Abstract: Doxorubicin, also known as Adriamycin, is an
anthracycline class of drug used in cancer chemotherapy. It is used in
the treatment of non-Hodgkin’s lymphoma, multiple myeloma, acute
leukemia, breast cancer, lung cancer, endometrium cancer and ovary
cancers. It functions via intercalating DNA and ultimately killing
cancer cells. The major side effects of doxorubicin are hair loss,
myelosuppression, nausea & vomiting, oesophagitis, diarrhea, heart
damage and liver dysfunction. The minor modifications in the
structure of compound exhibit large variation in the biological
activity, has prompted us to carry out the synthesis of sulfonamide
derivatives. Sulfonamide is an important feature with broad spectrum
of biological activity such as antiviral, antifungal, diuretics, antiinflammatory,
antibacterial and anticancer activities. Structure of the
synthesized compound N-(1-methyl-2-oxo-2-N-methyl anilinoethyl)
benzene sulfonamide confirmed by proton nuclear magnetic
resonance (1H NMR),13C NMR, Mass and FTIR spectroscopic tools
to assure the position of all protons and hence stereochemistry of the
molecule. Further we have reported the binding potential of
synthesized sulfonamide analogues in comparison to doxorubicin
drug using Auto Dock 4.2 software. Computational binding energy
(B.E.) and inhibitory constant (Ki) has been evaluated for the
synthesized compound in comparison of doxorubicin against Poly
(dA-dT).Poly (dA-dT) and Poly (dG-dC).Poly (dG-dC) sequences.
The in vitro cytotoxic study against human breast cancer cell lines
confirms the better anticancer activity of the synthesized compound
over currently in use anticancer drug doxorubicin. The IC50 value of
the synthesized compound is 7.12 μM whereas for doxorubicin is 7.2
μM.
Abstract: In review the generalized data about different methods
of synthesis of biological activity aminated hydroxyanthraquinones is
presented. The basic regularity of a synthesis is analyzed. Action of
temperature, pH, solubility, catalysts and other factors on a reaction
product yield is revealed.
Abstract: The Blue Nile Basin is the most important tributary of
the Nile River. Egypt and Sudan are almost dependent on water
originated from the Blue Nile. This multi-dependency creates
conflicts among the three countries Egypt, Sudan, and Ethiopia
making the management of these conflicts as an international issue.
Good assessment of the water resources of the Blue Nile is an
important to help in managing such conflicts. Hydrological models
are good tool for such assessment. This paper presents a critical
review of the nature and variability of the climate and hydrology of
the Blue Nile Basin as a first step of using hydrological modeling to
assess the water resources of the Blue Nile. Many several attempts
are done to develop basin-scale hydrological modeling on the Blue
Nile. Lumped and semi distributed models used averages of
meteorological inputs and watershed characteristics in hydrological
simulation, to analyze runoff for flood control and water resource
management. Distributed models include the temporal and spatial
variability of catchment conditions and meteorological inputs to
allow better representation of the hydrological process. The main
challenge of all used models was to assess the water resources of the
basin is the shortage of the data needed for models calibration and
validation. It is recommended to use distributed model for their
higher accuracy to cope with the great variability and complexity of
the Blue Nile basin and to collect sufficient data to have more
sophisticated and accurate hydrological modeling.
Abstract: This research was conducted in the Mae Sot
Watershed where located in the Moei River Basin at the Upper
Salween River Basin in Tak Province, Thailand. The Mae Sot
Municipality is the largest urban area in Tak Province and situated in
the midstream of the Mae Sot Watershed. It usually faces flash flood
problem after heavy rain due to poor flood management has been
reported since economic rapidly bloom up in recent years. Its
catchment can be classified as ungauged basin with lack of rainfall
data and no any stream gaging station was reported. It was attached
by most severely flood events in 2013 as the worst studied case for
all those communities in this municipality. Moreover, other problems
are also faced in this watershed, such shortage water supply for
domestic consumption and agriculture utilizations including a
deterioration of water quality and landslide as well. The research
aimed to increase capability building and strengthening the
participation of those local community leaders and related agencies to
conduct better water management in urban area was started by mean
of the data collection and illustration of the appropriated application
of some short period rainfall forecasting model as they aim for better
flood relief plan and management through the hydrologic model
system and river analysis system programs. The authors intended to
apply the global rainfall data via the integrated data viewer (IDV)
program from the Unidata with the aim for rainfall forecasting in a
short period of 7-10 days in advance during rainy season instead of
real time record. The IDV product can be present in an advance
period of rainfall with time step of 3-6 hours was introduced to the
communities. The result can be used as input data to the hydrologic
modeling system model (HEC-HMS) for synthesizing flood
hydrographs and use for flood forecasting as well. The authors
applied the river analysis system model (HEC-RAS) to present flood
flow behaviors in the reach of the Mae Sot stream via the downtown
of the Mae Sot City as flood extents as the water surface level at
every cross-sectional profiles of the stream. Both models of HMS and
RAS were tested in 2013 with observed rainfall and inflow-outflow
data from the Mae Sot Dam. The result of HMS showed fit to the
observed data at the dam and applied at upstream boundary discharge
to RAS in order to simulate flood extents and tested in the field, and
the result found satisfying. The product of rainfall from IDV was fair
while compared with observed data. However, it is an appropriate
tool to use in the ungauged catchment to use with flood hydrograph
and river analysis models for future efficient flood relief plan and
management.
Abstract: This article discusses issues related to the System of
Innovation: Comparing economies of Brazil and South Africa.
Having as this study aimed at comparing the Innovation System of
the countries mentioned. Then briefly describe the process of Venture
Capital and present the industry innovation in Brazil and South
Africa. The methodological approach described in this article is
descriptive and the approach is qualitative, taking as a basis
secondary data relating to research articles. The main results are
related to the different forms of financing of Venture Capital used by
countries compared, in addition to the training and economic policy.
And finally, it was highlighted the importance of implementation of
policy reforms for the Brazil and Africa in the innovation process.
Abstract: Based on the experimental data, the impact of
resistance and reactance of the winding, as well as the magnetic
permeability of the magnetic circuit steel material on the value of the
electromotive force of the induction converter is investigated. The
obtained results allow estimating the main technological spreads and
determining the maximum level of the electromotive force change.
By the method of experiment planning, the expression of a
polynomial for the electromotive force which can be used to estimate
the adequacy of mathematical models to be used at the investigation
and design of induction converters is obtained.
Abstract: Comparisons of financial development across
countries are central to answering many of the questions on factors
leading to economic development. For this reason this study analyzes
the implications of financial system’s development on country’s
economic development. The aim of the article: to analyze the impact
of financial system’s development on economic development. The
following research methods were used: systemic, logical and
comparative analysis of scientific literature, analysis of statistical
data, time series model (Autoregressive Distributed Lag (ARDL)
Model). The empirical results suggest about positive short and long
term effect of stock market development on GDP per capita.
Abstract: The planning of geological survey works is an
iterative process which involves planner, geologist, civil engineer and
other stakeholders, who perform different roles and have different
points of view. Traditionally, the team used paper maps or CAD
drawings to present the proposal which is not an efficient way to
present and share idea on the site investigation proposal such as
sitting of borehole location or seismic survey lines. This paper
focuses on how a GIS approach can be utilised to develop a webbased
system to support decision making process in the planning of
geological survey works and also to plan site activities carried out by
Singapore Geological Office (SGO). The authors design a framework
of building an interactive web-based GIS system, and develop a
prototype, which enables the users to obtain rapidly existing
geological information and also to plan interactively borehole
locations and seismic survey lines via a web browser. This prototype
system is used daily by SGO and has shown to be effective in
increasing efficiency and productivity as the time taken in the
planning of geological survey works is shortened. The prototype
system has been developed using the ESRI ArcGIS API 3.7 for Flex
which is based on the ArcGIS 10.2.1 platform.
Abstract: The organizations in the knowledge economy era have
recognized the importance of building knowledge assets for
sustainable growth and development. In comparison to other
industries, Information Technology (IT) enterprises, holds an edge in
developing an effective Knowledge Management (KM) programmethanks
to their in-house technological abilities. This paper tries to
study the various knowledge based incentive programmes and its
effect on Knowledge Sharing and Learning in the context of the
Indian IT sector. A conceptual model is developed linking KM
Incentives, Knowledge Sharing and Learning. A questionnaire study
is conducted to collect primary data from the knowledge workers of
the IT organizations located in India. The data was analysed using
Structural Equation Modeling using Partial Least Square method. The
results show a strong influence of knowledge management incentives
on knowledge sharing and an indirect influence on learning.
Abstract: The development of the United Arab Emirates (UAE)
into a regional trade, tourism, finance and logistics hub has
transformed its real estate markets. However, speculative activity and
price volatility remain concerns. UAE residential market values
(MV) are exposed to fluctuations in capital flows and migration
which, in turn, are affected by geopolitical uncertainty, oil price
volatility and global investment market sentiment. Internally, a
complex interplay between administrative boundaries, land tenure,
building quality and evolving location characteristics fragments UAE
residential property markets. In short, the UAE Residential Valuation
System (UAE-RVS) confronts multiple challenges to collect, filter
and analyze relevant information in complex and dynamic spatial and
capital markets. A robust (RVS) can mitigate the risk of unhelpful
volatility, speculative excess or investment mistakes. The research
outlines the institutional, ontological, dynamic and epistemological
issues at play. We highlight the importance of system capabilities,
valuation standard salience and stakeholders trust.
Abstract: A large amount of data is typically stored in relational
databases (DB). The latter can efficiently handle user queries which
intend to elicit the appropriate information from data sources.
However, direct access and use of this data requires the end users to
have an adequate technical background, while they should also cope
with the internal data structure and values presented. Consequently
the information retrieval is a quite difficult process even for IT or DB
experts, taking into account the limited contributions of relational
databases from the conceptual point of view. Ontologies enable users
to formally describe a domain of knowledge in terms of concepts and
relations among them and hence they can be used for unambiguously
specifying the information captured by the relational database.
However, accessing information residing in a database using
ontologies is feasible, provided that the users are keen on using
semantic web technologies. For enabling users form different
disciplines to retrieve the appropriate data, the design of a Graphical
User Interface is necessary. In this work, we will present an
interactive, ontology-based, semantically enable web tool that can be
used for information retrieval purposes. The tool is totally based on
the ontological representation of underlying database schema while it
provides a user friendly environment through which the users can
graphically form and execute their queries.
Abstract: Agriculture is the backbone of economy of Pakistan
and cotton is the major agricultural export and supreme source of raw
fiber for our textile industry. To combat severe problems of insect
and weed, combination of three genes namely Cry1Ac, Cry2A and
EPSPS genes was transferred in locally cultivated cotton variety
MNH-786 with the use of Agrobacterium mediated genetic
transformation. The present study focused on the molecular screening
of transgenic cotton plants at T3 generation in order to confirm
integration and expression of all three genes (Cry1Ac, Cry2A and
EPSP synthase) into the cotton genome. Initially, glyphosate spray
assay was used for screening of transgenic cotton plants containing
EPSP synthase gene at T3 generation. Transgenic cotton plants which
were healthy and showed no damage on leaves were selected after 07
days of spray. For molecular analysis of transgenic cotton plants in
the laboratory, the genomic DNA of these transgenic cotton plants
were isolated and subjected to amplification of the three genes. Thus,
seventeen out of twenty (Cry1Ac gene), ten out of twenty (Cry2A
gene) and all twenty (EPSP synthase gene) were produced positive
amplification. On the base of PCR amplification, ten transgenic plant
samples were subjected to protein expression analysis through
ELISA. The results showed that eight out of ten plants were actively
expressing the three transgenes. Real-time PCR was also done to
quantify the mRNA expression levels of Cry1Ac and EPSP synthase
gene. Finally, eight plants were confirmed for the presence and active
expression of all three genes at T3 generation.
Abstract: The restrained construction zoning, an important part
in the urban master plan, is a necessary planning tool to control the city
sprawl, to guarantee the reservation implementation of the various
types of protective elements, and to realize the storage of the essential
urban spatial resources. Simultaneously, owing to the diverse
constitutes of restrained construction area and the various stakeholders
involved in, its planning requires an overall consideration of all
elements from the perspective of coordination+, balance and
practicability to deal with the problems and conflicts in this process.
Taking Yangzijin Ecological Restrained Construction Area in
Yangzhou as an example, this study analyzes all the potential actors,
agencies and stakeholders in this restrained construction area, as well
as the relevant conflicts between each other. Besides, this study tries to
build up a planning procedure based on the framework of governance
theory, and proposes a possible planning method that combines
"rigidity" and "flexibility" to protect the ecological limitation
boundary, to take every interest into account, and to promote economic
development in a harmonious society.
Abstract: In this paper, we propose an intelligent system that is
used for monitoring the health conditions of patients. Monitoring the
health condition of patients is a complex problem that involves
different medical units and requires continuous monitoring especially
in rural areas because of inadequate number of available specialized
physicians. The proposed system will improve patient care and drive
costs down comparing to the existing system in Jordan. The proposed
system will be the start point to faster and improve the
communication between different units in the health system in
Jordan. Connecting patients and their physicians beyond hospital
doors regarding their geographical area is an important issue in
developing the health system in Jordan. The ability of making
medical decisions, the quality of medical is expected to be improved.
Abstract: Macro invertebrates have been used to monitor
organic pollution in rivers and streams. Several biotic indices based
on macro invertebrates have been developed over the years including
the Biological Monitoring Working Party (BMWP). A new biotic
index, the Gammarus:Asellus ratio has been recently proposed as an
index of organic pollution. This study tested the validity of the
Gammarus:Asellus ratio as an index of organic pollution, by
examining the relationship between the Gammarus:Asellus ratio and
physical chemical parameters, and other biotic indices such as
BMWP and, Average Score Per Taxon (ASPT) from lakes and
streams at Markeaton Park, Allestree Park and Kedleston Hall,
Derbyshire. Macro invertebrates were sampled using the standard
five minute kick sampling techniques physical and chemical
environmental variables were obtained based on standard sampling
techniques. Eighteen sites were sampled, six sites from Markeaton
Park (three sites across the stream and three sites across the lake). Six
sites each were also sampled from Allestree Park and Kedleston Hall
lakes. The Gammarus:Asellus ratio showed an opposite significant
positive correlations with parameters indicative of organic pollution
such as the level of nitrates, phosphates, and calcium and also
revealed a negatively significant correlations with other biotic indices
(BMWP/ASPT). The BMWP score correlated positively significantly
with some water quality parameters such as dissolved oxygen and
flow rate, but revealed no correlations with other chemical
environmental variables. The BMWP score was significantly higher
in the stream than the lake in Markeaton Park, also The ASPT scores
appear to be significantly higher in the upper Lakes than the middle
and lower lakes. This study has further strengthened the use of
BMWP/ASPT score as an index of organic pollution. But additional
application is required to validate the use of Gammarus:Asellus as a
rapid bio monitoring tool.
Abstract: The practice of freeing monuments from subsequent
additions crosses the entire history of conservation and it is
traditionally connected to the aim of valorisation, both for cultural
and educational purpose and recently even for touristic exploitation.
Defence heritage has been widely interested by these cultural and
technical moods from philological restoration to critic innovations. A
renovated critical analysis of Italian episodes and in particular the
Sardinian case of the area of San Pancrazio in Cagliari, constitute an
important lesson about the limits of this practice and the uncertainty
in terms of results, towards the definition of a sustainable good
practice in the restoration of military architectures.
Abstract: Although, arsenic trioxide has been the subject of
toxicological research, in vitro cytotoxicity and genotoxicity studies
using relevant cell models and uniform methodology are not well
elucidated. Hence, the aim of the present study was to evaluate the
cytotoxicity and genotoxicity induced by arsenic trioxide in human
keratinocytes (HaCaT) using the MTT [3-(4, 5-dimethylthiazol-2-yl)-
2,5-diphenyltetrazolium bromide] and alkaline single cell gel
electrophoresis (Comet) assays, respectively. Human keratinocytes
were treated with different doses of arsenic trioxide for 4 h prior to
cytogenetic assessment. Data obtained from the MTT assay indicated
that arsenic trioxide significantly reduced the viability of HaCaT cells
in a dose-dependent manner, showing an IC50 value of 34.18 ± 0.6
μM. Data generated from the comet assay also indicated a significant
dose-dependent increase in DNA damage in HaCaT cells associated
with arsenic trioxide exposure. We observed a significant increase in
comet tail length and tail moment, showing an evidence of arsenic
trioxide -induced genotoxic damage in HaCaT cells. This study
confirms that the comet assay is a sensitive and effective method to
detect DNA damage caused by arsenic.
Abstract: Neurons in the nervous system communicate with
each other by producing electrical signals called spikes. To
investigate the physiological function of nervous system it is essential
to study the activity of neurons by detecting and sorting spikes in the
recorded signal. In this paper a method is proposed for considering
the spike sorting problem which is based on the nonlinear modeling
of spikes using exponential autoregressive model. The genetic
algorithm is utilized for model parameter estimation. In this regard
some selected model coefficients are used as features for sorting
purposes. For optimal selection of model coefficients, self-organizing
feature map is used. The results show that modeling of spikes with
nonlinear autoregressive model outperforms its linear counterpart.
Also the extracted features based on the coefficients of exponential
autoregressive model are better than wavelet based extracted features
and get more compact and well-separated clusters. In the case of
spikes different in small-scale structures where principal component
analysis fails to get separated clouds in the feature space, the
proposed method can obtain well-separated cluster which removes
the necessity of applying complex classifiers.
Abstract: The aim of this study is to evaluate the effects of the
laser and partial vibration stimulation on the mice tibia with
morphological characteristics. Twenty female C57BL/6 mice (12
weeks old) were used for the experiment. The study was carried out on
four groups of animals each consisting of five mice. Four groups of
mice were ovariectomized. Animals were scanned at 0 and 2 weeks
after ovariectomy by using micro computed tomography to estimate
morphological characteristics of tibial trabecular bone. Morphological
analysis showed that structural parameters of multi-stimuli group
appear significantly better phase in BV/TV, BS/BV, Tb.Th, Tb.N,
Tb.Sp, and Tb.pf than single stimulation groups. However, single
stimulation groups didn’t show significant effect on tibia with Sham
group. This study suggests that multi-stimuli may restrain the change
as the degenerate phase on osteoporosis in the mice tibia.
Abstract: Waste silicon carbide (waste SiC) filled high-density
polyethylene (HDPE) with and without surface modifiers were
studied. Two types of surface modifiers namely; high-density
polyethylene-grafted-maleic anhydride (HDPE-g-MA) and 3-aminopropyltriethoxysilane have been used in this study. The
composites were produced using a two roll mill, extruder and shaped
in a hydraulic compression molding machine. The mechanical
properties of polymer composites such as flexural strength and
modulus, impact strength, tensile strength, stiffness and hardness
were investigated over a range of compositions. It was found that,
flexural strength and modulus, tensile modulus and hardness
increased, whereas impact strength and tensile strength decreased
with the increasing in filler contents, compared to the neat HDPE. At
similar filler content, the effect of both surface modifiers increased
flexural modulus, impact strength, tensile strength and stiffness but
reduced the flexural strength. Morphological investigation using
SEM revealed that the improvement in mechanical properties was
due to enhancement of the interfacial adhesion between waste SiC
and HDPE.