Abstract: In this paper we present a method for gene ranking
from DNA microarray data. More precisely, we calculate the correlation
networks, which are unweighted and undirected graphs, from
microarray data of cervical cancer whereas each network represents
a tissue of a certain tumor stage and each node in the network
represents a gene. From these networks we extract one tree for
each gene by a local decomposition of the correlation network. The
interpretation of a tree is that it represents the n-nearest neighbor
genes on the n-th level of a tree, measured by the Dijkstra distance,
and, hence, gives the local embedding of a gene within the correlation
network. For the obtained trees we measure the pairwise similarity
between trees rooted by the same gene from normal to cancerous
tissues. This evaluates the modification of the tree topology due to
progression of the tumor. Finally, we rank the obtained similarity
values from all tissue comparisons and select the top ranked genes.
For these genes the local neighborhood in the correlation networks
changes most between normal and cancerous tissues. As a result
we find that the top ranked genes are candidates suspected to be
involved in tumor growth and, hence, indicates that our method
captures essential information from the underlying DNA microarray
data of cervical cancer.
Abstract: The Improved Generalized Diversity Index (IGDI)
has been proposed as a tool that can be used to identify areas that
have high conservation value and measure the ecological condition of
an area. IGDI is based on the species relative abundances. This paper
is concerned with particular attention is given to comparisons
involving the MacArthur model of species abundances. The
properties and performance of various species indices were assessed.
Both IGDI and species richness increased with sampling area
according to a power function. IGDI were also found to be acceptable
ecological indicators of conditions and consistently outperformed
coefficient of conservatism indices.
Abstract: This paper proposes the numerical simulation of the
investment casting of gold jewelry. It aims to study the behavior of
fluid flow during mould filling and solidification and to optimize the
process parameters, which lead to predict and control casting defects
such as gas porosity and shrinkage porosity. A finite difference
method, computer simulation software FLOW-3D was used to
simulate the jewelry casting process. The simplified model was
designed for both numerical simulation and real casting production.
A set of sensor acquisitions were allocated on the different positions
of the wax tree of the model to detect filling times, while a set of
thermocouples were allocated to detect the temperature during
casting and cooling. Those detected data were applied to validate the
results of the numerical simulation to the results of the real casting.
The resulting comparisons signify that the numerical simulation can
be used as an effective tool in investment-casting-process
optimization and casting-defect prediction.
Abstract: Four design alternatives for lateral force-resisting
systems of tall buildings in Dubai, UAE are presented. Quantitative
comparisons between the different designs are also made. This paper
is intended to provide different feasible lateral systems to be used in
Dubai in light of the available seismic hazard studies of the UAE.
The different lateral systems are chosen in conformance with the
International Building Code (IBC). Moreover, the expected behavior
of each system is highlighted and light is shed on some of the cost
implications associated with lateral system selection.
Abstract: A high-frequency low-power sinusoidal quadrature
oscillator is presented through the use of two 2nd-order low-pass
current-mirror (CM)-based filters, a 1st-order CM low-pass filter and
a CM bilinear transfer function. The technique is relatively simple
based on (i) inherent time constants of current mirrors, i.e. the
internal capacitances and the transconductance of a diode-connected
NMOS, (ii) a simple negative resistance RN formed by a resistor load
RL of a current mirror. Neither external capacitances nor inductances
are required. As a particular example, a 1.9-GHz, 0.45-mW, 2-V
CMOS low-pass-filter-based all-current-mirror sinusoidal quadrature
oscillator is demonstrated. The oscillation frequency (f0) is 1.9 GHz
and is current-tunable over a range of 370 MHz or 21.6 %. The
power consumption is at approximately 0.45 mW. The amplitude
matching and the quadrature phase matching are better than 0.05 dB
and 0.15°, respectively. Total harmonic distortions (THD) are less
than 0.3 %. At 2 MHz offset from the 1.9 GHz, the carrier to noise
ratio (CNR) is 90.01 dBc/Hz whilst the figure of merit called a
normalized carrier-to-noise ratio (CNRnorm) is 153.03 dBc/Hz. The
ratio of the oscillation frequency (f0) to the unity-gain frequency (fT)
of a transistor is 0.25. Comparisons to other approaches are also
included.
Abstract: A five-class density histogram with an index named cumulative density was proposed to analyze the short-term HRV. 150 subjects participated in the test, falling into three groups with equal numbers -- the healthy young group (Young), the healthy old group (Old), and the group of patients with congestive heart failure (CHF). Results of multiple comparisons showed a significant differences of the cumulative density in the three groups, with values 0.0238 for Young, 0.0406 for Old and 0.0732 for CHF (p