Abstract: Today, cancer remains one of the major diseases that
lead to death. The main obstacle in chemotherapy as a main cancer
treatment is the toxicity to normal cells due to Multidrug Resistance
(MDR) after the use of anticancer drugs. Proposed solution to
overcome this problem is the use of MDR efflux inhibitor of cinchona
alkaloids which is delivered together with anticancer drugs
encapsulated in the form of polymeric nanoparticles. The particles
were prepared by the hydration method. The characterization of
nanoparticles was particle size, zeta potential, entrapment efficiency
and in vitro drug release. Combination nanoparticle size ranged 29-45
nm with a neutral surface charge. Entrapment efficiency was above
87% for the use quinine, quinidine or cinchonidine in combination
with etoposide. The release test results exhibited that the cinchona
alkaloids release released faster than that of etoposide. Collectively,
cinchona alkaloids can be packaged along with etoposide in
nanomicelles for better cancer therapy.
Abstract: The recent development of humanoid robots has led robot designers to imagine a great variety of anthropomorphic forms for human-like machine. Which form is the best ? We try to answer this question from a double meaning of the anthropomorphism : a positive anthropomorphism corresponing to the realization of an effective anthropomorphic form object and a negative one corresponding to our natural tendency in certain circumstances to give human attributes to non-human beings. We postulate that any humanoid robot is concerned by both these two anthropomorphism kinds. We propose to use gestalt theory and Heider-s balance theory in order to analyze how negative anthropomorphism can influence our perception of human-like robots. From our theoretical approach we conclude that an “even shape" as defined by gestalt theory is not a sufficient condition for a good integration of future humanoid robots into a human community. Aesthetic perception of the robot cannot be splitted from a social perception : a humanoid robot, any how the efforts made for improving its appearance, could be rejected if it is devoted to a task with too high affective implications.
Abstract: A novel path planning approach is presented to solve
optimal path in stochastic, time-varying networks under priori traffic
information. Most existing studies make use of dynamic programming
to find optimal path. However, those methods are proved to
be unable to obtain global optimal value, moreover, how to design
efficient algorithms is also another challenge.
This paper employs a decision theoretic framework for defining
optimal path: for a given source S and destination D in urban transit
network, we seek an S - D path of lowest expected travel time
where its link travel times are discrete random variables. To solve
deficiency caused by the methods of dynamic programming, such as
curse of dimensionality and violation of optimal principle, an integer
programming model is built to realize assignment of discrete travel
time variables to arcs. Simultaneously, pruning techniques are also
applied to reduce computation complexity in the algorithm. The final
experiments show the feasibility of the novel approach.
Abstract: The world demand for potable water is
increasing every day with growing population. Desalination
using solar energy is suitable for potable water production
from brackish and seawater. In this paper, we present a
theoretical study of solar distillation in a single basin under
the open environmental conditions of Chabahar-Iran. The still
has a base area of 2000mm×500mm with a glass cover
inclined at 25° in order to obtain extra solar energy. We model
the still and conduct its energy balance equations under minor
assumptions. We computed the temperatures of glass cover,
seawater interface, moist air and bottom using numerical
method. The investigation addressed the following: The still
productivity, distilled water salinity and still performance in
terms of the still efficiency. Calculated still productivity in
July was higher than December. So in this paper, we show
that still productivity is directly functioning of solar radiation.
Abstract: A five-class density histogram with an index named cumulative density was proposed to analyze the short-term HRV. 150 subjects participated in the test, falling into three groups with equal numbers -- the healthy young group (Young), the healthy old group (Old), and the group of patients with congestive heart failure (CHF). Results of multiple comparisons showed a significant differences of the cumulative density in the three groups, with values 0.0238 for Young, 0.0406 for Old and 0.0732 for CHF (p
Abstract: The paper presents the modeling of nonlinear
longitudinal aerodynamics using flight data of Hansa-3 aircraft at
high angles of attack near stall. The Kirchhoff-s quasi-steady stall
model has been used to incorporate nonlinear aerodynamic effects in
the aerodynamic model used to estimate the parameters, thereby,
making the aerodynamic model nonlinear. The Maximum Likelihood
method has been applied to the flight data (at high angles of attack)
for the estimation of parameters (aerodynamic and stall
characteristics) using the nonlinear aerodynamic model. To improve
the accuracy level of the estimates, an approach of fixing the strong
parameters has also been presented.
Abstract: Background: This investigated the mental health of the elderly survivors six months, ten months and two years after the “5.12 Wenchuan" earthquake. Methods: Two hundred and thirty-two physically healthy older survivors from earthquake-affected Mianyang County were interviewed. The measures included the Revised Impact of Event Scale (IES-R, Chinese version, for PTSD) and a Chinese Mental Health Inventory for the Elderly (MHIE). A repeated measures ANOVA test was used for statistical analysis. Results: The follow-up group had a statistically significant lower IES-R score and lower MHIE score than the initial group ten months after the earthquake. Two years later, the score of IES-R in follow-up group were still lower than that of non-follow-up group, but no differences were significant on the score of MHIE between groups. Furthermore, a negative relationship was found between scores of IES-R and MHIE. Conclusion: The earthquake has had a persistent negative impact on older survivors- mental health within the two-year period and that although the PTSD level declined significantly with time, it did not disappear completely.
Abstract: The Muslim faith requires individuals to fast between
the hours of sunrise and sunset during the month of Ramadan. Our
recent work has concentrated on some of the changes that take place
during the daytime when fasting. A questionnaire was developed to
assess subjective estimates of physical, mental and social activities,
and fatigue. Four days were studied: in the weeks before and after
Ramadan (control days) and during the first and last weeks of
Ramadan (experimental days). On each of these four days, this
questionnaire was given several times during the daytime and once
after the fast had been broken and just before individuals retired at
night.
During Ramadan, daytime mental, physical and social activities
all decreased below control values but then increased to abovecontrol
values in the evening. The desires to perform physical and
mental activities showed very similar patterns. That is, individuals
tried to conserve energy during the daytime in preparation for the
evenings when they ate and drank, often with friends. During
Ramadan also, individuals were more fatigued in the daytime and
napped more often than on control days. This extra fatigue probably
reflected decreased sleep, individuals often having risen earlier
(before sunrise, to prepare for fasting) and retired later (to enable
recovery from the fast).
Some physiological measures and objective measures of
performance (including the response to a bout of exercise) have also
been investigated. Urine osmolality fell during the daytime on
control days as subjects drank, but rose in Ramadan to reach values
at sunset indicative of dehydration. Exercise performance was also
compromised, particularly late in the afternoon when the fast had
lasted several hours. Self-chosen exercise work-rates fell and a set
amount of exercise felt more arduous. There were also changes in
heart rate and lactate accumulation in the blood, indicative of greater
cardiovascular and metabolic stress caused by the exercise in
subjects who had been fasting. Daytime fasting in Ramadan produces
widespread effects which probably reflect combined effects of sleep
loss and restrictions to intakes of water and food.
Abstract: This paper describes a system-level SoC energy
consumption estimation method based on a dynamic behavior of
embedded software in the early stages of the SoC development. A
major problem of SOC development is development rework caused by
unreliable energy consumption estimation at the early stages. The
energy consumption of an SoC used in embedded systems is strongly
affected by the dynamic behavior of the software. At the early stages
of SoC development, modeling with a high level of abstraction is
required for both the dynamic behavior of the software, and the
behavior of the SoC. We estimate the energy consumption by a UML
model-based simulation. The proposed method is applied for an actual
embedded system in an MFP. The energy consumption estimation of
the SoC is more accurate than conventional methods and this proposed
method is promising to reduce the chance of development rework in
the SoC development. ∈
Abstract: In this article, by using fuzzy AHP and TOPSIS
technique we propose a new method for project selection problem.
After reviewing four common methods of comparing alternatives
investment (net present value, rate of return, benefit cost analysis
and payback period) we use them as criteria in AHP tree. In this
methodology by utilizing improved Analytical Hierarchy Process
by Fuzzy set theory, first we try to calculate weight of each
criterion. Then by implementing TOPSIS algorithm, assessment of
projects has been done. Obtained results have been tested in a
numerical example.
Abstract: This research is a comparative study of complexity, as a multidimensional concept, in the context of streetscape composition in Algeria and Japan. 80 streetscapes visual arrays have been collected and then presented to 20 participants, with different cultural backgrounds, in order to be categorized and classified according to their degrees of complexity. Three analysis methods have been used in this research: cluster analysis, ranking method and Hayashi Quantification method (Method III). The results showed that complexity, disorder, irregularity and disorganization are often conflicting concepts in the urban context. Algerian daytime streetscapes seem to be balanced, ordered and regular, and Japanese daytime streetscapes seem to be unbalanced, regular and vivid. Variety, richness and irregularity with some aspects of order and organization seem to characterize Algerian night streetscapes. Japanese night streetscapes seem to be more related to balance, regularity, order and organization with some aspects of confusion and ambiguity. Complexity characterized mainly Algerian avenues with green infrastructure. Therefore, for Japanese participants, Japanese traditional night streetscapes were complex. And for foreigners, Algerian and Japanese avenues nightscapes were the most complex visual arrays.
Abstract: The importance of ensuring safe meat handling and
processing practices has been demonstrated in global reports on food
safety scares and related illness and deaths. This necessitated stricter
meat safety control strategies. Today, many countries have regulated
towards preventative and systematic control over safe meat
processing at abattoirs utilizing the Hazard Analysis Critical Control
Point (HACCP) principles. HACCP systems have been reported as
effective in managing food safety risks, if correctly implemented.
South Africa has regulated the Hygiene Management System (HMS)
based on HACCP principles applicable to abattoirs. Regulators utilise
the Hygiene Assessment System (HAS) to audit compliance at
abattoirs. These systems were benchmarked from the United
Kingdom (UK). Little research has been done them since inception as
of 2004. This paper presents a review of the two systems, its
implementation and comparison with HACCP. Recommendations are
made for future research to demonstrate the utility of the HMS and
HAS in assuring safe meat to consumers.
Abstract: One of the determinants of a firm-s prosperity is the
customers- perceived service quality and satisfaction. While service
quality is wide in scope, and consists of various dimensions, there
may be differences in the relative importance of these dimensions in
affecting customers- overall satisfaction of service quality.
Identifying the relative rank of different dimensions of service quality
is very important in that it can help managers to find out which
service dimensions have a greater effect on customers- overall
satisfaction. Such an insight will consequently lead to more effective
resource allocation which will finally end in higher levels of
customer satisfaction. This issue –despite its criticality- has not
received enough attention so far. Therefore, using a sample of 240
bank customers in Iran, an artificial neural network is developed to
address this gap in the literature. As customers- evaluation of service
quality is a subjective process, artificial neural networks –as a brain
metaphor- may appear to have a potentiality to model such a
complicated process. Proposing a neural network which is able to
predict the customers- overall satisfaction of service quality with a
promising level of accuracy is the first contribution of this study. In
addition, prioritizing the service quality dimensions in affecting
customers- overall satisfaction –by using sensitivity analysis of
neural network- is the second important finding of this paper.
Abstract: Intravitreal injection (IVI) is the most common treatment for eye posterior segment diseases such as endopthalmitis, retinitis, age-related macular degeneration, diabetic retinopathy, uveitis, and retinal detachment. Most of the drugs used to treat vitreoretinal diseases, have a narrow concentration range in which they are effective, and may be toxic at higher concentrations. Therefore, it is critical to know the drug distribution within the eye following intravitreal injection. Having knowledge of drug distribution, ophthalmologists can decide on drug injection frequency while minimizing damage to tissues. The goal of this study was to develop a computer model to predict intraocular concentrations and pharmacokinetics of intravitreally injected drugs. A finite volume model was created to predict distribution of two drugs with different physiochemical properties in the rabbit eye. The model parameters were obtained from literature review. To validate this numeric model, the in vivo data of spatial concentration profile from the lens to the retina were compared with the numeric data. The difference was less than 5% between the numerical and experimental data. This validation provides strong support for the numerical methodology and associated assumptions of the current study.
Abstract: Plasmodium vivax malaria differs from P. falciparum malaria in that a person suffering from P. vivax infection can suffer relapses of the disease. This is due the parasite being able to remain dormant in the liver of the patients where it is able to re-infect the patient after a passage of time. During this stage, the patient is classified as being in the dormant class. The model to describe the transmission of P. vivax malaria consists of a human population divided into four classes, the susceptible, the infected, the dormant and the recovered. The effect of a time delay on the transmission of this disease is studied. The time delay is the period in which the P. vivax parasite develops inside the mosquito (vector) before the vector becomes infectious (i.e., pass on the infection). We analyze our model by using standard dynamic modeling method. Two stable equilibrium states, a disease free state E0 and an endemic state E1, are found to be possible. It is found that the E0 state is stable when a newly defined basic reproduction number G is less than one. If G is greater than one the endemic state E1 is stable. The conditions for the endemic equilibrium state E1 to be a stable spiral node are established. For realistic values of the parameters in the model, it is found that solutions in phase space are trajectories spiraling into the endemic state. It is shown that the limit cycle and chaotic behaviors can only be achieved with unrealistic parameter values.
Abstract: The present study has been carried out with a view to calculate the coastal vulnerability index (CVI) to know the high and low sensitive areas and area of inundation due to future SLR. Both conventional and remotely sensed data were used and analyzed through the modelling technique. Out of the total study area, 8.26% is very high risk, 14.21% high, 9.36% medium, 22.46% low and 7.35% in the very low vulnerable category, due to costal components. Results of the inundation analysis indicate that 225.2 km² and 397 km² of the land area will be submerged by flooding at 1m and 10m inundation levels. The most severely affected sectors are expected to be the residential, industrial and recreational areas. As this coast is planned for future coastal developmental activities, measures such as industrializations, building regulation, urban growth planning and agriculture, development of an integrated coastal zone management, strict enforcement of the Coastal Regulation Zone (CRZ) Act, monitoring of impacts and further research in this regard are recommended for the study area.
Abstract: Undoubtedly, chassis is one of the most important
parts of a vehicle. Chassis that today are produced for vehicles are
made up of four parts. These parts are jointed together by screwing.
Transverse parts are called cross member.
This study reviews the stress generated by cyclic laboratory loads
in front cross member of Peugeot 405. In this paper the finite element
method is used to simulate the welding process and to determine the
physical response of the spot-welded joints. Analysis is done by the
Abaqus software.
The Stresses generated in cross member structure are generally
classified into two groups: The stresses remained in form of residual
stresses after welding process and the mechanical stress generated by
cyclic load. Accordingly the total stress must be obtained by
determining residual stress and mechanical stress separately and then
sum them according to the superposition principle.
In order to improve accuracy, material properties including
physical, thermal and mechanical properties were supposed to be
temperature-dependent. Simulation shows that maximum Von Misses
stresses are located at special points. The model results are then
compared to the experimental results which are reported by
producing factory and good agreement is observed.
Abstract: The fundamental defect inherent to the thermoforming
technology is wall-thickness variation of the products due to
inadequate thermal processing during production of polymer. A
nonlinear viscoelastic rheological model is implemented for
developing the process model. This model describes deformation
process of a sheet in thermoforming process. Because of relaxation
pause after plug-assist stage and also implementation of two stage
thermoforming process have minor wall-thickness variation and
consequently better mechanical properties of polymeric articles. For
model validation, a comparative analysis of the theoretical and
experimental data is presented.
Abstract: The oil and gas industry has moved towards Load and
Resistance Factor Design through API RP2A - LRFD and the
recently published international standard, ISO-19902, for design of
fixed steel offshore structures. The ISO 19902 is intended to provide
a harmonized design practice that offers a balanced structural fitness
for the purpose, economy and safety. As part of an ongoing work, the
reliability analysis of tubular joints of the jacket structure has been
carried out to calibrate the load and resistance factors for the design
of offshore platforms in Malaysia, as proposed in the ISO.
Probabilistic models have been established for the load effects (wave,
wind and current) and the tubular joints strengths. In this study the
First Order Reliability Method (FORM), coded in MATLAB
Software has been employed to evaluate the reliability index of the
typical joints, designed using API RP2A - WSD and ISO 19902.
Abstract: In projects like waterpower, transportation and
mining, etc., proving up the rock-mass structure and hidden tectonic
to estimate the geological body-s activity is very important.
Integrating the seismic results, drilling and trenching data,
CSAMT method was carried out at a planning dame site in southwest
China to evaluate the stability of a deformation. 2D and imitated 3D
inversion resistivity results of CSAMT method were analyzed. The
results indicated that CSAMT was an effective method for defining
an outline of deformation body to several hundred meters deep; the
Lung Pan Deformation was stable in natural conditions; but uncertain
after the future reservoir was impounded.
This research presents a good case study of the fine surveying and
research on complex geological structure and hidden tectonic in
engineering project.