Abstract: This research paper designs a unique motion planner
of multiple platoons of nonholonomic car-like robots as a feasible
solution to the lane changing/merging maneuvers. The decentralized
planner with a leaderless approach and a path-guidance principle
derived from the Lyapunov-based control scheme generates collision
free avoidance and safe merging maneuvers from multiple lanes to a
single lane by deploying a split/merge strategy. The fixed obstacles
are the markings and boundaries of the road lanes, while the moving
obstacles are the robots themselves. Real and virtual road lane
markings and the boundaries of road lanes are incorporated into a
workspace to achieve the desired formation and configuration of the
robots. Convergence of the robots to goal configurations and the
repulsion of the robots from specified obstacles are achieved by
suitable attractive and repulsive potential field functions,
respectively. The results can be viewed as a significant contribution
to the avoidance algorithm of the intelligent vehicle systems (IVS).
Computer simulations highlight the effectiveness of the split/merge
strategy and the acceleration-based controllers.
Abstract: Transdermal delivery of ondansetron hydrochloride (OdHCl) can prevent the problems encountered with oral ondansetron. In previously conducted studies, effect of amount of polyvinyl pyrrolidone, permeation enhancer and casting solvent on the physicochemical properties on OdHCl were investigated. It is feasible to develop ondansetron transdermal patch by using ethyl cellulose and polyvinyl pyrrolidone with dibutyl pthalate as plasticizer, however, the desired flux is not achieved. The primary aim of this study is to use dimethyl succinate (DMS) and propylene glycol that are not incorporated in previous studies to determine their effect on the physicochemical properties of an OdHCl transdermal patch using ethyl cellulose and polyvinyl pyrrolidone. This study also investigates the effect of permeation enhancer (eugenol and phosphatidylcholine) on the release of OdHCl. The results showed that propylene glycol is a more suitable plasticizer compared to DMS in the fabrication of OdHCl transdermal patch using ethyl cellulose and polyvinyl pyrrolidone as polymers. Propylene glycol containing patch has optimum drug content, thickness, moisture content and water absorption, tensile strength, and a better release profile than DMS. Eugenol and phosphatidylcholine can increase release of OdHCl from the patches. From the physicochemical result and permeation profile, a combination of 350mg of ethyl cellulose, 150mg polyvinyl pyrrolidone, 3% of total polymer weight of eugenol, and 40% of total polymer weight of propylene glycol is the most suitable formulation to develop an OdHCl patch. OdHCl release did not increase with increasing the percentage of plasticiser. DMS 4, PG 4, DMS 9, PG 9, DMS 14, and PG 14 gave better release profiles where using 300mg: 0mg, 300mg: 100mg, and 350mg: 150mg of EC: PVP. Thus, 40% of PG or DMS appeared to be the optimum amount of plasticiser when the above combination where EC: PVP was used. It was concluded from the study that a patch formulation containing 350mg EC, 150mg PVP, 40% PG and 3% eugenol is the best transdermal matrix patch compositions for the uniform and continuous release/permeation of OdHCl over an extended period. This patch design can be used for further pharmacokinetic and pharmacodynamic studies in suitable animal models.
Abstract: In this paper, a comparative study of application of
supervised and unsupervised learning algorithms on illumination
invariant face recognition has been carried out. The supervised
learning has been carried out with the help of using a bi-layered
artificial neural network having one input, two hidden and one output
layer. The gradient descent with momentum and adaptive learning
rate back propagation learning algorithm has been used to implement
the supervised learning in a way that both the inputs and
corresponding outputs are provided at the time of training the
network, thus here is an inherent clustering and optimized learning of
weights which provide us with efficient results.. The unsupervised
learning has been implemented with the help of a modified
Counterpropagation network. The Counterpropagation network
involves the process of clustering followed by application of Outstar
rule to obtain the recognized face. The face recognition system has
been developed for recognizing faces which have varying
illumination intensities, where the database images vary in lighting
with respect to angle of illumination with horizontal and vertical
planes. The supervised and unsupervised learning algorithms have
been implemented and have been tested exhaustively, with and
without application of histogram equalization to get efficient results.
Abstract: Mutations of the telomeric copy of the survival motor neuron 1 (SMN1) gene cause spinal muscular atrophy. A deletion of the Eef1a2 gene leads to lower motor neuron degeneration in wasted mice. Indirect evidences have been shown that the eEF1A protein family may interact with SMN, and our previous study showed that abnormalities of neuromuscular junctions in wasted mice were similar to those of Smn mutant mice. To determine potential colocalization between SMN and tissue-specific translation elongation factor 1A2 (eEF1A2), an immunochemical analysis of HeLa cells transfected with the plasmid pcDNA3.1(+)C-hEEF1A2- myc and a new quantitative test of colocalization by intensity correlation analysis (ICA) was used to explore the association of SMN and eEF1A2. Here the results showed that eEF1A2 redistributed from the cytoplasm to the nucleus in response to serum and epidermal growth factor. In the cytoplasm, compelling evidence showed that staining for myc-tagged eEF1A2 varied in synchrony with that for SMN, consistent with the formation of a SMN-eEF1A2 complex in the cytoplasm of HeLa cells. These findings suggest that eEF1A2 may colocalize with SMN in the cytoplasm and may be a component of the SMN complex. However, the limitation of the ICA method is an inability to resolve colocalization in components of small organelles such as the nucleus.
Abstract: The main emphasis of metallurgists has been to process the materials to obtain the balanced mechanical properties for the given application. One of the processing routes to alter the properties is heat treatment. Nearly 90% of the structural applications are related to the medium carbon an alloyed steels and hence are regarded as structural steels. The major requirement in the conventional steel is to improve workability, toughness, hardness and grain refinement. In this view, it is proposed to study the mechanical and tribological properties of unalloyed structural (AISI 1140) steel with different thermal (heat) treatments like annealing, normalizing, tempering and hardening and compared with as brought (cold worked) specimen. All heat treatments are carried out in atmospheric condition. Hardening treatment improves hardness of the material, a marginal decrease in hardness value with improved ductility is observed in tempering. Annealing and normalizing improve ductility of the specimen. Normalized specimen shows ultimate ductility. Hardened specimen shows highest wear resistance in the initial period of slide wear where as above 25KM of sliding distance, as brought steel dominates the hardened specimen. Both mild and severe wear regions are observed. Microstructural analysis shows the existence of pearlitic structure in normalized specimen, lath martensitic structure in hardened, pearlitic, ferritic structure in annealed specimen.
Abstract: Despite extensive study on wireless sensor network
security, defending internal attacks and finding abnormal behaviour
of the sensor are still difficult and unsolved task. The conventional
cryptographic technique does not give the robust security or detection
process to save the network from internal attacker that cause by
abnormal behavior. The insider attacker or abnormally behaved
sensor identificationand location detection framework using false
massage detection and Time difference of Arrival (TDoA) is
presented in this paper. It has been shown that the new framework
can efficiently identify and detect the insider attacker location so that
the attacker can be reprogrammed or subside from the network to
save from internal attack.
Abstract: An investigation of noise in a micro stepping motor is
considered to study in this article. Because of the trend towards higher
precision and more and more small 3C (including Computer,
Communication and Consumer Electronics) products, the micro
stepping motor is frequently used to drive the micro system or the
other 3C products. Unfortunately, noise in a micro stepped motor is
too large to accept by the customs. To depress the noise of a micro
stepped motor, the dynamic characteristics in this system must be
studied. In this article, a Visual Basic (VB) computer program speed
controlled micro stepped motor in a digital camera is investigated.
Karman KD2300-2S non-contract eddy current displacement sensor,
probe microphone, and HP 35670A analyzer are employed to analyze
the dynamic characteristics of vibration and noise in a motor. The
vibration and noise measurement of different type of bearings and
different treatment of coils are compared. The rotating components,
bearings, coil, etc. of the motor play the important roles in producing
vibration and noise. It is found that the noise will be depressed about
3~4 dB and 6~7 dB, when substitutes the copper bearing with plastic
one and coats the motor coil with paraffin wax, respectively.
Abstract: In Indonesia, goat milk is often consumed and
believed as anti-allergy. The objective of this research was to study
the effect of goat milk and their fractions (casein and whey)
supplementation on total serum IgE concentrations and leukocytes
count in rat sensitized with contact allergen dinitrochlorobenzene
(DNCB). Female Wistar rats 6-8 weeks old were divided into four
groups: 1) whey, 2) casein, 3) whole milk supplementation and 4)
phosphate-buffered saline/PBS (control). The results showed that
supplementation of goat milk on rats did not affects on total serum
IgE concentrations and number of leukocytes. After sensitized with
DNCB, the monocyte percentage in rats was higher (P
Abstract: Increasing use of cell phone as a medium of human interaction is playing a vital role in solving riddles of crime as well. A young girl went missing from her home late in the evening in the month of August, 2008 when her enraged relatives and villagers physically assaulted and chased her fiancée who often frequented her home. Two years later, her mother lodged a complaint against the relatives and the villagers alleging that after abduction her daughter was either sold or killed as she had failed to trace her. On investigation, a rusted cell phone with partial visible IMEI number, clothes, bangles, human skeleton etc. recovered from abandoned well in the month of May, 2011 were examined in the lab. All hopes pinned on identity of cell phone, for only linking evidence to fix the scene of occurrence supported by call detail record (CDR) and to dispel doubts about mode of sudden disappearance or death as DNA technology did not help in establishing identity of the deceased. The conventional scientific methods were used without success and international mobile equipment identification number of the cell phone could be generated by using statistical analysis followed by online verification.
Abstract: This study evaluates the performance of horizontal
subsurface flow constructed wetland (HSSF-CW) for the removal of
chlorinated resin and fatty acids (RFAs) from pulp and paper mill
wastewater. The dimensions of the treatment system were 3.5 m x 1.5
m x 0.28 m with surface area of 5.25 m2, filled with fine sand and
gravel. The cell was planted with an ornamental plant species Canna
indica. The removal efficiency of chlorinated RFAs was in the range
of 92-96% at the hydraulic retention time (HRT) of 5.9 days. Plant
biomass and soil (sand and gravel) were analyzed for chlorinated
RFAs content. No chlorinated RFAs were detected in plant biomass
but detected in soil samples. Mass balance studies of chlorinated
RFAs in HSSF-CW were also carried out.
Abstract: Deep cold rolling (DCR) is a cold working process, which easily produces a smooth and work-hardened surface by plastic deformation of surface irregularities. In the present study, the influence of main deep cold rolling process parameters on the surface roughness and the hardness of AISI 4140 steel were studied by using fractional factorial design of experiments. The assessment of the surface integrity aspects on work material was done, in terms of identifying the predominant factor amongst the selected parameters, their order of significance and setting the levels of the factors for minimizing surface roughness and/or maximizing surface hardness. It was found that the ball diameter, rolling force, initial surface roughness and number of tool passes are the most pronounced parameters, which have great effects on the work piece-s surface during the deep cold rolling process. A simple, inexpensive and newly developed DCR tool, with interchangeable collet for using different ball diameters, was used throughout the experimental work presented in this paper.
Abstract: Bone material is treated as heterogeneous and hierarchical in nature therefore appropriate size of bone specimen is required to analyze its tensile properties at a particular hierarchical level. Tensile properties of cortical bone are important to investigate the effect of drug treatment, disease and aging as well as for development of computational and analytical models. In the present study tensile properties of buffalo as well as goat femoral and tibiae cortical bone are analyzed using sub-size tensile specimens. Femoral cortical bone was found to be stronger in tension as compared to the tibiae cortical bone and the tensile properties obtained using sub-size specimens show close resemblance with the tensile properties of full-size cortical specimens. A two dimensional finite element (FE) modal was also applied to simulate the tensile behavior of sub-size specimens. Good agreement between experimental and FE model was obtained for sub-size tensile specimens of cortical bone.
Abstract: In most study fields, a phenomenon may not be
studied directly but it will be examined indirectly by phenomenon
model. Making an accurate model of system, there is attained new
information from modeled phenomenon without any charge, danger,
etc... there have been developed more solutions for describing and
analyzing the recent complicated systems but few of them have
analyzed the performance in the range of system description. Petri
nets are of limited solutions which may make such union. Petri nets
are being applied in problems related to modeling and designing the
systems. Theory of Petri nets allow a system to model
mathematically by a Petri net and analyzing the Petri net can then
determine main information of modeled system-s structure and
dynamic. This information can be used for assessing the performance
of systems and suggesting corrections in the system. In this paper,
beside the introduction of Petri nets, a real case study will be studied
in order to show the application of generalized stochastic Petri nets in
modeling a resource sharing production system and evaluating the
efficiency of its machines and robots. The modeling tool used here is
SHARP software which calculates specific indicators helping to
make decision.
Abstract: The antioxidant compounds are needed for the food, beverages, and pharmaceuticals industry. For this purpose, an appropriate method is required to measure the antioxidant properties in various types of samples. Spectrophotometric method usually used has some weaknesses, including the high price, long sample preparation time, and less sensitivity. Among the alternative methods developed to overcome these weaknesses is antioxidant biosensor based on superoxide dismutase (SOD) enzyme. Therefore, this study was carried out to measure the SOD activity originating from Deinococcus radiodurans and to determine its kinetics properties. Carbon paste electrode modified with ferrocene and immobilized SOD exhibited anode and cathode current peak at potential of +400 and +300mv respectively, in both pure SOD and SOD of D. radiodurans. This indicated that the current generated was from superoxide catalytic dismutation reaction by SOD. Optimum conditions for SOD activity was at pH 9 and temperature of 27.50C for D. radiodurans SOD, and pH 11 and temperature of 200C for pure SOD. Dismutation reaction kinetics of superoxide catalyzed by SOD followed the Lineweaver-Burk kinetics with D. radiodurans SOD KMapp value was smaller than pure SOD. The result showed that D. radiodurans SOD had higher enzyme-substrate affinity and specificity than pure SOD. It concluded that D. radiodurans SOD had a great potential as biological recognition component for antioxidant biosensor.
Abstract: Acetaminophen (Paracetamol) tablets are popular OTC products among patients as analgesics and antipyretics. Paracetamol is marketed by a lot of suppliers around the world. The aim of the present investigation was to compare between many types of paracetamol tablets obtained from different suppliers (six brands produced by different pharmaceutical companies in middle east countries, and Panadol® manufactured in Ireland), by different quality control tests according to USP pharmacopeia.Using Non official tests-hardness and friability; official tests- disintegration, dissolution, and drug content. Additionally, evaluate the influence of temperatures 4°C, 25°C and 40°C at 75% relative humidity on the stability of the same brands in their original packaging has been conducted for two months. The results revealed that all paracetamol tablet brands complied with the official USP specifications. In conclusion, paracetamol tablets preferred to be stored at 25°C. All the tested brands being biopharmaceutically and chemically equivalent.
Abstract: Hypertension is characterized with stress on the heart and blood vessels thus increasing the risk of heart attack and renal diseases. The Renin angiotensin system (RAS) plays a major role in blood pressure control. Renin is the enzyme that controls the RAS at the rate-limiting step. Our aim is to develop new drug-like leads which can inhibit renin and thereby emerge as therapeutics for hypertension. To achieve this, molecular dynamics (MD) simulation and receptor-based pharmacophore modeling were implemented, and three rennin-inhibitor complex structures were selected based on IC50 value and scaffolds of inhibitors. Three pharmacophore models were generated considering conformations induced by inhibitor. The compounds mapped to these models were selected and subjected to drug-like screening. The identified hits were docked into the active site of renin. Finally, hit1 satisfying the binding mode and interaction energy was selected as possible lead candidate to be used in novel renin inhibitors.
Abstract: Signature represents an individual characteristic of a
person which can be used for his / her validation. For such application
proper modeling is essential. Here we propose an offline signature
recognition and verification scheme which is based on extraction of
several features including one hybrid set from the input signature
and compare them with the already trained forms. Feature points
are classified using statistical parameters like mean and variance.
The scanned signature is normalized in slant using a very simple
algorithm with an intention to make the system robust which is
found to be very helpful. The slant correction is further aided by the
use of an Artificial Neural Network (ANN). The suggested scheme
discriminates between originals and forged signatures from simple
and random forgeries. The primary objective is to reduce the two
crucial parameters-False Acceptance Rate (FAR) and False Rejection
Rate (FRR) with lesser training time with an intension to make the
system dynamic using a cluster of ANNs forming a multiple classifier
system.
Abstract: One promising way to achieve low temperature
combustion regime is the use of a large amount of cooled EGR. In
this paper, the effect of injection timing on low temperature
combustion process and emissions were investigated via three
dimensional computational fluid dynamics (CFD) procedures in a DI
diesel engine using high EGR rates. The results show when
increasing EGR from low levels to levels corresponding to reduced
temperature combustion, soot emission after first increasing, is
decreased beyond 40% EGR and get the lowest value at 58% EGR
rate. Soot and NOx emissions are simultaneously decreased at
advanced injection timing before 20.5 ºCA BTDC in conjunction
with 58% cooled EGR rate in compared to baseline case.
Abstract: Self-organizing map (SOM) is a well known data reduction technique used in data mining. Data visualization can reveal structure in data sets that is otherwise hard to detect from raw data alone. However, interpretation through visual inspection is prone to errors and can be very tedious. There are several techniques for the automatic detection of clusters of code vectors found by SOMs, but they generally do not take into account the distribution of code vectors; this may lead to unsatisfactory clustering and poor definition of cluster boundaries, particularly where the density of data points is low. In this paper, we propose the use of a generic particle swarm optimization (PSO) algorithm for finding cluster boundaries directly from the code vectors obtained from SOMs. The application of our method to unlabeled call data for a mobile phone operator demonstrates its feasibility. PSO algorithm utilizes U-matrix of SOMs to determine cluster boundaries; the results of this novel automatic method correspond well to boundary detection through visual inspection of code vectors and k-means algorithm.
Abstract: Developments in communication technologies
especially in wireless have enabled the progress of low-cost and lowpower
wireless sensor networks (WSNs). The features of such WSN
are holding minimal energy, weak computational capabilities,
wireless communication and an open-medium nature where sensors
are deployed. WSN is underpinned by application driven such as
military applications, the health sector, etc. Due to the intrinsic nature
of the network and application scenario, WSNs are vulnerable to
many attacks externally and internally. In this paper we have focused
on the types of internal attacks of WSNs based on OSI model and
discussed some security requirements, characterizers and challenges
of WSNs, by which to contribute to the WSN-s security research.