Abstract: Recently, there has been a considerable increase in the
number of procedures carried out under regional anesthesia.
However, percutaneous nephrolithotomy (PCNL) procedures are
usually performed under general anesthesia. The aim of this study
was to assess the safety and efficacy of PCNL under spinal anesthesia
in patients with renal calculi. We describe our 9 years experience of
performing PCNL under spinal anesthesia for 387 patients with large
stones of the upper urinary tract, with regard to the effectiveness and
side effects. All patients received spinal anesthetics (Lidocain 5%, or
Bupivacaine 0.75%) and underwent PCNL in prone position. The
success rate was 94.1%. The incidence of complications was 11.6%.
PCNL under spinal anesthesia is feasible, safe, and well-tolerated in
management of patients with renal stones.
Abstract: Oxidative stress is considered to be the cause for onset
and the progression of type 2 diabetes mellitus (T2DM) and
complications including neuropathy. It is a deleterious process that
can be an important mediator of damage to cell structures: protein,
lipids and DNA. Data suggest that in patients with diabetes and
diabetic neuropathy DNA repair is impaired, which prevents effective
removal of lesions. Objective: The aim of our study was to evaluate
the association of the hOGG1 (326 Ser/Cys) and XRCC1 (194
Arg/Trp, 399 Arg/Gln) gene polymorphisms whose protein is
involved in the BER pathway with DNA repair efficiency in patients
with diabetes type 2 and diabetic neuropathy compared to the healthy
subjects. Genotypes were determined by PCR-RFLP analysis in 385
subjects, including 117 with type 2 diabetes, 56 with diabetic
neuropathy and 212 with normal glucose metabolism. The
polymorphisms studied include codon 326 of hOGG1 and 194, 399
of XRCC1 in the base excision repair (BER) genes. Comet assay was
carried out using peripheral blood lymphocytes from the patients and
controls. This test enabled the evaluation of DNA damage in cells
exposed to hydrogen peroxide alone and in the combination with the
endonuclease III (Nth). The results of the analysis of polymorphism
were statistically examination by calculating the odds ratio (OR) and
their 95% confidence intervals (95% CI) using the ¤ç2-tests. Our data
indicate that patients with diabetes mellitus type 2 (including those
with neuropathy) had higher frequencies of the XRCC1 399Arg/Gln
polymorphism in homozygote (GG) (OR: 1.85 [95% CI: 1.07-3.22],
P=0.3) and also increased frequency of 399Gln (G) allele (OR: 1.38
[95% CI: 1.03-1.83], P=0.3). No relation to other polymorphisms
with increased risk of diabetes or diabetic neuropathy. In T2DM
patients complicated by neuropathy, there was less efficient repair of
oxidative DNA damage induced by hydrogen peroxide in both the
presence and absence of the Nth enzyme. The results of our study
suggest that the XRCC1 399 Arg/Gln polymorphism is a significant
risk factor of T2DM in Polish population. Obtained data suggest a
decreased efficiency of DNA repair in cells from patients with
diabetes and neuropathy may be associated with oxidative stress.
Additionally, patients with neuropathy are characterized by even
greater sensitivity to oxidative damage than patients with diabetes,
which suggests participation of free radicals in the pathogenesis of
neuropathy.
Abstract: This paper describes a proposed support system which
enables applications designers to effectively create VR applications
using multiple haptic APIs. When the VR designers create
applications, it is often difficult to handle and understand many
parameters and functions that have to be set in the application program
using documentation manuals only. This complication may disrupt
creative imagination and result in inefficient coding. So, we proposed
the support application which improved the efficiency of VR
applications development and provided the interactive components of
confirmation of operations with haptic sense previously.
In this paper, we describe improvements of our former proposed
support application, which was applicable to multiple APIs and haptic
devices, and evaluate the new application by having participants
complete VR program. Results from a preliminary experiment suggest
that our application facilitates creation of VR applications.
Abstract: The aim of this study was to investigate the pregnancy
outcomes of teenage mothers at DanKhunThot hospital, Nakhon
Ratchasima, Thailand. A retrospective descriptive study was
conducted in 573 of teenage pregnant from charts reviewed from 1st
October 2010-31st March, 2012. Data were analyzed by frequency
distribution, mean and Standard Deviation.
The results shown several problems and negatives outcomes of
pregnancy in teenager such as not attended prenatal care, Low birth
weight infants, death fetus in utero and other complications. The
results of this study can be utilized in the development of prenatal,
perinatal and post natal care services, especially in DanKhunthot
Hospital contexts. Moreover, the results were present to the District
Health Care committees in order to enhance health care service
system for teenage pregnancy of DanKhunthot District in further.
Abstract: The use of polypropylene mesh devices for Pelvic
Organ Prolapse (POP) spread rapidly during the last decade, yet our
knowledge of the mesh-tissue interaction is far from complete. We
aimed to perform a thorough pathological examination of explanted
POP meshes and describe findings that may explain mechanisms of
complications resulting in product excision. We report a spectrum of
important findings, including nerve ingrowth, mesh deformation,
involvement of detrusor muscle with neural ganglia, and
polypropylene degradation. Analysis of these findings may improve
and guide future treatment strategies.
Abstract: Long term rainfall analysis and prediction is a
challenging task especially in the modern world where the impact of
global warming is creating complications in environmental issues.
These factors which are data intensive require high performance
computational modeling for accurate prediction. This research paper
describes a prototype which is designed and developed on grid
environment using a number of coupled software infrastructural
building blocks. This grid enabled system provides the demanding
computational power, efficiency, resources, user-friendly interface,
secured job submission and high throughput. The results obtained
using sequential execution and grid enabled execution shows that
computational performance has enhanced among 36% to 75%, for
decade of climate parameters. Large variation in performance can be
attributed to varying degree of computational resources available for
job execution.
Grid Computing enables the dynamic runtime selection, sharing
and aggregation of distributed and autonomous resources which plays
an important role not only in business, but also in scientific
implications and social surroundings. This research paper attempts to
explore the grid enabled computing capabilities on weather indices
from HOAPS data for climate impact modeling and change
detection.
Abstract: A two-dimensional moving mesh algorithm is developed to simulate the general motion of two rotating bodies with relative translational motion. The grid includes a background grid and two sets of grids around the moving bodies. With this grid arrangement rotational and translational motions of two bodies are handled separately, with no complications. Inter-grid boundaries are determined based on their distances from two bodies. In this method, the overset concept is applied to hybrid grid, and flow variables are interpolated using a simple stencil. To evaluate this moving mesh algorithm unsteady Euler flow is solved for different cases using dual-time method of Jameson. Numerical results show excellent agreement with experimental data and other numerical results. To demonstrate the capability of present algorithm for accurate solution of flow fields around moving bodies, some benchmark problems have been defined in this paper.
Abstract: A laboratory set-up was designed to survey the
effectiveness of UV/O3 advanced oxidation process (AOP) for the
removal of Carbaryl from polluted water in batch reactor. The study
was carried out by UV/O3 process for water samples containing 1 to
20 mg/L of Carbaryl in distilled water. Also the range of drinking
water resources adjusted in synthetic water and effects of contact
time, pH and Carbaryl concentration were studied. The residual
pesticide concentration was determined by applying high
performance liquid chromatography (HPLC). The results indicated
that increasing of retention time and pH, enhances pesticide removal
efficiency. The removal efficiency has been affected by pesticide
initial concentration. Samples with low pesticide concentration
showed a remarkable removal efficiency compared to the samples
with high pesticide concentration. AOP method showed the removal
efficiencies of 80% to 100%. Although process showed high
performance for removal of pesticide from water samples, this
process has different disadvantages including complication,
intolerability, difficulty of maintenance and equipmental and
structural requirements.
Abstract: Temperature rise in a transformer depends on variety
of parameters such as ambient temperature, output current and type
of the core. Considering these parameters, temperature rise estimation
is still complicated procedure. In this paper, we present a new model
based on simple electrical equivalent circuit. This method avoids the
complication associated to accurate estimation and is in very good
agreement with practice.
Abstract: The Linear discriminant analysis (LDA) can be
generalized into a nonlinear form - kernel LDA (KLDA) expediently
by using the kernel functions. But KLDA is often referred to a general
eigenvalue problem in singular case. To avoid this complication, this
paper proposes an iterative algorithm for the two-class KLDA. The
proposed KLDA is used as a nonlinear discriminant classifier, and the
experiments show that it has a comparable performance with SVM.
Abstract: The classic problem of recovering arbitrary values of
a band-limited signal from its samples has an added complication
in software radio applications; namely, the resampling calculations
inevitably fold aliases of the analog signal back into the original
bandwidth. The phenomenon is quantified by the spur-free dynamic
range. We demonstrate how a novel application of the Remez (Parks-
McClellan) algorithm permits optimal signal recovery and SFDR, far
surpassing state-of-the-art resamplers.
Abstract: The purpose of this study is to derive parameters
estimating for the Lyman–Kutcher–Burman (LKB) normal tissue
complication probability (NTCP) model using analysis of scintigraphy
assessments and quality of life (QoL) measurement questionnaires for
the parotid gland (xerostomia). In total, 31 patients with
head-and-neck (HN) cancer were enrolled. Salivary excretion factor
(SEF) and EORTC QLQ-H&N35 questionnaires datasets are used for
the NTCP modeling to describe the incidence of grade 4 xerostomia.
Assuming that n= 1, NTCP fitted parameters are given as TD50= 43.6
Gy, m= 0.18 in SEF analysis, and as TD50= 44.1 Gy, m= 0.11 in QoL
measurements, respectively. SEF and QoL datasets can validate the
Quantitative Analyses of Normal Tissue Effects in the Clinic
(QUANTEC) guidelines well, resulting in NPV-s of 100% for the both
datasets and suggests that the QUANTEC 25/20Gy gland-spared
guidelines are suitable for clinical used for the HN cohort to
effectively avoid xerostomia.
Abstract: Type 2 diabetes mellitus (T2DM) is a complex
metabolic disorder that characterized by the presence of high glucose
in blood that cause from insulin resistance and insufficiency due to
deterioration β-cell Langerhans functions. T2DM is commonly
caused by the combination of inherited genetic variations as well as
our own lifestyle. Metallothionein (MT) is a known cysteine-rich
protein responsible in helping zinc homeostasis which is important in
insulin signaling and secretion as well as protection our body from
reactive oxygen species (ROS). MT scavenged ROS and free
radicals in our body happen to be one of the reasons of T2DM and its
complications. The objective of this study was to investigate the
association of MT1A and MT2A polymorphisms between T2DM and
control subjects among Malay populations. This study involved 150
T2DM and 120 Healthy individuals of Malay ethnic with mixed
genders. The genomic DNA was extracted from buccal cells and
amplified for MT1A and MT2A loci; the 347bp and 238bp banding
patterns were respectively produced by mean of the Polymerase
Chain Reaction (PCR). The PCR products were digested with Mlucl
and Tsp451 restriction enzymes respectively and producing
fragments lengths of (158/189/347bp) and (103/135/238bp)
respectively. The ANOVA test was conducted and it shown that there
was a significant difference between diabetic and control subjects for
age, BMI, WHR, SBP, FPG, HBA1C, LDL, TG, TC and family
history with (P0.05). The genotype
frequency for AA, AG and GG of MT1A polymorphisms was 72.7%,
22.7% and 4.7% in cases and 15%, 55% and 30% in control
respectively. As for MT2A, genotype frequency of GG, GC and CC
was 42.7%, 27.3% and 30% in case and 5%, 40% and 55% for
control respectively. Both polymorphisms show significant difference
between two investigated groups with (P=0.000). The Post hoc test
was conducted and shows a significant difference between the
genotypes within each polymorphism (P=0. 000). The MT1A and
MT2A polymorphisms were believed to be the reliable molecular
markers to distinguish the T2DM subjects from healthy individuals in
Malay populations.
Abstract: Diabetes is one of the high prevalence diseases
worldwide with increased number of complications, with retinopathy
as one of the most common one. This paper describes how data
mining and case-based reasoning were integrated to predict
retinopathy prevalence among diabetes patients in Malaysia. The
knowledge base required was built after literature reviews and
interviews with medical experts. A total of 140 diabetes patients- data
were used to train the prediction system. A voting mechanism selects
the best prediction results from the two techniques used. It has been
successfully proven that both data mining and case-based reasoning
can be used for retinopathy prediction with an improved accuracy of
85%.
Abstract: Pharmacology curriculum plays an integral role in
medical education. Learning pharmacology to choose and prescribe
drugs is a major challenge encountered by students. We developed
pharmacology applied learning activities for first year medical
students that included realistic clinical situations with escalating
complications which required the students to analyze the situation
and think critically to choose a safe drug. Tutor feedback was
provided at the end of session. Evaluation was done to assess the
students- level of interest and usefulness of the sessions in rational
selection of drugs. Majority (98 %) of the students agreed that the
session was an extremely useful learning exercise and agreed that
similar sessions would help in rational selection of drugs. Applied
learning sessions in the early years of medical program may promote
deep learning and bridge the gap between pharmacology theory and
clinical practice. Besides, it may also enhance safe prescribing skills.
Abstract: The primary cause of Total Hip Replacement (THR)
failure for younger patients is aseptic loosening. This complication is
twice more likely to happen in acetabular cup than in femoral stem.
Excessive micromotion between bone and implant will cause
loosening and it depends in patient activities, age and bone. In this
project, the effects of different metal back design of press fit on
osseointegration of the acetabular cup are carried out. Commercial
acetabular cup designs, namely Spiked, Superfix and Quadrafix are
modelled and analyzed using commercial finite element software.
The diameter of acetabular cup is based on the diameter of acetabular
rim to make sure the component fit to the acetabular cavity. A new
design of acetabular cup are proposed and analyzed to get better
osseointegration between the bones and implant interface. Results
shows that the proposed acetabular cup designs are more stable
compared to other designs with respect to stress and displacement
aspects.
Abstract: Dengue fever is an important human arboviral disease. Outbreaks are now reported quite often from many parts of the world. The number of cases involving pregnant women and infant cases are increasing every year. The illness is often severe and complications may occur. Deaths often occur because of the difficulties in early diagnosis and in the improper management of the diseases. Dengue antibodies from pregnant women are passed on to infants and this protects the infants from dengue infections. Antibodies from the mother are transferred to the fetus when it is still in the womb. In this study, we formulate a mathematical model to describe the transmission of this disease in pregnant women. The model is formulated by dividing the human population into pregnant women and non-pregnant human (men and non-pregnant women). Each class is subdivided into susceptible (S), infectious (I) and recovered (R) subclasses. We apply standard dynamical analysis to our model. Conditions for the local stability of the equilibrium points are given. The numerical simulations are shown. The bifurcation diagrams of our model are discussed. The control of this disease in pregnant women is discussed in terms of the threshold conditions.