Abstract: Modeling and simulation of biochemical reactions is of great interest in the context of system biology. The central dogma of this re-emerging area states that it is system dynamics and organizing principles of complex biological phenomena that give rise to functioning and function of cells. Cell functions, such as growth, division, differentiation and apoptosis are temporal processes, that can be understood if they are treated as dynamic systems. System biology focuses on an understanding of functional activity from a system-wide perspective and, consequently, it is defined by two hey questions: (i) how do the components within a cell interact, so as to bring about its structure and functioning? (ii) How do cells interact, so as to develop and maintain higher levels of organization and functions? In recent years, wet-lab biologists embraced mathematical modeling and simulation as two essential means toward answering the above questions. The credo of dynamics system theory is that the behavior of a biological system is given by the temporal evolution of its state. Our understanding of the time behavior of a biological system can be measured by the extent to which a simulation mimics the real behavior of that system. Deviations of a simulation indicate either limitations or errors in our knowledge. The aim of this paper is to summarize and review the main conceptual frameworks in which models of biochemical networks can be developed. In particular, we review the stochastic molecular modelling approaches, by reporting the principal conceptualizations suggested by A. A. Markov, P. Langevin, A. Fokker, M. Planck, D. T. Gillespie, N. G. van Kampfen, and recently by D. Wilkinson, O. Wolkenhauer, P. S. Jöberg and by the author.
Abstract: Classifying biomedical literature is a difficult and
challenging task, especially when a large number of biomedical
articles should be organized into a hierarchical structure. In this paper,
we present an approach for classifying a collection of biomedical text
abstracts downloaded from Medline database with the help of
ontology alignment. To accomplish our goal, we construct two types
of hierarchies, the OHSUMED disease hierarchy and the Medline
abstract disease hierarchies from the OHSUMED dataset and the
Medline abstracts, respectively. Then, we enrich the OHSUMED
disease hierarchy before adapting it to ontology alignment process for
finding probable concepts or categories. Subsequently, we compute
the cosine similarity between the vector in probable concepts (in the
“enriched" OHSUMED disease hierarchy) and the vector in Medline
abstract disease hierarchies. Finally, we assign category to the new
Medline abstracts based on the similarity score. The results obtained
from the experiments show the performance of our proposed approach
for hierarchical classification is slightly better than the performance of
the multi-class flat classification.
Abstract: Article is devoted to the problem of Kazakhstan people national values in the conditions of the Republic of Kazakhstan independence. Formation of ethnos national values is viewed as the mandatory constituent of this process in contemporary conditions. The article shows the dynamics of forming socialspiritual basis of Kazakhstan people-s national values. It depicts peculiarities of interethnic relations in poly-ethnic and multiconfessional Kazakhstan. The study reviews in every detail various directions of the state social policy development in the sphere of national values. It is aimed to consolidation of the society to achieve the shared objective, i.e. building democratic and civilized state. The author discloses peculiarities of ethnos national values development using specific sources. It is underlined that renewal and modernization of Kazakhstan society represents new stage in the national value development, and its typical feature is integration process based on peoples- friendship, cultural principles of interethnic communication.
Abstract: In an era of knowledge explosion, the growth of data
increases rapidly day by day. Since data storage is a limited resource,
how to reduce the data space in the process becomes a challenge issue.
Data compression provides a good solution which can lower the
required space. Data mining has many useful applications in recent
years because it can help users discover interesting knowledge in large
databases. However, existing compression algorithms are not
appropriate for data mining. In [1, 2], two different approaches were
proposed to compress databases and then perform the data mining
process. However, they all lack the ability to decompress the data to
their original state and improve the data mining performance. In this
research a new approach called Mining Merged Transactions with the
Quantification Table (M2TQT) was proposed to solve these problems.
M2TQT uses the relationship of transactions to merge related
transactions and builds a quantification table to prune the candidate
itemsets which are impossible to become frequent in order to improve
the performance of mining association rules. The experiments show
that M2TQT performs better than existing approaches.
Abstract: One major difficulty that faces developers of
concurrent and distributed software is analysis for concurrency based
faults like deadlocks. Petri nets are used extensively in the
verification of correctness of concurrent programs. ECATNets [2] are
a category of algebraic Petri nets based on a sound combination of
algebraic abstract types and high-level Petri nets. ECATNets have
'sound' and 'complete' semantics because of their integration in
rewriting logic [12] and its programming language Maude [13].
Rewriting logic is considered as one of very powerful logics in terms
of description, verification and programming of concurrent systems.
We proposed in [4] a method for translating Ada-95 tasking
programs to ECATNets formalism (Ada-ECATNet). In this paper,
we show that ECATNets formalism provides a more compact
translation for Ada programs compared to the other approaches based
on simple Petri nets or Colored Petri nets (CPNs). Such translation
doesn-t reduce only the size of program, but reduces also the number
of program states. We show also, how this compact Ada-ECATNet
may be reduced again by applying reduction rules on it. This double
reduction of Ada-ECATNet permits a considerable minimization of
the memory space and run time of corresponding Maude program.
Abstract: In this paper, we propose a novel algorithm for
delineating the endocardial wall from a human heart ultrasound scan.
We assume that the gray levels in the ultrasound images are
independent and identically distributed random variables with
different Rician Inverse Gaussian (RiIG) distributions. Both synthetic
and real clinical data will be used for testing the algorithm. Algorithm
performance will be evaluated using the expert radiologist evaluation
of a soft copy of an ultrasound scan during the scanning process and
secondly, doctor’s conclusion after going through a printed copy of
the same scan. Successful implementation of this algorithm should
make it possible to differentiate normal from abnormal soft tissue and
help disease identification, what stage the disease is in and how best
to treat the patient. We hope that an automated system that uses this
algorithm will be useful in public hospitals especially in Third World
countries where problems such as shortage of skilled radiologists and
shortage of ultrasound machines are common. These public hospitals
are usually the first and last stop for most patients in these countries.
Abstract: In this paper, we propose effective system for digital music retrieval. We divided proposed system into Client and Server. Client part consists of pre-processing and Content-based feature extraction stages. In pre-processing stage, we minimized Time code Gap that is occurred among same music contents. As content-based feature, first-order differentiated MFCC were used. These presented approximately envelop of music feature sequences. Server part included Music Server and Music Matching stage. Extracted features from 1,000 digital music files were stored in Music Server. In Music Matching stage, we found retrieval result through similarity measure by DTW. In experiment, we used 450 queries. These were made by mixing different compression standards and sound qualities from 50 digital music files. Retrieval accurate indicated 97% and retrieval time was average 15ms in every single query. Out experiment proved that proposed system is effective in retrieve digital music and robust at various user environments of web.
Abstract: This paper presents a remote on-line diagnostic system
for vehicles via the use of On-Board Diagnostic (OBD), GPS, and 3G
techniques. The main parts of the proposed system are on-board
computer, vehicle monitor server, and vehicle status browser. First,
the on-board computer can obtain the location of deriver and vehicle
status from GPS receiver and OBD interface, respectively. Then
on-board computer will connect with the vehicle monitor server
through 3G network to transmit the real time vehicle system status.
Finally, vehicle status browser could show the remote vehicle status
including vehicle speed, engine rpm, battery voltage, engine coolant
temperature, and diagnostic trouble codes. According to the
experimental results, the proposed system can help fleet managers and
car knockers to understand the remote vehicle status. Therefore this
system can decrease the time of fleet management and vehicle repair
due to the fleet managers and car knockers who find the diagnostic
trouble messages in time.
Abstract: In this paper, Speed Sensorless Indirect Field Oriented Control (IFOC) of a Permanent Magnet Synchronous machine (PMSM) is studied. The closed loop scheme of the drive system utilizes fuzzy speed and current controllers. Due to the well known drawbacks of the speed sensor, an algorithm is proposed in this paper to eliminate it. In fact, based on the model of the PMSM, the stator currents and rotor speed are estimated simultaneously using adaptive Luenberger observer for currents and MRAS (Model Reference Adaptive System) observer for rotor speed. To overcome the sensivity of this algorithm against parameter variation, adaptive for on line stator resistance tuning is proposed. The validity of the proposed method is verified by an extensive simulation work.
Abstract: Prediction of fault-prone modules provides one way to
support software quality engineering. Clustering is used to determine
the intrinsic grouping in a set of unlabeled data. Among various
clustering techniques available in literature K-Means clustering
approach is most widely being used. This paper introduces K-Means
based Clustering approach for software finding the fault proneness of
the Object-Oriented systems. The contribution of this paper is that it
has used Metric values of JEdit open source software for generation
of the rules for the categorization of software modules in the
categories of Faulty and non faulty modules and thereafter
empirically validation is performed. The results are measured in
terms of accuracy of prediction, probability of Detection and
Probability of False Alarms.
Abstract: A numerical investigation of surface heat transfer
characteristics of turbulent air flows in different parallel plate
grooved channels is performed using CFD code. The results are
obtained for Reynolds number ranging from 10,000 to 30,000 and for
arc-shaped and rectangular grooved channels. The influence of
different geometric parameters of dimples as well as the number of
them and the geometric and thermophysical properties of channel
walls are studied. It is found that there exists an optimum value for
depth of dimples in which the largest wall heat flux can be achieved.
Also, the results show a critical value for the ratio of wall thermal
conductivity to the one of fluid in which the dependence of wall heat
flux to this ratio almost vanishes. In most cases examined, heat
transfer enhancement is larger for arc-shaped grooved channels than
rectangular ones.
Abstract: This paper aims at to develop a robust optimization methodology for the mechatronic modules of machine tools by considering all important characteristics from all structural and control domains in one single process. The relationship between these two domains is strongly coupled. In order to reduce the disturbance caused by parameters in either one, the mechanical and controller design domains need to be integrated. Therefore, the concurrent integrated design method Design For Control (DFC), will be employed in this paper. In this connect, it is not only applied to achieve minimal power consumption but also enhance structural performance and system response at same time. To investigate the method for integrated optimization, a mechatronic feed drive system of the machine tools is used as a design platform. Pro/Engineer and AnSys are first used to build the 3D model to analyze and design structure parameters such as elastic deformation, nature frequency and component size, based on their effects and sensitivities to the structure. In addition, the robust controller,based on Quantitative Feedback Theory (QFT), will be applied to determine proper control parameters for the controller. Therefore, overall physical properties of the machine tool will be obtained in the initial stage. Finally, the technology of design for control will be carried out to modify the structural and control parameters to achieve overall system performance. Hence, the corresponding productivity is expected to be greatly improved.
Abstract: The objective of the research was to evaluate the
quality of milk pomade sweet – sherbet packed in different packaging
materials (Multibarrier 60, met.BOPET/PE, Aluthen), by several
packaging technologies – active and modified atmosphere (MAP)
(consisting of 100% CO2), and control – in air ambiance.
Experiments were carried out at the Faculty of Food Technology of
Latvia University of Agriculture. Samples were stored at the room
temperature +21±1 °C. The physiochemical properties – weight
losses, moisture, hardening, colour and changes in headspace
atmosphere concentration (CO2 and O2) of packs were analysed
before packaging and after 2, 4, 6, 8, 10 and 12 storage weeks.
Abstract: Abrasive waterjet is a novel machining process capable of processing wide range of hard-to-machine materials. This research addresses modeling and optimization of the process parameters for this machining technique. To model the process a set of experimental data has been used to evaluate the effects of various parameter settings in cutting 6063-T6 aluminum alloy. The process variables considered here include nozzle diameter, jet traverse rate, jet pressure and abrasive flow rate. Depth of cut, as one of the most important output characteristics, has been evaluated based on different parameter settings. The Taguchi method and regression modeling are used in order to establish the relationships between input and output parameters. The adequacy of the model is evaluated using analysis of variance (ANOVA) technique. The pairwise effects of process parameters settings on process response outputs are also shown graphically. The proposed model is then embedded into a Simulated Annealing algorithm to optimize the process parameters. The optimization is carried out for any desired values of depth of cut. The objective is to determine proper levels of process parameters in order to obtain a certain level of depth of cut. Computational results demonstrate that the proposed solution procedure is quite effective in solving such multi-variable problems.
Abstract: In this work we investigated the behavior of methane
hydrates dispersed in crude oils from different fields at temperatures
below 0°C. In case of crude oil emulsion the size of water droplets is
in the range of 50e100"m. The size of hydrate particles formed from
droplets is the same. The self-preservation is not expected in this
field. However, the self-preservation of hydrates with the size of
particles 24±18"m (electron microscopy data) in suspensions is
observed. Similar results were obtained for four different kinds of
crude oil and model system such as asphaltenes, resins and wax in ndecane.
This result can allow developing effective methods to prevent
the formation and elimination of gas-hydrate plugs in pipelines under
low temperature conditions (e. g. in Eastern Siberia). There is a
prospective to use experiment results for working out the technology
of associated petroleum gas recovery.
Abstract: This paper presents a sensing system for 3D sensing
and mapping by a tracked mobile robot with an arm-type sensor
movable unit and a laser range finder (LRF). The arm-type sensor
movable unit is mounted on the robot and the LRF is installed at the
end of the unit. This system enables the sensor to change position and
orientation so that it avoids occlusions according to terrain by this
mechanism. This sensing system is also able to change the height of
the LRF by keeping its orientation flat for efficient sensing. In this kind
of mapping, it may be difficult for moving robot to apply mapping
algorithms such as the iterative closest point (ICP) because sets of the
2D data at each sensor height may be distant in a common surface. In
order for this kind of mapping, the authors therefore applied
interpolation to generate plausible model data for ICP. The results of
several experiments provided validity of these kinds of sensing and
mapping in this sensing system.
Abstract: We present a dual-band (Cellular & PCS) dual-path
zero-IF receiver for CDMA2000 diversity, monitoring and
simultaneous-GPS. The secondary path is a SAW-less diversity
CDMA receiver which can be also used for advanced features like
monitoring when supported with an additional external VCO. A GPS
receiver is integrated with its dedicated VCO allowing simultaneous
positioning during a cellular call. The circuit is implemented in a
0.25μm 40GHz-fT BiCMOS process and uses a HVQFN 56-pin
package. It consumes a maximum 300mW from a 2.8V supply in
dual-modes. The chip area is 12.8mm2.
Abstract: The paper presents the method developed to assess
rating points of objects with qualitative indexes. The novelty of the
method lies in the fact that the authors use linguistic scales that allow
to formalize the values of the indexes with the help of fuzzy sets. As
a result it is possible to operate correctly with dissimilar indexes on
the unified basis and to get stable final results. The obtained rating
points are used in decision making based on fuzzy expert opinions.
Abstract: The objective of this manuscript is to find area under the plasma concentration- time curve (AUC) for multiple doses of salbutamol sulphate sustained release tablets (Ventolin® oral tablets SR 8 mg, GSK, Pakistan) in the group of 18 healthy adults by using computational mathematics techniques. Following the administration of 4 doses of Ventolin® tablets 12 hourly to 24 healthy human subjects and bioanalysis of obtained plasma samples, plasma drug concentration-time profile was constructed. AUC, an important pharmacokinetic parameter, was measured using integrated equation of multiple oral dose regimens. The approximated AUC was also calculated by using computational mathematics techniques such as repeated rectangular, repeated trapezium and repeated Simpson's rule and compared with exact value of AUC calculated by using integrated equation of multiple oral dose regimens to find best computational mathematics method that gives AUC values closest to exact. The exact values of AUC for four consecutive doses of Ventolin® oral tablets were 150.5819473, 157.8131756, 164.4178231 and 162.78 ng.h/ml while the closest values approximated AUC values were 149.245962, 157.336171, 164.2585768 and 162.289224 ng.h/ml, respectively as found by repeated rectangular rule. The errors in the approximated values of AUC were negligible. It is concluded that all computational tools approximated values of AUC accurately but the repeated rectangular rule gives slightly better approximated values of AUC as compared to repeated trapezium and repeated Simpson's rules.
Abstract: In recent years, Radio Frequency Identification (RFID)
is followed with interest by many researches, especially for the
purpose of indoor positioning as the innate properties of RFID are
profitable for achieving it. A lot of algorithms or schemes are proposed
to be used in the RFID-based positioning system, but most of them are
lack of environmental consideration and it induces inaccuracy of
application. In this research, a lot of algorithms and schemes of RFID
indoor positioning are discussed to see whether effective or not on
application, and some rules are summarized for achieving accurate
positioning. On the other hand, a new term “Noise Factor" is involved
to describe the signal loss between the target and the obstacle. As a
result, experimental data can be obtained but not only simulation; and
the performance of the positioning system can be expressed
substantially.