Abstract: Cancer is still one of the serious diseases threatening
the lives of human beings. How to have an early diagnosis and
effective treatment for tumors is a very important issue. The animal
carcinoma model can provide a simulation tool for the studies of
pathogenesis, biological characteristics, and therapeutic effects.
Recently, drug delivery systems have been rapidly developed to
effectively improve the therapeutic effects. Liposome plays an
increasingly important role in clinical diagnosis and therapy for
delivering a pharmaceutic or contrast agent to the targeted sites.
Liposome can be absorbed and excreted by the human body, and is
well known that no harm to the human body. This study aimed to
compare the therapeutic effects between encapsulated (doxorubicin
liposomal, Lipodox) and un-encapsulated (doxorubicin, Dox)
anti-tumor drugs using magnetic resonance imaging (MRI).
Twenty-four New Zealand rabbits implanted with VX2 carcinoma at
left thighs were classified into three groups: control group (untreated),
Dox-treated group, and LipoDox-treated group, 8 rabbits for each
group. MRI scans were performed three days after tumor implantation.
A 1.5T GE Signa HDxt whole body MRI scanner with a high
resolution knee coil was used in this study. After a 3-plane localizer
scan was performed, three-dimensional (3D) fast spin echo (FSE)
T2-weighted Images (T2WI) was used for tumor volumetric
quantification. Afterwards, two-dimensional (2D) spoiled gradient
recalled echo (SPGR) dynamic contrast-enhanced (DCE) MRI was
used for tumor perfusion evaluation. DCE-MRI was designed to
acquire four baseline images, followed by contrast agent Gd-DOTA
injection through the ear vein of rabbit. A series of 32 images were
acquired to observe the signals change over time in the tumor and
muscle. The MRI scanning was scheduled on a weekly basis for a
period of four weeks to observe the tumor progression longitudinally.
The Dox and LipoDox treatments were prescribed 3 times in the first
week immediately after the first MRI scan; i.e. 3 days after VX2 tumor
implantation. ImageJ was used to quantitate tumor volume and time
course signal enhancement on DCE images. The changes of tumor size
showed that the growth of VX2 tumors was effectively inhibited for
both LipoDox-treated and Dox-treated groups. Furthermore, the tumor
volume of LipoDox-treated group was significantly lower than that of
Dox-treated group, which implies that LipoDox has better therapeutic effect than Dox. The signal intensity of LipoDox-treated group is
significantly lower than that of the other two groups, which implies
that targeted therapeutic drug remained in the tumor tissue. This study
provides a radiation-free and non-invasive MRI method for
therapeutic monitoring of targeted liposome on an animal tumor
model.
Abstract: A growing demand is felt today for realistic 3D
models enabling the cognition and popularization of historical-artistic
heritage. Evaluation and preservation of Cultural Heritage is
inextricably connected with the innovative processes of gaining,
managing, and using knowledge. The development and perfecting of
techniques for acquiring and elaborating photorealistic 3D models,
made them pivotal elements for popularizing information of objects
on the scale of architectonic structures.
Abstract: Underwater acoustic networks have attracted great
attention in the last few years because of its numerous applications.
High data rate can be achieved by efficiently modeling the physical
layer in the network protocol stack. In Acoustic medium,
propagation speed of the acoustic waves is dependent on many
parameters such as temperature, salinity, density, and depth.
Acoustic propagation speed cannot be modeled using standard
empirical formulas such as Urick and Thorp descriptions. In this
paper, we have modeled the acoustic channel using real time data of
temperature, salinity, and speed of Bay of Bengal (Indian Coastal
Region). We have modeled the acoustic channel by using Mackenzie
speed equation and real time data obtained from National Institute of
Oceanography and Technology. It is found that acoustic propagation
speed varies between 1503 m/s to 1544 m/s as temperature and
depth differs. The simulation results show that temperature, salinity,
depth plays major role in acoustic propagation and data rate
increases with appropriate data sets substituted in the simulated
model.
Abstract: Fires is one of the main types of disturbances that
shape ecosystems in the Mediterranean region. However nowadays,
climate alterations towards higher temperatures result on increased
levels of fire intensity, frequency and spread as well as difficulties for
natural regeneration to occur. Thasos Island is one of the Greek
islands that has experienced those problems. Since 1984, a series of
wildfires led to the reduction of forest cover from 61.6% to almost
20%. The negative impacts were devastating in many different
aspects for the island. The absence of plant cover, post-wildfire
precipitation and steep slopes were the major factors that induced
severe soil erosion and intense floods. That also resulted to serious
economic problems to the local communities and the inability of the
burnt areas to regenerate naturally. Despite the substantial amount of
published work regarding Thasos wildfires, there is no information
related to post-wildfire effects on factors such as soil erosion. More
research related to post-fire effects should help to an overall
assessment of the negative impacts of wildfires on land degradation
through processes such as soil erosion and flooding.
Abstract: This paper presents the design and implementation
details of a complete unmanned aerial system (UAS) based
on commercial-off-the-shelf (COTS) components, focusing on
safety, security, search and rescue scenarios in GPS-denied
environments. In particular, The aerial platform is capable
of semi-autonomously navigating through extremely low-light,
GPS-denied indoor environments based on onboard sensors only,
including a downward-facing optical flow camera. Besides, an
additional low-cost payload camera system is developed to stream
both infra-red video and visible light video to a ground station in
real-time, for the purpose of detecting sign of life and hidden humans.
The total cost of the complete system is estimated to be $1150,
and the effectiveness of the system has been tested and validated
in practical scenarios.
Abstract: In this paper a very simple and effective user
administration view of computing clusters systems is implemented in
order of friendly provide the configuration and monitoring of
distributed application executions. The user view, the administrator
view, and an internal control module create an illusionary
management environment for better system usability. The
architecture, properties, performance, and the comparison with others
software for cluster management are briefly commented.
Abstract: The garment manufacturing industry involves
sequential processes that are subjected to uncontrollable variations.
The industry depends on the skill of labour in handling the varieties
of fabrics and accessories, machines, as well as complicated sewing
operation. Due to these reasons, garment manufacturers have created
systems to monitor and to control the quality of the products on a
regular basis by conducting quality approaches to minimize variation.
With that, the aim of this research has been to ascertain the quality
approaches deployed by Malaysian garment manufacturers in three
key areas - quality systems and tools; quality control and types of
inspection; as well as sampling procedures chosen for garment
inspection. Besides, the focus of this research was to distinguish the
quality approaches adopted by companies that supplied finished
garments to both domestic and international markets. Feedback from
each company representative has been obtained via online survey,
which comprised of five sections and 44 questions on the
organizational profile and the quality approaches employed in the
garment industry. As a result, the response rate was 31%. The results
revealed that almost all companies have established their own
mechanism of process control by conducting a series of quality
inspections for daily production, either it was formally set up or
otherwise. In addition, quality inspection has been the predominant
quality control activity in the garment manufacturing, while the level
of complexity of these activities was substantially dictated by the
customers. Moreover, AQL-based sampling was utilized by
companies dealing with exports, whilst almost all the companies that
only concentrated on the domestic market were comfortable using
their own sampling procedures for garment inspection. Hence, this
research has provided insights into the implementation of a number
of quality approaches that were perceived as important and useful in
the garment manufacturing sector, which is truly labour-intensive.
Abstract: South Africa is in its post-industrial era moving from
the primary and secondary sector to the tertiary sector. The study
investigated the impact of the disaggregated energy consumption
(coal, oil, and electricity) on the primary, secondary and tertiary
sectors of the economy between 1980 and 2012 in South Africa.
Using vector error correction model, it was established that South
Africa is an energy dependent economy, and that energy (especially
electricity and oil) is a limiting factor of growth. This implies that
implementation of energy conservation policies may hamper
economic growth. Output growth is significantly outpacing energy
supply, which has necessitated load shedding. To meet up the excess
energy demand, there is a need to increase the generating capacity
which will necessitate increased investment in the electricity sector as
well as strategic steps to increase oil production. There is also need to
explore more renewable energy sources, in order to meet the growing
energy demand without compromising growth and environmental
sustainability. Policy makers should also pursue energy efficiency
policies especially at sectoral level of the economy.
Abstract: Hypertension is a common condition causing cardio
and cerebrovascular complications. Portugal has one of the highest
mortality rates from stroke and a high prevalence of hypertension.
Systolic Blood Pressure (SBP) is an important risk factor for
cardiovascular events (myocardial infarction and stroke) and
premature mortality, particularly in the elderly population. The
present study aims to estimate the prevalence of hypertension in a
Portuguese population living in a coastal city and to identify some of
its determinants (namely gender, age, the body mass index and
physical activity frequency). A total of 91 adults who attended three pharmacies of a coastal
city in the center of Portugal, between May and August of 2013 were
evaluated. Attendants who reported to have diabetes or taking
antihypertensive drugs in the 2 previous weeks were excluded from
the study. Sociodemographic factors, BMI, habits of exercise and BP
were assessed. Hypertension was defined as blood pressure ≥140/90
mmHg. The majority of the studied population was constituted by women
(75.8%), with a mean age of 54.2±1.6 years old, married or living in
civil union and that had completed secondary school or had higher
education (40%). They presented a mean BMI of 26.2±4.76 Kg/m2.,
and were sedentary. The mean BP was 127.0±17.77mmHg- 74.69 ±
9.53. In this population we found 4.3% of people with hypertension
and 16.1% with normal high blood pressure. Men exhibit a tendency to present higher systolic blood pressure
values than women. Of all the factors considered, SBP values also
tended to be higher with age and higher BMI values.
Despite the fact that the mean values of SBP did not present values
higher than 140 mmHg we must be concerned because the studied
population is undiagnosed for hypertension. Although this is a preliminary study, it might be a prelude to the
upcoming research about the underlying factors responsible for the
occurrence of SBP.
Abstract: The aim of this study is to empirically investigate the
mediating impact of export performance (EP) between technological
advancement capabilities and business performance (BP) of
Malaysian manufacturing micro, small and medium sized enterprises
(MSME’s). Firm’s technological advancement resources are
hypothesized as a platform to enhance both exports and BP of
manufacturing MSMEs in Malaysia. This study is twofold, primary it
has investigated that technological advancement capabilities helps to
appreciates main performance measures noted in terms of EP and
Secondly, it investigates that how efficiently and effectively
technological advancement capabilities can contribute in overall
Malaysian MSME’s BP. Smart PLS-3 statistical software is used to
know the association between technological advancement
capabilities, MSME’s EP and BP. In this study, the data was
composed from Malaysian manufacturing MSME’s in east coast
industrial zones known as the manufacturing hub of MSMEs. Seven
hundred and fifty (750) questionnaires were distributed, but only 148
usable questionnaires are returned. The finding of this study indicated
that technological advancement capabilities helps to strengthen the
export in term of time and cost efficient and it plays a significant role
in appreciating their BP. This study is helpful for small and medium
enterprise owners who intend to expand their business overseas and
though smart technological advancement resources they can achieve
their business competitiveness and excellence both at local and
international markets.
Abstract: Hydraulic fracturing is one of the most important
stimulation techniques available to the petroleum engineer to extract
hydrocarbons in tight gas sandstones. It allows more oil and gas
production in tight reservoirs as compared to conventional means.
The main aim of the study is to optimize the hydraulic fracturing as
technique and for this purpose three multi-zones layer formation is
considered and fractured contemporaneously. The three zones are
named as Zone1 (upper zone), Zone2 (middle zone) and Zone3
(lower zone) respectively and they all occur in shale rock. Simulation was performed with Mfrac integrated software which
gives a variety of 3D fracture options. This simulation process
yielded an average fracture efficiency of 93.8%for the three
respective zones and an increase of the average permeability of the
rock system. An average fracture length of 909 ft with net height
(propped height) of 210 ft (average) was achieved. Optimum
fracturing results was also achieved with maximum fracture width of
0.379 inches at an injection rate of 13.01 bpm with 17995 Mscf of
gas production.
Abstract: The steady flow of a second order fluid through
constricted tube with slip velocity at wall is modeled and analyzed
theoretically. The governing equations are simplified by implying no
slip in radial direction. Based on Karman Pohlhausen procedure
polynomial solution for axial velocity profile is presented.
Expressions for pressure gradient, shear stress, separation and
reattachment points, and radial velocity are also calculated. The
effect of slip and no slip velocity on magnitude velocity, shear stress,
and pressure gradient are discussed and depicted graphically. It is
noted that when Reynolds number increases magnitude velocity of
the fluid decreases in both slip and no slip conditions. It is also found
that the wall shear stress, separation, and reattachment points are
strongly affected by Reynolds number.
Abstract: In this work, repaired crack in 6061- T6 aluminum
plate with composite patches presented, firstly we determine the
displacement, strain and stress, also the first six mode shape of the
plate, secondly we took the same model adding central crack
initiation, which is located in the center of the plate, its seize vary
from 20 mm to 60 mm and we compare the first results with second.
Thirdly we repair various cracks with composite patch (carbon/
epoxy) and for (2 layers, 4 layers). Finally the comparison of stress,
strain, displacement and six first natural frequencies between un-cracked
specimen, crack propagation and composite patch repair.
Abstract: Obturator Foramen is a specific structure in Pelvic
bone images and recognition of it is a new concept in medical image
processing. Moreover, segmentation of bone structures such as
Obturator Foramen plays an essential role for clinical research in
orthopedics. In this paper, we present a novel method to analyze the
similarity between the substructures of the imaged region and a hand
drawn template as a preprocessing step for computation of Pelvic
bone rotation on hip radiographs. This method consists of integrated
usage of Marker-controlled Watershed segmentation and Zernike
moment feature descriptor and it is used to detect Obturator Foramen
accurately. Marker-controlled Watershed segmentation is applied to
separate Obturator Foramen from the background effectively. Then,
Zernike moment feature descriptor is used to provide matching
between binary template image and the segmented binary image for
final extraction of Obturator Foramens. Finally, Pelvic bone rotation
rate calculation for each hip radiograph is performed automatically to
select and eliminate hip radiographs for further studies which depend
on Pelvic bone angle measurements. The proposed method is tested
on randomly selected 100 hip radiographs. The experimental results
demonstrated that the proposed method is able to segment Obturator
Foramen with 96% accuracy.
Abstract: Mixed-use development is one of the most important
trends in new island house transformation along southeast coastal area
in China. Unique island geographical environment and profound
fishing village culture coexist for a long time in this. With artistic
creation for the purpose of the "live-work" houses are in a large
number of emergence, however, still lack of systematic strategy.
Based on space effect from marine resources to regional human
settlements, this article teases out the evolution regularity of island
settlement context and architectural form, then, puts forward the
formation mechanism and construction model of art island houses.
Thereby, to further explore space design method and site creation
strategy of mixed-use development.
Abstract: Detecting changes in multiple images of the same
scene has recently seen increased interest due to the many
contemporary applications including smart security systems, smart
homes, remote sensing, surveillance, medical diagnosis, weather
forecasting, speed and distance measurement, post-disaster forensics
and much more. These applications differ in the scale, nature, and
speed of change. This paper presents an application of image
processing techniques to implement a real-time change detection
system. Change is identified by comparing the RGB representation of
two consecutive frames captured in real-time. The detection threshold
can be controlled to account for various luminance levels. The
comparison result is passed through a filter before decision making to
reduce false positives, especially at lower luminance conditions. The
system is implemented with a MATLAB Graphical User interface
with several controls to manage its operation and performance.
Abstract: Presently various computational techniques are used
in modeling and analyzing environmental engineering data. In the
present study, an intra-comparison of polynomial and radial basis
kernel functions based on Support Vector Regression and, in turn, an
inter-comparison with Multi Linear Regression has been attempted in
modeling mass transfer capacity of vertical (θ = 90O) and inclined (θ
multiple plunging jets (varying from 1 to 16 numbers). The data set
used in this study consists of four input parameters with a total of
eighty eight cases, forty four each for vertical and inclined multiple
plunging jets. For testing, tenfold cross validation was used.
Correlation coefficient values of 0.971 and 0.981 along with
corresponding root mean square error values of 0.0025 and 0.0020
were achieved by using polynomial and radial basis kernel functions
based Support Vector Regression respectively. An intra-comparison
suggests improved performance by radial basis function in
comparison to polynomial kernel based Support Vector Regression.
Further, an inter-comparison with Multi Linear Regression
(correlation coefficient = 0.973 and root mean square error = 0.0024)
reveals that radial basis kernel functions based Support Vector
Regression performs better in modeling and estimating mass transfer
by multiple plunging jets.
Abstract: The aim of this paper is to analyze the impact of
literature review software on researchers. The aim of this study was
achieved by analyzing models in terms of perceived usefulness,
perceived ease of use, and acceptance level. Collected data were
analyzed using WarpPLS 4.0 software. This study used two
theoretical frameworks, namely, Technology Acceptance Model and
the Training Needs Assessment Model. The study was experimental
and was conducted at a public university in South Africa. The results
of the study showed that acceptance level has a high impact on
research productivity followed by perceived usefulness and perceived
ease of use.
Abstract: An early diagnosis of bone metastasis is very
important for making a right decision on a subsequent therapy. One
of the most important steps to be taken initially, for developing a new
radiopharmaceutical is the measurement of organ radiation exposure
dose. In this study, the dosimetric studies of a novel agent for
SPECT-imaging of the bone metastasis, 111In-(4-
{[(bis(phosphonomethyl))carbamoyl]methyl}7,10bis(carboxymethyl)
-1,4,7,10-tetraazacyclododec-1-yl) acetic acid (111In-BPAMD)
complex, have been carried out to estimate the dose in human organs
based on the data derived from mice. The radiolabeled complex was
prepared with high radiochemical purity in the optimal conditions.
Biodistribution studies of the complex was investigated in the male
Syrian mice at the selected times after injection (2, 4, 24 and 48 h).
The human absorbed dose estimation of the complex was made based
on data derived from the mice by the radiation absorbed dose
assessment resource (RADAR) method. 111In-BPAMD complex was prepared with high radiochemical
purity >95% (ITLC) and specific activities of 2.85 TBq/mmol. Total
body effective absorbed dose for 111In-BPAMD was 0.205
mSv/MBq. This value is comparable to the other 111In clinically used
complexes. The results show that the dose with respect to the critical
organs is satisfactory within the acceptable range for diagnostic
nuclear medicine procedures. Generally, 111In-BPAMD has
interesting characteristics and it can be considered as a viable agent
for SPECT-imaging of the bone metastasis in the near future.
Abstract: Cesium molybdates with general formula
CsMIII(MoO4)2, where MIII = Bi, Dy, Pr, Er, exhibit rich
polymorphism, and crystallize in a layered structure. These properties
cause intensive studies on cesium molybdates. CsBi(MoO4)2 was synthesized by microwave method by using
cerium sulphate, bismuth oxide and molybdenum (VI) oxide in an
appropriate molar ratio. Characterizations were done by x-ray
diffraction (XRD), fourier transform infrared (FTIR) spectroscopy,
scanning electron microscopy/energy dispersive analyze (SEM/EDS),
thermo gravimetric/differantial thermal analysis (TG/DTA).