Abstract: Mycophenolic acid “MPA" is a secondary metabolite
of Penicillium bervicompactum with antibiotic and
immunosuppressive properties. In this study, fermentation process
was established for production of mycophenolic acid by Penicillium
bervicompactum MUCL 19011 in shake flask. The maximum MPA
production, product yield and productivity were 1.379 g/L, 18.6 mg/g
glucose and 4.9 mg/L.h respectively. Glucose consumption, biomass
and MPA production profiles were investigated during fermentation
time. It was found that MPA production starts approximately after
180 hours and reaches to a maximum at 280 h. In the next step, the
effects of methionine and acetate concentrations on MPA production
were evaluated. Maximum MPA production, product yield and
productivity (1.763 g/L, 23.8 mg/g glucose and 6.30 mg/L. h
respectively) were obtained with using 2.5 g/L methionine in culture
medium. Further addition of methionine had not more positive effect
on MPA production. Finally, results showed that the addition of
acetate to the culture medium had not any observable effect on MPA
production
Abstract: Generally, administrative systems in an academic
environment are disjoint and support independent queries. The
objective in this work is to semantically connect these independent
systems to provide support to queries run on the integrated platform.
The proposed framework, by enriching educational material in the
legacy systems, provides a value-added semantics layer where
activities such as annotation, query and reasoning can be carried out
to support management requirements. We discuss the development of
this ontology framework with a case study of UAE University
program administration to show how semantic web technologies can
be used by administration to develop student profiles for better
academic program management.
Abstract: In today-s era of plasma and laser cutting, machines using oxy-acetylene flame are also meritorious due to their simplicity and cost effectiveness. The objective to devise a Computer controlled Oxy-Fuel profile cutting machine arose from the increasing demand for metal cutting with respect to edge quality, circularity and lesser formation of redeposit material. The System has an 8 bit micro controller based embedded system, which assures stipulated time response. A new window based Application software was devised which takes a standard CAD file .DXF as input and converts it into numerical data required for the controller. It uses VB6 as a front end whereas MS-ACCESS and AutoCAD as back end. The system is designed around AT89C51RD2, powerful 8 bit, ISP micro controller from Atmel and is optimized to achieve cost effectiveness and also maintains the required accuracy and reliability for complex shapes. The backbone of the system is a cleverly designed mechanical assembly along with the embedded system resulting in an accuracy of about 10 microns while maintaining perfect linearity in the cut. This results in substantial increase in productivity. The observed results also indicate reduced inter laminar spacing of pearlite with an increase in the hardness of the edge region.
Abstract: The Prediction of aerodynamic characteristics and
shape optimization of airfoil under the ground effect have been carried
out by integration of computational fluid dynamics and the multiobjective
Pareto-based genetic algorithm. The main flow
characteristics around an airfoil of WIG craft are lift force, lift-to-drag
ratio and static height stability (H.S). However, they show a strong
trade-off phenomenon so that it is not easy to satisfy the design
requirements simultaneously. This difficulty can be resolved by the
optimal design. The above mentioned three characteristics are chosen
as the objective functions and NACA0015 airfoil is considered as a
baseline model in the present study. The profile of airfoil is
constructed by Bezier curves with fourteen control points and these
control points are adopted as the design variables. For multi-objective
optimization problems, the optimal solutions are not unique but a set
of non-dominated optima and they are called Pareto frontiers or Pareto
sets. As the results of optimization, forty numbers of non- dominated
Pareto optima can be obtained at thirty evolutions.
Abstract: A conjugate heat transfer for steady two-dimensional
mixed convection with magnetic hydrodynamic (MHD) flow of an
incompressible quiescent fluid over an unsteady thermal forming
stretching sheet has been studied. A parameter, M, which is used to
represent the dominance of the magnetic effect has been presented in
governing equations. The similar transformation and an implicit
finite-difference method have been used to analyze the present
problem. The numerical solutions of the flow velocity distributions,
temperature profiles, the wall unknown values of f''(0) and '(θ (0) for
calculating the heat transfer of the similar boundary-layer flow are
carried out as functions of the unsteadiness parameter (S), the Prandtl
number (Pr), the space-dependent parameter (A) and
temperature-dependent parameter (B) for heat source/sink and the
magnetic parameter (M). The effects of these parameters have also
discussed. At the results, it will produce greater heat transfer effect
with a larger Pr and M, S, A, B will reduce heat transfer effects. At
last, conjugate heat transfer for the free convection with a larger G has
a good heat transfer effect better than a smaller G=0.
Abstract: Proteins levels produced by bacteria may be increased
in stressful surroundings, such as in the presence of antibiotics. It
appears that many antimicrobial agents or antibiotics, when used at
low concentrations, have in common the ability to activate or repress
gene transcription, which is distinct from their inhibitory effect.
There have been comparatively few studies on the potential of
antibiotics or natural compounds in nature as a specific chemical
signal that can trigger a variety of biological functions. Therefore,
this study was focusing on the effect of essential oils from
Cymbopogon flexuosus and C. nardus in regulating proteins
production by Bacillus subtilis ATCC 21332. The Minimum
Inhibition Concentrations (MICs) of both essential oils on B. subtilis
were determined by using microdilution assay, resulting 0.2% and
1.56% for each C. flexuosus and C. nardus subsequently. The
bacteria were further exposed to each essential oils at concentration
of 0.01XMIC for 2 days. The proteins were then isolated and
analyzed by sodium dodecyl sulfate polyacrylamide gel
electrophoresis (SDS-PAGE). Protein profile showed that a band
with approximate size of 250 kD was appeared for the treated
bacteria with essential oils. Thus, Bacillus subtilis ATCC 21332 in
stressful condition with the presence of essential oils at low
concentration could induce the protein production.
Abstract: Computational fluid dynamics (CFD) simulations
carried out in this paper show that spacer orientation has a major
influence on temperature patterns and on the heat transfer rates. The
local heat flux values significantly vary from high to very low values
at each filament when spacer touches the membrane surface. The
heat flux profile is more uniform when spacer filaments are not in
contact with the membrane thus making this arrangement more
beneficial. The temperature polarization is also found to be less in
this case when compared to the empty channel.
Abstract: Team distillation assisted by microwave extraction
(SDAM) considered as accelerated technique extraction is a
combination of microwave heating and steam distillation, performed
at atmospheric pressure. SDAM has been compared with the same
technique coupled with the cryogrinding of seeds (SDAM -CG).
Isolation and concentration of volatile compounds are performed by a
single stage for the extraction of essential oil from Cuminum
cyminum seeds. The essential oils extracted by these two methods for
5 min were quantitatively (yield) and qualitatively (aromatic profile)
no similar. These methods yield an essential oil with higher amounts
of more valuable oxygenated compounds, and allow substantial
savings of costs, in terms of time, energy and plant material. SDAM
and SDAM-CG is a green technology and appears as a good
alternative for the extraction of essential oils from aromatic plants.
Abstract: When the profile information of an existing road is
missing or not up-to-date and the parameters of the vertical
alignment are needed for engineering analysis, the engineer has to recreate
the geometric design features of the road alignment using
collected profile data. The profile data may be collected using
traditional surveying methods, global positioning systems, or digital
imagery. This paper develops a method that estimates the parameters
of the geometric features that best characterize the existing vertical
alignments in terms of tangents and the expressions of the curve, that
may be symmetrical, asymmetrical, reverse, and complex vertical
curves. The method is implemented using an Excel-based
optimization method that minimizes the differences between the
observed profile and the profiles estimated from the equations of the
vertical curve. The method uses a 'wireframe' representation of the
profile that makes the proposed method applicable to all types of
vertical curves. A secondary contribution of this paper is to introduce
the properties of the equal-arc asymmetrical curve that has been
recently developed in the highway geometric design field.
Abstract: The present paper considers the steady free
convection boundary layer flow of a viscoelastics fluid with constant
temperature in the presence of heat generation. The boundary layer
equations are an order higher than those for the Newtonian (viscous)
fluid and the adherence boundary conditions are insufficient to
determine the solution of these equations completely. The governing
boundary layer equations are first transformed into non-dimensional
form by using special dimensionless group. Computations are
performed numerically by using Keller-box method by augmenting
an extra boundary condition at infinity and the results are displayed
graphically to illustrate the influence of viscoelastic K, heat
generation γ , and Prandtl Number, Pr parameters on the velocity
and temperature profiles. The results of the surface shear stress in
terms of the local skin friction and the surface rate of heat transfer in
terms of the local Nusselt number for a selection of the heat
generation parameterγ (=0.0, 0.2, 0.5, 0.8, 1.0) are obtained and
presented in both tabular and graphical formats. Without effect of the
internal heat generation inside the fluid domain for which we take
γ = 0.0, the present numerical results show an excellent agreement
with previous publication.
Abstract: Methanol-to-olefins (MTO) coupled with
transformation of coal or natural gas to methanol gives an interesting
and promising way to produce ethylene and propylene. To investigate
solid concentration in gas-solid fluidized bed for methanol-to-olefins
process catalyzed by SAPO-34, a cold model experiment system is
established in this paper. The system comprises a gas distributor in a
300mm internal diameter and 5000mm height acrylic column, the
fiber optic probe system and series of cyclones. The experiments are
carried out at ambient conditions and under different superficial gas
velocity ranging from 0.3930m/s to 0.7860m/s and different initial bed
height ranging from 600mm to 1200mm. The effects of radial
distance, axial distance, superficial gas velocity, initial bed height on
solid concentration in the bed are discussed. The effects of distributor
shape and porosity on solid concentration are also discussed. The
time-averaged solid concentration profiles under different conditions
are obtained.
Abstract: The combustion of liquid fuel in the porous burner
(PB) was experimented to investigate evaporation mechanism and
combustion behavior. The diesel oil was used as fuel and the pebbles
carefully chosen in the same size like the solid sphere homogeneously
was adopted as the porous media. Two structures of the liquid porous
burner, i.e. the PB without and with installation of porous emitter
(PE), were performed. PE was installed by lower than PB with
distance of 20 cm. The pebbles having porosity (φ) of 0.45 and 0.52
were, respectively, used in PB and PE. The fuel was supplied dropwise
from the top through the PB and the combustion was occurred between
PB and PE. Axial profiles of temperature along the burner length were
measured to clarify the evaporation and combustion phenomena. The
pollutant emission characteristics were monitored at the burner exit.
From the experiment, it was found that the temperature profiles of both
structures decreased with the three ways swirling air flows (QA)
increasing. On the other hand, the temperature profiles increased with
fuel heat input (QF). Obviously, the profile of the porous burner
installed with PE was higher than that of the porous burner without
PE
Abstract: This is the second part of the paper. It, aside from the
core subroutine test reported previously, focuses on the simulation of
turbulence governed by the full STF Navier-Stokes equations on a
large scale. Law of the wall is found plausible in this study as a model
of the boundary layer dynamics. Model validations proceed to
include velocity profiles of a stationary turbulent Couette flow, pure
sloshing flow simulations, and the identification of water-surface
inclination due to fluid accelerations. Errors resulting from the
irrotational and hydrostatic assumptions are explored when studying
a wind-driven water circulation with no shakings. Illustrative
examples show that this numerical strategy works for the simulation
of sloshing-shear mixed flow in a 3-D rigid rectangular base tank.
Abstract: Latvia is the fourth in the world by means of broadband internet speed. The total number of internet users in Latvia exceeds 70% of its population. The number of active mailboxes of the local internet e-mail service Inbox.lv accounts for 68% of the population and 97.6% of the total number of internet users. The Latvian portal Draugiem.lv is a phenomenon of social media, because 58.4 % of the population and 83.5% of internet users use it. A majority of Latvian company profiles are available on social networks, the most popular being Twitter.com. These and other parameters prove the fact consumers and companies are actively using the Internet.
However, after the authors in a number of studies analyzed how enterprises are employing the e-environment, namely, e-environment tools, they arrived to the conclusions that are not as flattering as the aforementioned statistics. There is an obvious contradiction between the statistical data and the actual studies. As a result, the authors have posed a question: Why are entrepreneurs resistant to e-tools? In order to answer this question, the authors have addressed the Technology Acceptance Model (TAM). The authors analyzed each phase and determined several factors affecting the use of e-environment, reaching the main conclusion that entrepreneurs do not have a sufficient level of e-literacy (digital literacy).
The authors employ well-established quantitative and qualitative methods of research: grouping, analysis, statistic method, factor analysis in SPSS 20 environment etc.
The theoretical and methodological background of the research is formed by, scientific researches and publications, that from the mass media and professional literature, statistical information from legal institutions as well as information collected by the author during the survey.
Abstract: The increasing usage of antibiotics in the animal
farming industry is an emerging worldwide problem contributing to
the development of antibiotic resistance. The purpose of this work was
to investigate the prevalence and antibiotic resistance profile of
bacterial isolates collected from aquatic environments and meats in a
peri-urban community in Daejeon, Korea. In an antibacterial
susceptibility test, the bacterial isolates showed a high incidence of
resistance (~ 26.04 %) to cefazolin, tetracycline, gentamycin,
norfloxacin, erythromycin and vancomycin. The results from a test for
multiple antibiotic resistance indicated that the isolates were
displaying an approximately 5-fold increase in the incidence of
multiple antibiotic resistance to combinations of two different
antibiotics compared to combinations of three or more antibiotics.
Most of the isolates showed multi-antibiotic resistance, and the
resistance patterns were similar among the sampling groups.
Sequencing data analysis of 16S rRNA showed that most of the
resistant isolates appeared to be dominated by the classes
Betaproteobacteria and Gammaproteobacteria in the phylum
Proteobacteria.
Abstract: The mechanism of microwave heating is essentially
that of dielectric heating. After exposing the emulsion to the
microwave Electromagnetic (EM) field, molecular rotation and ionic
conduction due to the penetration of (EM) into the emulsion are
responsible for the internal heating. To determine the capability of
microwave technology in demulsification of crude oil emulsions,
microwave demulsification method was applied in a 50-50 % and 20-
80 % water-in-oil emulsions with microwave exposure time varied
from 20-180 sec. Transient temperature profiles of water-in-oil
emulsions inside a cylindrical container were measured. The
temperature rise at a given location was almost horizontal (linear).
The average rates of temperature increase of 50-50 % and 20-80 %
water-in-oil emulsions are 0.351 and 0.437 oC/sec, respectively. The
rate of temperature increase of emulsions decreased at higher
temperature due to decreasing dielectric loss of water. These results
indicate that microwave demulsification of water-in-oil emulsions
does not require chemical additions. Microwave has the potential to
be used as an alternative way in the demulsification process.
Abstract: Individually Network reconfiguration or Capacitor control
perform well in minimizing power loss and improving voltage
profile of the distribution system. But for heavy reactive power loads
network reconfiguration and for heavy active power loads capacitor
placement can not effectively reduce power loss and enhance
voltage profiles in the system. In this paper, an hybrid approach
that combine network reconfiguration and capacitor placement using
Harmony Search Algorithm (HSA) is proposed to minimize power
loss reduction and improve voltage profile. The proposed approach
is tested on standard IEEE 33 and 16 bus systems. Computational
results show that the proposed hybrid approach can minimize losses
more efficiently than Network reconfiguration or Capacitor control.
The results of proposed method are also compared with results
obtained by Simulated Annealing (SA). The proposed method has
outperformed in terms of the quality of solution compared to SA.
Abstract: A mathematical model for the hydrodynamic
lubrication of parabolic slider bearings with couple stress lubricants
is presented. A numerical solution for the mathematical model using
finite element scheme is obtained using three nodes isoparametric
quadratic elements. Stiffness integrals obtained from the weak form
of the governing equations were solved using Gauss Quadrature to
obtain a finite number of stiffness matrices. The global system of
equations was obtained for the bearing and solved using Gauss Seidel
iterative scheme. The converged pressure solution was used to obtain
the load capacity of the bearing. Parametric studies were carried out
and it was shown that the effect of couple stresses and profile
parameter are to increase the load carrying capacity of the parabolic
slider bearing. Numerical experiments reveal that the magnitude of
the profile parameter at which maximum load is obtained increases
with decrease in couple stress parameter. The results are presented in
graphical form.
Abstract: Solid dispersions (SD) of curcuminpolyvinylpyrrolidone
in the ratio of 1:2, 1:4, 1:5, 1:6, and 1:8 were
prepared in an attempt to increase the solubility and dissolution.
Solubility, dissolution, powder X-ray diffraction (XRD), differential
scanning calorimetry (DSC) and Fourier transform infrared
spectroscopy (FTIR) of solid dispersions, physical mixtures (PM)
and curcumin were evaluated. Both solubility and dissolution of
curcumin solid dispersions were significantly greater than those
observed for physical mixtures and intact curcumin. The powder
X-ray diffractograms indicated that the amorphous curcumin was
obtained from all solid dispersions. It was found that the optimum
weight ratio for curcumin:PVP K-30 is 1:6. The 1:6 solid dispersion
still in the amorphous from after storage at ambient temperature for 2
years and the dissolution profile did not significantly different from
freshly prepared.
Abstract: Unified Modeling Language (UML) extensions for real time embedded systems (RTES) co-design, are taking a growing interest by a great number of industrial and research communities. The extension mechanism is provided by UML profiles for RTES. It aims at improving an easily-understood method of system design for non-experts. On the other hand, one of the key items of the co- design methods is the Hardware/Software partitioning and scheduling tasks. Indeed, it is mandatory to define where and when tasks are implemented and run. Unfortunately the main goals of co-design are not included in the usual practice of UML profiles. So, there exists a need for mapping used models to an execution platform for both schedulability test and HW/SW partitioning. In the present work, test schedulability and design space exploration are performed at an early stage. The proposed approach adopts Model Driven Engineering MDE. It starts from UML specification annotated with the recent profile for the Modeling and Analysis of Real Time Embedded systems MARTE. Following refinement strategy, transformation rules allow to find a feasible schedule that satisfies timing constraints and to define where tasks will be implemented. The overall approach is experimented for the design of a football player robot application.