Abstract: Some Chromium (III) complexes were synthesized
with three amino acids: L Glutamic Acid, Glycine, and L-cysteine as
the ligands, in order to provide a new supplement containing Cr(III)
for patients with type 2 diabetes mellitus. The complexes have been
prepared by refluxing a mixture of Chromium(III) chloride in
aqueous solution with L-glutamic acid, Glycine, and L-cysteine after
pH adjustment by sodium hydroxide. These complexes were
characterized by Infrared and Uv-Vis spectrophotometer and
Elemental analyzer. The product yields of four products were 87.50
and 56.76% for Cr-Glu complexes, 46.70% for Cr-Gly complex and
40.08% for Cr-Cys complex respectively. The predicted structure of
the complexes are [Cr(glu)2(H2O)2].xH2O, Cr(gly)3..xH2O and
Cr(cys)3.xH2O., respectively.
Abstract: Patients with diabetes are susceptible to chronic foot
wounds which may be difficult to manage and slow to heal.
Diagnosis and treatment currently rely on the subjective judgement of
experienced professionals. An objective method of tissue assessment
is required. In this paper, a data fusion approach was taken to wound
tissue classification. The supervised Maximum Likelihood and
unsupervised Multi-Modal Expectation Maximisation algorithms
were used to classify tissues within simulated wound models by
weighting the contributions of both colour and 3D depth information.
It was found that, at low weightings, depth information could show
significant improvements in classification accuracy when compared
to classification by colour alone, particularly when using the
maximum likelihood method. However, larger weightings were
found to have an entirely negative effect on accuracy.
Abstract: Oxidative stress and overwhelming free radicals
associated with diabetes mellitus are likely to be linked with
development of certain complication such as retinopathy,
nephropathy and neuropathy. Treatment of diabetic subjects with
antioxidant may be of advantage in attenuating these complications.
Olive leaf (Oleaeuropaea), has been endowed with many beneficial
and health promoting properties mostly linked to its antioxidant
activity. This study aimed to evaluate the significance of
supplementation of Olive leaves extract (OLE) in reducing oxidative
stress, hyperglycemia and hyperlipidemia in Sterptozotocin (STZ)-
induced diabetic rats. After induction of diabetes, a significant rise in
plasma glucose, lipid profiles except High density lipoproteincholestrol
(HDLc), malondialdehyde (MDA) and significant decrease
of plasma insulin, HDLc and Plasma reduced glutathione GSH as
well as alteration in enzymatic antioxidants was observed in all
diabetic animals. During treatment of diabetic rats with 0.5g/kg body
weight of Olive leaves extract (OLE) the levels of plasma (MDA)
,(GSH), insulin, lipid profiles along with blood glucose and
erythrocyte enzymatic antioxidant enzymes were significantly
restored to establish values that were not different from normal
control rats. Untreated diabetic rats on the other hand demonstrated
persistent alterations in the oxidative stress marker (MDA), blood
glucose, insulin, lipid profiles and the antioxidant parameters. These
results demonstrate that OLE may be of advantage in inhibiting
hyperglycemia, hyperlipidemia and oxidative stress induced by
diabetes and suggest that administration of OLE may be helpful in
the prevention or at least reduced of diabetic complications
associated with oxidative stress.
Abstract: Bay leaves have been shown to improve insulin
function in vitro but the effects on people have not been determined.
The objective of this study was to determine if bay leaves may be
important in the prevention and/or alleviation of type 1 diabetes.
Methods: Fifty five people with type 1 diabetes were divided into
two groups, 45 given capsules containing 3 g of bay leaves per day
for 30 days and 10 given a placebo capsules. Results All the patients
consumed bay leaves shows reduced serum glucose with significant
decreases 27% after 30 d. Total cholesterol decreased, 21 %, after 30
days with larger decreases in low density lipoprotein (LDL) 24%.
High density lipoprotein (HDL) increased 20% and Triglycerides
also decreased 26%. There were no significant changes in the
placebo group. Conclusion, this study demonstrates that consumption
of bay leaves, 3 g/d for 30 days, decreases risk factors for diabetes
and cardiovascular diseases and suggests that bay leaves may be
beneficial for people with type 1 diabetes.
Abstract: Diabetes Mellitus is a chronic metabolic disorder, where the improper management of the blood glucose level in the diabetic patients will lead to the risk of heart attack, kidney disease and renal failure. This paper attempts to enhance the diagnostic accuracy of the advancing blood glucose levels of the diabetic patients, by combining principal component analysis and wavelet neural network. The proposed system makes separate blood glucose prediction in the morning, afternoon, evening and night intervals, using dataset from one patient covering a period of 77 days. Comparisons of the diagnostic accuracy with other neural network models, which use the same dataset are made. The comparison results showed overall improved accuracy, which indicates the effectiveness of this proposed system.
Abstract: Understanding patient factors related to physical activity behavior is important in the management of Type 2 Diabetes. This study applied the Theory of Planned Behavior model to understand physical activity behavior among sampled Type 2 diabetics in Kenya. The study was conducted within the diabetic clinic at Kisii Level 5 Hospital and adopted sequential mixed methods design beginning with qualitative phase and ending with quantitative phase. Qualitative data was analyzed using grounded theory analysis method. Structural equation modeling using maximum likelihood was used to analyze quantitative data. The common fit indices revealed that the theory of planned behavior fitted the data acceptably well among the Type 2 diabetes and within physical activity behavior {¤ç2 = 213, df = 84, n=230, p = .061, ¤ç2/df = 2.53; TLI = .97; CFI =.96; RMSEA (90CI) = .073(.029, .08)}. This theory proved to be useful in understanding physical activity behavior among Type 2 diabetics.
Abstract: The aim of this study was to demonstrate the possible
effect of some variables such as age, gender, blood sugar level, and
duration of diabetes on the serum level of zinc in diabetic individuals
from Murzuk area. Serum zinc (Zn), Fasting blood sugar (FBS),
hemoglobin HbA1c (HbA1c) were evaluated in 46 type I diabetic
subjects (group 1), 48 type II diabetic subjects (group 2) and 43
healthy individuals (control) of both genders aged (30-81) years. Data
showed that both diabetic groups have significantly higher (P0.05) differences in serum Zn levels were observed
between Males and Females. Serum Zn levels were non-significantly
decreased with increasing age. In type II diabetic subjects, serum Zn
levels were non-significantly decreased with increasing duration of
disease whereas those in type I were non-significantly increased.
Abstract: Many studies have applied the Theory of Planned
Behavior (TPB) in predicting health behaviors among unique
populations. However, a new paradigm is emerging where focus is
now directed to modification and expansion of the TPB model rather
than utilization of the traditional theory. This review proposes new
models modified from the Theory of Planned Behavior and suggest
an appropriate study design that can be used to test the models within
physical activity and dietary practice domains among Type 2
diabetics in Kenya. The review was conducted by means of literature
search in the field of nutrition behavior, health psychology and
mixed methods using predetermined key words. The results identify
pre-intention and post intention gaps within the TPB model that need
to be filled. Additional psychosocial factors are proposed to be
included in the TPB model to generate new models and the efficacy
of these models tested using mixed methods design.
Abstract: This study was designed to investigate the role of serum nitric oxide and sialic acid in the development of diabetic nephropathy as disease marker. Total 210 diabetic patients (age and sex matched) were selected followed by informed consent and divided into four groups (70 each) as I: control; II: diabetic; III: diabetic hypertensive; IV: diabetic nephropathy. The blood samples of all subjects were collected and analyzed for serum nitric oxide, sialic acid, fasting blood glucose, serum urea, creatinine, HbA1c and GFR. The BMI, systolic and diastolic blood pressures, blood glucose, HbA1c and serum sialic acid levels were high (p
Abstract: Visfatin and apelin are two new adipokines that recently gained a special interest in diabetes research. This study was conducted to study the interplay between these two adipokines and their correlation with other inflammatory and biochemical parameters in type 2 diabetic (T2D) postmenopausal women with CAD. Visfatin and apelin were measured by enzyme-linked immunoassay (ELISA). Visfatin was found to be significantly higher in the following groups: T2D patients without CAD, non-obese and obese T2D patients with CAD when compared to control group. Apelin was found to be significantly lower in non-obese and obese T2D patients with CAD when compared to control group. Visfatin and apelin were found to be significantly associated with each other and with other biochemical parameters. The current study provides evidence for the interplay between visfatin and apelin through the inflammatory milieu characteristic of T2D and their possible role in the pathogenesis of CAD complication of T2D.
Abstract: It is established that the instantaneous heart rate (HR) of healthy humans keeps on changing. Analysis of heart rate variability (HRV) has become a popular non invasive tool for assessing the activities of autonomic nervous system. Depressed HRV has been found in several disorders, like diabetes mellitus (DM) and coronary artery disease, characterised by autonomic nervous dysfunction. A new technique, which searches for pattern repeatability in a time series, is proposed specifically for the analysis of heart rate data. These set of indices, which are termed as pattern repeatability measure and pattern repeatability ratio are compared with approximate entropy and sample entropy. In our analysis, based on the method developed, it is observed that heart rate variability is significantly different for DM patients, particularly for patients with diabetic foot ulcer.
Abstract: Recently, the health of retired National Football
League players, particularly lineman has been investigated. A
number of studies have reported increased cardiometabolic risk,
premature cardiovascular disease and incidence of type 2 diabetes.
Rugby union players have somatotypes very similar to National
Football League players which suggests that rugby players may have
similar health risks. The International Golden Oldies World Rugby
Festival (GORF) provided a unique opportunity to investigate the
demographics of veteran rugby players. METHODOLOGIES: A
cross-sectional, observational study was completed using an online
web-based questionnaire that consisted of medical history and
physiological measures. Data analysis was completed using a one
sample t-test (50yrs) and Chi-square test. RESULTS:
A total of 216 veteran rugby competitors (response rate = 6.8%)
representing 10 countries, aged 35-72 yrs (mean 51.2, S.D. ±8.0),
participated in the online survey. As a group, the incidence of current
smokers was low at 8.8% (avg 72.4 cigs/wk) whilst the percentage
consuming alcohol was high (93.1% (avg 11.2 drinks/wk).
Competitors reported the following top six chronic
diseases/disorders; hypertension (18.6%), arthritis (OA/RA, 11.5%),
asthma (9.3%), hyperlipidemia (8.2%), diabetes (all types, 7.5%) and
gout (6%), there were significant differences between groups with
regard to cancer (all types) and migraines. When compared to the
Australian general population (Australian Bureau of Statistics data,
n=18,000), GORF competitors had a significantly lower incidence of
anxiety (p
Abstract: Mushrooms are a group of fleshy macroscopic fungi.
They have been valued throughout the world as both edible and
medicine. They are highly nutritious with good amount of quality
proteins, vitamins and minerals. An edible mushroom, Calocybe
indica was selected to validate its nutritional and medicinal
properties. Since tissue damage in hyperglycemia has been related to
oxidative stress, we evaluated the enzymatic and non-enzymatic
antioxidant status in the serum, liver and kidney since they are the
target organs in diabetic complications. From the results, increased
oxidative stress and decreased antioxidants might be related to the
causation of diabetes mellitus. The treatment in the diabetic rats with
the Calocybe indica showed an increase in the antioxidant system
and decrease in the production of free radicals. The mushrooms
which contain antioxidant phytochemicals has potential free radical
scavenging capacity and hence can induce the antioxidant system in
the body significantly reduces the generated free radicals thereby
maintaining the normal levels of the antioxidants
Abstract: Oxidative stress is considered to be the cause for onset
and the progression of type 2 diabetes mellitus (T2DM) and
complications including neuropathy. It is a deleterious process that
can be an important mediator of damage to cell structures: protein,
lipids and DNA. Data suggest that in patients with diabetes and
diabetic neuropathy DNA repair is impaired, which prevents effective
removal of lesions. Objective: The aim of our study was to evaluate
the association of the hOGG1 (326 Ser/Cys) and XRCC1 (194
Arg/Trp, 399 Arg/Gln) gene polymorphisms whose protein is
involved in the BER pathway with DNA repair efficiency in patients
with diabetes type 2 and diabetic neuropathy compared to the healthy
subjects. Genotypes were determined by PCR-RFLP analysis in 385
subjects, including 117 with type 2 diabetes, 56 with diabetic
neuropathy and 212 with normal glucose metabolism. The
polymorphisms studied include codon 326 of hOGG1 and 194, 399
of XRCC1 in the base excision repair (BER) genes. Comet assay was
carried out using peripheral blood lymphocytes from the patients and
controls. This test enabled the evaluation of DNA damage in cells
exposed to hydrogen peroxide alone and in the combination with the
endonuclease III (Nth). The results of the analysis of polymorphism
were statistically examination by calculating the odds ratio (OR) and
their 95% confidence intervals (95% CI) using the ¤ç2-tests. Our data
indicate that patients with diabetes mellitus type 2 (including those
with neuropathy) had higher frequencies of the XRCC1 399Arg/Gln
polymorphism in homozygote (GG) (OR: 1.85 [95% CI: 1.07-3.22],
P=0.3) and also increased frequency of 399Gln (G) allele (OR: 1.38
[95% CI: 1.03-1.83], P=0.3). No relation to other polymorphisms
with increased risk of diabetes or diabetic neuropathy. In T2DM
patients complicated by neuropathy, there was less efficient repair of
oxidative DNA damage induced by hydrogen peroxide in both the
presence and absence of the Nth enzyme. The results of our study
suggest that the XRCC1 399 Arg/Gln polymorphism is a significant
risk factor of T2DM in Polish population. Obtained data suggest a
decreased efficiency of DNA repair in cells from patients with
diabetes and neuropathy may be associated with oxidative stress.
Additionally, patients with neuropathy are characterized by even
greater sensitivity to oxidative damage than patients with diabetes,
which suggests participation of free radicals in the pathogenesis of
neuropathy.
Abstract: In Mauritius, much emphasis is put on measures to
combat the high prevalence of non-communicable diseases (NCDs).
Health promotion campaigns for the adoption of healthy behaviors
and screening programs are done regularly by local authorities and
NCD surveys are carried out at intervals. However, the health
behaviors of the poor have not been investigated so far. This study
aims to give an insight on the perceptions of health status and
lifestyle health behaviors of poor people in Mauritius. A crosssectional
study among 83 persons benefiting from social aid in a
selected urban district was carried out. Results showed that 51.8% of
respondents perceived that they had good health status. 57.8% had no
known NCD whilst 25.3% had hypertension, followed by diabetes
(16.9%), asthma (9.6%) and heart disease (7.2%).They had low
smoking (10.8%) and alcohol consumption (6.0%) as well as high
physical activity prevalence (54.2%). These results were significantly
different from the NCD survey carried out in the general population.
Consumption of vegetables in the study was high. Overweight and
obesity trends were however similar to the NCD survey report 2009.
These findings contrast with other international studies showing poor
people having poor perceptions of health status and unhealthy
behavioral choices. Whether these positive health behaviors of poor
people in Mauritius arise out of choice or whether it is because the
alternative behavior is too costly remains to be investigated further.
Abstract: Dilated cardiomyopathy (DCM) is a severe
cardiovascular disorder characterized by progressive systolic
dysfunction due to cardiac chamber dilatation and inefficient
myocardial contractility often leading to chronic heart failure.
Recently, a genome-wide association studies (GWASs) on DCM
indicate that the ZBTB17 gene rs10927875 single nucleotide
polymorphism is associated with DCM. The aim of the study was to
identify the distribution of ZBTB17 gene rs10927875 polymorphism
in 50 Slovak patients with DCM and 80 healthy control subjects
using the Custom Taqman®SNP Genotyping assays. Risk factors
detected at baseline in each group included age, sex, body mass
index, smoking status, diabetes and blood pressure. The mean age of
patients with DCM was 52.9±6.3 years; the mean age of individuals
in control group was 50.3±8.9 years. The distribution of investigated
genotypes of rs10927875 polymorphism within ZBTB17 gene in the
cohort of Slovak patients with DCM was as follows: CC (38.8%), CT
(55.1%), TT (6.1%), in controls: CC (43.8%), CT (51.2%), TT
(5.0%). The risk allele T was more common among the patients with
dilated cardiomyopathy than in normal controls (33.7% versus
30.6%). The differences in genotype or allele frequencies of ZBTB17
gene rs10927875 polymorphism were not statistically significant
(p=0.6908; p=0.6098). The results of this study suggest that ZBTB17
gene rs10927875 polymorphism may be a risk factor for
susceptibility to DCM in Slovak patients with DCM. Studies of
numerous files and additional functional investigations are needed to
fully understand the roles of genetic associations.
Abstract: Although backpropagation ANNs generally predict
better than decision trees do for pattern classification problems, they
are often regarded as black boxes, i.e., their predictions cannot be
explained as those of decision trees. In many applications, it is
desirable to extract knowledge from trained ANNs for the users to
gain a better understanding of how the networks solve the problems.
A new rule extraction algorithm, called rule extraction from artificial
neural networks (REANN) is proposed and implemented to extract
symbolic rules from ANNs. A standard three-layer feedforward ANN
is the basis of the algorithm. A four-phase training algorithm is
proposed for backpropagation learning. Explicitness of the extracted
rules is supported by comparing them to the symbolic rules generated
by other methods. Extracted rules are comparable with other methods
in terms of number of rules, average number of conditions for a rule,
and predictive accuracy. Extensive experimental studies on several
benchmarks classification problems, such as breast cancer, iris,
diabetes, and season classification problems, demonstrate the
effectiveness of the proposed approach with good generalization
ability.
Abstract: Hyperglycaemia is a key factor that contributes to the
development of diabetes-related microvascular disease and a major
risk factor for endothelial dysfunction. In the current study, we have
explored glucose-induced abnormal intracellular calcium (Ca2+
i)
homeostasis in mouse microvessel endothelial cells (MMECs) in
high glucose (HG) (40mmol/L) versus control (low glucose, LG) (11
mmol/L). We demonstrated that the exposure of MMECs to HG for 3
days did not change basal Ca2+
i, however, there was a significant
increase of acetylcholine-induced Ca2+ entry. Western blots
illustrated that exposure to HG also increased STIM1 (Stromal
Interaction Molecule 1), but not Orai1 (the pore forming subunit),
protein expression levels. Although the link between HG-induced
changes in STIM1 expression, enhanced Ca2+ entry and endothelial
dysfunction requires further study, the current data are suggestive
that targeting these pathways may reduce the impact of HG on
endothelial function.
Abstract: In this paper, we present user pattern learning
algorithm based MDSS (Medical Decision support system) under
ubiquitous. Most of researches are focus on hardware system, hospital
management and whole concept of ubiquitous environment even
though it is hard to implement. Our objective of this paper is to design
a MDSS framework. It helps to patient for medical treatment and
prevention of the high risk patient (COPD, heart disease, Diabetes).
This framework consist database, CAD (Computer Aided diagnosis
support system) and CAP (computer aided user vital sign prediction
system). It can be applied to develop user pattern learning algorithm
based MDSS for homecare and silver town service. Especially this
CAD has wise decision making competency. It compares current vital
sign with user-s normal condition pattern data. In addition, the CAP
computes user vital sign prediction using past data of the patient. The
novel approach is using neural network method, wireless vital sign
acquisition devices and personal computer DB system. An intelligent
agent based MDSS will help elder people and high risk patients to
prevent sudden death and disease, the physician to get the online
access to patients- data, the plan of medication service priority (e.g.
emergency case).
Abstract: Life is beautiful. But, it is decided by genes, environment and the individual and shattered by the natural and / or the invited problems. Most of the global rural helpless masses are struggling for their survival since; they are neglected in all aspects of life including health. Amidst a countless number of miserable diseases in man, diabetes is becoming a dreaded killer and ramifying the entire globe in a jet speed. Diabetes control continues as a Herculean task to the scientific community and the modern society in the 21st century also. T2DM is not pertaining to any age and it can develop even during the childhood. This multifactorial disease abruptly changes the activities of certain vital biomarkers in the present rural T2DM cases. A remarkable variation in the levels of biomarkers like AST, ALT, GGT, ALP, LDH, HbA1C, C- peptide, fasting sugar, post-prandial sugar, sodium, potassium, BUN, creatinine and insulin show the rampant nature of T2DM in this physically active rural agrarian community.