Abstract: Co-crystal is believed to improve the solubility and
dissolution rates and thus, enhanced the bioavailability of poor water
soluble drugs particularly during the oral route of administration.
With the existing of poorly soluble drugs in pharmaceutical industry,
the screening of co-crystal formation using carbamazepine (CBZ) as
a model drug compound with dicarboxylic acids co-crystal formers
(CCF) namely fumaric (FA) and succinic (SA) acids in ethanol has
been studied. The co-crystal formations were studied by varying the
mol ratio values of CCF to CBZ to access the effect of CCF
concentration on the formation of the co-crystal. Solvent evaporation,
slurry and cooling crystallization which representing the solution
based method co-crystal screening were used. Based on the
differential scanning calorimetry (DSC) analysis, the melting point of
CBZ-SA in different ratio was in the range between 188oC-189oC.
For CBZ-FA form A and CBZ-FA form B the melting point in
different ratio were in the range of 174oC-175oC and 185oC-186oC
respectively. The product crystal from the screening was also
characterized using X-ray powder diffraction (XRPD). The XRPD
pattern profile analysis has shown that the CBZ co-crystals with FA
and SA were successfully formed for all ratios studied. The findings
revealed that CBZ-FA co-crystal were formed in two different
polymorphs. It was found that CBZ-FA form A and form B were
formed from evaporation and slurry crystallization methods
respectively. On the other hand, in cooling crystallization method,
CBZ-FA form A was formed at lower mol ratio of CCF to CBZ and
vice versa. This study disclosed that different methods and mol ratios
during the co-crystal screening can affect the outcome of co-crystal
produced such as polymorphic forms of co-crystal and thereof. Thus,
it was suggested that careful attentions is needed during the screening
since the co-crystal formation is currently one of the promising
approach to be considered in research and development for
pharmaceutical industry to improve the poorly soluble drugs.
Abstract: This paper presents development results of the method
of seismoacoustic activity monitoring based on usage vibrosensitive
properties of optical fibers. Analysis of Rayleigh backscattering
radiation parameters changes, which take place due to microscopic
seismoacoustic impacts on the optical fiber, allows to determine
seismoacoustic emission sources positions and to identify their types.
Results of using this approach are successful for complex monitoring
of railways.
Abstract: Gypsum (CaSO4.2H2O) is a mineral that is found in
large quantities in the Turkey and in the World. In this study, the
dissolution of this mineral in the diammonium hydrogen phosphate
solutions has been studied. The dissolution and dissolution kinetics of
gypsum in diammonium hydrogen phosphate solutions will be useful
for evaluating of solid wastes containing gypsum. Parameters such as
diammonium hydrogen phosphate concentration, temperature and
stirring speed affecting on the dissolution rate of the gypsum in
diammonium hydrogen phosphate solutions were investigated. In
experimental studies have researched effectiveness of the selected
parameters. The dissolution of gypsum were examined in two parts at
low and high temperatures. The experimental results were
successfully correlated by linear regression using Statistica program.
Dissolution curves were evaluated shrinking core models for solidfluid
systems. The activation energy was found to be 34.58 kJ/mol
and 44.45 kJ/mol for the low and the high temperatures. The
dissolution of gypsum was controlled by chemical reaction both low
temperatures and high temperatures.
Abstract: This paper describes an Action Research project
which was undertaken to inform professional practice in order to
develop a newly created Centre for Student Success in the specific
context of transnational medical and nursing education in the Middle
East. The objectives were to enhance the academic performance,
persistence, integration and personal and professional development of
a multinational study body, in particular in relation to pre-clinical
medical students, and to establish a comfortable, friendly and
student-driven environment within an Irish medical university
recently established in Bahrain. The outcomes of the project resulted
in the development of a specific student success ‘signature’ for this
particular transnational higher education context.
Abstract: The adaptation of social networking sites within
higher education has garnered significant interest in the recent years
with numerous researches considering it as a possible shift from the
traditional classroom based learning paradigm. Notwithstanding this
increase in research and conducted studies however, the adaption of
SNS based modules have failed to proliferate within Universities.
This paper commences its contribution by analyzing the various
models and theories proposed in literature and amalgamate together
various effective aspects for the inclusion of social technology within
e-Learning. A three phased framework is further proposed which
details the necessary considerations for the successful adaptation of
SNS in enhancing the students learning experience. This proposal
outlines the theoretical foundations which will be analyzed in
practical implementation across international university campuses.
Abstract: Essential oils have a significant antimicrobial activity.
These oils can successfully replace the antibiotics. So, the
microorganisms show their inefficiencies resistant for the antibiotics.
For this reason, we study the physicochemical analysis and
antimicrobial activity of the essential oil of Daucus carota. The
extraction is done by steam distillation of water which brought us a
very significant return of 4.65%. The analysis of the essential oil is
performed by GC / MS and has allowed us to identify 32 compounds
in the oil of D. carota flowering tops of Bouira. Three of which are in
the majority are the α-Pinene (22.3%), the carotol (21.7%) and the
limonene (15.8%).
Abstract: This paper argues nation-building theories that
prioritize democratic governance best explain the successful postindependence
development of Botswana. Three main competing
schools of thought exist regarding the sequencing of policies that
should occur to re-build weakened or failed states. The first posits
that economic development should receive foremost attention, while
democratization and a binding sense of nationalism can wait. A
second group of experts identified constructing a sense of nationalism
among a populace is necessary first, so that the state receives popular
legitimacy and obedience that are prerequisites for development.
Botswana, though, transitioned into a multi-party democracy and
prosperous open economy due to the utilization of traditional
democratic structures, enlightened and accountable leadership, and an
educated technocratic civil service. With these political foundations
already in place when the discovery of diamonds occurred, the
resulting revenues were spent wisely on projects that grew the
economy, improved basic living standards, and attracted foreign
investment. Thus democratization preceded, and therefore provided
an accountable basis for, economic development that might otherwise
have been squandered by greedy and isolated elites to the detriment
of the greater population. Botswana was one of the poorest nations in
the world at the time of its independence in 1966, with little
infrastructure, a dependence on apartheid South Africa for trade, and
a largely subsistence economy. Over the next thirty years, though, its
economy grew the fastest of any nation in the world. The transparent
and judicious use of diamond returns is only a partial explanation, as
the government also pursued economic diversification, mass
education, and rural development in response to public needs.
As nation-building has become a project undertaken by nations
and multilateral agencies such as the United Nations and the North
Atlantic Treaty Organization, Botswana may provide best practices
that others should follow in attempting to reconstruct economically
and politically unstable states.
Abstract: The value co-creation has gained much attention in
sales research, but less is known about how salespeople and
customers interact in the authentic business to business (B2B) sales
meetings. The study presented in this paper empirically contributes to
existing research by presenting authentic B2B sales meetings that
were video recorded and analyzed using observation and qualitative
content analysis methods. This paper aims to study key elements of
successful sales interactions between salespeople and customers/
buyers. This study points out that salespeople are selling value rather
than the products or services themselves, which are only enablers in
realizing business benefits. Therefore, our findings suggest that
promoting and easing open discourse is an essential part of a
successful sales encounter. A better understanding of how
salespeople and customers successfully interact would help
salespeople to develop their interpersonal sales skills.
Abstract: Catalytic combustion of methane is imperative due to
stability of methane at low temperature. Methane (CH4), therefore,
remains unconverted in vehicle exhausts thereby causing greenhouse
gas GHG emission problem. In this study, heterogeneous catalysts of
palladium with bio-char (2 wt% Pd/Bc) and Al2O3 (2wt% Pd/ Al2O3)
supports were prepared by incipient wetness impregnation and then
subsequently tested for catalytic combustion of CH4. Support-porous
heterogeneous catalytic combustion (HCC) material were selected
based on factors such as surface area, porosity, thermal stability,
thermal conductivity, reactivity with reactants or products, chemical
stability, catalytic activity, and catalyst life. Sustainable and
renewable support-material of bio-mass char derived from palm shell
waste material was compared with those from the conventional
support-porous materials. Kinetic rate of reaction was determined for
combustion of methane on Palladium (Pd) based catalyst with Al2O3
support and bio-char (Bc). Material characterization was done using
TGA, SEM, and BET surface area. The performance test was
accomplished using tubular quartz reactor with gas mixture ratio of
3% methane and 97% air. The methane porous-HCC conversion was
carried out using online gas analyzer connected to the reactor that
performed porous-HCC. BET surface area for prepared 2 wt% Pd/Bc
is smaller than prepared 2wt% Pd/ Al2O3 due to its low porosity
between particles. The order of catalyst activity based on kinetic rate
on reaction of catalysts in low temperature was 2wt%
Pd/Bc>calcined 2wt% Pd/ Al2O3> 2wt% Pd/ Al2O3>calcined 2wt%
Pd/Bc. Hence agro waste material can successfully be utilized as an
inexpensive catalyst support material for enhanced CH4 catalytic
combustion.
Abstract: The dissimilar joint between aluminum/titanium
alloys (Al 6082 and Ti G2) were successfully achieved by CO2 laser
welding with a single pass and without filler material using the
overlap joint design. Laser welding parameters ranges combinations
were experimentally determined using Taguchi approach with the
objective of producing welded joint with acceptable welding profile
and high quality of mechanical properties. In this study a joining of
dissimilar Al 6082 / Ti G2 was resulted in three distinct regions
fusion area in the weldment. These regions are studied in terms of its
microstructural characteristics and microhardness which are directly
affecting the welding quality.
The weld metal was mainly composed of martensite alpha prime.
In two different metals in the two different sides of joint HAZ, grain
growth was detected. The microhardness of the joint distribution also
has shown microhardness increasing in the HAZ of two base metals
and a varying microhardness in fusion zone.
Abstract: Comparing other methods of waste water treatment,
constructed wetlands are one of the most fascinating practices
because being a natural process they are eco-friendly have low
construction and maintenance cost and have considerable capability
of wastewater treatment. The current research was focused mainly on
comparison of Ranunculus muricatus and Typha latifolia as wetland
plants for domestic wastewater treatment by designing and
constructing efficient pilot scale horizontal subsurface flow
mesocosms. Parameters like chemical oxygen demand, biological
oxygen demand, phosphates, sulphates, nitrites, nitrates, and
pathogenic indicator microbes were studied continuously with
successive treatments. Treatment efficiency of the system increases
with passage of time and with increase in temperature. Efficiency of
T. latifolia planted setups in open environment was fairly good for
parameters like COD and BOD5 which was showing reduction up to
82.5% for COD and 82.6% for BOD5 while DO was increased up to
125%. Efficiency of R. muricatus vegetated setup was also good but
lowers than that of T. latifolia planted showing 80.95% removal of
COD and BOD5. Ranunculus muricatus was found effective in
reducing bacterial count in wastewater. Both macrophytes were
found promising in wastewater treatment.
Abstract: Hurling a successful Construction and Demolition
Waste (C&DW) recycling operation around the globe is a challenge
today, predominantly because secondary materials markets are yet to
be integrated. Reducing, Reusing and recycling of (C&DW) have
been employed over the years, and various techniques have been
investigated. However, the economic and environmental viability of
its application seems limited. This paper discusses the costs and
benefits in using secondary materials and focus on investigating reuse
and recycling process for five major types of construction materials:
concrete, metal, wood, cardboard/paper and plasterboard. Data
obtained from demolition specialists and contractors are considered
and evaluated. The research paper found that construction material
recovery process fully incorporate a 3R’s principle contributing to
saving energy and natural resources. This scrutiny leads to the
empathy of grand challenges in construction material recovery
process. Recommendations to deepen material recovery process are
also discussed.
Abstract: Robotic surgery is used to enhance minimally invasive
surgical procedure. It provides greater degree of freedom for surgical
tools but lacks of haptic feedback system to provide sense of touch to
the surgeon. Surgical robots work on master-slave operation, where
user is a master and robotic arms are the slaves. Current, surgical
robots provide precise control of the surgical tools, but heavily rely
on visual feedback, which sometimes cause damage to the inner
organs. The goal of this research was to design and develop a realtime
Simulink based robotic system to study force feedback
mechanism during instrument-object interaction. Setup includes three
VelmexXSlide assembly (XYZ Stage) for three dimensional
movement, an end effector assembly for forceps, electronic circuit for
four strain gages, two Novint Falcon 3D gaming controllers,
microcontroller board with linear actuators, MATLAB and Simulink
toolboxes. Strain gages were calibrated using Imada Digital Force
Gauge device and tested with a hard-core wire to measure
instrument-object interaction in the range of 0-35N. Designed
Simulink model successfully acquires 3D coordinates from two
Novint Falcon controllers and transfer coordinates to the XYZ stage
and forceps. Simulink model also reads strain gages signal through
10-bit analog to digital converter resolution of a microcontroller
assembly in real time, converts voltage into force and feedback the
output signals to the Novint Falcon controller for force feedback
mechanism. Experimental setup allows user to change forward
kinematics algorithms to achieve the best-desired movement of the
XYZ stage and forceps. This project combines haptic technology
with surgical robot to provide sense of touch to the user controlling
forceps through machine-computer interface.
Abstract: Since the initial creation of the Barbie doll in 1959, it
became a symbol of US society. Likewise, the Licca-chan, a Japanese
doll created in 1967, also became a Japanese symbolic doll of Japanese
society. Prior to the introduction of Licca-chan, Barbie was already
marketed in Japan but their sales were dismal. Licca-chan (an actual
name: Kayama Licca) is a plastic doll with a variety of sizes ranging
from 21.0 cm to 29.0 cm which many Japanese girls dream of having.
For over 35 years, the manufacturer, Takara Co., Ltd. has sold over 48
million dolls and has produced doll houses, accessories, clothes, and
Licca-chan video games for the Nintendo DS. Many First-generation
Licca-chan consumers still are enamored with Licca-chan, and go to
Licca-chan House, in an amusement park with their daughters. These
people are called Licca-chan maniacs, as they enjoy touring the
Licca-chan’s factory in Tohoku or purchase various Licca-chan
accessories. After the successful launch of Licca-chan into the
Japanese market, a mixed-like doll from the US and Japan, a doll,
JeNny, was later sold in the same Japanese market by Takara Co., Ltd.
in 1982.
Comparison of these cultural iconic dolls, Barbie and Licca-chan,
are analyzed in this paper. In fact, these dolls have concepts of girls’
dreams. By using concepts of mythology of Jean Baudrillard, these
dolls can be represented idealized images of figures in the products for
consumers, but at the same time, consumers can see products with
different perspectives, which can cause controversy.
Abstract: A well designed and executed Production Planning
and Control (PPC) system is one of the key levers for superior
performance in the current manufacturing set-up. Hence, measuring
the PPC system performance has become a necessity for long term
success. The present study examined PPC related issues which
impact the production capacity and productivity of leather companies
with special focus on Kombolcha Tannery Share Company (KTSC),
Ethiopia. Physical observation, interview, and questionnaire were
used to generate necessary information from the respondents and
reach valid conclusions. Company annual reports were referred and
analyzed to triangulate primary data. Consequently, the study
revealed that KTSC runs below its capacity due to its inefficient PPC
system being in use for which the root causes were identified. The
study thereby conceptualizes a PPC system improvement framework
comprising three pillars viz., management culture, internal capability
and performance measurement together with key considerations in
each case. The study findings enable the company to recognize the
importance of efficient PPC system as a source of competitive
advantage. It also aid managers in evaluating various PPC execution
schemes to enhance productivity.
Abstract: Activated carbons (M4P0, M4P2, and M5P2) used in
this research were produced from palm shell and polyetherether
ketone (PEEK) via carbonization, impregnation and microwave
activation. The adsorption/desorption process was carried out using
static volumetric adsorption. Regeneration is important in the overall
economy of the process and waste minimization. This work focuses
on the thermal regeneration of the CO2 exhausted microwave
activated carbons. The regeneration strategy adopted was thermal
with nitrogen purge desorption with N2 feed flow rate of 20 ml/min
for 1 h at atmospheric pressure followed by drying at 150oC.Seven
successive adsorption/regeneration processes were carried out on the
material. It was found that after seven adsorption regeneration cycles;
the regeneration efficiency (RE) for CO2 activated carbon from palm
shell only (M4P0) was more than 90% while that of hybrid palm
shell-PEEK (M4P2, M5P2) was above 95%. The cyclic adsorption
and regeneration shows the stability of the adsorbent materials.
Abstract: The purpose of this study is to investigate the kinematic
characteristics and differences of the snatch barbell trajectory of 53 kg
class female weight lifters. We take the 2014 Taiwan College Cup
players as examples, and tend to make kinematic applications through
the proven weightlifting barbell track system. The competition videos
are taken by consumer camcorder with a tripod which set up at the side
of the lifter. The results will be discussed in three parts, the first part is
various lifting phase, the second part is the compare lifting between
success and unsuccessful, and the third part is to compare the
outstanding player with the general. Conclusion through the barbell
can be used to observe the trajectories of our players lifting the usual
process cannot be observed in the presence of malfunction or habits, so
that the coach can find the problem and guide the players more
accurately. Our system can be applied in practice and competition to
increase the resilience of the lifter on the field.
Abstract: In this study, several crossplots of the P-impedance
with the lithology logs (gamma ray, neutron porosity, deep resistivity,
water saturation and Vp/Vs curves) were made in three available
wells, which were drilled in central part of the Blue Nile basin in
depths varies from 1460m to 1600m. These crossplots were
successful to discriminate between sand and shale when using PImpedance
values, and between the wet sand and the pay sand when
using both P-impedance and Vp/Vs together. Also some impedance
sections were converted to porosity sections using linear formula to
characterize the reservoir in terms of porosity. The used crossplots
were created on log resolution, while the seismic resolution can
identify only the reservoir, unless a 3D seismic angle stacks were
available; then it would be easier to identify the pay sand with great
confidence; through high resolution seismic inversion and
geostatistical approach when using P-impedance and Vp/Vs volumes.
Abstract: Epidermal Growth Factor (EGF, Mw=6,045) has been
reported to have high efficiency of wound repair and anti-wrinkle
effect. However, the half-life of EGF in the body is too short to exert
the biological activity effectively when applied in free form. Growth
Factors can be stabilized by immobilization with carbohydrates from
thermal and proteolytic degradation. Low molecular weight chitosan
(LMCS) and its derivate prepared by hydrogen peroxide has high
solubility. LM6A6DC was successfully prepared as a reactive
carbohydrate for the stabilization of EGF by the reactions of LMCS
with alkalization, tosylation, azidation and reduction. The structure of
LM6A6DC was confirmed by FT-IR, 1H NMR and elementary
analysis. For enhancing the stability of free EGF, EGF was attached
with LM6A6DC by using water-soluble carbodiimide.
EGF-LM6A6DC conjugates did not show any cytotoxicity on the
Normal Human Dermal Fibroblast (NHDF) 3T3 proliferation at least
under 100 μg/ml. In the result, it was considered that LM6A6DC is
suitable to immobilize of growth factor.
Abstract: This study investigated some results of the use of
digital art tools by junior school children in order to discover if these
tools could promote artistic ability and creativity. The study considers
the ease of use and usefulness of the tools as well as how to assess
artwork produced by digital means. As the use of these tools is a
relatively new development in Art education, this study may help
educators in their choice of which tools to use and when to use them.
The study also aims to present a model for the assessment of
students’ artistic development and creativity by studying their artistic
activity. This model can help in determining differences in students’
creative ability and could be useful both for teachers, as a means of
assessing digital artwork, and for students, by providing the
motivation to use the tools to their fullest extent. Sixteen students
aged nine to ten years old were observed and recorded while they
used the digital drawing tools. The study found that, according to the
students’ own statements, it was not the ease of use but the successful
effects the tools provided which motivated the children to use them.