Abstract: The aim of this article is to narrate the utility of novel simulation approach i.e. convolution method to predict blood concentration of drug utilizing dissolution data of salbutamol sulphate microparticulate formulations with different release patterns (1:1, 1:2 and 1:3, drug:polymer). Dissolution apparatus II USP 2007 and 900 ml double distilled water stirrd at 50 rpm was employed for dissolution analysis. From dissolution data, blood drug concentration was determined, and in return predicted blood drug concentration data was used to calculate the pharmacokinetic parameters i.e. Cmax, Tmax, and AUC. Convolution is a good biwaiver technique; however its better utility needs it application in the conditions where biorelevant dissolution media are used.
Abstract: Several approaches such as linear programming, network
modeling, greedy heuristic and decision support system are well-known
approaches in solving irregular airline operation problem. This paper
presents an alternative approach based on Multi Objective Micro Genetic
Algorithm. The aim of this research is to introduce the concept of Multi
Objective Micro Genetic Algorithm as a tool to solve irregular airline
operation, combine and reroute problem. The experiment result indicated
that the model could obtain optimal solutions within a few second.
Abstract: The implementation of electronic government started since the initiation of Multimedia Super Corridor (MSC) by the Malaysia government. The introduction of ICT in the public sector especially e-Government initiatives opens up a new book in the government administration throughout the world. The aim or this paper is to discuss the implementation of e-government in Malaysia, covering the result of public user self assessment on Malaysia's electronic government applications. E-services, e-procurement, Generic Office Environment (GOE), Human Resources Management Information System (HRMIS), Project Monitoring System (PMS), Electronic Labor Exchange (ELX) and e-syariah(religion) were the seven flagship application assessed. The study adopted a crosssectional survey research approach and information system literature were used. The analysis was done for 35 responden in pilot test and there was evidence from public user's perspective to suggest that the e-government applications were generally successful.
Abstract: A new generation of manufacturing machines
so-called MIMCA (modular and integrated machine control
architecture) capable of handling much increased complexity in
manufacturing control-systems is presented. Requirement for more
flexible and effective control systems for manufacturing machine
systems is investigated and dimensioned-which highlights a need for
improved means of coordinating and monitoring production
machinery and equipment used to- transport material. The MIMCA
supports simulation based on machine modeling, was conceived by
the authors to address the issues. Essentially MIMCA comprises an
organized unification of selected architectural frameworks and
modeling methods, which include: NISTRCS, UMC and Colored
Timed Petri nets (CTPN). The unification has been achieved; to
support the design and construction of hierarchical and distributed
machine control which realized the concurrent operation of reusable
and distributed machine control components; ability to handle
growing complexity; and support requirements for real- time control
systems. Thus MIMCA enables mapping between 'what a machine
should do' and 'how the machine does it' in a well-defined but
flexible way designed to facilitate reconfiguration of machine
systems.
Abstract: This research investigates the design of a low-cost 3D
spatial interaction approach using the Wii Remote for immersive
Head-Mounted Display (HMD) virtual reality. Current virtual reality
applications that incorporate the Wii Remote are either desktop
virtual reality applications or systems that use large screen displays.
However, the requirements for an HMD virtual reality system differ
from such systems. This is mainly because in HMD virtual reality,
the display screen does not remain at a fixed location. The user views
the virtual environment through display screens that are in front of
the user-s eyes and when the user moves his/her head, these screens
move as well. This means that the display has to be updated in realtime
based on where the user is currently looking. Normal usage of
the Wii Remote requires the controller to be pointed in a certain
direction, typically towards the display. This is too restrictive for
HMD virtual reality systems that ideally require the user to be able to
turn around in the virtual environment. Previous work proposed a
design to achieve this, however it suffered from a number of
drawbacks. The aim of this study is to look into a suitable method of
using the Wii Remote for 3D interaction in a space around the user
for HMD virtual reality. This paper presents an overview of issues
that had to be considered, the system design as well as experimental
results.
Abstract: Calcium is a vital second messenger used in signal transduction. Calcium controls secretion, cell movement, muscular contraction, cell differentiation, ciliary beating and so on. Two theories have been used to simplify the system of reaction-diffusion equations of calcium into a single equation. One is excess buffer approximation (EBA) which assumes that mobile buffer is present in excess and cannot be saturated. The other is rapid buffer approximation (RBA), which assumes that calcium binding to buffer is rapid compared to calcium diffusion rate. In the present work, attempt has been made to develop a model for calcium diffusion under excess buffer approximation in neuron cells. This model incorporates the effect of [Na+] influx on [Ca2+] diffusion,variable calcium and sodium sources, sodium-calcium exchange protein, Sarcolemmal Calcium ATPase pump, sodium and calcium channels. The proposed mathematical model leads to a system of partial differential equations which have been solved numerically using Forward Time Centered Space (FTCS) approach. The numerical results have been used to study the relationships among different types of parameters such as buffer concentration, association rate, calcium permeability.
Abstract: This paper describes a new approach of classification
using genetic programming. The proposed technique consists of
genetically coevolving a population of non-linear transformations on
the input data to be classified, and map them to a new space with a
reduced dimension, in order to get a maximum inter-classes
discrimination. The classification of new samples is then performed
on the transformed data, and so become much easier. Contrary to the
existing GP-classification techniques, the proposed one use a
dynamic repartition of the transformed data in separated intervals, the
efficacy of a given intervals repartition is handled by the fitness
criterion, with a maximum classes discrimination. Experiments were
first performed using the Fisher-s Iris dataset, and then, the KDD-99
Cup dataset was used to study the intrusion detection and
classification problem. Obtained results demonstrate that the
proposed genetic approach outperform the existing GP-classification
methods [1],[2] and [3], and give a very accepted results compared to
other existing techniques proposed in [4],[5],[6],[7] and [8].
Abstract: On-line handwritten scripts are usually dealt with pen tip traces from pen-down to pen-up positions. Time evaluation of the pen coordinates is also considered along with trajectory information. However, the data obtained needs a lot of preprocessing including filtering, smoothing, slant removing and size normalization before recognition process. Instead of doing such lengthy preprocessing, this paper presents a simple approach to extract the useful character information. This work evaluates the use of the counter- propagation neural network (CPN) and presents feature extraction mechanism in full detail to work with on-line handwriting recognition. The obtained recognition rates were 60% to 94% using the CPN for different sets of character samples. This paper also describes a performance study in which a recognition mechanism with multiple thresholds is evaluated for counter-propagation architecture. The results indicate that the application of multiple thresholds has significant effect on recognition mechanism. The method is applicable for off-line character recognition as well. The technique is tested for upper-case English alphabets for a number of different styles from different peoples.
Abstract: Nowadays, manufacturers are facing great challenges
with regard to the production of green products due to the emerging issue of hazardous substance management (HSM). In particular,
environmental legislation pressures have yielded to increased risk,
manufacturing complexity and green components demands. The green principles were expanded to many departments within
organization, including supply chain. Green supply chain
management (GSCM) was emerging in the last few years. This idea
covers every stage in manufacturing from the first to the last stage of
life cycle. From product lifecycle concept, the cycle starts at the design of a product. QFD is a customer-driven product development
tool, considered as a structured management approach for efficiently
translating customer needs into design requirements and parts deployment, as well as manufacturing plans and controls in order to
achieve higher customer satisfaction. This paper develops an Eco-
QFD to provide a framework for designing Eco-mobile phone by integrating the life cycle analysis LCA into QFD throughout the entire product development process.
Abstract: In this article, LQR based PID controller design for
3DOF helicopter system is investigated. The 3-DOF helicopter
system is a benchmark laboratory model having strongly nonlinear
characteristics and unstable dynamics which make the control of such
system a challenging task. This article first presents the mathematical
model of the 3DOF helicopter system and then illustrates the basic
idea and technical formulation for controller design. The paper
explains the simple approach for the approximation of PID design
parameters from the LQR controller gain matrix. The simulation
results show that the investigated controller has both static and
dynamic performance, therefore the stability and the quick control
effect can be obtained simultaneously for the 3DOF helicopter
system.
Abstract: Nowadays predicting political risk level of country
has become a critical issue for investors who intend to achieve
accurate information concerning stability of the business
environments. Since, most of the times investors are layman and
nonprofessional IT personnel; this paper aims to propose a
framework named GECR in order to help nonexpert persons to
discover political risk stability across time based on the political
news and events.
To achieve this goal, the Bayesian Networks approach was
utilized for 186 political news of Pakistan as sample dataset.
Bayesian Networks as an artificial intelligence approach has been
employed in presented framework, since this is a powerful technique
that can be applied to model uncertain domains. The results showed
that our framework along with Bayesian Networks as decision
support tool, predicted the political risk level with a high degree of
accuracy.
Abstract: In this paper we introduce new data oriented modeling
of uniform random variable well-matched with computing systems. Due to this conformity with current computers structure, this modeling will be efficiently used in statistical inference.
Abstract: Facing the concern of the population to its environment and to climatic change, city planners are now considering the urban climate in their choices of planning. The urban climate, representing different urban morphologies across central Bangkok metropolitan area (BMA), are used to investigates the effects of both the composition and configuration of variables of urban morphology indicators on the summer diurnal range of urban climate, using correlation analyses and multiple linear regressions. Results show first indicate that approximately 92.6% of the variation in the average maximum daytime near-surface air temperature (Ta) was explained jointly by the two composition variables of urban morphology indicators including open space ratio (OSR) and floor area ratio (FAR). It has been possible to determine the membership of sample areas to the local climate zones (LCZs) using these urban morphology descriptors automatically computed with GIS and remote sensed data. Finally result found the temperature differences among zones of large separation, such as the city center could be respectively from 35.48±1.04ºC (Mean±S.D.) warmer than the outskirt of Bangkok on average for maximum daytime near surface temperature to 28.27±0.21ºC for extreme event and, can exceed as 8ºC. A spatially disaggregation of urban thermal responsiveness map would be helpful for several reasons. First, it would localize urban areas concerned by different climate behavior over summer daytime and be a good indicator of urban climate variability. Second, when overlaid with a land cover map, this map may contribute to identify possible urban management strategies to reduce heat wave effects in BMA.
Abstract: While in practice negotiation is always a mix of
cooperation and competition, these two elements correspond to
different approaches of the relationship and also different orientations
in term of strategy, techniques, tactics and arguments employed by
the negotiators with related effects and in the end leading to different
outcomes. The levels of honesty, trust and therefore cooperation are
influenced not only by the uncertainty of the situation, the objectives,
stakes or power but also by the orientation given from the very
beginning of the relationship. When negotiation is reduced to a
confrontation of power, participants rely on coercive measures, using
different kinds of threats or make false promises and bluff in order to
establish a more acceptable balance of power.
Most of the negotiators have a tendency to complain about the
unethical aspects of the tactics used by their counterparts while, as
the same time, they are mostly unaware of the sources of influence of
their own vision and practices. In this article, our intention is to
clarify these sources and try to understand what can lead negotiators
to unethical practices.
Abstract: The paper presents a multimodal approach for biometric authentication, based on multiple classifiers. The proposed solution uses a post-classification biometric fusion method in which the biometric data classifiers outputs are combined in order to improve the overall biometric system performance by decreasing the classification error rates. The paper shows also the biometric recognition task improvement by means of a carefully feature selection, as much as not all of the feature vectors components support the accuracy improvement.
Abstract: Generation system reliability assessment is an
important task which can be performed using deterministic or
probabilistic techniques. The probabilistic approaches have
significant advantages over the deterministic methods. However,
more complicated modeling is required by the probabilistic
approaches. Power generation model is a basic requirement for this
assessment. One form of the generation models is the well known
capacity outage probability table (COPT). Different analytical
techniques have been used to construct the COPT. These approaches
require considerable mathematical modeling of the generating units.
The unit-s models are combined to build the COPT which will add
more burdens on the process of creating the COPT. Decimal to
Binary Conversion (DBC) technique is widely and commonly applied
in electronic systems and computing This paper proposes a novel
utilization of the DBC to create the COPT without engaging in
analytical modeling or time consuming simulations. The simple
binary representation , “0 " and “1 " is used to model the states o f
generating units. The proposed technique is proven to be an effective
approach to build the generation model.
Abstract: Optimal routing in communication networks is a
major issue to be solved. In this paper, the application of Tabu Search
(TS) in the optimum routing problem where the aim is to minimize
the computational time and improvement of quality of the solution in
the communication have been addressed. The goal is to minimize the
average delays in the communication. The effectiveness of Tabu
Search method is shown by the results of simulation to solve the
shortest path problem. Through this approach computational cost can
be reduced.
Abstract: This study proposes novel hybrid social network analysis and collaborative filtering approach to enhance the performance of recommender systems. The proposed model selects subgroups of users in Internet community through social network analysis (SNA), and then performs clustering analysis using the information about subgroups. Finally, it makes recommendations using cluster-indexing CF based on the clustering results. This study tries to use the cores in subgroups as an initial seed for a conventional clustering algorithm. This model chooses five cores which have the highest value of degree centrality from SNA, and then performs clustering analysis by using the cores as initial centroids (cluster centers). Then, the model amplifies the impact of friends in social network in the process of cluster-indexing CF.
Abstract: To achieve reliable solutions, today-s numerical and
experimental activities need developing more accurate methods and
utilizing expensive facilities, respectfully in microchannels. The analytical
study can be considered as an alternative approach to alleviate
the preceding difficulties. Among the analytical solutions, those with
high robustness and low complexities are certainly more attractive.
The perturbation theory has been used by many researchers to analyze
microflows. In present work, a compressible microflow with constant
heat flux boundary condition is analyzed. The flow is assumed to be
fully developed and steady. The Mach and Reynolds numbers are also
assumed to be very small. For this case, the creeping phenomenon
may have some effect on the velocity profile. To achieve robustness
solution it is assumed that the flow is quasi-isothermal. In this study,
the creeping term which appears in the slip boundary condition
is formulated by different mathematical formulas. The difference
between this work and the previous ones is that the creeping term
is taken into account and presented in non-dimensionalized form.
The results obtained from perturbation theory are presented based
on four non-dimensionalized parameters including the Reynolds,
Mach, Prandtl and Brinkman numbers. The axial velocity, normal
velocity and pressure profiles are obtained. Solutions for velocities
and pressure for two cases with different Br numbers are compared
with each other and the results show that the effect of creeping
phenomenon on the velocity profile becomes more important when
Br number is less than O(ε).
Abstract: PPG is a potential tool in clinical applications. Among such, the relationship between respiration and PPG signal has attracted attention in past decades. In this research, a bivariate AR spectral estimation method was utilized for the coherence analysis between these two signals. Ten healthy subjects participated in this research with signals measured at different respiratory rates. The results demonstrate that high coherence exists between respiration and PPG signal, whereas the coherence disappears in breath-holding experiments. These results imply that PPG signal reveals the respiratory information. The utilized method may provide an attractive alternative approach for the related researches.