Abstract: Advanced head and neck cancers are aggressive
tumours, which require aggressive treatment. Treatment efficiency is
often hindered by cancer cell repopulation during radiotherapy,
which is due to various mechanisms triggered by the loss of tumour
cells and involves both stem and differentiated cells. The aim of the
current paper is to present in silico simulations of radiotherapy
schedules on a virtual head and neck tumour grown with biologically
realistic kinetic parameters. Using the linear quadratic formalism of
cell survival after radiotherapy, altered fractionation schedules
employing various treatment breaks for normal tissue recovery are
simulated and repopulation mechanism implemented in order to
evaluate the impact of various cancer cell contribution on tumour
behaviour during irradiation. The model has shown that the timing of
treatment breaks is an important factor influencing tumour control in
rapidly proliferating tissues such as squamous cell carcinomas of the
head and neck. Furthermore, not only stem cells but also
differentiated cells, via the mechanism of abortive division, can
contribute to malignant cell repopulation during treatment.
Abstract: Let F(x, y) = ax2 + bxy + cy2 be a positive definite
binary quadratic form with discriminant Δ whose base points lie on
the line x = -1/m for an integer m ≥ 2, let p be a prime number
and let Fp be a finite field. Let EF : y2 = ax3 + bx2 + cx be an
elliptic curve over Fp and let CF : ax3 + bx2 + cx ≡ 0(mod p) be
the cubic congruence corresponding to F. In this work we consider
some properties of positive definite quadratic forms, elliptic curves
and cubic congruences.
Abstract: In this work, we consider the number of integer solutions
of Diophantine equation D : y2 - 2yx - 3 = 0 over Z and
also over finite fields Fp for primes p ≥ 5. Later we determine the
number of rational points on curves Ep : y2 = Pp(x) = yp
1 + yp
2
over Fp, where y1 and y2 are the roots of D. Also we give a formula
for the sum of x- and y-coordinates of all rational points (x, y) on
Ep over Fp.
Abstract: In this paper, we derive some algebraic identities on
right and left neighbors R(F) and L(F) of an indefinite binary
quadratic form F = F(x, y) = ax2 + bxy + cy2 of discriminant
Δ = b2 -4ac. We prove that the proper cycle of F can be given by
using its consecutive left neighbors. Also we construct a connection
between right and left neighbors of F.
Abstract: Let D = 1 be a positive non-square integer and let δ = √D or 1+√D 2 be a real quadratic irrational with trace t =δ + δ and norm n = δδ. Let γ = P+δ Q be a quadratic irrational for positive integers P and Q. Given a quadratic irrational γ, there exist a quadratic ideal Iγ = [Q, δ + P] and an indefinite quadratic form Fγ(x, y) = Q(x−γy)(x−γy) of discriminant Δ = t
2−4n. In the first section, we give some preliminaries form binary quadratic forms, quadratic irrationals and quadratic ideals. In the second section, we obtain some results on γ, Iγ and Fγ for some specific values of Q and P.