Development and in vitro Characterization of Self-nanoemulsifying Drug Delivery Systems of Valsartan

The present study is aim to prepare and evaluate the selfnanoemulsifying drug delivery (SNEDDS) system of a poorly water soluble drug valsartan in order to achieve a better dissolution rate which would further help in enhancing oral bioavailability. The present research work describes a SNEDDS of valsartan using labrafil M 1944 CS, Tween 80 and Transcutol HP. The pseudoternary phase diagrams with presence and absence of drug were plotted to check for the emulsification range and also to evaluate the effect of valsartan on the emulsification behavior of the phases. The mixtures consisting of oil (labrafil M 1944 CS) with surfactant (tween 80), co-surfactant (Transcutol HP) were found to be optimum formulations. Prepared formulations were evaluated for its particle size distribution, nanoemulsifying properties, robustness to dilution, self emulsication time, turbidity measurement, drug content and invitro dissolution. The optimized formulations are further evaluated for heating cooling cycle, centrifugation studies, freeze thaw cycling, particle size distribution and zeta potential were carried out to confirm the stability of the formed SNEDDS formulations. The prepared formulation revealed t a significant improvement in terms of the drug solubility as compared with marketed tablet and pure drug.

The Predictability and Abstractness of Language: A Study in Understanding and Usage of the English Language through Probabilistic Modeling and Frequency

Accounts of language acquisition differ significantly in their treatment of the role of prediction in language learning. In particular, nativist accounts posit that probabilistic learning about words and word sequences has little to do with how children come to use language. The accuracy of this claim was examined by testing whether distributional probabilities and frequency contributed to how well 3-4 year olds repeat simple word chunks. Corresponding chunks were the same length, expressed similar content, and were all grammatically acceptable, yet the results of the study showed marked differences in performance when overall distributional frequency varied. It was found that a distributional model of language predicted the empirical findings better than a number of other models, replicating earlier findings and showing that children attend to distributional probabilities in an adult corpus. This suggested that language is more prediction-and-error based, rather than on abstract rules which nativist camps suggest.

Numerical Study of Airfoils Aerodynamic Performance in Heavy Rain Environment

Heavy rainfall greatly affects the aerodynamic performance of the aircraft. There are many accidents of aircraft caused by aerodynamic efficiency degradation by heavy rain. In this Paper we have studied the heavy rain effects on the aerodynamic efficiency of cambered NACA 64-210 and symmetric NACA 0012 airfoils. Our results show significant increase in drag and decrease in lift. We used preprocessing software gridgen for creation of geometry and mesh, used fluent as solver and techplot as postprocessor. Discrete phase modeling called DPM is used to model the rain particles using two phase flow approach. The rain particles are assumed to be inert. Both airfoils showed significant decrease in lift and increase in drag in simulated rain environment. The most significant difference between these two airfoils was the NACA 64-210 more sensitivity than NACA 0012 to liquid water content (LWC). We believe that the results showed in this paper will be useful for the designer of the commercial aircrafts and UAVs, and will be helpful for training of the pilots to control the airplanes in heavy rain.

Analysis of the Ambient Media Approach of Advertisement Samples from the Adman Awards and Symposium under the Category of Outdoor and Ambience

This research is to study the types of products and services that employs 'ambient media and respective techniques in its advertisement materials. Data collection has been done via analyses of a total of 62 advertisements that employed ambient media approach in Thailand during the years 2004 to 2011. The 62 advertisement were qualifying advertisements of the Adman Awards & Symposium under the category of Outdoor & Ambience. Analysis results reveal that there is a total of 14 products and services that chooses to utilize ambient media in its advertisement. Amongst all ambient media techniques, 'intrusion' uses the value of a medium in its representation of content most often. Following intrusion is 'interaction', where consumers are invited to participate and interact with the advertising materials. 'Illusion' ranks third in its ability to subject the viewers to distortions of reality that makes the division between reality and fantasy less clear.

Effect of Natural Fibres Inclusion in Clay Bricks: Physico-Mechanical Properties

In spite of the advent of new materials, clay bricks remain, arguably, the most popular construction materials today. Nevertheless the low cost and versatility of clay bricks cannot always be associated with high environmental and sustainable values, especially in terms of raw material sources and manufacturing processes. At the same time, the worldwide agricultural footprint is fast growing, with vast agricultural land cultivation and active expansion of the agro-based industry. The resulting large quantities of agricultural wastes, unfortunately, are not always well managed or utilised. These wastes can be recycled, such as by retrieving fibres from disposed leaves and fruit bunches, and then incorporated in brick-making. This way the clay bricks are made a 'greener' building material and the discarded natural wastes can be reutilised, avoiding otherwise wasteful landfill and harmful open incineration. This study examined the physical and mechanical properties of clay bricks made by adding two natural fibres to a clay-water mixture, with baked and non-baked conditions. The fibres were sourced from pineapple leaves (PF) and oil palm fruit bunch (OF), and added within the range of 0.25-0.75 %. Cement was added as a binder to the mixture at 5-15 %. Although the two fibres had different effects on the bricks produced, cement appeared to dominate the compressive strength. The non-baked bricks disintegrated when submerged in water, while the baked ones displayed cement-dependent characteristics in water-absorption and density changes. Interestingly, further increase in fibre content did not cause significant density decrease in both the baked and non-baked bricks.

Grouping and Indexing Color Features for Efficient Image Retrieval

Content-based Image Retrieval (CBIR) aims at searching image databases for specific images that are similar to a given query image based on matching of features derived from the image content. This paper focuses on a low-dimensional color based indexing technique for achieving efficient and effective retrieval performance. In our approach, the color features are extracted using the mean shift algorithm, a robust clustering technique. Then the cluster (region) mode is used as representative of the image in 3-D color space. The feature descriptor consists of the representative color of a region and is indexed using a spatial indexing method that uses *R -tree thus avoiding the high-dimensional indexing problems associated with the traditional color histogram. Alternatively, the images in the database are clustered based on region feature similarity using Euclidian distance. Only representative (centroids) features of these clusters are indexed using *R -tree thus improving the efficiency. For similarity retrieval, each representative color in the query image or region is used independently to find regions containing that color. The results of these methods are compared. A JAVA based query engine supporting query-by- example is built to retrieve images by color.

A Noble Flow Rate Control based on Leaky Bucket Method for Multi-Media OBS Networks

Optical burst switching (OBS) has been proposed to realize the next generation Internet based on the wavelength division multiplexing (WDM) network technologies. In the OBS, the burst contention is one of the major problems. The deflection routing has been designed for resolving the problem. However, the deflection routing becomes difficult to prevent from the burst contentions as the network load becomes high. In this paper, we introduce a flow rate control methods to reduce burst contentions. We propose new flow rate control methods based on the leaky bucket algorithm and deflection routing, i.e. separate leaky bucket deflection method, and dynamic leaky bucket deflection method. In proposed methods, edge nodes which generate data bursts carry out the flow rate control protocols. In order to verify the effectiveness of the flow rate control in OBS networks, we show that the proposed methods improve the network utilization and reduce the burst loss probability through computer simulations.

Microstructure and Corrosion Behavior of Laser Welded Magnesium Alloys with Silver Nanoparticles

Magnesium alloys have gained increased attention in recent years in automotive, electronics, and medical industry. This because of magnesium alloys have better properties than aluminum alloys and steels in respects of their low density and high strength to weight ratio. However, the main problems of magnesium alloy welding are the crack formation and the appearance of porosity during the solidification. This paper proposes a unique technique to weld two thin sheets of AZ31B magnesium alloy using a paste containing Ag nanoparticles. The paste containing Ag nanoparticles of 5 nm in average diameter and an organic solvent was used to coat the surface of AZ31B thin sheet. The coated sheet was heated at 100 °C for 60 s to evaporate the solvent. The dried sheet was set as a lower AZ31B sheet on the jig, and then lap fillet welding was carried out by using a pulsed Nd:YAG laser in a closed box filled with argon gas. The characteristics of the microstructure and the corrosion behavior of the joints were analyzed by opticalmicroscopy (OM), energy dispersive spectrometry (EDS), electron probe micro-analyzer (EPMA), scanning electron microscopy (SEM), and immersion corrosion test. The experimental results show that the wrought AZ31B magnesium alloy can be joined successfully using Ag nanoparticles. Ag nanoparticles insert promote grain refinement, narrower the HAZ width and wider bond width compared to weld without and insert. Corrosion rate of welded AZ31B with Ag nanoparticles reduced up to 44 % compared to base metal. The improvement of corrosion resistance of welded AZ31B with Ag nanoparticles due to finer grains and large grain boundaries area which consist of high Al content. β-phase Mg17Al12 could serve as effective barrier and suppressed further propagation of corrosion. Furthermore, Ag distribution in fusion zone provide much more finer grains and may stabilize the magnesium solid solution making it less soluble or less anodic in aqueous

Continuous Text Translation Using Text Modeling in the Thetos System

In the paper a method of modeling text for Polish is discussed. The method is aimed at transforming continuous input text into a text consisting of sentences in so called canonical form, whose characteristic is, among others, a complete structure as well as no anaphora or ellipses. The transformation is lossless as to the content of text being transformed. The modeling method has been worked out for the needs of the Thetos system, which translates Polish written texts into the Polish sign language. We believe that the method can be also used in various applications that deal with the natural language, e.g. in a text summary generator for Polish.

Brand Placement Strategies in Turkey: The Case of “Yalan Dünya”

This study examines appearances of brand placement as an alternative communication strategy in television series by focusing on Yalan Dünya which is one of the most popular television series in Turkey. Consequently, this study has a descriptive research design and quantitative content analysis method is used in order to analyze frequency and time data of brand placement appearances in first 3 seasons of Yalan Dünya with 16 episodes. Analysis of brand placement practices in Yalan Dünya is dealt in three categories: episode-based analysis, season-based analysis and comparative analysis. At the end, brand placement practices in Yalan Dünya are evaluated in terms of type, form, duration and legal arrangements. As a result of this study, it is seen that brand placement plays a determinant role in Yalan Dünya content. Also, current legal arrangements make brand placement closer to other traditional communication strategies instead of differing brand placement from them distinctly.

Optical Reflectance of Pure and Doped Tin Oxide: From Thin Films to Poly-Crystalline Silicon/Thin Film Device

Films of pure tin oxide SnO2 and in presence of antimony atoms (SnO2-Sb) deposited onto glass substrates have shown a sufficiently high energy gap to be transparent in the visible region, a high electrical mobility and a carrier concentration which displays a good electrical conductivity [1]. In this work, the effects of polycrystalline silicon substrate on the optical properties of pure and Sb doped tin oxide is investigated. We used the APCVD (atmospheric pressure chemical vapour deposition) technique, which is a low-cost and simple technique, under nitrogen ambient, for growing this material. A series of SnO2 and SnO2-Sb have been deposited onto polycrystalline silicon substrates with different contents of antimony atoms at the same conditions of deposition (substrate temperature, flow oxygen, duration and nitrogen atmosphere of the reactor). The effect of the substrate in terms of morphology and nonlinear optical properties, mainly the reflectance, was studied. The reflectance intensity of the device, compared to the reflectance of tin oxide films deposited directly on glass substrate, is clearly reduced on the overall wavelength range. It is obvious that the roughness of the poly-c silicon plays an important role by improving the reflectance and hence the optical parameters. A clear shift in the minimum of the reflectance upon doping level is observed. This minimum corresponds to strong free carrier absorption, resulting in different plasma frequency. This effect is followed by an increase in the reflectance depending of the antimony doping. Applying the extended Drude theory to the combining optical and electrical obtained results these effects are discussed.

Different Teaching Methods for Program Design and Algorithmic Language

This paper covers the present situation and problem of experimental teaching of mathematics specialty in recent years, puts forward and demonstrates experimental teaching methods for different education. From the aspects of content and experimental teaching approach, uses as an example the course “Experiment for Program Designing & Algorithmic Language" and discusses teaching practice and laboratory course work. In addition a series of successful methods and measures are introduced in experimental teaching.

Dimethyl Ether as an Ignition Improver for Hydrous Methanol Fuelled Homogeneous Charge Compression Ignition (HCCI) Engine

Homogeneous Charge Compression (HCCI) Ignition technology has been around for a long time, but has recently received renewed attention and enthusiasm. This paper deals with experimental investigations of HCCI engine using hydrous methanol as a primary fuel and Dimethyl Ether (DME) as an ignition improver. A regular diesel engine has been modified to work as HCCI engine for this investigation. The hydrous methanol is inducted and DME is injected into a single cylinder engine. Hence, hydrous methanol is used with 15% water content in HCCI engine and its performance and emission behavior is documented. The auto-ignition of Methanol is enabled by DME. The quantity of DME varies with respect to the load. In this study, the experiments are conducted independently and the effect of the hydrous methanol on the engine operating limit, heat release rate and exhaust emissions at different load conditions are investigated. The investigation also proves that the Hydrous Methanol with DME operation reduces the oxides of Nitrogen and smoke to an extreme low level which is not possible by the direct injection CI engine. Therefore, it is beneficial to use hydrous methanol-DME HCCI mode while using hydrous methanol in internal Combustion Engines.

Strategies of Education and Training Practice of Small and Medium Sized Enterprises

The role of knowledge is a determinative factor in the life of economy and society. To determine knowledge is not an easy task yet the real task is to determine the right knowledge. From this view knowledge is a sum of experience, ideas and cognitions which can help companies to remain in markets and to realize a maximum profit. At the same time changes of circumstances project in advance that contents and demands of the right knowledge are changing. In this paper we will analyse a special segment on the basis of an empirical survey. We investigated the behaviour and strategies of small and medium sized enterprises (SMEs) in the area of knowledge-handling. This survey was realized by questionnaires and wide range statistical methods were used during processing. As a result we will show how these companies are prepared to operate in a knowledge-based economy and in which areas they have prominent deficiencies.

Some Characteristics of Biodegradable Film Substituted by Yam (Dioscorea alata) Starch from Thailand

Yam starch obtained from the water yam (munlued) by the wet milling process was studied for some physicochemical properties. Yam starch film was prepared by casting using glycerol as a plasticizer. The effect of different glycerol (1.30, 1.65 and 2.00g/100g of filmogenic solution) and starch concentrations (3.30, 3.65 and 4.00g /100g of filmogenic solution) were evaluated on some characteristics of the film. The temperature for obtaining the gelatinized starch solution was 70-80°C and then dried at 45°C for 4 hours. The resulting starch from munlued granular morphology was triangular and the average size of the granule was 26.68 μm. The amylose content by colorimetric method was 26 % and the gelatinize temperature was 70-80°C. The appearance of the film was smooth, transparent, and glossy with average moisture content of 25.96% and thickness of 0.01mm. Puncture deformation and flexibility increased with glycerol content. The starch and glycerol concentration were a significant factor of the yam starch film characteristics. Yam starch film can be described as a biofilm providing many applications and developments with the advantage of biodegradability.

Protecting the Privacy and Trust of VIP Users on Social Network Sites

There is a real threat on the VIPs personal pages on the Social Network Sites (SNS). The real threats to these pages is violation of privacy and theft of identity through creating fake pages that exploit their names and pictures to attract the victims and spread of lies. In this paper, we propose a new secure architecture that improves the trusting and finds an effective solution to reduce fake pages and possibility of recognizing VIP pages on SNS. The proposed architecture works as a third party that is added to Facebook to provide the trust service to personal pages for VIPs. Through this mechanism, it works to ensure the real identity of the applicant through the electronic authentication of personal information by storing this information within content of their website. As a result, the significance of the proposed architecture is that it secures and provides trust to the VIPs personal pages. Furthermore, it can help to discover fake page, protect the privacy, reduce crimes of personality-theft, and increase the sense of trust and satisfaction by friends and admirers in interacting with SNS.

Influence of Active Packaging on the Shelf Life of Apple-Black Currant Marmalade Candies

The research object was apple-black currant marmalade candies. Experiments were carried out at the Faculty of Food Technology of the Latvia University of Agriculture. An active packaging in combination with modified atmosphere (MAP, CO2 100%) was examined and compared with traditional packaging in air ambiance. Polymer Multibarrier 60 and paper bags were used. Influence of iron based oxygen absorber in sachets of 500 cc obtained from Mitsubishi Gas Chemical Europe Ageless® was tested on the quality during the shelf of marmalade. Samples of 80±5 g were packaged in polymer pouches (110 mm x 110 mm), hermetically sealed by MULTIVAC C300 vacuum chamber machine, and stored in room temperature +20.0±1.0 °C. The physiochemical properties – weight losses, moisture content, hardness, aw, pH, colour, changes of atmosphere content (CO2 and O2) in headspace of packs, and microbial conditions were analysed before packaging and in the 1st, 3rd , 5th, 8th, 11th and 15th weeks of storage.

Bio-inspired Audio Content-Based Retrieval Framework (B-ACRF)

Content-based music retrieval generally involves analyzing, searching and retrieving music based on low or high level features of a song which normally used to represent artists, songs or music genre. Identifying them would normally involve feature extraction and classification tasks. Theoretically the greater features analyzed, the better the classification accuracy can be achieved but with longer execution time. Technique to select significant features is important as it will reduce dimensions of feature used in classification and contributes to the accuracy. Artificial Immune System (AIS) approach will be investigated and applied in the classification task. Bio-inspired audio content-based retrieval framework (B-ACRF) is proposed at the end of this paper where it embraces issues that need further consideration in music retrieval performances.

Some Physical and Mechanical Properties of Russian Olive Fruit

Physical and mechanical properties of Russian olive fruits were measured at moisture content of 14.43% w.b. The results revealed that the mean length, width and thickness of Russian olive fruits were 20.72, 15.73 and 14.69mm, respectively. Mean mass and volume of Russian olive fruits were measured as 1.45 g and 2.55 cm3, respectively. The sphericity, aspect ratio and surface area were calculated as 0.81, 0.72 and 8.96 cm2, respectively, while arithmetic mean diameter, geometric mean diameter and equivalent diameter of Russian olive fruits were 17.05, 16.83 and 16.84 mm, respectively. Whole fruit density, bulk density and porosity of jujube fruits were measured and found to be 1.01 g/cm3, 0.29 g/cm3 and 69.5%, respectively. The values of static coefficient of friction on three surfaces of glass, galvanized iron and plywood were 0.35, 0.36 and 0.43, respectively. The skin color (L*, a*, b*) varied from 9.92 to 16.08; 2.04 to 3.91 and 1.12 to 3.83, respectively. The values of rupture force, deformation, energy absorbed and hardness were found to be between 12.14-16.85 N, 2.16-4.25 mm, 3.42-6.99 N mm and 17.1-23.85 N/mm.

Robust Digital Cinema Watermarking

With the advent of digital cinema and digital broadcasting, copyright protection of video data has been one of the most important issues. We present a novel method of watermarking for video image data based on the hardware and digital wavelet transform techniques and name it as “traceable watermarking" because the watermarked data is constructed before the transmission process and traced after it has been received by an authorized user. In our method, we embed the watermark to the lowest part of each image frame in decoded video by using a hardware LSI. Digital Cinema is an important application for traceable watermarking since digital cinema system makes use of watermarking technology during content encoding, encryption, transmission, decoding and all the intermediate process to be done in digital cinema systems. The watermark is embedded into the randomly selected movie frames using hash functions. Embedded watermark information can be extracted from the decoded video data. For that, there is no need to access original movie data. Our experimental results show that proposed traceable watermarking method for digital cinema system is much better than the convenient watermarking techniques in terms of robustness, image quality, speed, simplicity and robust structure.