Abstract: Geometric design is an important part of planning
process design for physical highway to fill up basic function of roads,
to give good traffic service. It is found that most of the road safety
problems occur at the horizontal curves and complex-compound
curves. In this paper, review on Sagarinn-Myinsain Portion of Nay
Pyi Taw - Mandalay highway has been conducted in aspect of
geometric design induced road safety condition. Horizontal
alignment of geometric features and curve details are reviewed based
on (AASHTO) standard and revised by Autodesk Land Desktop
Software. Moreover, 85th Percentile Operation Speeds (V85) with
driver confidence on horizontal curves is evaluated in order to obtain
the range of highway safety factor (FS). The length of the selected
highway portion is 13.65 miles and 8 lanes. The results of this study
can be used to investigate the possible hazardous locations in
advance and to revise how design radius and super elevation should
be for better road safety performance for the selected portion.
Moreover, the relationship between highway safety and highway
geometry characteristics can also be known.
Abstract: In this paper, a two-dimensional (2D) numerical
model for the tidal currents simulation in Persian Gulf is presented.
The model is based on the depth averaged equations of shallow water
which consider hydrostatic pressure distribution. The continuity
equation and two momentum equations including the effects of bed
friction, the Coriolis effects and wind stress have been solved. To
integrate the 2D equations, the Alternative Direction Implicit (ADI)
technique has been used. The base of equations discritization was
finite volume method applied on rectangular mesh. To evaluate the
model validation, a dam break case study including analytical
solution is selected and the comparison is done. After that, the
capability of the model in simulation of tidal current in a real field is
represented by modeling the current behavior in Persian Gulf. The
tidal fluctuations in Hormuz Strait have caused the tidal currents in
the area of study. Therefore, the water surface oscillations data at
Hengam Island on Hormoz Strait are used as the model input data.
The check point of the model is measured water surface elevations at
Assaluye port. The comparison between the results and the
acceptable agreement of them showed the model ability for modeling
marine hydrodynamic.
Abstract: Anti-allergic effects of royal jelly were evaluated in a human-like mouse model of atopic dermatitis. NC/Nga mice were cutaneously applied with royal jelly for 6 weeks. Royal jelly-treated mice exhibited lower levels of serum total immunoglobulin E in comparison with controls. We found that the treatment decreased (11% to the control) expression of mRNA for aquaporin-3, which is involved in the modulation of epidermal hydration. Microarray analysis revealed more than 10-fold changes in the expression of several genes, such as transglutaminase 2, repetin, and keratins. In normal human epidermal keratinocytes, royal jelly extract suppressed interleukin-8 elevation induced by TNF-α and interferon-γ, suggesting direct anti-inflammatory activity in keratinocytes. Collectively, topical application of royal jelly may be useful for amelioration of lesions and inflammation in atopic dermatitis.
Abstract: This paper has introduced a slope photogrammetric mapping using unmanned aerial vehicle. There are two units of UAV has been used in this study; namely; fixed wing and multi-rotor. Both UAVs were used to capture images at the study area. A consumer digital camera was mounted vertically at the bottom of UAV and captured the images at an altitude. The objectives of this study are to obtain three dimensional coordinates of slope area and to determine the accuracy of photogrammetric product produced from both UAVs. Several control points and checkpoints were established Real Time Kinematic Global Positioning System (RTK-GPS) in the study area. All acquired images from both UAVs went through all photogrammetric processes such as interior orientation, exterior orientation, aerial triangulation and bundle adjustment using photogrammetric software. Two primary results were produced in this study; namely; digital elevation model and digital orthophoto. Based on results, UAV system can be used to mapping slope area especially for limited budget and time constraints project.
Abstract: Planar systems of electrodes arranged on both sides of dielectric piezoelectric layer are applied in numerous transducers. They are capable of electronic beam-steering of generated wave both in azimuth and elevation. The wave-beam control is achieved by addressable driving of two-dimensional transducer through proper voltage supply of electrodes on opposite surfaces of the layer. In this paper a semi-analytical method of analysis of the considered transducer is proposed, which is a generalization of the well-known BIS-expansion method. It was earlier exploited with great success in the theory of interdigital transducers of surface acoustic waves, theory of elastic wave scattering by cracks and certain advanced electrostatic problems. The corresponding nontrivial electrostatic problem is formulated and solved numerically.
Abstract: The possible therapeutic effect of cannabidiol, the major non-psychotropic Cannabis constituent, was investigated against acute hepatotoxicity induced by a single oral dose of acetaminophen (500mg/kg) in mice. Cannabidiol (two intraperitoneal injections, 5mg/kg, each) was given 1 hour and 12 hours following acetaminophen administration. Acetaminophen administration caused significant elevations of serum alanine aminotransferase, and hepatic malondialdehyde, and nitric oxide levels, and a significant decrease in hepatic reduced glutathione. Cannabidiol significantly attenuated the deterioration in the measured biochemical parameters resulted from acetaminophen administration. Also, histopathological examination showed that cannabidiol markedly attenuated ameliorated acetaminophen-induced liver tissue damage. These results emphasize that cannabidiol represents a potential therapeutic option to protect against acetaminophen hepartotoxicity which is a common clinical problem.
Abstract: Sensitive and predictive DILI (Drug Induced Liver
Injury) biomarkers are needed in drug R&D to improve early
detection of hepatotoxicity. The discovery of DILI biomarkers that
demonstrate the predictive power to identify individuals at risk to
DILI would represent a major advance in the development of
personalized healthcare approaches. In this healthy volunteer
acetaminophen study (4g/day for 7 days, with 3 monitored nontreatment
days before and 4 after), 450 serum samples from 32
subjects were analyzed using protein profiling by antibody
suspension bead arrays. Multiparallel protein profiles were generated
using a DILI target protein array with 300 antibodies, where the
antibodies were selected based on previous literature findings of
putative DILI biomarkers and a screening process using pre dose
samples from the same cohort. Of the 32 subjects, 16 were found to
develop an elevated ALT value (2Xbaseline, responders). Using the
plasma profiling approach together with multivariate statistical
analysis some novel findings linked to lipid metabolism were found
and more important, endogenous protein profiles in baseline samples
(prior to treatment) with predictive power for ALT elevations were
identified.
Abstract: The purpose of this research is to develop and apply the
RSCMAC to enhance the dynamic accuracy of Global Positioning
System (GPS). GPS devices provide services of accurate positioning,
speed detection and highly precise time standard for over 98% area on
the earth. The overall operation of Global Positioning System includes
24 GPS satellites in space; signal transmission that includes 2
frequency carrier waves (Link 1 and Link 2) and 2 sets random
telegraphic codes (C/A code and P code), on-earth monitoring stations
or client GPS receivers. Only 4 satellites utilization, the client position
and its elevation can be detected rapidly. The more receivable
satellites, the more accurate position can be decoded. Currently, the
standard positioning accuracy of the simplified GPS receiver is greatly
increased, but due to affected by the error of satellite clock, the
troposphere delay and the ionosphere delay, current measurement
accuracy is in the level of 5~15m. In increasing the dynamic GPS
positioning accuracy, most researchers mainly use inertial navigation
system (INS) and installation of other sensors or maps for the
assistance. This research utilizes the RSCMAC advantages of fast
learning, learning convergence assurance, solving capability of
time-related dynamic system problems with the static positioning
calibration structure to improve and increase the GPS dynamic
accuracy. The increasing of GPS dynamic positioning accuracy can be
achieved by using RSCMAC system with GPS receivers collecting
dynamic error data for the error prediction and follows by using the
predicted error to correct the GPS dynamic positioning data. The
ultimate purpose of this research is to improve the dynamic positioning
error of cheap GPS receivers and the economic benefits will be
enhanced while the accuracy is increased.
Abstract: Radio wave propagation on the road surface is a major
problem on wireless sensor network for traffic monitoring. In this
paper, we compare receiving signal strength on two scenarios 1) an
empty road and 2) a road with a vehicle. We investigate the effect of
antenna polarization and antenna height to the receiving signal
strength. The transmitting antenna is installed on the road surface.
The receiving signal is measured 360 degrees around the transmitting
antenna with the radius of 2.5 meters. Measurement results show the
receiving signal fluctuation around the transmitting antenna in both
scenarios. Receiving signal with vertical polarization antenna results
in higher signal strength than horizontal polarization antenna. The
optimum antenna elevation is 1 meter for both horizon and vertical
polarizations with the vehicle on the road. In the empty road, the
receiving signal level is unvarying with the elevation when the
elevation is greater than 1.5 meters.
Abstract: The autonomous mobile robot was designed and implemented which was capable of navigating in the industrial environments and did a job of picking objects from variable height and delivering it to another location following a predefined trajectory. In developing country like Bangladesh industrial robotics is not very prevalent yet, due to the high installation cost. The objective of this project was to develop an autonomous mobile robot for industrial application using the available resources in the local market at lower manufacturing cost. The mechanical system of the robot was comprised of locomotion, gripping and elevation system. Grippers were designed to grip objects of a predefined shape. Cartesian elevation system was designed for vertical movement of the gripper. PIC18F452 microcontroller was the brain of the control system. The prototype autonomous robot was fabricated for relatively lower load than the industry and the performance was tested in a virtual industrial environment created within the laboratory to realize the effectiveness.
Abstract: Historic religious buildings located in seismic areas
have developed different failure mechanisms. Simulation of failure
modes is done with computer programs through a nonlinear dynamic
analysis or simplified using the method of failure blocks. Currently
there are simulation methodologies of failure modes based on the
failure rigid blocks method only for Roman Catholic churches type.
Due to differences of shape in plan, elevation and construction
systems between Orthodox churches and Catholic churches, for the
first time there were initiated researches in the development of this
simulation methodology for Orthodox churches. In this article are
presented the first results from the researches. The theoretical results
were compared with real failure modes recorded at an Orthodox
church from Banat region, severely damaged by earthquakes in
1991. Simulated seismic response, using a computer program based
on finite element method was confirmed by cracks after earthquakes.
The consolidation of the church was made according to these
theoretical results, realizing a rigid floor connecting all the failure
blocks.
Abstract: Protection and proper management of archaeological heritage are an essential process of studying and interpreting the generations present and future. Protecting the archaeological heritage is based upon multidiscipline professional collaboration. This study aims to gather data by different sources (Photogrammetry and Geographic Information System (GIS)) integrated for the purpose of documenting one the of significant archeological sites (Ahl-Alkahf, Jordan). 3D modeling deals with the actual image of the features, shapes and texture to represent reality as realistically as possible by using texture. The 3D coordinates that result of the photogrammetric adjustment procedures are used to create 3D-models of the study area. Adding Textures to the 3D-models surfaces gives a 'real world' appearance to the displayed models. GIS system combined all data, including boundary maps, indicating the location of archeological sites, transportation layer, digital elevation model and orthoimages. For realistic representation of the study area, 3D - GIS model prepared, where efficient generation, management and visualization of such special data can be achieved.
Abstract: The impact of a proposed pier on tidal current
alteration was evaluated. The proposed pier location was in Salad
Bay on Koa Kood Island, Trat province, Thailand, and was designed
to accommodate passenger ships with a draft of less than 2 m. The
study began with collecting necessary data, including bathymetric,
water elevation and tidal current characteristics. The impact was
assessed using a software package (MIKE21). Although the results
showed that the pier would affect the existing current pattern, the
change was determined to be insignificant, as the design of the piles
for the pier provided sufficient spacing to let the current flow as
freely as possible. Consequences of the altered current, such as
seabed erosion, water stagnation, sediment deposition and
navigational risk were assessed. Environmental mitigation measures
might be necessary if the impacts were considered unacceptable.
Abstract: We investigated the response of testosterone (T),
growth hormone (GH), cortisol (C), steroid hormone binding
globulin (SHBG), insulin-like growth factor (IGF-1), insulin-like
growth factor binding protein-3 (IGFBP-3), and some anaboliccatabolic
indexes, i.e.: T/C, T/SHBG, and IGF-1/IGFBP-3 to
maximal exercise in endurance-trained athletes (TREN) and
untrained subjects (CG). The baseline concentration of IGF-1 was
higher in athletes (TREN) when compared to the CG (p
Abstract: The need to evaluate and understand the natural
drainage pattern in a flood prone, and fast developing environment is
of paramount importance. This information will go a long way to
help the town planners to determine the drainage pattern, road
networks and areas where prominent structures are to be located. This
research work was carried out with the aim of studying the Bayelsa
landscape topography using digitized topographic information, and to
model the natural drainage flow pattern that will aid the
understanding and constructions of workable drainages. To achieve
this, digitize information of elevation and coordinate points were
extracted from a global imagery map. The extracted information was
modeled into 3D surfaces. The result revealed that the average
elevation for Bayelsa State is 12 m above sea level. The highest
elevation is 28 m, and the lowest elevation 0 m, along the coastline.
In Yenagoa the capital city of Bayelsa were a detail survey was
carried out showed that average elevation is 15 m, the highest
elevation is 25 m and lowest is 3 m above the mean sea level. The
regional elevation in Bayelsa, showed a gradation decrease from the
North Eastern zone to the South Western Zone. Yenagoa showed an
observed elevation lineament, were low depression is flanked by high
elevation that runs from the North East to the South west. Hence,
future drainages in Yenagoa should be directed from the high
elevation, from South East toward the North West and from the
North West toward South East, to the point of convergence which is
at the center that flows from South East toward the North West.
Bayelsa when considered on a regional Scale, the flow pattern is from
the North East to the South West, and also North South. It is
recommended that in the event of any large drainage construction at
municipal scale, it should be directed from North East to the South
West or from North to South. Secondly, detail survey should be
carried out to ascertain the local topography and the drainage pattern
before the design and construction of any drainage system in any part
of Bayelsa.
Abstract: This paper presents a constrained valley detection
algorithm. The intent is to find valleys in the map for the path planning
that enables a robot or a vehicle to move safely. The constraint to the
valley is a desired width and a desired depth to ensure the space for
movement when a vehicle passes through the valley. We propose an
algorithm to find valleys satisfying these 2 dimensional constraints.
The merit of our algorithm is that the pre-processing and the
post-processing are not necessary to eliminate undesired small valleys.
The algorithm is validated through simulation using digitized
elevation data.
Abstract: Because of the global warming and the rising sea level, residents living in southwestern coastland, Taiwan are faced with the submerged land and may move to higher elevation area. It is desirable to discuss the key consideration factor for selecting the migration location under five dimensions of ಯ security”, “health”, “convenience”, “comfort” and “socio-economic” based on the document reviews. This paper uses the Structural Equation Modeling (SEM) and the questionnaire survey. The analysis results show that the convenience is the most key factor for residents in Taiwan.
Abstract: In this paper, to optimize the “Characteristic Straight Line Method" which is used in the soil displacement analysis, a “best estimate" of the geodetic leveling observations has been achieved by taking in account the concept of 'Height systems'. This concept has been discussed in detail and consequently the concept of “height". In landslides dynamic analysis, the soil is considered as a mosaic of rigid blocks. The soil displacement has been monitored and analyzed by using the “Characteristic Straight Line Method". Its characteristic components have been defined constructed from a “best estimate" of the topometric observations. In the measurement of elevation differences, we have used the most modern leveling equipment available. Observational procedures have also been designed to provide the most effective method to acquire data. In addition systematic errors which cannot be sufficiently controlled by instrumentation or observational techniques are minimized by applying appropriate corrections to the observed data: the level collimation correction minimizes the error caused by nonhorizontality of the leveling instrument's line of sight for unequal sight lengths, the refraction correction is modeled to minimize the refraction error caused by temperature (density) variation of air strata, the rod temperature correction accounts for variation in the length of the leveling rod' s Invar/LO-VAR® strip which results from temperature changes, the rod scale correction ensures a uniform scale which conforms to the international length standard and the introduction of the concept of the 'Height systems' where all types of height (orthometric, dynamic, normal, gravity correction, and equipotential surface) have been investigated. The “Characteristic Straight Line Method" is slightly more convenient than the “Characteristic Circle Method". It permits to evaluate a displacement of very small magnitude even when the displacement is of an infinitesimal quantity. The inclination of the landslide is given by the inverse of the distance reference point O to the “Characteristic Straight Line". Its direction is given by the bearing of the normal directed from point O to the Characteristic Straight Line (Fig..6). A “best estimate" of the topometric observations was used to measure the elevation of points carefully selected, before and after the deformation. Gross errors have been eliminated by statistical analyses and by comparing the heights within local neighborhoods. The results of a test using an area where very interesting land surface deformation occurs are reported. Monitoring with different options and qualitative comparison of results based on a sufficient number of check points are presented.
Abstract: Psoriasis is a widespread skin disease affecting up to 2% population with plaque psoriasis accounting to about 80%. It can be identified as a red lesion and for the higher severity the lesion is usually covered with rough scale. Psoriasis Area Severity Index (PASI) scoring is the gold standard method for measuring psoriasis severity. Scaliness is one of PASI parameter that needs to be quantified in PASI scoring. Surface roughness of lesion can be used as a scaliness feature, since existing scale on lesion surface makes the lesion rougher. The dermatologist usually assesses the severity through their tactile sense, therefore direct contact between doctor and patient is required. The problem is the doctor may not assess the lesion objectively. In this paper, a digital image analysis technique is developed to objectively determine the scaliness of the psoriasis lesion and provide the PASI scaliness score. Psoriasis lesion is modelled by a rough surface. The rough surface is created by superimposing a smooth average (curve) surface with a triangular waveform. For roughness determination, a polynomial surface fitting is used to estimate average surface followed by a subtraction between rough and average surface to give elevation surface (surface deviations). Roughness index is calculated by using average roughness equation to the height map matrix. The roughness algorithm has been tested to 444 lesion models. From roughness validation result, only 6 models can not be accepted (percentage error is greater than 10%). These errors occur due the scanned image quality. Roughness algorithm is validated for roughness measurement on abrasive papers at flat surface. The Pearson-s correlation coefficient of grade value (G) of abrasive paper and Ra is -0.9488, its shows there is a strong relation between G and Ra. The algorithm needs to be improved by surface filtering, especially to overcome a problem with noisy data.
Abstract: Recent years, adaptive pushover methods have been
developed for seismic analysis of structures. Herein, the accuracy of
the displacement-based adaptive pushover (DAP) method, which is
introduced by Antoniou and Pinho [2004], is evaluated for Irregular
buildings. The results are compared to the force-based procedure.
Both concrete and steel frame structures, asymmetric in plan and
elevation are analyzed and also torsional effects are taking into the
account. These analyses are performed using both near fault and far
fault records. In order to verify the results, the Incremental Dynamic
Analysis (IDA) is performed.