Abstract: The aim of this article is to narrate the utility of novel simulation approach i.e. convolution method to predict blood concentration of drug utilizing dissolution data of salbutamol sulphate microparticulate formulations with different release patterns (1:1, 1:2 and 1:3, drug:polymer). Dissolution apparatus II USP 2007 and 900 ml double distilled water stirrd at 50 rpm was employed for dissolution analysis. From dissolution data, blood drug concentration was determined, and in return predicted blood drug concentration data was used to calculate the pharmacokinetic parameters i.e. Cmax, Tmax, and AUC. Convolution is a good biwaiver technique; however its better utility needs it application in the conditions where biorelevant dissolution media are used.
Abstract: This paper compares planning results of the electricity and water generation inventory up to year 2030 in the State of
Kuwait. Currently, the generation inventory consists of oil and gas fired technologies only. The planning study considers two main cases. The first case, Reference case, examines a generation inventory based on oil and gas fired generation technologies only.
The second case examines the inclusion of renewables as part of the generation inventory under two scenarios. In the first scenario, Ref-RE, renewable build-out is based on optimum economic performance
of overall generation system. Result shows that the optimum installed
renewable capacity with electric energy generation of 11% . In the second scenario, Ref-RE20, the renewable capacity build-out is
forced to provide 20% of electric energy by 2030. The respective energy systems costs of Reference, Ref-RE and Ref-RE20 case
scenarios reach US dollar 24, 10 and 14 billion annually in 2030.
Abstract: The need of high frame-rate imaging has been triggered by the new applications of ultrasound imaging to transient elastography and real-time 3D ultrasound. Using plane wave excitation (PWE) is one of the methods to achieve very high frame-rate imaging since an image can be formed with a single insonification. However, due to the lack of transmit focusing, the image quality with PWE is lower compared with those using conventional focused transmission. To solve this problem, we propose a filter-retrieved transmit focusing (FRF) technique combined with cross-correlation weighting (FRF+CC weighting) for high frame-rate imaging with PWE. A restrospective focusing filter is designed to simultaneously minimize the predefined sidelobe energy associated with single PWE and the filter energy related to the signal-to-noise-ratio (SNR). This filter attempts to maintain the mainlobe signals and to reduce the sidelobe ones, which gives similar mainlobe signals and different sidelobes between the original PWE and the FRF baseband data. Normalized cross-correlation coefficient at zero lag is calculated to quantify the degree of similarity at each imaging point and used as a weighting matrix to the FRF baseband data to further suppress sidelobes, thus improving the filter-retrieved focusing quality.
Abstract: This paper studies a vital issue in wireless
communications, which is the transmission of images over Wireless
Personal Area Networks (WPANs) through the Bluetooth network. It
presents a simple method to improve the efficiency of error control
code of old Bluetooth versions over mobile WPANs through
Interleaved Error Control Code (IECC) technique. The encoded
packets are interleaved by simple block interleaver. Also, the paper
presents a chaotic interleaving scheme as a tool against bursts of
errors which depends on the chaotic Baker map. Also, the paper
proposes using the chaotic interleaver instead of traditional block
interleaver with Forward Error Control (FEC) scheme. A comparison
study between the proposed and standard techniques for image
transmission over a correlated fading channel is presented.
Simulation results reveal the superiority of the proposed chaotic
interleaving scheme to other schemes. Also, the superiority of FEC
with proposed chaotic interleaver to the conventional interleavers
with enhancing the security level with chaotic interleaving packetby-
packet basis.
Abstract: Knowledge capabilities are increasingly important for
the innovative technology enterprises to enhance the business
performance in terms of product competitiveness, innovation and
sales. Recognition of the company capability by auditing allows them
to further pursue advancement, strategic planning and hence gain
competitive advantages. This paper attempts to develop an
Organizations- Knowledge Capabilities Assessment (OKCA) method
to assess the knowledge capabilities of technology companies. The
OKCA is a questionnaire-based assessment tool which has been
developed to uncover the impact of various knowledge capabilities on
different organizational performance. The collected data is then
analyzed to find out the crucial elements for different technological
companies. Based on the results, innovative technology enterprises are
able to recognize the direction for further improvement on business
performance and future development plan. External environmental
factors affecting organization performance can be found through the
further analysis of some selected reference companies.
Abstract: 20 years of dentistry was a period of transition from
communist to market economy but Romanian doctors have
insufficient management knowledge. Recently, the need for modern
management has increased due to technologies and superior materials
appearance, as patient-s demands.
Research goal is to increase efficiency by evaluating dental
medical office cost categories in real pricing procedures.
Empirical research is based on guided study that includes
information about the association between categories of cost
perception and therapeutic procedures commonly used in dental
offices.
Due to the obtained results to identify all the labours that make up
a settled procedure costs were determined for each procedure.
Financial evaluation software was created with the main functions:
introducing and maintaining patient records, treatment and
appointments made, procedures cost and monitoring office
productivity.
We believe that the study results can significantly improve the
financial management of dental offices, increasing the effectiveness
and quality of services.
Abstract: Components of a software system may be related in a
wide variety of ways. These relationships need to be represented in
software architecture in order develop quality software. In practice, software architecture is immensely challenging, strikingly
multifaceted, extravagantly domain based, perpetually changing,
rarely cost-effective, and deceptively ambiguous. This paper analyses
relations among the major components of software systems and
argues for using several broad categories for software architecture for
assessment purposes: strongly adequate, weakly adequate and
functionally adequate software architectures among other categories.
These categories are intended for formative assessments of
architectural designs.
Abstract: A new generation of manufacturing machines
so-called MIMCA (modular and integrated machine control
architecture) capable of handling much increased complexity in
manufacturing control-systems is presented. Requirement for more
flexible and effective control systems for manufacturing machine
systems is investigated and dimensioned-which highlights a need for
improved means of coordinating and monitoring production
machinery and equipment used to- transport material. The MIMCA
supports simulation based on machine modeling, was conceived by
the authors to address the issues. Essentially MIMCA comprises an
organized unification of selected architectural frameworks and
modeling methods, which include: NISTRCS, UMC and Colored
Timed Petri nets (CTPN). The unification has been achieved; to
support the design and construction of hierarchical and distributed
machine control which realized the concurrent operation of reusable
and distributed machine control components; ability to handle
growing complexity; and support requirements for real- time control
systems. Thus MIMCA enables mapping between 'what a machine
should do' and 'how the machine does it' in a well-defined but
flexible way designed to facilitate reconfiguration of machine
systems.
Abstract: Use of fly ash as a supplementary cementing material
in large volumes can bring both technological and economic benefits
for concrete industry. In this investigation mix proportions for high
volume fly ash concrete were determined at cement replacement
levels of 50%, 55%, 60% and 65% with low calcium fly ash. Flexural
and compressive strengths of different mixes were measured at ages
of 7, 28 and 90 days. Flexural strength of composite section prepared
from pavement quality and lean high volume fly ash concrete was
determined at the age of 28 days. High volume fly ash concrete mixes
exhibited higher rate of strength gain and age factors than
corresponding reference concrete mixes. The optimum cement
replacement level for pavement quality concrete was found to be
60%. The consideration of bond between pavement quality and lean
of high volume fly ash concrete will be beneficial in design of rigid
pavements.
Abstract: Ultrastructure of duodenum mucosa of irradiated rat
was studied versus dose rate of irradiation following exposure to
gamma rays from 60-Cobalt source. The animals were whole body
irradiated at two dose rates (1 Gy.mn-1 and 1 Gy.h-1) and three total
doses (1, 2 or 4 Gy) for each dose rate. 24 or 48 h after irradiation,
their small intestine was removed and samples of duodenum were
processed for observations under a transmission electron microscopy.
Samples of duodenum mucosa of control rats were processed in the
same way. For the lower dose rate of 1 Gy.h-1, main lesions
characteristic of apoptosis were detected within irradiated enterocytes
at a total dose of 2 Gy and 24 h after exposure. Necrosis was noted in
the samples, 48 h after exposition. For the higher dose rate of 1
Gy.mn-1, fewer changes were detected at all total doses 24 or 48 h
irradiation. Thus, it was shown that the appearance of radiationinduced
alterations varies not only with increasing total dose and
post-irradiation time but especially with decreasing dose rate.
Abstract: Rooted in the study of social functioning of space in architecture, Space Syntax (SS) and the more recent Network Pattern (NP) researches demonstrate the 'spatial structures' of city, i.e. the hierarchical patterns of streets, junctions and alley ends. Applying SS and NP models, planners can conceptualize the real city-s patterns. Although, both models yield the optimal path of the city their underpinning displays of the city-s spatial configuration differ. The Axial Map analyzes the topological non-distance-based connectivity structure, whereas, the Central-Node Map and the Shortcut-Path Map, in contrast, analyze the metrical distance-based structures. This research contrasts and combines them to understand various forms of city-s structures. It concludes that, while they reveal different spatial structures, Space Syntax and Network Pattern urban models support each the other. Combining together they simulate the global access and the locally compact structures namely the central nodes and the shortcuts for the city.
Abstract: After reporting a literature review on Customer
Relationship Management (CRM) and knowledge management, some
important issued arise, in particular related to the lack of success of
CRM strategies implementation. The paper contributes to this
proposing an integrated model of CRM success taking into account
complementary factors such as organizational factors, technology,
knowledge management and customer orientation.
Abstract: Early detection of dementia by testing the spatial
memory can be applied using a virtual environment. This paper
presents guidelines on how to design a virtual environment
specifically for elderly in early detection of dementia. The specific
design needs to be considered because the effectiveness of the
technology relies on the ability of the end user to use it. The primary
goal of these guidelines is to promote accessibility. Based on these
guidelines, a virtual simulation was developed and evaluated. The
results on usability of acceptance and satisfaction that are tested on
young (control group) and elderly participants indicate that these
guidelines are reliable and useful for use with elderly people.
Abstract: We present a label-free biosensor based on
electrochemical impedance spectroscopy for the detection of proinflammatory
cytokine Tumor Necrosis Factor (TNF-α). Secretion of
TNF-α has been correlated to the onset of various diseases including
rheumatoid arthritis, Crohn-s disease etc. Gold electrodes were
patterned on a silicon substrate and self assembled monolayer of
dithiobis-succinimidyl propionate was used to develop the biosensor
which achieved a detection limit of ~57fM. A linear relationship was
also observed between increasing TNF-α concentrations and chargetransfer
resistance within a dynamic range of 1pg/ml – 1ng/ml.
Abstract: This paper describes a new approach of classification
using genetic programming. The proposed technique consists of
genetically coevolving a population of non-linear transformations on
the input data to be classified, and map them to a new space with a
reduced dimension, in order to get a maximum inter-classes
discrimination. The classification of new samples is then performed
on the transformed data, and so become much easier. Contrary to the
existing GP-classification techniques, the proposed one use a
dynamic repartition of the transformed data in separated intervals, the
efficacy of a given intervals repartition is handled by the fitness
criterion, with a maximum classes discrimination. Experiments were
first performed using the Fisher-s Iris dataset, and then, the KDD-99
Cup dataset was used to study the intrusion detection and
classification problem. Obtained results demonstrate that the
proposed genetic approach outperform the existing GP-classification
methods [1],[2] and [3], and give a very accepted results compared to
other existing techniques proposed in [4],[5],[6],[7] and [8].
Abstract: On-line handwritten scripts are usually dealt with pen tip traces from pen-down to pen-up positions. Time evaluation of the pen coordinates is also considered along with trajectory information. However, the data obtained needs a lot of preprocessing including filtering, smoothing, slant removing and size normalization before recognition process. Instead of doing such lengthy preprocessing, this paper presents a simple approach to extract the useful character information. This work evaluates the use of the counter- propagation neural network (CPN) and presents feature extraction mechanism in full detail to work with on-line handwriting recognition. The obtained recognition rates were 60% to 94% using the CPN for different sets of character samples. This paper also describes a performance study in which a recognition mechanism with multiple thresholds is evaluated for counter-propagation architecture. The results indicate that the application of multiple thresholds has significant effect on recognition mechanism. The method is applicable for off-line character recognition as well. The technique is tested for upper-case English alphabets for a number of different styles from different peoples.
Abstract: An on-line condition monitoring method for transmission line is proposed using electrical circuit theory and IT technology in this paper. It is reasonable that the circuit parameters such as resistance (R), inductance (L), conductance (g) and capacitance (C) of a transmission line expose the electrical conditions and physical state of the line. Those parameters can be calculated from the linear equation composed of voltages and currents measured by synchro-phasor measurement technique at both end of the line. A set of linear voltage drop equations containing four terminal constants (A, B ,C ,D ) are mathematical models of the transmission line circuits. At least two sets of those linear equations are established from different operation condition of the line, they may mathematically yield those circuit parameters of the line. The conditions of line connectivity including state of connecting parts or contacting parts of the switching device may be monitored by resistance variations during operation. The insulation conditions of the line can be monitored by conductance (g) and capacitance(C) measurements. Together with other condition monitoring devices such as partial discharge, sensors and visual sensing device etc.,they may give useful information to monitor out any incipient symptoms of faults. The prototype of hardware system has been developed and tested through laboratory level simulated transmission lines. The test has shown enough evident to put the proposed method to practical uses.
Abstract: This paper presents the optimal controller design of
the generator control unit in the aircraft power system. The adaptive
tabu search technique is applied to tune the controller parameters
until the best terminal output voltage of generator is achieved. The
output response from the system with the controllers designed by the
proposed technique is compared with those from the conventional
method. The transient simulations using the commercial software
package show that the controllers designed from the adaptive tabu
search algorithm can provide the better output performance compared
with the result from the classical method. The proposed design
technique is very flexible and useful for electrical aircraft engineers.
Abstract: In this article, LQR based PID controller design for
3DOF helicopter system is investigated. The 3-DOF helicopter
system is a benchmark laboratory model having strongly nonlinear
characteristics and unstable dynamics which make the control of such
system a challenging task. This article first presents the mathematical
model of the 3DOF helicopter system and then illustrates the basic
idea and technical formulation for controller design. The paper
explains the simple approach for the approximation of PID design
parameters from the LQR controller gain matrix. The simulation
results show that the investigated controller has both static and
dynamic performance, therefore the stability and the quick control
effect can be obtained simultaneously for the 3DOF helicopter
system.
Abstract: Nowadays predicting political risk level of country
has become a critical issue for investors who intend to achieve
accurate information concerning stability of the business
environments. Since, most of the times investors are layman and
nonprofessional IT personnel; this paper aims to propose a
framework named GECR in order to help nonexpert persons to
discover political risk stability across time based on the political
news and events.
To achieve this goal, the Bayesian Networks approach was
utilized for 186 political news of Pakistan as sample dataset.
Bayesian Networks as an artificial intelligence approach has been
employed in presented framework, since this is a powerful technique
that can be applied to model uncertain domains. The results showed
that our framework along with Bayesian Networks as decision
support tool, predicted the political risk level with a high degree of
accuracy.