Abstract: It has been known that a characteristic
Burst-Suppression (BS) pattern appears in EEG during the early
recovery period following Cardiac Arrest (CA). Here, to explore the
relationship between cortical and subcortical neural activities
underlying BS, extracellular activity in the parietal cortex and the
centromedian nucleus of the thalamus and extradural EEG were
recorded in a rodent CA model. During the BS, the cortical firing rate
is extraordinarily high, and that bursts in EEG correlate to dense spikes
in cortical neurons. Newly observed phenomena are that 1) thalamic
activity reemerges earlier than cortical activity following CA, and 2)
the correlation coefficient of cortical and thalamic activities rises
during BS period. These results would help elucidate the underlying
mechanism of brain recovery after CA injury.
Abstract: This work proposes a data-driven multiscale based
quantitative measures to reveal the underlying complexity of
electroencephalogram (EEG), applying to a rodent model of
hypoxic-ischemic brain injury and recovery. Motivated by that real
EEG recording is nonlinear and non-stationary over different
frequencies or scales, there is a need of more suitable approach over
the conventional single scale based tools for analyzing the EEG data.
Here, we present a new framework of complexity measures
considering changing dynamics over multiple oscillatory scales. The
proposed multiscale complexity is obtained by calculating entropies of
the probability distributions of the intrinsic mode functions extracted
by the empirical mode decomposition (EMD) of EEG. To quantify
EEG recording of a rat model of hypoxic-ischemic brain injury
following cardiac arrest, the multiscale version of Tsallis entropy is
examined. To validate the proposed complexity measure, actual EEG
recordings from rats (n=9) experiencing 7 min cardiac arrest followed
by resuscitation were analyzed. Experimental results demonstrate that
the use of the multiscale Tsallis entropy leads to better discrimination
of the injury levels and improved correlations with the neurological
deficit evaluation after 72 hours after cardiac arrest, thus suggesting an
effective metric as a prognostic tool.
Abstract: The technological concepts such as wireless hospital
and portable cardiac telemetry system require the development of
physiological signal acquisition devices to be easily integrated into
the hospital database. In this paper we present the low cost, portable
wireless ECG acquisition hardware that transmits ECG signals to a
dedicated computer.The front end of the system obtains and
processes incoming signals, which are then transmitted via a
microcontroller and wireless Bluetooth module. A monitoring
purpose Bluetooth based end user application integrated with patient
database management module is developed for the computers. The
system will act as a continuous event recorder, which can be used to
follow up patients who have been resuscitatedfrom cardiac arrest,
ventricular tachycardia but also for diagnostic purposes for patients
with arrhythmia symptoms. In addition, cardiac information can be
saved into the patient-s database of the hospital.