Abstract: Since hyaluronic acid (HA) receptor such as CD44 is
over-expressed at sites of cancer cells, HA can be used as a targeting
vehicles for anti-cancer drugs. The aim of this study is to synthesize
block copolymer composed of hyaluronic acid and
poly(ε-caprolactone) (HAPCL) and to fabricate polymeric micelles for
anticancer drug targeting against CD44 receptor of tumor cells.
Chemical composition of HAPCL was confirmed using 1H NMR
spectroscopy. Doxorubicin (DOX) was incorporated into polymeric
micelles of HAPCL. The diameters of HAPHS polymeric micelles
were changed around 80nm and have spherical shapes. Targeting
potential was investigated using CD44-overexpressing. When
DOX-incorporated polymeric micelles was added to KB cells, they
revealed strong red fluorescence color while blocking of CD44
receptor by pretreatment of free HA resulted in reduced intensity,
indicating that HAPCL polymeric micelles have targetability against
CD44 receptor.
Abstract: Mobile Ad hoc networks (MANETs) are collections
of wireless mobile nodes dynamically reconfiguring and collectively
forming a temporary network. These types of networks assume
existence of no fixed infrastructure and are often useful in battle-field
tactical operations or emergency search-and-rescue type of
operations where fixed infrastructure is neither feasible nor practical.
They also find use in ad hoc conferences, campus networks and
commercial recreational applications carrying multimedia traffic. All
of the above applications of MANETs require guaranteed levels of
performance as experienced by the end-user. This paper focuses on
key challenges in provisioning predetermined levels of such Quality
of Service (QoS). It also identifies functional areas where QoS
models are currently defined and used. Evolving functional areas
where performance and QoS provisioning may be applied are also
identified and some suggestions are provided for further research in
this area. Although each of the above functional areas have been
discussed separately in recent research studies, since these QoS
functional areas are highly correlated and interdependent, a
comprehensive and comparative analysis of these areas and their
interrelationships is desired. In this paper we have attempted to
provide such an overview.
Abstract: Selective harmonic elimination-pulse width modulation techniques offer a tight control of the harmonic spectrum of a given voltage waveform generated by a power electronic converter along with a low number of switching transitions. Traditional optimization methods suffer from various drawbacks, such as prolonged and tedious computational steps and convergence to local optima; thus, the more the number of harmonics to be eliminated, the larger the computational complexity and time. This paper presents a novel method for output voltage harmonic elimination and voltage control of PWM AC/AC voltage converters using the principle of hybrid Real-Coded Genetic Algorithm-Pattern Search (RGA-PS) method. RGA is the primary optimizer exploiting its global search capabilities, PS is then employed to fine tune the best solution provided by RGA in each evolution. The proposed method enables linear control of the fundamental component of the output voltage and complete elimination of its harmonic contents up to a specified order. Theoretical studies have been carried out to show the effectiveness and robustness of the proposed method of selective harmonic elimination. Theoretical results are validated through simulation studies using PSIM software package.
Abstract: Stocking density is considered one of the important
factors affecting fish growth. But, information related to impact of
stocking density on growth performance of monosex tilapia population
under the ecological conditions of Gangetic plains in West Bengal,
India is limited. The aim of our study was to compare the growth
potential of monosex tilapia at various stocking densities and to
determine an ideal stocking density for culture of all-male monosex
fish. The males were isolated by examination of genital papilla region
and were stocked separately in 0.01 ha earthen ponds at different
stocking densities (5000, 10000, 15000, 20000, 25000 and 30000
fingerlings/ha). It was found that the highest weight, length, daily
weight gain, growth rate and protein content were observed for the
20000 fish/ha density class. Thus, culture of monosex tilapia at a
density of 20000 fish/ha can be considered ideal for augmented
production of the fish under Indian context.
Abstract: Ad hoc networks are characterized by multi-hop
wireless connectivity and frequently changing network topology.
Forming security association among a group of nodes in ad-hoc
networks is more challenging than in conventional networks due to the
lack of central authority, i.e. fixed infrastructure. With that view in
mind, group key management plays an important building block of
any secure group communication. The main contribution of this paper
is a low complexity key management scheme that is suitable for fully
self-organized ad-hoc networks. The protocol is also password
authenticated, making it resilient against active attacks. Unlike other
existing key agreement protocols, ours make no assumption about the
structure of the underlying wireless network, making it suitable for
“truly ad-hoc" networks. Finally, we will analyze our protocol to show
the computation and communication burden on individual nodes for
key establishment.
Abstract: The process of laser absorption in the skin during
laser irradiation was a critical point in medical application
treatments. Delivery the correct amount of laser light is a critical
element in photodynamic therapy (PDT). More amounts of laser
light able to affect tissues in the skin and small amount not able to
enhance PDT procedure in skin. The knowledge of the skin tone
laser dependent distribution of 635 nm radiation and its penetration
depth in skin is a very important precondition for the investigation of
advantage laser induced effect in (PDT) in epidermis diseases
(psoriasis). The aim of this work was to estimate an optimum effect
of diode laser (635 nm) on the treatment of epidermis diseases in
different color skin. Furthermore, it is to improve safety of laser in
PDT in epidermis diseases treatment. Advanced system analytical
program (ASAP) which is a new approach in investigating the PDT,
dependent on optical properties of different skin color was used in
present work. A two layered Realistic Skin Model (RSM); stratum
corneum and epidermal with red laser (635 nm, 10 mW) were used
for irradiative transfer to study fluence and absorbance in different
penetration for various human skin colors. Several skin tones very
fair, fair, light, medium and dark are used to irradiative transfer. This
investigation involved the principles of laser tissue interaction when
the skin optically injected by a red laser diode. The results
demonstrated that the power characteristic of a laser diode (635 nm)
can affect the treatment of epidermal disease in various color skins.
Power absorption of the various human skins were recorded and
analyzed in order to find the influence of the melanin in PDT
treatment in epidermal disease. A two layered RSM show that the
change in penetration depth in epidermal layer of the color skin has a
larger effect on the distribution of absorbed laser in the skin; this is
due to the variation of the melanin concentration for each color.
Abstract: This paper details the application of a genetic
programming framework for induction of useful classification rules
from a database of income statements, balance sheets, and cash flow
statements for North American public companies. Potentially
interesting classification rules are discovered. Anomalies in the
discovery process merit further investigation of the application of
genetic programming to the dataset for the problem domain.
Abstract: To extract the important physiological factors related to
diabetes from an oral glucose tolerance test (OGTT) by mathematical
modeling, highly informative but convenient protocols are required.
Current models require a large number of samples and extended
period of testing, which is not practical for daily use. The purpose
of this study is to make model assessments possible even from a
reduced number of samples taken over a relatively short period.
For this purpose, test values were extrapolated using a support
vector machine. A good correlation was found between reference and
extrapolated values in evaluated 741 OGTTs. This result indicates
that a reduction in the number of clinical test is possible through a
computational approach.
Abstract: Fatigue is the major threat in service of steel structure
subjected to fluctuating loads. With the additional effect of corrosion
and presence of weld joints the fatigue failure may become more
critical in structural steel. One of the apt examples of such structural
is the sailing ship. This is experiencing a constant stress due to
floating and a pulsating bending load due to the waves. This paper
describes an attempt to verify theory of fatigue in fracture mechanics
approach with experimentation to determine the constants of crack
growth curve. For this, specimen is prepared from the ship building
steel and it is subjected to a pulsating bending load with a known
defect. Fatigue crack and its nature is observed in this experiment.
Application of fracture mechanics approach in fatigue with a simple
practical experiment is conducted and constants of crack growth
equation are investigated.
Abstract: EPA (Ethernet for Plant Automation) resolves the nondeterministic problem of standard Ethernet and accomplishes real-time communication by means of micro-segment topology and deterministic scheduling mechanism. This paper studies the real-time performance of EPA periodic data transmission from theoretical and experimental perspective. By analyzing information transmission characteristics and EPA deterministic scheduling mechanism, 5 indicators including delivery time, time synchronization accuracy, data-sending time offset accuracy, utilization percentage of configured timeslice and non-RTE bandwidth that can be used to specify the real-time performance of EPA periodic data transmission are presented and investigated. On this basis, the test principles and test methods of the indicators are respectively studied and some formulas for real-time performance of EPA system are derived. Furthermore, an experiment platform is developed to test the indicators of EPA periodic data transmission in a micro-segment. According to the analysis and the experiment, the methods to improve the real-time performance of EPA periodic data transmission including optimizing network structure, studying self-adaptive adjustment method of timeslice and providing data-sending time offset accuracy for configuration are proposed.
Abstract: One of the main consequences of the ubiquitous usage of Internet as a means to conduct business has been the progressive internationalization of contracts created to support such transactions. As electronic commerce becomes International commerce, the reality is that commercial disputes will occur creating such questions as: "In which country do I bring proceedings?" and "Which law is to be applied to solve disputes?" The decentralized and global structure of the Internet and its decentralized operation have given e-commerce a transnational element that affects two questions essential to any transaction: applicable law and jurisdiction in the event of dispute. The sharing of applicable law and jurisdiction among States in respect of international transactions traditionally has been based on the use of contact factors generally of a territorial nature (the place where real estate is located, customary residence, principal establishment, place of shipping goods). The characteristics of the Internet as a new space sometimes make it difficult to apply these rules, and may make them inoperative or lead to results that are surprising or totally foreign to the contracting parties and other elements and circumstances of the case.
Abstract: In a BFWA (Broadband Fixed Wireless Access Network) the evolved SINR (Signal to Interference plus Noise Ratio) is relevant influenced by the applied duplex method. The TDD (Time Division Duplex), especially adaptive TDD method has some advantage contrary to FDD (Frequency Division Duplex), for example the spectrum efficiency and flexibility. However these methods are suffering several new interference situations that can-t occur in a FDD system. This leads to reduced SINR in the covered area what could cause some connection outages. Therefore, countermeasure techniques against interference are necessary to apply in TDD systems. Synchronization is one way to handling the interference. In this paper the TDD systems – applying different system synchronization degree - will be compared by the evolved SINR at different locations of the BFWA service area and the percentage of the covered area by the system.
Abstract: According to the masonry standard the compressive
strength is basically dependent on factors such as the mortar strength
and the relative values of unit and mortar strength. However
interlocking brick has none or less use of mortar. Therefore there is a need to investigate the behavior of masonry walls using interlocking
bricks. In this study a series of tests have been conducted; physical
properties and compressive strength of brick units and masonry walls
were constructed from interlocking bricks and tested under constant
vertical load at different eccentricities. The purpose of the
experimental investigations is to obtain the force displacement curves, analyze the behavior of masonry walls. The results showed
that the brick is categorized as common brick (BS 3921:1985) and severe weathering grade (ASTM C62). The maximum compressive stress of interlocking brick wall is 3.6 N/mm2 and fulfilled the requirement of standard for residential building.
Abstract: Chatter vibration has been a troublesome problem for a
machine tool toward the high precision and high speed machining.
Essentially, the machining performance is determined by the dynamic
characteristics of the machine tool structure and dynamics of cutting
process. Therefore the dynamic vibration behavior of spindle tool
system greatly determines the performance of machine tool. The
purpose of this study is to investigate the influences of the machine
frame structure on the dynamic frequency of spindle tool unit through
finite element modeling approach. To this end, a realistic finite
element model of the vertical milling system was created by
incorporated the spindle-bearing model into the spindle head stock of
the machine frame. Using this model, the dynamic characteristics of
the milling machines with different structural designs of spindle head
stock and identical spindle tool unit were demonstrated. The results of
the finite element modeling reveal that the spindle tool unit behaves
more compliant when the excited frequency approaches the natural
mode of the spindle tool; while the spindle tool show a higher dynamic
stiffness at lower frequency that may be initiated by the structural
mode of milling head. Under this condition, it is concluded that the
structural configuration of spindle head stock associated with the
vertical column of milling machine plays an important role in
determining the machining dynamics of the spindle unit.
Abstract: The Economic factors are leading to the rise of
infrastructures provides software and computing facilities as a
service, known as cloud services or cloud computing. Cloud services
can provide efficiencies for application providers, both by limiting
up-front capital expenses, and by reducing the cost of ownership over
time. Such services are made available in a data center, using shared
commodity hardware for computation and storage. There is a varied
set of cloud services available today, including application services
(salesforce.com), storage services (Amazon S3), compute services
(Google App Engine, Amazon EC2) and data services (Amazon
SimpleDB, Microsoft SQL Server Data Services, Google-s Data
store). These services represent a variety of reformations of data
management architectures, and more are on the horizon.
Abstract: Present paper presents a parametric performancebased
design model for optimizing hospital design. The design model
operates with geometric input parameters defining the functional
requirements of the hospital and input parameters in terms of
performance objectives defining the design requirements and
preferences of the hospital with respect to performances. The design
model takes point of departure in the hospital functionalities as a set
of defined parameters and rules describing the design requirements
and preferences.
Abstract: The main goal in this paper is to quantify the quality of
different techniques for radiation treatment plans, a back-propagation
artificial neural network (ANN) combined with biomedicine theory
was used to model thirteen dosimetric parameters and to calculate
two dosimetric indices. The correlations between dosimetric indices
and quality of life were extracted as the features and used in the ANN
model to make decisions in the clinic. The simulation results show
that a trained multilayer back-propagation neural network model can
help a doctor accept or reject a plan efficiently. In addition, the
models are flexible and whenever a new treatment technique enters
the market, the feature variables simply need to be imported and the
model re-trained for it to be ready for use.
Abstract: Data Structures and Algorithms is a module in most
Computer Science or Information Technology curricula. It is one of
the modules most students identify as being difficult. This paper
demonstrates how programming a solution for Sudoku can make
abstract concepts more concrete. The paper relates concepts of a
typical Data Structures and Algorithms module to a step by step
solution for Sudoku in a human type as opposed to a computer
oriented solution.
Abstract: Background noise is particularly damaging to speech
intelligibility for people with hearing loss especially for sensorineural
loss patients. Several investigations on speech intelligibility have
demonstrated sensorineural loss patients need 5-15 dB higher SNR
than the normal hearing subjects. This paper describes Discrete
Cosine Transform Power Normalized Least Mean Square algorithm
to improve the SNR and to reduce the convergence rate of the LMS
for Sensory neural loss patients. Since it requires only real arithmetic,
it establishes the faster convergence rate as compare to time domain
LMS and also this transformation improves the eigenvalue
distribution of the input autocorrelation matrix of the LMS filter.
The DCT has good ortho-normal, separable, and energy compaction
property. Although the DCT does not separate frequencies, it is a
powerful signal decorrelator. It is a real valued function and thus
can be effectively used in real-time operation. The advantages of
DCT-LMS as compared to standard LMS algorithm are shown via
SNR and eigenvalue ratio computations. . Exploiting the symmetry
of the basis functions, the DCT transform matrix [AN] can be
factored into a series of ±1 butterflies and rotation angles. This
factorization results in one of the fastest DCT implementation. There
are different ways to obtain factorizations. This work uses the fast
factored DCT algorithm developed by Chen and company. The
computer simulations results show superior convergence
characteristics of the proposed algorithm by improving the SNR at
least 10 dB for input SNR less than and equal to 0 dB, faster
convergence speed and better time and frequency characteristics.
Abstract: Stirred tanks have applications in many chemical
processes where mixing is important for the overall performance of
the system. In present work 5%v of the tank is filled by solid particles
with diameter of 700 m that Rushton Turbine and Propeller impeller
is used for stirring. An Eulerian-Eulerian Multi Fluid Model coupled
and for modeling rotating of impeller, moving reference frame
(MRF) technique was used and standard-k- model was selected for
turbulency. Flow field, radial velocity and axial distribution of solid
for both of impellers was investigation and comparison. Comparisons
of simulation results between Rushton Turbine and propeller impeller
shows that final quality of solid-liquid slurry in different rotating
speed for propeller impeller is better than the Rushton Turbine.