Abstract: Bone growth factors, such as Bone Morphogenic
Protein-2 (BMP-2) have been approved by the FDA to replace grafting for some surgical interventions, but the high dose requirement limits its use in patients. Noggin, an extracellular protein, blocks the effect of BMP-2 by binding to BMP. Preventing
the BMP-2/noggin interaction will help increase the free
concentration of BMP-2 and therefore should enhance its efficacy to
induce bone formation. The work presented here involves
computational design of novel small molecule inhibitory agents of BMP-2/noggin interaction, based on our current understanding of
BMP-2, and its known putative ligands (receptors and antagonists). A
successful acquisition of such an inhibitory agent of BMP-2/noggin interaction would allow clinicians to reduce the dose required of
BMP-2 protein in clinical applications to promote osteogenesis. The
available crystal structures of the BMPs, its receptors, and the binding partner noggin were analyzed to identify the critical residues
involved in their interaction. In presenting this study, LUDI de novo design method was utilized to perform virtual screening of a large
number of compounds from a commercially available library against the binding sites of noggin to identify the lead chemical compounds
that could potentially block BMP-noggin interaction with a high specificity.
Abstract: Environmental impact assessment (EIA) is a procedure tool of environmental management for identifying, predicting, evaluating and mitigating the adverse effects of development proposals. EIA reports usually analyze how the amounts or concentrations of pollutants obey the relevant standards. Actually, many analytical tools can deepen the analysis of environmental impacts in EIA reports, such as life cycle assessment (LCA) and environmental risk assessment (ERA). Life cycle impact assessment (LCIA) is one of steps in LCA to introduce the causal relationships among environmental hazards and damage. Incorporating the LCIA concept into ERA as an integrated tool for EIA can extend the focus of the regulatory compliance of environmental impacts to determine of the significance of environmental impacts. Sometimes, when using integrated tools, it is necessary to consider fuzzy situations due to insufficient information; therefore, ERA should be generalized to fuzzy risk assessment (FRA). Finally, the use of the proposed methodology is demonstrated through the study case of the expansion plan of the world-s largest plastics processing factory.
Abstract: The range of the output power is a very important and evident limitation of two-level inverters. In order to overcome this disadvantage, multilevel inverters are introduced. Recently, Cascade H-Bridge inverters have emerged as one of the popular converter topologies used in numerous industrial applications. The modulation switching strategies such as phase shifted carrier based Pulse Width Modulation (PWM) technique and Stair case modulation with Selective Harmonic Elimination (SHE) PWM technique are generally used. NR method is used to solve highly non linear transcendental equations which are formed by SHEPWM method. Generally NR method has a drawback of requiring good initial guess but in this paper a new approach is implemented for NR method with any random initial guess. A three phase CHB 11-level inverter is chosen for analysis. MATLAB/SIMULINK programming environment and harmonic profiles are compared. Finally this paper presents a method at fundamental switching frequency with least % THDV.
Abstract: In the paper the research of flat textile products for use
as electrodes was presented. Material-s resistance measurements were
carried out to determine the suitability of the textiles. Based on the received results of studies different types of textile electrodes were
designed. Textile electrodes tests were carried out on human
phantoms. The electro-conductive properties of human forearm
phantom were also described. Based on this results special electroconductive
hydrogels with electro-conductive particles were feasible. The hydrogel is an important element of the forearm-s phantom
model of a survey of electrodes for muscle electrostimulation. The
hydrogel is an equivalent human skin and tissue. The hydrogel should
have a permanence and recurrence of the electro-conductive properties.
Abstract: A power cable is widely used for power supply in
power distributing networks and power transmission lines. Due to
limitations in the production, delivery and setting up power cables,
they are produced and delivered in several separate lengths. Cable
itself, consists of two cable terminations and arbitrary number of
cable joints, depending on the cable route length. Electrical stress
control is needed to prevent a dielectric breakdown at the end of the
insulation shield in both the air and cable insulation. Reliability of
cable joint depends on its materials, design, installation and operating
environment. The paper describes design and performance results for
new modeled cable joints. Design concepts, based on numerical
calculations, must be correct. An Equivalent Electrodes
Method/Boundary Elements Method-hybrid approach that allows
electromagnetic field calculations in multilayer dielectric media,
including inhomogeneous regions, is presented.
Abstract: Biodiesel production results in glycerol production as
the main by-product in biodiesel industry.One of the utilizations of
glycerol obtained from biodiesel production is as a cement grinding
aid (CGA). Results showed that crude glycerol content was 40.19%
whereas pure glycerol content was 82.15%. BSS value of the cement
with CGA supplementation was higher than that of nonsupplemented
cement (blank) indicating that CGA-supplemented
cement had higher fineness than the non-supplemented one. It was
also found that pure glycerol 95% and TEA 5% at 80ºC was the
optimum CGA used to result in finest cement with BSS value of
4.836 cm2/g. Residue test showed that the smallest percent residue
value (0.11%) was obtained in cement with supplementation of pure
glycerol 95% and TEA 5%. Results of residue test confirmed those of
BSS test showing that cement with supplementation of pure glycerol
95% and TEA 5% had the finest particle size.
Abstract: To measure the thickness of the subcutaneous adipose
tissue layer, a non-invasive optical measurement system (λ=1300 nm)
is introduced. Animal and human subjects are used for the
experiments. The results of human subjects are compared with the data
of ultrasound device measurements, and a high correlation (r=0.94 for
n=11) is observed. There are two modes in the corresponding signals
measured by the optical system, which can be explained by
two-layered and three-layered tissue models. If the target tissue is
thinner than the critical thickness, detected data using diffuse
reflectance method follow the three-layered tissue model, so the data
increase as the thickness increases. On the other hand, if the target
tissue is thicker than the critical thickness, the data follow the
two-layered tissue model, so they decrease as the thickness increases.
Abstract: A high performance clarification system has been
discussed for advanced aqueous reprocessing of FBR spent fuel.
Dissolver residue gives the cause of troubles on the plant operation of
reprocessing. In this study, the new clarification system based on the
hybrid of centrifuge and filtration was proposed to get the high
separation ability of the component of whole insoluble sludge. The
clarification tests of simulated solid species were carried out to
evaluate the clarification performance using small-scale test apparatus
of centrifuge and filter unit. The density effect of solid species on the
collection efficiency was mainly evaluated in the centrifugal
clarification test. In the filtration test using ceramic filter with pore
size of 0.2μm, on the other hand, permeability and filtration rate
were evaluated in addition to the filtration efficiency. As results, it was
evaluated that the collection efficiency of solid species on the new
clarification system was estimated as nearly 100%. In conclusion, the
high clarification performance of dissolver liquor can be achieved by
the hybrid of the centrifuge and filtration system.
Abstract: Today modern simulations solutions in the wind turbine industry have achieved a high degree of complexity and detail in result. Limitations exist when it is time to validate model results against measurements. Regarding Model validation it is of special interest to identify mode frequencies and to differentiate them from the different excitations. A wind turbine is a complex device and measurements regarding any part of the assembly show a lot of noise. Input excitations are difficult or even impossible to measure due to the stochastic nature of the environment. Traditional techniques for frequency analysis or features extraction are widely used to analyze wind turbine sensor signals, but have several limitations specially attending to non stationary signals (Events). A new technique based on autoregresive analysis techniques is introduced here for a specific application, a comparison and examples related to different events in the wind turbine operations are presented.
Abstract: The purpose of this paper is to provide an overview on methodological aspects of the information technology outsourcing (ITO) surveys, in an attempt to improve the data quality and reporting in survey research. It is based on a review of thirty articles on ITO surveys and focuses on two commonly explored dimensions of ITO, namely what are outsourced and why should there be ITO. This study highlights weaknesses in ITO surveys including lack of a clear definition of population, lack of information regarding the sampling method used, not citing the response rate, no information pertaining to pilot testing of survey instrument and absence of information on internal validity in the use or reporting of surveys. This study represents an attempt with a limited scope to point to shortfalls in the use survey methodology in ITO, and thus raise awareness among researchers in enhancing the reliability of survey findings.
Abstract: Reasonably priced and well-constructed housing must
be an integral and element supporting a healthy society. The absence
of housing everyone in society can afford negatively affects the
people's health, education, ability to get jobs, develop their
community. Without access to decent housing, economic
development, integration of immigrants and inclusiveness, the society
is negatively impacted. Canada has a sterling record in creating
housing compared to many other nations around the globe. Canadian
housing gets support from a mature and responsive mortgage network
and a top-quality construction industry as well as safe and excellent
quality building materials that are readily available. Yet 1.7 million
Canadian households occupy substandard abodes. During the past
hundred years, Canada's government has made a wide variety of
attempts to provide decent residential facilities every Canadian can
afford. Despite these laudable efforts, today Canada is left with
housing that is inadequate for many Canadians. People who own their
housing are given all kinds of privileges and perks, while people with
relatively low incomes who rent their apartments or houses are
discriminated against.
To help solve these problems, zoning that is based on an
"inclusionary" philosophy is tool developed to help provide people
the affordable residences that they need. No, thirty years after its
introduction, this type of zoning has been shown effective in helping
build and provide Canadians with a houses or apartments they can
afford to pay for. Using this form of zoning can have different results
+depending on where and how it is used. After examining Canadian
affordable housing and four American cases where this type of
zoning was enforced in the USA, this makes various
recommendations for expanding Canadians' access to housing they
can afford.
Abstract: A zero dimensional model has been used to investigate
the combustion performance of a single cylinder direct injection
diesel engine fueled by biofuels with options like supercharging and
exhaust gas recirculation. The numerical simulation was performed at
constant speed. The indicated pressure, temperature diagrams are
plotted and compared for different fuels. The emissions of soot and
nitrous oxide are computed with phenomenological models. The
experimental work was also carried out with biodiesel (palm stearin
methyl ester) diesel blends, ethanol diesel blends to validate
simulation results with experimental results, and observed that the
present model is successful in predicting the engine performance with
biofuels.
Abstract: Transition theory has been used to derive the elasticplastic
and transitional stresses. Results obtained have been discussed
numerically and depicted graphically. It is observed that the rotating
disk made of incompressible material with inclusion require higher
angular speed to yield at the internal surface as compared to disk
made of compressible material. It is seen that the radial and
circumferential stresses are maximum at the internal surface with and
without edge load (for flat disk). With the increase in thickness
parameter (k = 2, 4), the circumferential stress is maximum at the
external surface while the radial stress is maximum at the internal
surface. From the figures drawn the disk with exponentially varying
thickness (k = 2), high angular speed is required for initial yielding at
internal surface as compared to flat disk and exponentially varying
thickness for k = 4 onwards. It is concluded that the disk made of
isotropic compressible material is on the safer side of the design as
compared to disk made of isotropic incompressible material as it
requires higher percentage increase in an angular speed to become
fully plastic from its initial yielding.
Abstract: People from different cultures favor web pages
characterized by the values of their culture and, therefore, tend to
prefer different characteristics of a website according to their cultural
values in terms of navigation, security, product information, customer
service, shopping and design tools. For a company aiming to
globalize its market it is useful to implement country specific cultural
interfaces and different web sites for countries with different cultures.
This paper, following the conclusions proposed by two models of
Hall and Hofstede, and the studies of Marcus and Gould, defines,
through an empirical analysis, the guidelines of web design for both
the Scandinavian countries and Malaysia.
Abstract: This paper describes an automated event detection and location system for water distribution pipelines which is based upon low-cost sensor technology and signature analysis by an Artificial
Neural Network (ANN). The development of a low cost failure sensor which measures the opacity or cloudiness of the local water
flow has been designed, developed and validated, and an ANN based system is then described which uses time series data produced by
sensors to construct an empirical model for time series prediction and
classification of events. These two components have been installed,
tested and verified in an experimental site in a UK water distribution
system. Verification of the system has been achieved from a series of
simulated burst trials which have provided real data sets. It is concluded that the system has potential in water distribution network
management.
Abstract: In this paper we use quintic non-polynomial
spline functions to develop numerical methods for approximation
to the solution of a system of fourth-order boundaryvalue
problems associated with obstacle, unilateral and contact
problems. The convergence analysis of the methods has been
discussed and shown that the given approximations are better
than collocation and finite difference methods. Numerical
examples are presented to illustrate the applications of these
methods, and to compare the computed results with other
known methods.
Abstract: The Learning Management Systems present learning
environment which offers a collection of e-learning tools in a
package that allows a common interface and information sharing
among the tools. South East European University initial experience
in LMS was with the usage of the commercial LMS-ANGEL. After a
three year experience on ANGEL usage because of expenses that
were very high it was decided to develop our own software. As part
of the research project team for the in-house design and development
of the new LMS, we primarily had to select the features that would
cover our needs and also comply with the actual trends in the area of
software development, and then design and develop the system. In
this paper we present the process of LMS in-house development for
South East European University, its architecture, conception and
strengths with a special accent on the process of migration and
integration with other enterprise applications.
Abstract: Data compression is used operationally to reduce bandwidth and storage requirements. An efficient method for achieving lossless weather radar data compression is presented. The characteristics of the data are taken into account and the optical linear prediction is used for the PPI images in the weather radar data in the proposed method. The next PPI image is identical to the current one and a dramatic reduction in source entropy is achieved by using the prediction algorithm. Some lossless compression methods are used to compress the predicted data. Experimental results show that for the weather radar data, the method proposed in this paper outperforms the other methods.
Abstract: Electronic seal is an electronic device to check the
authenticity and integrity of freight containers at the point of arrival.
While RFID-based eSeals are gaining more acceptances and there are
also some standardization processes for these devices, a recent
research revealed that the current RFID-based eSeals are vulnerable to
various attacks. In this paper, we provide a feasible solution to
enhance the security of active RFID-based eSeals. Our approach is to
use an authentication and key agreement protocol between eSeal and
reader device, enabling data encryption and integrity check. Our
protocol is based on the use of block cipher AES, which is reasonable
since a block cipher can also be used for many other security purposes
including data encryption and pseudo-random number generation. Our
protocol is very simple, and it is applicable to low-end active RFID
eSeals.
Abstract: The aim of this work is to study the possible use of
stone cutting sludge waste in concrete production, which would
reduce both the environmental impact and the production cost .Slurry
sludge was used a source of water in concrete production, which was
obtained from Samara factory/Jordan, The physico-chemical and
mineralogical characterization of the sludge was carried out to
identify the major components and to compare it with the typical
sand used to produce concrete. Samples analysis showed that 96% of
slurry sludge volume is water, so it should be considered as an
important source of water. Results indicated that the use of slurry
sludge as water source in concrete production has insignificant effect
on compression strength, while it has a sharp effect on the slump
values. Using slurry sludge with a percentage of 25% of the total
water content obtained successful concrete samples regarding slump
and compression tests. To clarify slurry sludge, settling process can
be used to remove the suspended solid. A settling period of 30 min.
obtained 99% removal efficiency. The clarified water is suitable for
using in concrete mixes, which reduce water consumption, conserve
water recourses, increase the profit, reduce operation cost and save
the environment. Additionally, the dry sludge could be used in the
mix design instead of the fine materials with sizes < 160 um. This
application could conserve the natural materials and solve the
environmental and economical problem caused by sludge
accumulation.