyber Physical Systems and the Internet of Things into
manufacturing industry, like industry 4.0, as discussed in German-speaking
countries.
Abstract: The building sector is responsible, in many
industrialized countries, for about 40% of the total energy
requirements, so it seems necessary to devote some efforts in this
area in order to achieve a significant reduction of energy
consumption and of greenhouse gases emissions.
The paper presents a study aiming at providing a design
methodology able to identify the best configuration of the system
building/plant, from a technical, economic and environmentally point
of view.
Normally, the classical approach involves a building's energy
loads analysis under steady state conditions, and subsequent selection
of measures aimed at improving the energy performance, based on
previous experience made by architects and engineers in the design
team. Instead, the proposed approach uses a sequence of two wellknown
scientifically validated calculation methods (TRNSYS and
RETScreen), that allow quite a detailed feasibility analysis.
To assess the validity of the calculation model, an existing,
historical building in Central Italy, that will be the object of
restoration and preservative redevelopment, was selected as a casestudy.
The building is made of a basement and three floors, with a
total floor area of about 3,000 square meters.
The first step has been the determination of the heating and
cooling energy loads of the building in a dynamic regime by means,
which allows simulating the real energy needs of the building in
function of its use. Traditional methodologies, based as they are on
steady-state conditions, cannot faithfully reproduce the effects of
varying climatic conditions and of inertial properties of the structure.
With this model is possible to obtain quite accurate and reliable
results that allow identifying effective combinations building-HVAC
system.
The second step has consisted of using output data obtained as
input to the calculation model, which enables to compare different
system configurations from the energy, environmental and financial
point of view, with an analysis of investment, and operation and
maintenance costs, so allowing determining the economic benefit of
possible interventions.
The classical methodology often leads to the choice of
conventional plant systems, while our calculation model provides a
financial-economic assessment for innovative energy systems and
low environmental impact.
Computational analysis can help in the design phase, particularly
in the case of complex structures with centralized plant systems, by
comparing the data returned by the calculation model for different
design options.
Abstract: This study examines analytically the effect of tsunami loads on reinforced concrete (RC) frame buildings. The impact of tsunami wave loads and waterborne objects are analyzed using a typical substandard full-scale two-story RC frame building tested as part of the EU-funded Ecoleader project. The building was subjected to shake table tests in bare condition, and subsequently strengthened using Carbon Fiber Reinforced Polymers (CFRP) composites and retested. Numerical models of the building in both bare and CFRP-strengthened conditions are calibrated in DRAIN-3DX software to match the test results. To investigate the response of wave loads and impact forces, the numerical models are subjected to nonlinear dynamic analyses using force time-history input records. The analytical results are compared in terms of displacements at the floors and at the “impact point” of a boat. The results show that the roof displacement of the CFRP-strengthened building reduced by 63% when compared to the bare building. The results also indicate that strengthening only the mid-height of the impact column using CFRP is more effective at reducing damage when compared to strengthening other parts of the column. Alternative solutions to mitigate damage due to tsunami loads are suggested.
Abstract: Sports games conducted as a group are a form of
therapeutic exercise for aged people with decreased strength and for
people suffering from permanent damage of stroke and other
conditions. However, it is difficult for patients with different athletic
abilities to play a game on an equal footing. This study specifically
examines a computer video game designed for therapeutic exercise,
and a game system with support given depending on athletic ability.
Thereby, anyone playing the game can participate equally. This
video-game, to be specific, is a popular variant of balloon volleyball,
in which players hit a balloon by hand before it falls to the floor. In this
game system, each player plays the game watching a monitor on which
the system displays tailor-made video-game images adjusted to the
person’s athletic ability, providing players with player-adaptive assist
support. We have developed a multiplayer game system with an image
generation technique for the tailor-made video-game and conducted
tests to evaluate it.
Abstract: The majority of contemporary insulation materials
commonly used in the building industry is made from non-renewable
raw materials; furthermore, their production often brings high energy
costs. A long-term trend as far as sustainable development is
concerned has been the reduction of energy and material demands of
building material production. One of the solutions is the possibility of
using easily renewable natural raw material sources which are
considerably more ecological and their production is mostly less
energy-consuming compared to the production of normal insulations
(mineral wool, polystyrene). The paper describes the results of
research focused on the development of thermal and acoustic
insulation materials based on natural fibres intended for floor
constructions. Given the characteristic open porosity of natural fibre
materials, the hygrothermal behaviour of the developed materials was
studied. Especially the influence of relative humidity and temperature
on thermal insulation properties was observed.
Abstract: Heating, cooling and lighting appliances in buildings
account for more than one third of the world’s primary energy
demand. Therefore, main components of the building heating systems
play an essential role in terms of energy consumption. In this context,
efficient energy and exergy utilization in HVAC-R systems has been
very essential, especially in developing energy policies towards
increasing efficiencies. The main objective of the present study is to
assess the performance of a family house with a volume of 326.7 m3
and a net floor area of 121 m2, located in the city of Izmir, Turkey in
terms of energetic, exergetic and sustainability aspects. The indoor
and exterior air temperatures are taken as 20°C and 1°C, respectively.
In the analysis and assessment, various metrics (indices or indicators)
such as exergetic efficiency, exergy flexibility ratio and sustainability
index are utilized. Two heating options (Case 1: condensing boiler
and Case 2: air heat pump) are considered for comparison purposes.
The total heat loss rate of the family house is determined to be
3770.72 W. The overall energy efficiencies of the studied cases are
calculated to be 49.4% for Case 1 and 54.7% for Case 2. The overall
exergy efficiencies, the flexibility factor and the sustainability index
of Cases 1 and 2 are computed to be around 3.3%, 0.17 and 1.034,
respectively.
Abstract: Bangnoi Floating Market located at Bangkhonthi
Districts Samut Songkhram Province is a valuable architectural
market. The lifestyle of the community's relationship with the living
space and the relationship between the architectural style of the area's
residential waterfront communities of Bangnoi Floating Bangkhonthi
Districts Samut Songkhram Province, which deserves to be
preserved.
Therefore, this research it helps to know the value of the
architectural style of the area's residential waterfront communities of
Bangnoi Floating Bangkhonthi Districts SamutSongkhram Province,
which deserves to be preserved.
Abstract: Intrabody communication (IBC) is a new way of transferring data using human body as a medium. Minute current can travel though human body without any harm. IBC can remove electrical wires for human area network. IBC can be also a secure communication network system unlike wireless networks which can be accessed by anyone with bad intentions. One of the IBC systems is based on frequency shift keying modulation where individual data are transmitted to the external devices for the purpose of secure access such as digital door lock. It was found that the quality of IBC data transmission was heavily dependent on ground configurations of electronic circuits. Reliable IBC transmissions were not possible when both of the transmitter and receiver used batteries as circuit power source. Transmission was reliable when power supplies were used as power source for both transmitting and receiving sites because the common ground was established through the grounds of instruments such as power supply and oscilloscope. This was due to transmission dipole size and the ground effects of floor and AC power line. If one site used battery as power source and the other site used the AC power as circuit power source, transmission was possible.
Abstract: The aim of this research is to design and implement line-tracking mobile robot. The robot must follow a line drawn on the floor with different color, avoids hitting moving object like another moving robot or walking people and achieves color sensing. The control system reacts by controlling each of the motors to keep the tracking sensor over the middle of the line. Proximity sensors used to avoid hitting moving objects that may pass in front of the robot. The programs have been written using micro c instructions, then converted into PIC16F887 ATmega48/88/168 microcontrollers counterparts. Practical simulations show that the walking robot accurately achieves line following action and exactly recognizes the colors and avoids any obstacle in front of it.
Abstract: In this paper, we propose an optimization technique
that can be used to optimize the placements of reference nodes and
improve the location determination performance for the multi-floor
building. The proposed technique is based on Simulated Annealing
algorithm (SA) and is called MSMR-M. The performance study in
this work is based on simulation. We compare other node-placement
techniques found in the literature with the optimal node-placement
solutions obtained from our optimization. The results show that using
the optimal node-placement obtained by our proposed technique can
improve the positioning error distances up to 20% better than those of
the other techniques. The proposed technique can provide an average
error distance within 1.42 meters.
Abstract: Indoor wireless localization systems have played an
important role to enhance context-aware services. Determining the
position of mobile objects in complex indoor environments, such as
those in multi-floor buildings, is very challenging problems. This
paper presents an effective floor estimation algorithm, which can
accurately determine the floor where mobile objects located. The
proposed algorithm is based on the confidence interval of the
summation of online Received Signal Strength (RSS) obtained from
the IEEE 802.15.4 Wireless Sensor Networks (WSN).We compare
the performance of the proposed algorithm with those of other floor
estimation algorithms in literature by conducting a real
implementation of WSN in our facility. The experimental results and
analysis showed that the proposed floor estimation algorithm
outperformed the other algorithms and provided highest percentage
of floor accuracy up to 100% with 95-percent confidence interval.
Abstract: Hanging to the trapezoidal sheet by decking hanger is a very widespread solution used in civil engineering to lead the distribution of energy, sanitary, air distribution system etc. under the roof or floor structure. The trapezoidal decking hanger is usually a part of the whole installation system for specific distribution medium. The leading companies offer installation systems for each specific distribution e.g. pipe rings, sprinkler systems, installation channels etc. Every specific part is connected to the base connector which is decking hanger. The own connection has three main components: decking hanger, threaded bar with nuts and web of trapezoidal sheet. The aim of this contribution is determinate the failure mechanism of each component in connection. Load bearing capacity of most components in connection could be calculated by formulas in European codes. This contribution is focused on problematic of bearing resistance of threaded bar in web of trapezoidal sheet. This issue is studied by experimental research and numerical modelling. This contribution presented the initial results of experiment which is compared with numerical model of specimen.
Abstract: The paper reports on the subject of recycling and
further use of secondary raw materials obtained from solar panels,
which is becoming a very up to date topic in recent years. Recycling
these panels is very difficult and complex, and the use of resulting
secondary raw materials is still not fully resolved. Within the
research carried out at the Brno University of Technology, new
polymer materials used for industrial floors are being developed.
Secondary raw materials are incorporated into these polymers as
fillers. One of the tested filler materials was glass obtained from solar
panels. The following text describes procedures and results of the
tests that were performed on these materials, confirming the
possibility of the use of solar panel glass in industrial polymer
flooring systems.
Abstract: The ice rink floor is the largest heat exchanger in an ice rink. The important part of the floor consists of concrete, and the thermophysical properties of this concrete have strong influence on the energy usage of the ice rink. The thermal conductivity of concrete can be increased by using iron ore as ballast. In this study, the Transient Plane Source (TPS) method showed an increase up to 58.2% of thermal conductivity comparing the improved concrete to standard concrete. Moreover, two alternative ice rink floor designs are suggested to incorporate the improved concrete. A 2D simulation was developed to investigate the temperature distribution in the conventional and the suggested designs. The results show that the suggested designs reduce the temperature difference between the ice surface and the brine by 1-4˚C, when comparing with convectional designs at equal heat flux. This primarily leads to an increased coefficient of performance (COP) in the primary refrigeration cycle and secondly to a decrease in the secondary refrigerant pumping power. The suggested designs have great potential to reduce the energy usage of ice rinks. Depending on the load scenario in the ice rink, the saving potential lies in the range of 3-10% of the refrigeration system energy usage. This calculation is based on steady state conditions and the potential with improved dynamic behavior is expected to increase the potential saving.
Abstract: Damages from noise and vibration are increasing
every year, most of which are noises between floors in deteriorated
building caused by floor impact sound. In this study, the concrete slab
measured vibration impact sound for evaluation floor vibration of
deteriorated buildings that fails to satisfy with the minimum thickness.
In this experimental study, the vibration scale by impact sound was
calibrated and compared with ISO and AIJ standard for vibration. The
results show that vibration in slab with thickness used in existing
building reach human perception levels.
Abstract: Building code-related literature provides
recommendations on normalizing approaches to the calculation of
the dynamic properties of structures. Most building codes make a
distinction among types of structural systems, construction material,
and configuration through a numerical coefficient in the
expression for the fundamental period. The period is then used in
normalized response spectra to compute base shear. The typical
parameter used in simplified code formulas for the fundamental
period is overall building height raised to a power determined from
analytical and experimental results. However, reinforced concrete
buildings which constitute the majority of built space in less
developed countries pose additional challenges to the ones built with
homogeneous material such as steel, or with concrete under stricter
quality control. In the present paper, the particularities of reinforced
concrete buildings are explored and related to current methods of
equivalent static analysis. A comparative study is presented between
the Uniform Building Code, commonly used for buildings within
and outside the USA, and data from the Middle East used to model
151 reinforced concrete buildings of varying number of bays, number
of floors, overall building height, and individual story height. The
fundamental period was calculated using eigenvalue matrix
computation. The results were also used in a separate regression
analysis where the computed period serves as dependent variable,
while five building properties serve as independent variables. The
statistical analysis shed light on important parameters that simplified
code formulas need to account for including individual story height,
overall building height, floor plan, number of bays, and concrete
properties. Such inclusions are important for reinforced concrete
buildings of special conditions due to the level of concrete damage,
aging, or materials quality control during construction.
Overall results of the present analysis show that simplified code
formulas for fundamental period and base shear may be applied but
they require revisions to account for multiple parameters. The
conclusion above is confirmed by the analytical model where
fundamental periods were computed using numerical techniques and
eigenvalue solutions. This recommendation is particularly relevant
to code upgrades in less developed countries where it is customary to
adopt, and mildly adapt international codes.
We also note the necessity of further research using empirical data
from buildings in Lebanon that were subjected to severe damage due
to impulse loading or accelerated aging. However, we excluded this
study from the present paper and left it for future research as it has its
own peculiarities and requires a different type of analysis.