Mathematical Modeling of Uncompetitive Inhibition of Bi-Substrate Enzymatic Reactions

Currently, mathematical and computer modeling are widely used in different biological studies to predict or assess behavior of such a complex systems as a biological are. This study deals with mathematical and computer modeling of bi-substrate enzymatic reactions, which play an important role in different biochemical pathways. The main objective of this study is to represent the results from in silico investigation of bi-substrate enzymatic reactions in the presence of uncompetitive inhibitors, as well as to describe in details the inhibition effects. Four models of uncompetitive inhibition were designed using different software packages. Particularly, uncompetitive inhibitor to the first [ES1] and the second ([ES1S2]; [FS2]) enzyme-substrate complexes have been studied. The simulation, using the same kinetic parameters for all models allowed investigating the behavior of reactions as well as determined some interesting aspects concerning influence of different cases of uncompetitive inhibition. Besides, it has been shown that uncompetitive inhibitors exhibit specific selectivity depending on mechanism of bi-substrate enzymatic reaction. 

Limit State of Trapezoidal Metal Sheets Exposed to Concentrated Load

In most industrial compounds are used trapezoidal metal sheets like a roof decks. These trapezoidal metal sheets are exposed by concentrated loads, usually by service loads arise from installation of air distribution, sanitary distribution, sprinkler system or wiring installation. In objects of public facilities (like shopping centre, tennis hall, etc.) they can be used for hanging advertising posters etc, too. These systems work as “building kit”. These anchoring systems are represented by clamps in shape of “V”. This paper is occupy with recapitulation of installation systems available in trade with focus on load-bearing capacity specified by producer and on possible methods, how exactly define load bearing capacity of trapezoidal sheet loaded by concentrated load. The load bearing capacity was verified at experimental samples to determine real behavior of trapezoidal metal sheets exposed to concentrated loads.

Experimental Testing of Statistical Size Effect in Civil Engineering Structures

The presented paper copes with an experimental evaluation of a model based on modified Weibull size effect theory. Classical statistical Weibull theory was modified by introducing a new parameter (correlation length lp) representing the spatial autocorrelation of a random mechanical properties of material. This size effect modification was observed on two different materials used in civil engineering: unreinforced (plain) concrete and multi-filament yarns made of alkaliresistant (AR) glass which are used for textile-reinforced concrete. The behavior under flexural, resp. tensile loading was investigated by laboratory experiments. A high number of specimens of different sizes was tested to obtain statistically significant data which were subsequently corrected and statistically processed. Due to a distortion of the measured displacements caused by the unstiff experiment device, only the maximal load values were statistically evaluated. Results of the experiments showed a decreasing strength with an increasing sample length. Size effect curves were obtained and the correlation length was fitted according to measured data. Results did not exclude the existence of the proposed new parameter lp.

Stabilization of Steel Beams of Monosymmetric Thin-Walled Cross-Section by Trapezoidal Sheeting

Steel thin-walled beams have been widely used in civil engineering as purlins, ceiling beams or wall substructure beams. There are often planar members such as trapezoidal sheeting or sandwich panels used as roof or wall cladding fastened to the steel beams. The planar members also serve as stabilization of thin-walled beams against buckling due to loss of stability. This paper focuses on problem of stabilization of steel monosymmetric thin-walled beams by trapezoidal sheeting. Some factors having influence on overall behavior of this structural system are investigated using numerical analysis. Thin-walled beams in bending stabilized by trapezoidal sheeting are of primarily interest of this study.

Analysis of Behaviour of Real Estate Rates in India- A Case Study of Pune City

Decisions for investment, buying and selling of properties depend upon the market value of that property. Issues arise in arriving at the actual value of the property as well as computing the rate of returns from the estate. Addressing valuation related issues through an understanding of behavior of real property rates provide the means to explore the quality of past decisions and to make valid future decisions. Pune, an important city in India, has witnessed a high rate of growth in past few years. Increased demand for housing and investment in properties has led to increase in the rates of real estate. An attempt has been made to study the change and behavior of rates of real estate and factors influencing the same in Pune city.

Numerical Simulation of High Pressure Hydrogen Emerges to Air

Numerical simulation performed to investigate the behavior of the high pressure hydrogen jetting of air. High pressure hydrogen (30–40 MPa) was injected to air at atmospheric pressure through 2mm orifice. Numerical simulations were performed with Kiva3V code with 2D axisymmetric geometry. Numerical simulations showed that auto ignition of high pressure hydrogen to air are possible due to molecular diffusion. Auto ignition was predicted at hydrogen-air contact surface due to mass and energy exchange between high temperature hydrogen and air heated by shock wave.

Advances on LuGre Friction Model

LuGre friction model is an ordinary differential equation that is widely used in describing the friction phenomenon for mechanical systems. The importance of this model comes from the fact that it captures most of the friction behavior that has been observed including hysteresis. In this paper, we study some aspects related to the hysteresis behavior induced by the LuGre friction model.

Fermat’s Last Theorem a Simple Demonstration

This paper presents two solutions to the Fermat’s Last Theorem (FLT). The first one using some algebraic basis related to the Pythagorean theorem, expression of equations, an analysis of their behavior, when compared with power  and power  and using " the “Well Ordering Principle” of natural numbers it is demonstrated that in Fermat equation . The second one solution is using the connection between  and power  through the Pascal’s triangle or  Newton’s binomial coefficients, where de Fermat equation do not fulfill the first coefficient, then it is impossible that: zn=xn+yn for n>2 and (x, y, z) E Z+ - {0}  

Mathematical Model of Depletion of Forestry Resource: Effect of Synthetic Based Industries

A mathematical model is proposed considering the forest biomass density B(t), density of wood based industries W(t) and density of synthetic industries S(t). It is assumed that the forest biomass grows logistically in the absence of wood based industries, but depletion of forestry biomass is due to presence of wood based industries. The growth of wood based industries depends on B(t), while S(t) grows at a constant rate, independent of B(t). Further there is a competition between W(t) and S(t) according to market demand. The proposed model has four ecologically feasible steady states, namely, E1: forest biomass free and wood industries free equilibrium; E2: wood industries free equilibrium and two coexisting equilibria E∗1 , E∗2 . Behavior of the system near all feasible equilibria is analyzed using the stability theory of differential equations. In the proposed model, the natural depletion rate h1 is a crucial parameter and system exhibits Hopf-bifurcation about the non-trivial equilibrium with respect to h1. The analytical results are verified using numerical simulation.

Study of Heat Transfer of Nanofluids in a Circular Tube

Heat transfer behavior of three different types of nanofluids flowing through a horizontal tube under laminar regime has been investigated numerically. The wall of tube is maintained at constant temperature. Al2O3-water, CuO-water and TiO2-water are used with different Reynolds number and different volume fraction. The numerical results of heat transfer indicate that the Nusselt number of nanofluids is larger than that of the base fluid. The Pressure loss coefficient decreases by increasing Reynolds number for all types of nanofluids. Results of Nusselt number enhancement and pressure loss coefficient enhancement indicate that Al2O3 nanoparticules give the best results in term of thermal-hydrolic properties.

Behavior of Concrete Slab Track on Asphalt Trackbed Subjected to Thermal Load

Concrete track slab and asphalt trackbed are being introduced in Korea for providing good bearing capacity, durability to the track and comfortable rideness to passengers. Such a railway system has been designed by the train load so as to ensure stability. But there is lack of research and design for temperature changes which influence the behavior characteristics of concrete and asphalt. Therefore, in this study, the behavior characteristics of concrete track slab subjected to varying temperatures were analyzed through structural analysis using the finite element analysis program. The structural analysis was performed by considering the friction condition on the boundary surfaces in order to analyze the interaction between concrete slab and asphalt trackbed. As a result, the design of the railway system should be designed by considering the interaction and temperature changes between concrete track slab and asphalt trackbed.

Modeling Moisture and Density Behaviors of Wood in Biomass Torrefaction Environments

Worldwide interests for the renewable energy are increasing due to environmental and climate changes from traditional petroleum related energy sources. To account for these social needs, ligneous biomass energy is considered as one of the environmentally friend energy solutions. The wood torrefaction process is a feasible method to improve the properties of the biomass fuel and makes the wood have low moisture, lower smoke emission and increased heating value. In this work, therefore, the moisture evaporation model which largely affects energy efficiency of ligneous biomass through moisture contents and heating value relative to its weight is studied with numerical modeling approach by analyzing the effects of torrefaction furnace temperature. The results show that the temperature and moisture fraction of wood decrease by increasing the furnace temperature. When the torrefaction temperature is lower than 423K, there were little changes of the moisture fraction in the wood. Also, it can be found that charcoal is produced more slowly when the torrefaction temperature is lower than 573K.

Influence of Vortex Generator on Flow Behavior of Air Stream

  This research studied the influence of delta wing and delta winglet vortex generators on air flow characteristic. Normally, the vortex generator has been used for enhancing the heat transfer performance by promote the helical flow of air stream. The vortex generator was setup in the wind tunnel and the flow pattern of air stream passing the vortex generator was observed by using smoke generator. The Reynolds number of air stream was between 30,000 and 80,000. It is found that the delta winglet having 20mm fin height and 30 degree of air stream contact angle generates the maximum helical flow of air stream.

A DMB-TCA Simulation Method for On-Road Traffic Travel Demand Impact Analysis

Travel Demands influence micro-level traffic behavior, furthermore traffic states. In order to evaluate the effect of travel demands on traffic states, this paper introduces the Demand- Motivation-Behaviors (DMB) micro traffic behavior analysis model which denotes that vehicles behaviors are determines by motivations that relies on traffic demands from the perspective of behavior science. For vehicles, there are two kinds of travel demands: reaching travel destinations from orientations and meeting expectations of travel speed. To satisfy travel demands, the micro traffic behaviors are delivered such as car following behavior, optional and mandatory lane changing behaviors. Especially, mandatory lane changing behaviors depending on travel demands take strong impact on traffic states. In this paper, we define the DMB-based cellular automate traffic simulation model to evaluate the effect of travel demands on traffic states under the different δ values that reflect the ratio of mandatory lane-change vehicles.

Effects of Position and Cut-Out Lengths on the Axial Crushing Behavior of Aluminum Tubes: Experimental and Simulation

Axial compression tests are performed on circular tubes made of Aluminum EN AW 6060 (AlMgSi0.5 alloy) in T66 state. All the received tubes have the uniform outer diameter of 40mm and thickness of 1.5mm. Two different lengths 100mm and 200mm are used in the analysis. After performing compression tests on the uniform tube, important crashworthy parameters like peak force, average force, crush efficiency and energy absorption are measured. The present paper has given importance to increase the percentage of crush efficiency without decreasing the value energy absorption of a tube, so a circumferential notch was introduced on the top section of the tube. The effects of position and cut-out lengths of a circumferential notch on the crush efficiency are well explained with relative deformation modes and force-displacement curves. The numerical simulations were carried on the software tool ANSYS/LS-DYNA. It is seen that the numerical results are reasonably good in agreement with the experimental results. 

Driving Behaviors at Intersections (Case Study- Tehran-Zone 3-Region 3)

In this article we research on the drivers’ behavior at intersections. Some significant behaviors are chosen and designed a questionnaire which was about 2 pages. In this questionnaire, samples were being asked to answer by checking the box. The answers have been from always to never. This questionnaire related to our selection’s behaviors. Finally it has been resulted that most of aggressive behaviors were being common in them. Also it has been suggested some solutions for each of them.

Thermodynamic Analysis of Ventilated Façades under Operating Conditions in Southern Spain

In this work we study the thermodynamic behavior of some ventilated facades under summer operating conditions in Southern Spain. Under these climatic conditions, indoor comfort implies a high energetic demand due to high temperatures that usually are reached in this season in the considered geographical area. The aim of this work is to determine if during summer operating conditions in Southern Spain, ventilated façades provide some energy saving compared to the non-ventilated façades and to deduce their behavior patterns in terms of energy efficiency. The modelization of the air flow in the channel has been performed by using Navier-Stokes equations for thermodynamic flows. Numerical simulations have been carried out with a 2D Finite Element approach. This way, we analyze the behavior of ventilated façades under different weather conditions as variable wind, variable temperature and different levels of solar irradiation. CFD computations show the combined effect of the shading of the external wall and the ventilation by the natural convection into the air gap achieve a reduction of the heat load during the summer period. This reduction has been evaluated by comparing the thermodynamic performances of two ventilated and two unventilated façades with the same geometry and thermophysical characteristics.

Data Mining Determination of Sunlight Average Input for Solar Power Plant

A method is proposed to extract faithful representative patterns from data set of observations when they are suffering from non-negligible fluctuations. Supposing time interval between measurements to be extremely small compared to observation time, it consists in defining first a subset of intermediate time intervals characterizing coherent behavior. Data projection on these intervals gives a set of curves out of which an ideally “perfect” one is constructed by taking the sup limit of them. Then comparison with average real curve in corresponding interval gives an efficiency parameter expressing the degradation consecutive to fluctuation effect. The method is applied to sunlight data collected in a specific place, where ideal sunlight is the one resulting from direct exposure at location latitude over the year, and efficiency is resulting from action of meteorological parameters, mainly cloudiness, at different periods of the year. The extracted information already gives interesting element of decision, before being used for analysis of plant control.

Switching Behaviors of HfO2/NiSix Based RRAM

This paper presents a study of Ni-silicides as the bottom electrode of HfO2-based RRAM. Various silicidation conditions were used to obtain different Ni concentrations within the Ni-silicide bottom electrode, namely Ni2Si, NiSi, and NiSi2. A 10nm HfO2 switching material and 50nm TiN top electrode was then deposited and etched into 500nm by 500nm square RRAM cells. Cell performance of the Ni2Si and NiSi cells were good, while the NiSi2 cell could not switch reliably, indicating that the presence of Ni in the bottom electrode is important for good switching.

Switching Behaviors of TiN/HfOx/Pt Based RRAM

Resistive Random Access Memory (RRAM) had received great amount of attention from various research efforts in recent years, owing to its promising performance as a next generation memory device. In this paper, samples based on TiN/HfOx/Pt stack were prepared and its electrical switching behaviors were characterized and discussed in brief.