Abstract: Syringe pumps are commonly used for drug delivery in hospitals and clinical environments. These instruments are critical in neonatology and oncology, where any variation in the flow rate and drug dosing quantity can lead to severe incidents and even death of the patient. Therefore it is very important to determine the accuracy and precision of these devices using the suitable calibration methods. The Volume Laboratory of the Portuguese Institute for Quality (LVC/IPQ) uses two different methods to calibrate syringe pumps from 16 nL/min up to 20 mL/min. The Interferometric method uses an interferometer to monitor the distance travelled by a pusher block of the syringe pump in order to determine the flow rate. Therefore, knowing the internal diameter of the syringe with very high precision, the travelled distance, and the time needed for that travelled distance, it was possible to calculate the flow rate of the fluid inside the syringe and its uncertainty. As an alternative to the gravimetric and the interferometric method, a methodology based on the application of optical technology was also developed to measure flow rates. Mainly this method relies on measuring the increase of volume of a drop over time. The objective of this work is to compare the results of the calibration of two syringe pumps using the different methodologies described above. The obtained results were consistent for the three methods used. The uncertainties values were very similar for all the three methods, being higher for the optical drop method due to setup limitations.
Abstract: Higher Education is resisting the pull of technology, especially as this concerns the issuance and verification of degrees and certificates. It is widely known that education certificates are largely produced in paper form making them vulnerable to damage while holders of such certificates are dependent on the universities and other issuing organisations. QualiChain is an EU Horizon 2020 (H2020) research project aiming to transform and revolutionise the domain of public education and its ties with the job market by leveraging blockchain, analytics and decision support to develop a platform for the verification and sharing of education certificates. Blockchain plays an integral part in the QualiChain solution in providing a trustworthy environment to store, share and manage such accreditations. Under the context of this paper, three prominent blockchain platforms (Ethereum, Hyperledger Fabric, Hyperledger Iroha) were considered as a means of experimentation for creating a system with the basic functionalities that will be needed for trustworthy degree verification. The methodology and respective system developed and presented in this paper used Hyperledger Iroha and proved that this specific platform can be used to easily develop decentralize applications. Future papers will attempt to further experiment with other blockchain platforms and assess which has the best potential.
Abstract: A decline in visual sensitivity at arbitrary points on the retina can be measured using a precise perimetry apparatus along with a fundus camera. However, the retinal layer associated with this decline cannot be identified accurately with current medical technology. To investigate cryptogenic diseases, such as macular dystrophy, acute zonal occult outer retinopathy (AZOOR), and multiple evanescent white dot syndrome (MEWDS), we evaluated an electroretinogram (ERG) function that allows moving the center of the multifocal hexagonal stimulus array to a chosen position. Macular dystrophy is a generalized term used for a variety of functional disorders of the macula lutea, and the ERG shows a diminution of the b-wave in these disorders. AZOOR causes an acute functional disorder to an outer layer of the retina, and the ERG shows a-wave and b-wave amplitude reduction as well as delayed 30 Hz flicker responses. MEWDS causes acute visual loss and the ERG shows a decrease in a-wave amplitude. We combined an electroretinographic optical system and a perimetric optical system into an experimental apparatus that has the same optical system as that of a fundus camera. We also deployed an EO-50231 Edmund infrared camera, a 45-degree cold mirror, a lens with a 25-mm focal length, a halogen lamp, and an 8-inch monitor. Then, we also employed a differential amplifier with gain 10, a 50 Hz notch filter, a high-pass filter with a 21.2 Hz cut-off frequency, and two non-inverting amplifiers with gains 1001 and 11. In addition, we used a USB-6216 National Instruments I/O device, a NE-113A Nihon Kohden plate electrode, a SCB-68A shielded connector block, and LabVIEW 2017 software for data retrieval. The software was used to generate the multifocal hexagonal stimulus array on the computer monitor with C++Builder 10.2 and to move the center of the array toward the left and right and up and down. Cone and bright flash ERG results were observed using the moving ERG function. The a-wave, b-wave, c-wave, and the photopic negative response were identified with cone ERG. The moving ERG function allowed the identification of the retinal layer causing visual alterations.
Abstract: The security aspect of the IoT occupies a place of great
importance especially after the evolution that has known this field
lastly because it must take into account the transformations and the
new applications .Blockchain is a new technology dedicated to the
data sharing. However, this does not work the same way in the
different systems with different operating principles. This article will
discuss network security using the Blockchain to facilitate the sending
of messages and information, enabling the use of new processes and
enabling autonomous coordination of devices. To do this, we will
discuss proposed solutions to ensure a high level of security in these
networks in the work of other researchers. Finally, our article will
propose a method of security more adapted to our needs as a team
working in the ad hoc networks, this method is based on the principle
of the Blockchain and that we named ”MPR Blockchain”.
Abstract: The economic scenario of any region does not show the real picture for the measurement of overall development. Therefore, economic development must be accompanied by social development to be able to make an assessment to measure the level of development. The spatial variation with respect to social development has been discussed taking into account the quality of functioning of a social system in a specific area. In this paper, an attempt has been made to study the spatial distribution of social infrastructural facilities and analyze the magnitude of regional disparities at inter- block level in Barddhman district. It starts with the detailed account of the selection process of social infrastructure indicators and describes the methodology employed in the empirical analysis. Analyzing the block level data, this paper tries to identify the disparity among the blocks in the levels of social development. The results have been subsequently explained using both statistical analysis and geo spatial technique. The paper reveals that the social development is not going on at the same rate in every part of the district. Health facilities and educational facilities are concentrated at some selected point. So overall development activities come to be concentrated in a few centres and the disparity is seen over the blocks.
Abstract: Nanotherapy is an actual newest mode of treatment numerous diseases using nanoparticles (NPs) loading with different pharmaceuticals. NPs of biodegradable polymeric micelles (PMs) are gaining increased attention for their numerous and attractive abilities to be used in a variety of applications in the various fields of medicine. The present paper deals with the synthesis of a class of biodegradable micelle-forming polymers, namely ABA triblock-copolymer in which A-blocks represent amino-poly(ethylene glycol) (H2N-PEG) and B-block is biodegradable amino acid-based poly(ester amide) constituted of α-amino acid – L-phenylalanine. The obtained copolymer formed micelles of 70±4 nm size at 10 mg/mL concentration.
Abstract: In this work, a five step continuous method for the solution of third order ordinary differential equations was developed in block form using collocation and interpolation techniques of the shifted Legendre polynomial basis function. The method was found to be zero-stable, consistent and convergent. The application of the method in solving third order initial value problem of ordinary differential equations revealed that the method compared favorably with existing methods.
Abstract: The Canadian Used Fuel Container (UFC) is a mid-size hemispherical headed copper coated steel container measuring 2.5 meters in length and 0.5 meters in diameter containing 48 used fuel bundles. The contained used fuel produces significant gamma radiation requiring automated assembly processes to complete the assembly. The design throughput of 2,500 UFCs per year places constraints on equipment and hot cell design for repeatability, speed of processing, robustness and recovery from upset conditions. After UFC assembly, the UFC is inserted into a Buffer Box (BB). The BB is made from adequately pre-shaped blocks (lower and upper block) and Highly Compacted Bentonite (HCB) material. The blocks are practically ‘sandwiching’ the UFC between them after assembly. This paper identifies one possible approach for the BB automatic assembly cell and processes. Automation of the BB assembly will have a significant positive impact on nuclear safety, quality, productivity, and reliability.
Abstract: Hammerstein–Wiener model is a block-oriented model
where a linear dynamic system is surrounded by two static
nonlinearities at its input and output and could be used to model
various processes. This paper contains an optimization approach
method for analysing the problem of Hammerstein–Wiener systems
identification. The method relies on reformulate the identification
problem; solve it as constraint quadratic problem and analysing its
solutions. During the formulation of the problem, effects of adding
noise to both input and output signals of nonlinear blocks and
disturbance to linear block, in the emerged equations are discussed.
Additionally, the possible parametric form of matrix operations
to reduce the equation size is presented. To analyse the possible
solutions to the mentioned system of equations, a method to reduce
the difference between the number of equations and number of
unknown variables by formulate and importing existing knowledge
about nonlinear functions is presented. Obtained equations are applied
to an instance H–W system to validate the results and illustrate the
proposed method.
Abstract: In this paper, an improved motion estimation (ME) approach based on weighted constrained one-bit transform is proposed for block-based ME employed in video encoders. Binary ME approaches utilize low bit-depth representation of the original image frames with a Boolean exclusive-OR based hardware efficient matching criterion to decrease computational burden of the ME stage. Weighted constrained one-bit transform (WC‑1BT) based approach improves the performance of conventional C-1BT based ME employing 2-bit depth constraint mask instead of a 1-bit depth mask. In this work, the range of constraint mask is further extended to increase ME performance of WC-1BT approach. Experiments reveal that the proposed method provides better ME accuracy compared existing similar ME methods in the literature.
Abstract: The global capacity of wind power has dramatically increased in recent years. Therefore, improving the technology of wind turbines to take different advantages of this enormous potential in the power grid, could be interesting subject for scientists. The doubly-fed induction generator (DFIG) wind turbine is a popular system due to its many advantages such as the improved power quality, high energy efficiency and controllability, etc. With an increase in wind power penetration in the network and with regard to the flexible control of wind turbines, the use of wind turbine systems to improve the dynamic stability of power systems has been of significance importance for researchers. Subsynchronous oscillations are one of the important issues in the stability of power systems. Damping subsynchronous oscillations by using wind turbines has been studied in various research efforts, mainly by adding an auxiliary control loop to the control structure of the wind turbine. In most of the studies, this control loop is composed of linear blocks. In this paper, simple adaptive control is used for this purpose. In order to use an adaptive controller, the convergence of the controller should be verified. Since adaptive control parameters tend to optimum values in order to obtain optimum control performance, using this controller will help the wind turbines to have positive contribution in damping the network subsynchronous oscillations at different wind speeds and system operating points. In this paper, the application of simple adaptive control in DFIG wind turbine systems to improve the dynamic stability of power systems is studied and the essential condition for using this controller is considered. It is also shown that this controller has an insignificant effect on the dynamic stability of the wind turbine, itself.
Abstract: Background: Hypertensive response during maximal exercise test provides important information on the level of blood pressure control and evaluation of treatment. Method: A single center retrospective descriptive study was conducted among 117 young (aged 20 to 40) and middle age (aged 40 to 65) hypertensive patients, who underwent treadmill stress test. Currently on maintenance frontline medication either monotherapy (Angiotensin-converting enzyme inhibitor/Angiotensin receptor blocker [ACEi/ARB], Calcium channel blocker [CCB], Diuretic - Hydrochlorthiazide [HCTZ]) or combination therapy (ARB+CCB, ARB+HCTZ), who attained a maximal exercise on treadmill stress test (TMST) with hypertensive response (systolic blood pressure: male >210 mm Hg, female >190 mm Hg, diastolic blood pressure >100 mmHg, or increase of >10 mm Hg at any time during the test), on Bruce and Modified Bruce protocol. Exaggerated blood pressure response during exercise (systolic [SBP] and diastolic [DBP]), peak exercise blood pressure (SBP and DBP), recovery period (SBP and DBP) and test for ischemia and their antihypertensive medication/s were investigated. Analysis of variance and chi-square test were used for statistical analysis. Results: Hypertensive responses on maximal exercise test were seen mostly among female population (P < 0.000) and middle age (P < 0.000) patients. Exaggerated diastolic blood pressure responses were significantly lower in patients who were taking CCB (P < 0.004). A longer recovery period that showed a delayed decline in SBP was observed in patients taking ARB+HCTZ (P < 0.036). There were no significant differences in the level of exaggerated systolic blood pressure response and during peak exercise (both systolic and diastolic) in patients using either monotherapy or combination antihypertensives. Conclusion: Calcium channel blockers provided lower exaggerated diastolic BP response during maximal exercise test in hypertensive middle age patients. Patients on combination therapy using ARB+HCTZ exhibited a longer recovery period of systolic blood pressure.
Abstract: Energization of a transformer results in sudden flow of current which is an effect of core magnetization. This current will be dominated by the presence of second harmonic, which in turn is used to segregate fault and inrush current, thus guaranteeing proper operation of the relay. This additional security in the relay sometimes obstructs or delays differential protection in a specific scenario, when the 2nd harmonic content was present during a genuine fault. This kind of scenario can result in isolation of the transformer by Buchholz and pressure release valve (PRV) protection, which is acted when fault creates more damage in transformer. Such delays involve a huge impact on the insulation failure, and chances of repairing or rectifying fault of problem at site become very dismal. Sometimes this delay can cause fire in the transformer, and this situation becomes havoc for a sub-station. Such occurrences have been observed in field also when differential relay operation was delayed by 10-15 ms by second harmonic blocking in some specific conditions. These incidences have led to the need for an alternative solution to eradicate such unwarranted delay in operation in future. Modern numerical relay, called as intelligent electronic device (IED), is embedded with advanced protection features which permit higher flexibility and better provisions for tuning of protection logic and settings. Such flexibility in transformer protection IEDs, enables incorporation of alternative methods such as dynamic switching of second harmonic feature for blocking the differential protection with additional security. The analysis and precautionary measures carried out in this case, have been simulated and discussed in this paper to ensure that similar solutions can be adopted to inhibit analogous issues in future.
Abstract: Recursive combination of an algorithm based on Karatsuba multiplication is exploited to design a generalized transpose and parallel Finite Impulse Response (FIR) Filter. Mid-range Karatsuba multiplication and Carry Save adder based on Karatsuba multiplication reduce time complexity for higher order multiplication implemented up to n-bit. As a result, we design modified N-tap Transpose and Parallel Symmetric FIR Filter Structure using Karatsuba algorithm. The mathematical formulation of the FFA Filter is derived. The proposed architecture involves significantly less area delay product (APD) then the existing block implementation. By adopting retiming technique, hardware cost is reduced further. The filter architecture is designed by using 90 nm technology library and is implemented by using cadence EDA Tool. The synthesized result shows better performance for different word length and block size. The design achieves switching activity reduction and low power consumption by applying with and without retiming for different combination of the circuit. The proposed structure achieves more than a half of the power reduction by adopting with and without retiming techniques compared to the earlier design structure. As a proof of the concept for block size 16 and filter length 64 for CKA method, it achieves a 51% as well as 70% less power by applying retiming technique, and for CSA method it achieves a 57% as well as 77% less power by applying retiming technique compared to the previously proposed design.
Abstract: The end of the line controls of the finished products in
the automotive industry is important. The control that has been
conducted with the manual methods for the sliding doors tracks is not
sufficient and faulty products cannot be identified. As a result, the
customer has the faulty products. In the scope of this study, the
design criteria of the PLC integrated modular end of line control unit
has been examined, designed and manufactured to make the control
of the 10 different track profile to 2 different vehicles with an
objective to minimize the salvage costs by obtaining more sensitive,
certain and accurate measurement results. In the study that started
with literature and patent review, the design inputs have been
specified, the technical concept has been developed, computer
supported mechanic design, control system and automation design,
design review and design improvement have been made. Laser
analog sensors at high sensitivity, probes and modular blocks have
been used in the unit. The measurement has been conducted in the
system and it is observed that measurement results are more sensitive
than the previous methods that we use.
Abstract: The properties of hollow sandcrete blocks produced in
Minna, Nigeria are presented. Sandcrete block is made of cement,
water and sand binded together in certain mix proportions. For the
purpose of this work, fifty (50) commercial sandcrete block industries
were visited in Minna, Nigeria to obtain block samples and
aggregates used for the manufacture, and to take inventory of the mix
composition and the production process. Sieve analysis tests were
conduction on the soil sample from various block industries to
ascertain their quality to be used for block making. The mix ratios
were also investigated. Five (5) nine inches (9’’ or 225mm) blocks
were obtained from each block industry and tested for dimensional
compliance and compressive strength. The results of the soil test
shows that the grading fall within the limit for natural aggregate and
can easily are used to obtain workable mix. Physical examinations of
the block sizes show slight deviation from the standard requirement
in NIS 87:2000. Compressive strength of hollow sandcrete blocks in
range of 0.12 N/mm2 to 0.54 N/mm2 was obtained which is below the
recommendable value of 3.45 N/mm2 for load bearing hollow
sandcrete blocks. This indicates that these blocks are below the
standard for load-bearing sandcrete blocks and cannot be used as load
bearing walling units. The mix composition also indicated low
cement content resulting in low compressive strength. Most of the
commercial block industries visited does not take curing very serious.
Water were only sprinkled ones or twice before the blocks were
stacked and made readily available for sale. It is recommended that a
mix ratio of 1:4 to 1:6 should be used for the production of sandcrete
blocks and proper curing practice should be adhered. Blocks should
also be cured for 14 days before making them available for
consumers.
Abstract: It is the patient compliance and stability in
combination with controlled drug delivery and biocompatibility that
forms the core feature in present research and development of
sustained biodegradable patch formulation intended for wound
healing. The aim was to impart sustained degradation, sterile
formulation, significant folding endurance, elasticity,
biodegradability, bio-acceptability and strength. The optimized
formulation comprised of polymers including Hydroxypropyl methyl
cellulose, Ethylcellulose, and Gelatin, and Citric Acid PEG Citric
acid (CPEGC) triblock dendrimers and active Curcumin. Polymeric
mixture dissolved in geometric order in suitable medium through
continuous stirring under ambient conditions. With continued stirring
Curcumin was added with aid of DCM and Methanol in optimized
ratio to get homogenous dispersion. The dispersion was sonicated
with optimum frequency and for given time and later casted to form a
patch form. All steps were carried out under strict aseptic conditions.
The formulations obtained in the acceptable working range were
decided based on thickness, uniformity of drug content, smooth
texture and flexibility and brittleness. The patch kept on stability
using butter paper in sterile pack displayed folding endurance in
range of 20 to 23 times without any evidence of crack in an
optimized formulation at room temperature (RT) (24 ± 2°C). The
patch displayed acceptable parameters after stability study conducted
in refrigerated conditions (8±0.2°C) and at RT (24 ± 2°C) up to 90
days. Further, no significant changes were observed in critical
parameters such as elasticity, biodegradability, drug release and drug
content during stability study conducted at RT 24±2°C for 45 and 90
days. The drug content was in range 95 to 102%, moisture content
didn’t exceeded 19.2% and patch passed the content uniformity test.
Percentage cumulative drug release was found to be 80% in 12h and
matched the biodegradation rate as drug release with correlation
factor R2>0.9. The biodegradable patch based formulation developed
shows promising results in terms of stability and release profiles.
Abstract: Adequate analgesia following caesarean section
decreases morbidity, hastens ambulation, improves patient outcome
and facilitates care of the newborn. Intrathecal magnesium, an
NMDA antagonist, has been shown to prolong analgesia without
significant side effects in healthy parturients. The aim of this study
was to evaluate the onset and duration of sensory and motor block,
hemodynamic effect, postoperative analgesia, and adverse effects of
magnesium or fentanyl given intrathecally with hyperbaric 0.5%
bupivacaine in patients with mild preeclampsia undergoing caesarean
section. Sixty women with mild preeclampsia undergoing elective
caesarean section were included in a prospective, double blind,
controlled trial. Patients were randomly assigned to receive spinal
anesthesia with 2 mL 0.5% hyperbaric bupivacaine with 12.5 μg
fentanyl (group F) or 0.1 ml of 50% magnesium sulphate (50 mg)
(group M) with 0.15ml preservative free distilled water. Onset,
duration and recovery of sensory and motor block, time to maximum
sensory block, duration of spinal anaesthesia and postoperative
analgesic requirements were studied. Statistical comparison was
carried out using the Chi-square or Fisher’s exact tests and
Independent Student’s t-test where appropriate. The onset of both
sensory and motor block was slower in the magnesium group. The
duration of spinal anaesthesia (246 vs. 284) and motor block (186.3
vs. 210) were significantly longer in the magnesium group. Total
analgesic top up requirement was less in group M. Hemodynamic
parameters were similar in both the groups. Intrathecal magnesium
caused minimal side effects. Since Fentanyl and other opioid
congeners are not available throughout the country easily,
magnesium with its easy availability and less side effect profile can
be a cost effective alternative to fentanyl in managing pregnancy
induced hypertension (PIH) patients given along with Bupivacaine
intrathecally in caesarean section.
Abstract: This paper is focused on the reference current
calculation in the compensation mode of the active DC traction
substations. The so-called p-q theory of the instantaneous reactive
power is used as theoretical foundation. The compensation goal of
total compensation is taken into consideration for the operation under
both sinusoidal and nonsinusoidal voltage conditions, through the
two objectives of unity power factor and perfect harmonic
cancelation. Four blocks of reference current generation implement
the conceived algorithms and they are included in a specific Simulink
library, which is useful in a DSP dSPACE-based platform working
under Matlab/Simulink. The simulation results validate the
correctness of the implementation and fulfillment of the
compensation tasks.
Abstract: In this research numerical simulations are performed,
using the multi-relaxation-time lattice Boltzmann method, in the
range 3 ≤ β = w[d] ≤ 30 at Re = 100, 200 and 300, where β the
blockage ratio, w is the equispaced distance between centers of
cylinders, d is the diameter of the cylinder and Re is the Reynolds
number, respectively. Special attention is paid to the effect of the
equispaced distance between centers of cylinders. Visualization of
the vorticity contour visualization are presented for some simulation
showing the flow dynamics and patterns for blockage effect. Results
show that the drag and mean drag coefficients, and Strouhal number,
in general, decrease with the increase of β for fixed Re. It is found
that the decreasing rate of drag and mean drag coefficients and
Strouhal number is more distinct in the range 3 ≤ β ≤ 15. We found
that when β > 15, the blockage effect almost diminishes. Our results
further indicate that the drag and mean drag coefficients, peak value
of the lift coefficient, root-mean-square value of the lift and drag
coefficients and the ratio between lift and drag coefficients decrease
with the increase of Re. The results indicate that symmetry boundary
condition have more blockage effect as compared to periodic
boundary condition.