Abstract: Human heart valves diseased by congenital heart
defects, rheumatic fever, bacterial infection, cancer may cause stenosis
or insufficiency in the valves. Treatment may be with medication but
often involves valve repair or replacement (insertion of an artificial
heart valve). Bileaflet mechanical heart valves (BMHVs) are widely
implanted to replace the diseased heart valves, but still suffer from
complications such as hemolysis, platelet activation, tissue
overgrowth and device failure. These complications are closely related
to both flow characteristics through the valves and leaflet dynamics. In
this study, the physiological flow interacting with the moving leaflets
in a bileaflet mechanical heart valve (BMHV) is simulated with a
strongly coupled implicit fluid-structure interaction (FSI) method
which is newly organized based on the Arbitrary-Lagrangian-Eulerian
(ALE) approach and the dynamic mesh method (remeshing) of
FLUENT. The simulated results are in good agreement with previous
experimental studies. This study shows the applicability of the present
FSI model to the complicated physics interacting between fluid flow
and moving boundary.
Abstract: The purpose of this paper is to assess the value of neural networks for classification of cancer and noncancer prostate cells. Gauss Markov Random Fields, Fourier entropy and wavelet average deviation features are calculated from 80 noncancer and 80 cancer prostate cell nuclei. For classification, artificial neural network techniques which are multilayer perceptron, radial basis function and learning vector quantization are used. Two methods are utilized for multilayer perceptron. First method has single hidden layer and between 3-15 nodes, second method has two hidden layer and each layer has between 3-15 nodes. Overall classification rate of 86.88% is achieved.
Abstract: Purpose of this work is the development of an
automatic classification system which could be useful for radiologists
in the investigation of breast cancer. The software has been designed
in the framework of the MAGIC-5 collaboration.
In the automatic classification system the suspicious regions with
high probability to include a lesion are extracted from the image as
regions of interest (ROIs). Each ROI is characterized by some
features based on morphological lesion differences.
Some classifiers as a Feed Forward Neural Network, a K-Nearest
Neighbours and a Support Vector Machine are used to distinguish the
pathological records from the healthy ones.
The results obtained in terms of sensitivity (percentage of
pathological ROIs correctly classified) and specificity (percentage of
non-pathological ROIs correctly classified) will be presented through
the Receive Operating Characteristic curve (ROC). In particular the
best performances are 88% ± 1 of area under ROC curve obtained
with the Feed Forward Neural Network.
Abstract: Breast cancer is one of the most frequent occurring cancers in women throughout the world including U.K. The grading of this cancer plays a vital role in the prognosis of the disease. In this paper we present an overview of the use of advanced computational method of fuzzy inference system as a tool for the automation of breast cancer grading. A new spectral data set obtained from Fourier Transform Infrared Spectroscopy (FTIR) of cancer patients has been used for this study. The future work outlines the potential areas of fuzzy systems that can be used for the automation of breast cancer grading.
Abstract: Purpose: To explore the use of Curvelet transform to
extract texture features of pulmonary nodules in CT image and support
vector machine to establish prediction model of small solitary
pulmonary nodules in order to promote the ratio of detection and
diagnosis of early-stage lung cancer. Methods: 2461 benign or
malignant small solitary pulmonary nodules in CT image from 129
patients were collected. Fourteen Curvelet transform textural features
were as parameters to establish support vector machine prediction
model. Results: Compared with other methods, using 252 texture
features as parameters to establish prediction model is more proper.
And the classification consistency, sensitivity and specificity for the
model are 81.5%, 93.8% and 38.0% respectively. Conclusion: Based
on texture features extracted from Curvelet transform, support vector
machine prediction model is sensitive to lung cancer, which can
promote the rate of diagnosis for early-stage lung cancer to some
extent.
Abstract: Segmentation, filtering out of measurement errors and
identification of breakpoints are integral parts of any analysis of
microarray data for the detection of copy number variation (CNV).
Existing algorithms designed for these tasks have had some successes
in the past, but they tend to be O(N2) in either computation time or
memory requirement, or both, and the rapid advance of microarray
resolution has practically rendered such algorithms useless. Here we
propose an algorithm, SAD, that is much faster and much less thirsty
for memory – O(N) in both computation time and memory requirement
-- and offers higher accuracy. The two key ingredients of SAD are the
fundamental assumption in statistics that measurement errors are
normally distributed and the mathematical relation that the product of
two Gaussians is another Gaussian (function). We have produced a
computer program for analyzing CNV based on SAD. In addition to
being fast and small it offers two important features: quantitative
statistics for predictions and, with only two user-decided parameters,
ease of use. Its speed shows little dependence on genomic profile.
Running on an average modern computer, it completes CNV analyses
for a 262 thousand-probe array in ~1 second and a 1.8 million-probe
array in 9 seconds
Abstract: This paper focuses on the data-driven generation
of fuzzy IF...THEN rules. The resulted fuzzy rule base can be
applied to build a classifier, a model used for prediction, or
it can be applied to form a decision support system. Among
the wide range of possible approaches, the decision tree and
the association rule based algorithms are overviewed, and two
new approaches are presented based on the a priori fuzzy
clustering based partitioning of the continuous input variables.
An application study is also presented, where the developed
methods are tested on the well known Wisconsin Breast Cancer
classification problem.
Abstract: In this study, a three-dimensional haptotaxis model to simulate the migration of a population of cancer cells has been proposed. The invasion of cancer cells is related with the hapto-attractant and the effect of the interface energies between the cells and the ECM. The diffuse interface model, which incorporates the haptotaxis mechanism and interface energies, is employed. The semi-implicit Fourier spectral scheme is adopted for efficient evaluation of the simulation. The simulation results thoroughly reveal the dynamics of cancer-cell migration.
Abstract: The paper aims to specify and build a system, a learning support in radiology-senology (breast radiology) dedicated to help assist junior radiologists-senologists in their radiologysenology- related activity based on experience of expert radiologistssenologists. This system is named SAFRS (i.e. system supporting the training of radiologists-senologists). It is based on the exploitation of radiologic-senologic images (primarily mammograms but also echographic images or MRI) and their related clinical files. The aim of such a system is to help breast cancer screening in education. In order to acquire this expert radiologist-senologist knowledge, we have used the CBR (case-based reasoning) approach. The SAFRS system will promote the evolution of teaching in radiology-senology by offering the “junior radiologist" trainees an advanced pedagogical product. It will permit a strengthening of knowledge together with a very elaborate presentation of results. At last, the know-how will derive from all these factors.
Abstract: This paper presents an approach for early breast
cancer diagnostic by employing combination of artificial neural
networks (ANN) and multiwaveletpacket based subband image
decomposition. The microcalcifications correspond to high-frequency
components of the image spectrum, detection of microcalcifications
is achieved by decomposing the mammograms into different
frequency subbands,, reconstructing the mammograms from the
subbands containing only high frequencies. For this approach we
employed different types of multiwaveletpacket. We used the result
as an input of neural network for classification. The proposed
methodology is tested using the Nijmegen and the Mammographic
Image Analysis Society (MIAS) mammographic databases and
images collected from local hospitals. Results are presented as the
receiver operating characteristic (ROC) performance and are
quantified by the area under the ROC curve.
Abstract: Tumor cells have an invasive and metastatic phenotype
that is the main cause of death for cancer patients. Tumor
establishment and penetration consists of a series of complex
processes involving multiple changes in gene expression. In this study,
intraperitoneal administration of a high concentration of ascorbic acid
inhibited tumor establishment and decreased tumor mass in BALB/C
mice implanted with S-180 sarcoma cancer cells. To identify proteins
involved in the ascorbic acid-mediated inhibition of tumor
progression, changes in the tumor proteome associated with ascorbic
acid treatment of BALB/C mice implanted with S-180 were
investigated using two-dimensional gel electrophoresis and mass
spectrometry. Twenty protein spots were identified whose expression
was different between control and ascorbic acid treatment groups.
Abstract: We propose a method for discrimination and
classification of ovarian with benign, malignant and normal tissue
using independent component analysis and neural networks. The
method was tested for a proteomic patters set from A database, and
radial basis functions neural networks. The best performance was
obtained with probabilistic neural networks, resulting I 99% success
rate, with 98% of specificity e 100% of sensitivity.
Abstract: In article the data of chronic toxicity for pre-clinical
researches of Ramon preparation is described. Ramon effects to
hormone system and gastrointestinal tract; local irritative effect,
allergic, pyrogenic properties and reaction to the immune system
were studied.
Abstract: In article the data of acute toxicity for pre-clinical
researches of Ramon preparation is described. Ramon effects to
clinical characteristics of blood, cardio-vascular system, hepatotoxic
and diuretic effects were studied.
Abstract: Early detection of breast cancer is considered as a
major public health issue. Breast cancer screening is not generalized
to the entire population due to a lack of resources, staff and
appropriate tools. Systematic screening can result in a volume of data
which can not be managed by present computer architecture, either in
terms of storage capabilities or in terms of exploitation tools. We
propose in this paper to design and develop a data warehouse system
in radiology-senology (DWRS). The aim of such a system is on one
hand, to support this important volume of information providing from
multiple sources of data and images and for the other hand, to help
assist breast cancer screening in diagnosis, education and research.
Abstract: In this paper, we propose disease diagnosis hardware
architecture by using Hypernetworks technique. It can be used to
diagnose 3 different diseases (SPECT Heart, Leukemia, Prostate
cancer). Generally, the disparate diseases require specified diagnosis
hardware model for each disease. Using similarities of three diseases
diagnosis processor, we design diagnosis processor that can diagnose
three different diseases. Our proposed architecture that is combining
three processors to one processor can reduce hardware size without
decrease of the accuracy.
Abstract: Competing risks survival data that comprises of more
than one type of event has been used in many applications, and one
of these is in clinical study (e.g. in breast cancer study). The
decision tree method can be extended to competing risks survival
data by modifying the split function so as to accommodate two or
more risks which might be dependent on each other. Recently,
researchers have constructed some decision trees for recurrent
survival time data using frailty and marginal modelling. We further
extended the method for the case of competing risks. In this paper,
we developed the decision tree method for competing risks survival
time data based on proportional hazards for subdistribution of
competing risks. In particular, we grow a tree by using deviance
statistic. The application of breast cancer data is presented. Finally,
to investigate the performance of the proposed method, simulation
studies on identification of true group of observations were executed.
Abstract: P16/INK4A is tumor suppressor protein that plays a critical role in cell cycle regulation. Loss of P16 protein expression has been implicated in pathogenesis of many cancers, including lymphoma. Therefore, we sought to investigate if loss of P16 protein expression is associated with lymphoma and/or any specific lymphoma subtypes (Hodgkin-s lymphoma (HL) and nonHodgkin-s lymphoma (NHL)). Fifty-five lymphoma cases consisted of 30 cases of HL and 25 cases of NHL, with an age range of 3 to 78 years, were examined for loss of P16 by immunohistochemical technique using a specific antibody reacting against P16. In total, P16 loss was seen in 33% of all lymphoma cases. P16 loss was identified in 47.7% of HL cases. In contrast, only 16% of NHL showed loss of P16. Loss of P16 was seen in 67% of HL patients with 50 years of age or older, whereas P16 loss was found in only 42% of HL patients with less than 50 years of age. P16 loss in HL is somewhat higher in male (55%) than in female (30%). In subtypes of HL, P16 loss was found exclusively in all cases of lymphocyte depletion, lymphocyte predominance and unclassified cases, whereas P16 loss was seen in 39% of mixed cellularity and 29% of nodular sclerosis cases. In low grade NHL patients, P16 loss was seen in approximately one-third of cases, whereas no or very rare of P16 loss was found in intermediate and high grade cases. P16 loss did not show any correlation with age or gender of NHL patients. In conclusion, the high rate of P16 loss seen in our study suggests that loss of P16 expression plays a critical role in the pathogenesis of lymphoma, particularly with HL.
Abstract: The Neuro-Fuzzy hybridization scheme has become
of research interest in pattern classification over the past decade. The
present paper proposes a novel Modified Adaptive Fuzzy Inference
Engine (MAFIE) for pattern classification. A modified Apriori
algorithm technique is utilized to reduce a minimal set of decision
rules based on input output data sets. A TSK type fuzzy inference
system is constructed by the automatic generation of membership
functions and rules by the fuzzy c-means clustering and Apriori
algorithm technique, respectively. The generated adaptive fuzzy
inference engine is adjusted by the least-squares fit and a conjugate
gradient descent algorithm towards better performance with a
minimal set of rules. The proposed MAFIE is able to reduce the
number of rules which increases exponentially when more input
variables are involved. The performance of the proposed MAFIE is
compared with other existing applications of pattern classification
schemes using Fisher-s Iris and Wisconsin breast cancer data sets and
shown to be very competitive.
Abstract: Bladder carcinoma is an important worldwide health problem. Both cystoscopy and urine cytology used in detecting bladder cancer suffer from drawbacks where cystoscopy is an invasive method and urine cytology shows low sensitivity in low grade tumors. This study validates easier and less time-consuming techniques to evaluate the value of combined use of angiogenin and clusterin in comparison and combination with voided urine cytology in the detection of bladder cancer patients. This study includes malignant (bladder cancer patients, n= 50), benign (n=20) and healthy (n=20) groups. The studied groups were subjected to cystoscopic examination, detection of bilharzial antibodies, urine cytology, and estimation of urinary angiogenin and clusterin by ELISA. The overall sensitivity and specificity were 66% and 75% for angiogenin, 70% and 82.5% for clusterin and 46% and 80% for voided urine cytology. Combined sensitivity of angiogenin and clusterin with urine cytology increased from 82 to 88%.